Goserelin (acetate)_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Goserelin (acetate) perturbation in H4 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Goserelin (acetate)_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.143733
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.135456
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.100756
DGKD diacylglycerol kinase, delta 130kDa 0.0871077
FNDC3B fibronectin type III domain containing 3B 0.0824812
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0764212
MT2A metallothionein 2A 0.0653138
CANX calnexin 0.0648027
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0638437
ERRFI1 ERBB receptor feedback inhibitor 1 0.0627534
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0624063
STC1 stanniocalcin 1 0.0607281
MYH9 myosin, heavy chain 9, non-muscle 0.0603126
AHNAK AHNAK nucleoprotein 0.0586333
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.055852
ELL2 elongation factor, RNA polymerase II, 2 0.0544194
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0539704
GOLGB1 golgin B1 0.0513774
PRELID2 PRELI domain containing 2 0.0510736
GRAMD1B GRAM domain containing 1B 0.0485965
COL6A3 collagen, type VI, alpha 3 0.0477026
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0472076
KYNU kynureninase 0.0436339
WWTR1 WW domain containing transcription regulator 1 0.042701
SMAD3 SMAD family member 3 0.0416841
FAM13A family with sequence similarity 13, member A 0.0413516
NDRG1 N-myc downstream regulated 1 0.0400681
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0384579
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0372347
PDIA4 protein disulfide isomerase family A, member 4 0.0369831
HSPA8 heat shock 70kDa protein 8 0.0350706
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0349104
ASPH aspartate beta-hydroxylase 0.0333638
VMP1 vacuole membrane protein 1 0.032984
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0329172
BACE2 beta-site APP-cleaving enzyme 2 0.0329003
DOCK5 dedicator of cytokinesis 5 0.0328731
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0313898
TMED9 transmembrane emp24 protein transport domain containing 9 0.0313632
COL5A1 collagen, type V, alpha 1 0.0312976
HYOU1 hypoxia up-regulated 1 0.0309777
ZNF395 zinc finger protein 395 0.0304357
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0300527
ANKRD28 ankyrin repeat domain 28 0.0299219
ANO6 anoctamin 6 0.0298622
NFE2L1 nuclear factor, erythroid 2-like 1 0.0295054
ZNF292 zinc finger protein 292 0.0289027
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0285304
INHBA inhibin, beta A 0.0279625
MT1X metallothionein 1X 0.0275958
CENPF centromere protein F, 350/400kDa 0.0273917
YEATS2 YEATS domain containing 2 0.0271385
BRD2 bromodomain containing 2 0.0270487
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0269828
MKI67 marker of proliferation Ki-67 0.0269141
HDLBP high density lipoprotein binding protein 0.0268217
ZBTB38 zinc finger and BTB domain containing 38 0.0263151
HELZ helicase with zinc finger 0.0260424
FNIP1 folliculin interacting protein 1 0.0260206
EHBP1L1 EH domain binding protein 1-like 1 0.0259342
SEPTIN9 septin 9 0.0254305
PRKCSH protein kinase C substrate 80K-H 0.0248758
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.0244647
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0244101
TIMP3 TIMP metallopeptidase inhibitor 3 0.0241131
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0240207
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0239551
CD44 CD44 molecule (Indian blood group) 0.0238834
ATP13A3 ATPase type 13A3 0.0236452
SERINC1 serine incorporator 1 0.0234992
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0234348
RASA2 RAS p21 protein activator 2 0.0233013
DNMBP dynamin binding protein 0.023301
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0230451
FLNB filamin B, beta 0.0230055
ZNF146 zinc finger protein 146 0.0228363
MIB1 mindbomb E3 ubiquitin protein ligase 1 0.0227154
SAMD4A sterile alpha motif domain containing 4A 0.0226097
CLTC clathrin, heavy chain (Hc) 0.0225673
GYS1 glycogen synthase 1 (muscle) 0.0225454
BRD4 bromodomain containing 4 0.0224241
SFTPA2 surfactant protein A2 0.02214
EIF4A2 eukaryotic translation initiation factor 4A2 0.0220715
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0218066
HIPK2 homeodomain interacting protein kinase 2 0.0216398
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0214798
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0214307
TMEM39A transmembrane protein 39A 0.0213946
MACF1 microtubule-actin crosslinking factor 1 0.0213235
EIF4B eukaryotic translation initiation factor 4B 0.0211892
PCBP3 poly(rC) binding protein 3 0.0211066
FAM219A family with sequence similarity 219, member A 0.0210235
RPS2 ribosomal protein S2 0.0208785
YBX3 Y box binding protein 3 0.020819
PHF3 PHD finger protein 3 0.0207523
NIPBL Nipped-B homolog (Drosophila) 0.0206583
PPIA peptidylprolyl isomerase A (cyclophilin A) 0.0206346
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0205069
BHLHE40 basic helix-loop-helix family, member e40 0.0204737
