Goserelin (acetate)_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Goserelin (acetate) perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Goserelin (acetate)_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.16534
TLE4 transducin-like enhancer of split 4 0.133656
VCL vinculin 0.130157
FMN1 formin 1 0.0902381
RPS6 ribosomal protein S6 0.0839492
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0808782
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0702737
ZSWIM6 zinc finger, SWIM-type containing 6 0.0672367
B2M beta-2-microglobulin 0.0666023
VMP1 vacuole membrane protein 1 0.0661978
RPS3 ribosomal protein S3 0.0608165
LPIN1 lipin 1 0.0557273
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0548287
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0530506
RIGI RNA sensor RIG-I 0.0528874
DST dystonin 0.0470023
PLAT plasminogen activator, tissue 0.0467754
PTPRK protein tyrosine phosphatase, receptor type, K 0.0463088
ACTG1 actin gamma 1 0.0458794
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.044512
CTSB cathepsin B 0.0433518
RPL35A ribosomal protein L35a 0.0432982
RPL26 ribosomal protein L26 0.0423065
RNF213 ring finger protein 213 0.0419635
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0409412
MYH9 myosin, heavy chain 9, non-muscle 0.0407318
PTMA prothymosin, alpha 0.0401735
NPAS2 neuronal PAS domain protein 2 0.0398779
RPL23 ribosomal protein L23 0.0394308
RAD51B RAD51 paralog B 0.0394305
ANTXR1 anthrax toxin receptor 1 0.0394223
TPT1 tumor protein, translationally-controlled 1 0.0386837
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.03801
ASPH aspartate beta-hydroxylase 0.0380073
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0375055
RPL34 ribosomal protein L34 0.0374022
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.036269
SP100 SP100 nuclear antigen 0.0360019
RPS12 ribosomal protein S12 0.0346936
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0338544
PLPP1 phospholipid phosphatase 1 0.0335594
RPL37A ribosomal protein L37a 0.0335306
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0333088
RPS8 ribosomal protein S8 0.0329984
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0329656
PCBP3 poly(rC) binding protein 3 0.0329614
KTN1 kinectin 1 (kinesin receptor) 0.0322469
RPL19 ribosomal protein L19 0.0318254
PCBP2 poly(rC) binding protein 2 0.0314232
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0310703
GOLGB1 golgin B1 0.0309653
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0307114
RBM39 RNA binding motif protein 39 0.0306833
TPR translocated promoter region, nuclear basket protein 0.030577
SLIT2 slit homolog 2 (Drosophila) 0.0305019
NALF1 NALCN channel auxiliary factor 1 0.0304617
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0299736
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.0299673
STK38L serine/threonine kinase 38 like 0.0299136
NAP1L1 nucleosome assembly protein 1-like 1 0.0298527
RABGAP1L RAB GTPase activating protein 1-like 0.0297778
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0297713
MYO6 myosin VI 0.0296994
APLP2 amyloid beta (A4) precursor-like protein 2 0.0296625
MACF1 microtubule-actin crosslinking factor 1 0.0294924
BRD2 bromodomain containing 2 0.0294187
CENPF centromere protein F, 350/400kDa 0.0293687
RPS27A ribosomal protein S27a 0.0292884
ATXN1 ataxin 1 0.0292853
FERMT2 fermitin family member 2 0.0291991
HSPA8 heat shock 70kDa protein 8 0.029139
MYO1E myosin IE 0.0290066
CTNND1 catenin (cadherin-associated protein), delta 1 0.0289871
CSNK1A1 casein kinase 1, alpha 1 0.0282396
MX2 MX dynamin-like GTPase 2 0.0279077
RACK1 receptor for activated C kinase 1 0.0278551
FNBP1 formin binding protein 1 0.0275451
NFE2L1 nuclear factor, erythroid 2-like 1 0.0274851
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0274532
EXT1 exostosin glycosyltransferase 1 0.0274531
RPS2 ribosomal protein S2 0.0272948
PTPRD protein tyrosine phosphatase, receptor type, D 0.0271209
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0268363
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0265688
ZMIZ1 zinc finger, MIZ-type containing 1 0.0265132
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0264492
TRIO trio Rho guanine nucleotide exchange factor 0.0263038
RPL5 ribosomal protein L5 0.0262393
KDM4C lysine (K)-specific demethylase 4C 0.0261361
RPL36 ribosomal protein L36 0.0261015
TIMP3 TIMP metallopeptidase inhibitor 3 0.0260152
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0258293
RPS19 ribosomal protein S19 0.02576
RPS21 ribosomal protein S21 0.0257418
RPL11 ribosomal protein L11 0.0253727
PEAK1 pseudopodium-enriched atypical kinase 1 0.0252177
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0250507
SENP6 SUMO1/sentrin specific peptidase 6 0.0247597
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0247517
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0247471

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.331347
NRG1 neuregulin 1 -0.157465
