Goserelin (acetate)_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Goserelin (acetate) perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Goserelin (acetate)_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ONECUT3 one cut homeobox 3 0.114908
RPS6 ribosomal protein S6 0.10744
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0980153
PTMA prothymosin, alpha 0.0807185
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0717194
TMSB10 thymosin beta 10 0.0689661
RPS3 ribosomal protein S3 0.0590725
RPL35A ribosomal protein L35a 0.0583164
RPS8 ribosomal protein S8 0.0568496
RPS21 ribosomal protein S21 0.0517046
LOC102724023 ES1 protein homolog, mitochondrial 0.0507085
RPS19 ribosomal protein S19 0.0506482
RPS12 ribosomal protein S12 0.0491956
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0489213
MT2A metallothionein 2A 0.0468942
RPS2 ribosomal protein S2 0.0442364
H1-0 H1.0 linker histone 0.0435798
RPL26 ribosomal protein L26 0.0429634
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0428624
LMO7 LIM domain 7 0.0421958
AREG amphiregulin 0.0404128
HSPA8 heat shock 70kDa protein 8 0.0389
BRD2 bromodomain containing 2 0.0381402
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0357682
SMAD2 SMAD family member 2 0.0355363
PLAUR plasminogen activator, urokinase receptor 0.034501
RPL36 ribosomal protein L36 0.0344885
KLF6 Kruppel-like factor 6 0.0336296
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.033533
KRT19 keratin 19, type I 0.0333701
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0329332
RNF145 ring finger protein 145 0.032871
PFN1 profilin 1 0.0326089
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0318329
MACF1 microtubule-actin crosslinking factor 1 0.0316742
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0308733
RPL37A ribosomal protein L37a 0.0302946
MAP4 microtubule-associated protein 4 0.0302823
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0298234
FAT1 FAT atypical cadherin 1 0.0297864
RPL9 ribosomal protein L9 0.0293475
EIF5B eukaryotic translation initiation factor 5B 0.0292266
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0291751
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0287673
SOX4 SRY (sex determining region Y)-box 4 0.0287258
MYH9 myosin, heavy chain 9, non-muscle 0.0279362
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0279318
RPL18 ribosomal protein L18 0.0276987
RPL34 ribosomal protein L34 0.0275928
TFF1 trefoil factor 1 0.0272923
RIGI RNA sensor RIG-I 0.0268916
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 0.0268164
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0266442
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.026256
KRT18 keratin 18, type I 0.0261288
EXT1 exostosin glycosyltransferase 1 0.0260802
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0258133
H1-4 H1.4 linker histone, cluster member 0.0250106
CENPF centromere protein F, 350/400kDa 0.0249288
CD47 CD47 molecule 0.0249077
RPLP2 ribosomal protein, large, P2 0.0248888
GOLGB1 golgin B1 0.0246065
VEGFA vascular endothelial growth factor A 0.0246055
MYO1E myosin IE 0.0245977
TMED9 transmembrane emp24 protein transport domain containing 9 0.0244853
DUSP4 dual specificity phosphatase 4 0.0244255
TUBB4B tubulin, beta 4B class IVb 0.0243503
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0240334
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0239848
PLS1 plastin 1 0.0236162
HYOU1 hypoxia up-regulated 1 0.0235433
KLF5 Kruppel-like factor 5 (intestinal) 0.0230667
RPL32 ribosomal protein L32 0.0228977
POTEF POTE ankyrin domain family, member F 0.0222783
ACTG1 actin gamma 1 0.0222202
FTL ferritin, light polypeptide 0.0221708
SRP9 signal recognition particle 9kDa 0.021987
ZFP36L1 ZFP36 ring finger protein-like 1 0.0219727
PDE10A phosphodiesterase 10A 0.0219087
TFF3 trefoil factor 3 (intestinal) 0.0217367
TPT1 tumor protein, translationally-controlled 1 0.0217112
NFXL1 nuclear transcription factor, X-box binding-like 1 0.0214289
EGFR epidermal growth factor receptor 0.0208478
GOLGA4 golgin A4 0.0207611
TPI1 triosephosphate isomerase 1 0.0204346
KTN1 kinectin 1 (kinesin receptor) 0.0199083
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0197878
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 0.0197431
GAK cyclin G associated kinase 0.0197379
RPL12 ribosomal protein L12 0.0195905
FBXO11 F-box protein 11 0.0193483
PABPN1 poly(A) binding protein, nuclear 1 0.0192561
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0192543
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0190886
DUSP16 dual specificity phosphatase 16 0.0190369
SON SON DNA binding protein 0.0189803
GSTP1 glutathione S-transferase pi 1 0.0188814
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0187932
PGM3 phosphoglucomutase 3 0.0184631
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0183839

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.10558
EZR ezrin -0.105103