APLP2 amyloid beta (A4) precursor-like protein 2 0.0203141

decreased expression

Symbol Name Standardized Value
NALF1 NALCN channel auxiliary factor 1 -0.229993
IGFBP3 insulin-like growth factor binding protein 3 -0.216784
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.159363
FN1 fibronectin 1 -0.127164
GRB10 growth factor receptor-bound protein 10 -0.126485
PDE4D phosphodiesterase 4D, cAMP-specific -0.0971677
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0933144
VIM vimentin -0.0892782
TMSB10 thymosin beta 10 -0.0844442
TPM4 tropomyosin 4 -0.0749153
IGF2 insulin-like growth factor 2 -0.0616089
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0600555
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0598353
PSD3 pleckstrin and Sec7 domain containing 3 -0.0549805
EXT1 exostosin glycosyltransferase 1 -0.0534864
ZBTB20 zinc finger and BTB domain containing 20 -0.053231
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0530117
NLGN1 neuroligin 1 -0.0525495
SOX5 SRY (sex determining region Y)-box 5 -0.0515455
VCL vinculin -0.0514049
AUTS2 autism susceptibility candidate 2 -0.0491106
POTEF POTE ankyrin domain family, member F -0.0490154
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0471761
SPAG9 sperm associated antigen 9 -0.0452416
SDK1 sidekick cell adhesion molecule 1 -0.0449787
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0447022
PTPRG protein tyrosine phosphatase, receptor type, G -0.0443629
TENM3 teneurin transmembrane protein 3 -0.0431197
HLA-A major histocompatibility complex, class I, A -0.0425263
PKM pyruvate kinase, muscle -0.0423883
SYT1 synaptotagmin I -0.0409146
SBF2 SET binding factor 2 -0.0405369
NAV3 neuron navigator 3 -0.0401739
CCND1 cyclin D1 -0.0396839
TGFBI transforming growth factor, beta-induced, 68kDa -0.0380718
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0377847
EGR1 early growth response 1 -0.036803
ARHGAP24 Rho GTPase activating protein 24 -0.0367832
COL5A2 collagen, type V, alpha 2 -0.0363349
CADM1 cell adhesion molecule 1 -0.0362214
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0360885
IGFBP5 insulin-like growth factor binding protein 5 -0.0359268
PTK2 protein tyrosine kinase 2 -0.0357626
RIGI RNA sensor RIG-I -0.0355615
HLA-B major histocompatibility complex, class I, B -0.0354082
TNS3 tensin 3 -0.0352371
LPP LIM domain containing preferred translocation partner in lipoma -0.0352007
PRR16 proline rich 16 -0.0349066
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0343069
CDH12 cadherin 12, type 2 (N-cadherin 2) -0.0341301
PDIA3 protein disulfide isomerase family A, member 3 -0.0338348
ZNF804A zinc finger protein 804A -0.0334923
ANKRD11 ankyrin repeat domain 11 -0.0334271
VDAC1 voltage-dependent anion channel 1 -0.0333749
NAV1 neuron navigator 1 -0.0331206
LYPD6B LY6/PLAUR domain containing 6B -0.0328443
DPYD dihydropyrimidine dehydrogenase -0.0323708
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0313209
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0313008
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.0312005
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0311663
IL7R interleukin 7 receptor -0.0311651
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0310302
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.0309593
WARS1 tryptophanyl-tRNA synthetase 1 -0.0309384
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.030748
PTPRK protein tyrosine phosphatase, receptor type, K -0.030712
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0306112
PLCB4 phospholipase C, beta 4 -0.0305285
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0299568
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0295116
CDK14 cyclin-dependent kinase 14 -0.028774
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0285751
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0283862
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0279939
PRSS23 protease, serine, 23 -0.0278776
RTN4 reticulon 4 -0.0271764
DMD dystrophin -0.0268878
CALD1 caldesmon 1 -0.0268698
TNNC1 troponin C type 1 (slow) -0.0265867
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0262837
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0261879
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0261525
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0260848
CLMP CXADR-like membrane protein -0.0253618
JAZF1 JAZF zinc finger 1 -0.0251783
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0251482
STK17A serine/threonine kinase 17a -0.0251228
HS6ST3 heparan sulfate 6-O-sulfotransferase 3 -0.0249956
FAF1 Fas (TNFRSF6) associated factor 1 -0.0248604
USP34 ubiquitin specific peptidase 34 -0.0248139
DENND1A DENN/MADD domain containing 1A -0.0243692
TCF12 transcription factor 12 -0.0239129
MRC2 mannose receptor, C type 2 -0.0237314
OASL 2'-5'-oligoadenylate synthetase-like -0.023731
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 -0.0234184
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0233751
HMGA1 high mobility group AT-hook 1 -0.0230768
CKAP4 cytoskeleton-associated protein 4 -0.022975
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0227606