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.154434
MEIS2 Meis homeobox 2 -0.0611891
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0502151
CADM2 cell adhesion molecule 2 -0.044027
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0428751
SYT1 synaptotagmin I -0.0425234
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0380934
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0358642
MSI2 musashi RNA-binding protein 2 -0.0335565
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0318765
MAP1B microtubule-associated protein 1B -0.0310472
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0303302
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0289604
GNAS GNAS complex locus -0.0278172
CD36 CD36 molecule (thrombospondin receptor) -0.027792
ATXN10 ataxin 10 -0.0275353
NREP neuronal regeneration related protein -0.0274279
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0271037
SEC31A SEC31 homolog A (S. cerevisiae) -0.0268388
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.0262927
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0258348
SREBF2 sterol regulatory element binding transcription factor 2 -0.0252918
NBEA neurobeachin -0.0244631
KPNB1 karyopherin (importin) beta 1 -0.0243686
EDEM3 ER degradation enhancer, mannosidase alpha-like 3 -0.0239236
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0236029
TENT5A terminal nucleotidyltransferase 5A -0.0229508
USP3 ubiquitin specific peptidase 3 -0.0229118
COL4A5 collagen, type IV, alpha 5 -0.0228518
PDZRN3 PDZ domain containing ring finger 3 -0.0228122
FKBP1A FK506 binding protein 1A, 12kDa -0.0224917
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0224875
COL4A6 collagen, type IV, alpha 6 -0.0224216
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0221609
RPS24 ribosomal protein S24 -0.022151
GPC6 glypican 6 -0.0220994
CDON cell adhesion associated, oncogene regulated -0.0219613
ZNF124 zinc finger protein 124 -0.021375
SAMD5 sterile alpha motif domain containing 5 -0.0212151
ADAMTS19 ADAM metallopeptidase with thrombospondin type 1 motif, 19 -0.0211753
USP34 ubiquitin specific peptidase 34 -0.0210258
MBD5 methyl-CpG binding domain protein 5 -0.0209849
AHR aryl hydrocarbon receptor -0.0208762
TCERG1 transcription elongation regulator 1 -0.0205767
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0205289
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 -0.0200709
DTNA dystrobrevin, alpha -0.0196784
RPTOR regulatory associated protein of MTOR, complex 1 -0.0193968
FNBP4 formin binding protein 4 -0.0185425
KCNIP4 Kv channel interacting protein 4 -0.018387
CDC27 cell division cycle 27 -0.0179893
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.017907
SOS1 son of sevenless homolog 1 (Drosophila) -0.0178724
DLC1 DLC1 Rho GTPase activating protein -0.0178178
ACBD3 acyl-CoA binding domain containing 3 -0.0178113
IARS1 isoleucyl-tRNA synthetase 1 -0.0177864
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.0176675
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0172315
SETD5 SET domain containing 5 -0.0171578
SEPTIN2 septin 2 -0.0170583
PCDH9 protocadherin 9 -0.0170349
CARD16 caspase recruitment domain family, member 16 -0.0170086
XPR1 xenotropic and polytropic retrovirus receptor 1 -0.0168939
ADGRL3 adhesion G protein-coupled receptor L3 -0.0168084
SSBP2 single-stranded DNA binding protein 2 -0.0167664
PHKB phosphorylase kinase, beta -0.0167618
PIBF1 progesterone immunomodulatory binding factor 1 -0.0167162
RFX7 regulatory factor X, 7 -0.0166341
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0164166
NUP160 nucleoporin 160kDa -0.0163998
CSMD3 CUB and Sushi multiple domains 3 -0.0163507
TMEM123 transmembrane protein 123 -0.0163292
WDR45B WD repeat domain 45B -0.0163109
MYLK myosin light chain kinase -0.0161471
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.016
EVL Enah/Vasp-like -0.0158826
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0158604
HMGA1 high mobility group AT-hook 1 -0.0158038
SSH2 slingshot protein phosphatase 2 -0.0157483
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0156845
EYA4 EYA transcriptional coactivator and phosphatase 4 -0.0156256
PPP1R15B protein phosphatase 1, regulatory subunit 15B -0.0156207
DISP1 dispatched homolog 1 (Drosophila) -0.0155148
UNC5C unc-5 homolog C (C. elegans) -0.015497
ATRNL1 attractin-like 1 -0.0153517
ACACA acetyl-CoA carboxylase alpha -0.0153348
NUP58 nucleoporin 58 -0.0152797
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.0152086
TET2 tet methylcytosine dioxygenase 2 -0.0151546
KIF26B kinesin family member 26B -0.0151067
SCFD2 sec1 family domain containing 2 -0.0149912
GAS7 growth arrest-specific 7 -0.0149906
SEC24D SEC24 family member D -0.0149058
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0147564
KIF26A kinesin family member 26A -0.014573
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0143816
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0143018
SH3PXD2B SH3 and PX domains 2B -0.0141817