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.103664
EEF2 eukaryotic translation elongation factor 2 -0.0915422
ITGA6 integrin, alpha 6 -0.0821842
FLNB filamin B, beta -0.0819944
ANXA2 annexin A2 -0.0798599
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0791242
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0747512
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0715472
CEMIP cell migration inducing protein, hyaluronan binding -0.068946
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0629247
PIGR polymeric immunoglobulin receptor -0.0600148
FAM13A family with sequence similarity 13, member A -0.0597184
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0596526
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.059296
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0589364
GPHN gephyrin -0.0588405
EMP1 epithelial membrane protein 1 -0.0567859
PKM pyruvate kinase, muscle -0.0558474
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0554752
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0536784
NALF1 NALCN channel auxiliary factor 1 -0.0534455
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -0.0527779
SHROOM3 shroom family member 3 -0.0502321
UBC ubiquitin C -0.0499784
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.049858
DIAPH2 diaphanous-related formin 2 -0.0478738
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0475924
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.046269
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.045351
MED13L mediator complex subunit 13-like -0.0437212
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0435391
ANXA1 annexin A1 -0.0430874
KDM4C lysine (K)-specific demethylase 4C -0.0427341
PTPRB protein tyrosine phosphatase, receptor type, B -0.0422616
FTH1 ferritin, heavy polypeptide 1 -0.0421873
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0419182
ERBIN erbb2 interacting protein -0.0417103
ANKRD17 ankyrin repeat domain 17 -0.0415373
FNBP1L formin binding protein 1-like -0.0414072
AFF1 AF4/FMR2 family, member 1 -0.0414001
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0410712
ESYT2 extended synaptotagmin-like protein 2 -0.0406577
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 -0.0401573
PCBP2 poly(rC) binding protein 2 -0.0399222
TBC1D5 TBC1 domain family, member 5 -0.0395999
NFIA nuclear factor I/A -0.0393355
AHNAK AHNAK nucleoprotein -0.0392463
PPARG peroxisome proliferator-activated receptor gamma -0.0391301
ZNF292 zinc finger protein 292 -0.0383279
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0380941
GREB1L growth regulation by estrogen in breast cancer-like -0.03719
MBNL2 muscleblind-like splicing regulator 2 -0.0370331
TRIM2 tripartite motif containing 2 -0.0367451
MBNL1 muscleblind-like splicing regulator 1 -0.036642
USP34 ubiquitin specific peptidase 34 -0.0364406
MUC17 mucin 17, cell surface associated -0.036297
EREG epiregulin -0.0357782
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.0349787
IGF1R insulin-like growth factor 1 receptor -0.0343415
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0334931
DENND1A DENN/MADD domain containing 1A -0.0328923
ZNF638 zinc finger protein 638 -0.0326208
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 -0.0326203
PTPRK protein tyrosine phosphatase, receptor type, K -0.0325112
ATXN1 ataxin 1 -0.0324642
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0323689
EPCAM epithelial cell adhesion molecule -0.0322048
COBL cordon-bleu WH2 repeat protein -0.0320888
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0318624
CAMK2D calcium/calmodulin-dependent protein kinase II delta -0.0318305
ZMYM2 zinc finger, MYM-type 2 -0.0316031
SLC35F3 solute carrier family 35, member F3 -0.031422
RPLP1 ribosomal protein, large, P1 -0.0314107
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0313117
SBF2 SET binding factor 2 -0.0311472
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0310817
NF1 neurofibromin 1 -0.0310609
INSIG1 insulin induced gene 1 -0.030856
WDR45B WD repeat domain 45B -0.0305725
CCSER1 coiled-coil serine-rich protein 1 -0.0304005
RPS27A ribosomal protein S27a -0.0302393
MUC6 mucin 6, oligomeric mucus/gel-forming -0.0300817
SREBF2 sterol regulatory element binding transcription factor 2 -0.0299922
MAML2 mastermind-like 2 (Drosophila) -0.0298676
BIRC6 baculoviral IAP repeat containing 6 -0.0298382
ETV6 ets variant 6 -0.0295347
FHL2 four and a half LIM domains 2 -0.0294459
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0293947
ZBTB20 zinc finger and BTB domain containing 20 -0.0293286
EFNB2 ephrin-B2 -0.0292101
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0287997
RIN2 Ras and Rab interactor 2 -0.0285242
PKP4 plakophilin 4 -0.0284708
GCC2 GRIP and coiled-coil domain containing 2 -0.0279729
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0278591
TMEM123 transmembrane protein 123 -0.0278033
AGR2 anterior gradient 2 -0.0277098
RTN4 reticulon 4 -0.0276611