Goserelin (acetate)_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Goserelin (acetate) perturbation in LoVo cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Goserelin (acetate)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS6 ribosomal protein S6 0.0987884
EZR ezrin 0.0933786
DSPP dentin sialophosphoprotein 0.0866113
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0847016
HSPA8 heat shock 70kDa protein 8 0.0841076
RPS12 ribosomal protein S12 0.0798384
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0766231
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0765006
RPS3 ribosomal protein S3 0.0740449
ZSWIM6 zinc finger, SWIM-type containing 6 0.0735755
ITPRID2 ITPR interacting domain containing 2 0.071835
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0716856
FAT1 FAT atypical cadherin 1 0.070631
ASPH aspartate beta-hydroxylase 0.0632927
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0626509
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0588717
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0559006
KTN1 kinectin 1 (kinesin receptor) 0.0551717
RIMKLB ribosomal modification protein rimK-like family member B 0.0524081
OXSR1 oxidative stress responsive 1 0.0523698
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0498528
LMO7 LIM domain 7 0.0498255
EIF4A2 eukaryotic translation initiation factor 4A2 0.0489633
BRD2 bromodomain containing 2 0.0486304
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0483275
RPS17 ribosomal protein S17 0.0479289
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0461828
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0458588
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0453034
MYH9 myosin, heavy chain 9, non-muscle 0.0433175
RPS2 ribosomal protein S2 0.0429071
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0421221
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0419828
RACK1 receptor for activated C kinase 1 0.0416713
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.041614
SLC38A2 solute carrier family 38, member 2 0.0414896
RPL14 ribosomal protein L14 0.0411765
GOLGA4 golgin A4 0.0411288
APLP2 amyloid beta (A4) precursor-like protein 2 0.0409809
RPS8 ribosomal protein S8 0.0404152
LDHA lactate dehydrogenase A 0.0399564
EEF1G eukaryotic translation elongation factor 1 gamma 0.0393453
LOC102724023 ES1 protein homolog, mitochondrial 0.0392286
TJP1 tight junction protein 1 0.0391257
VMP1 vacuole membrane protein 1 0.0390332
EMP1 epithelial membrane protein 1 0.0389928
PCBP2 poly(rC) binding protein 2 0.0387994
PARD3B par-3 family cell polarity regulator beta 0.0383999
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0369355
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0353676
DST dystonin 0.0350403
RPL3 ribosomal protein L3 0.0347716
EXT1 exostosin glycosyltransferase 1 0.0340281
ERRFI1 ERBB receptor feedback inhibitor 1 0.03364
TAPBP TAP binding protein (tapasin) 0.0335823
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0334692
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0331928
MUC13 mucin 13, cell surface associated 0.0331212
RPL11 ribosomal protein L11 0.0324548
PLK2 polo-like kinase 2 0.0318483
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.031515
NAP1L1 nucleosome assembly protein 1-like 1 0.0314966
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 0.0309596
SKP1 S-phase kinase-associated protein 1 0.030696
CCSER1 coiled-coil serine-rich protein 1 0.0306752
CXCL8 chemokine (C-X-C motif) ligand 8 0.0304481
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0304467
RPL7 ribosomal protein L7 0.0303327
AREG amphiregulin 0.0295544
CHD1 chromodomain helicase DNA binding protein 1 0.0295312
CD47 CD47 molecule 0.0290814
NDRG1 N-myc downstream regulated 1 0.0290228
ARRDC3 arrestin domain containing 3 0.0284765
PRELID2 PRELI domain containing 2 0.0284255
PEAK1 pseudopodium-enriched atypical kinase 1 0.0282238
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0282148
FNDC3B fibronectin type III domain containing 3B 0.0281764
TXNRD1 thioredoxin reductase 1 0.0281625
RPL13A ribosomal protein L13a 0.0278511
ARL15 ADP-ribosylation factor-like 15 0.0278033
LOC105378220 macrophage receptor MARCO-like 0.0277026
MYO1E myosin IE 0.0275885
KRT8 keratin 8, type II 0.0275364
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0275267
INTS6 integrator complex subunit 6 0.0274346
ANO6 anoctamin 6 0.0273439
RPS18 ribosomal protein S18 0.0270012
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0269427
SRRM2 serine/arginine repetitive matrix 2 0.0267476
RPL23 ribosomal protein L23 0.0266604
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0265249
SQSTM1 sequestosome 1 0.0264795
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0260827
TMF1 TATA element modulatory factor 1 0.0258097
RSRC2 arginine/serine-rich coiled-coil 2 0.0257964
CCNYL1 cyclin Y-like 1 0.0257832
SLTM SAFB-like, transcription modulator 0.0257696
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0257262
NRDC nardilysin convertase 0.0256478
GOLGB1 golgin B1 0.0256265

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.171233
THSD4 thrombospondin, type I, domain containing 4 -0.151327
RPLP1 ribosomal protein, large, P1 -0.147694
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0955782
PTPRR protein tyrosine phosphatase, receptor type, R -0.0904782
F3 coagulation factor III (thromboplastin, tissue factor) -0.0772579
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0729955
PLAC8 placenta-specific 8 -0.0677689
PDE4D phosphodiesterase 4D, cAMP-specific -0.0665306
AOPEP aminopeptidase O (putative) -0.0643387
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -0.0578509
TMSB10 thymosin beta 10 -0.0570231
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0568111
FOXO1 forkhead box O1 -0.0515562
RREB1 ras responsive element binding protein 1 -0.0515115
KLF5 Kruppel-like factor 5 (intestinal) -0.051164
CALB1 calbindin 1, 28kDa -0.0500005
ITGB4 integrin, beta 4 -0.0475
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0470312
P3H2 prolyl 3-hydroxylase 2 -0.0453297
RRBP1 ribosome binding protein 1 -0.0451924
NPSR1 neuropeptide S receptor 1 -0.0451867
TSPAN8 tetraspanin 8 -0.0451704
MSI2 musashi RNA-binding protein 2 -0.0430349
CUX1 cut-like homeobox 1 -0.0425906
ANXA2 annexin A2 -0.0422402
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0421631
FERMT1 fermitin family member 1 -0.041892
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0413005
FLNB filamin B, beta -0.0411935
BACE2 beta-site APP-cleaving enzyme 2 -0.0411339
PKM pyruvate kinase, muscle -0.0380408
NT5C2 5'-nucleotidase, cytosolic II -0.0364802
RPL38 ribosomal protein L38 -0.0358579
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0357768
DENND1A DENN/MADD domain containing 1A -0.0356868
PPARG peroxisome proliferator-activated receptor gamma -0.0351595
MX1 MX dynamin-like GTPase 1 -0.0350497
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0340056
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0336803
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0328916
RIGI RNA sensor RIG-I -0.032538
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0320083
RBM25 RNA binding motif protein 25 -0.0318817
PALLD palladin, cytoskeletal associated protein -0.0317741
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0315586
S100A6 S100 calcium binding protein A6 -0.0314601
RPL27A ribosomal protein L27a -0.030008
MCU mitochondrial calcium uniporter -0.0293465
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 -0.0291444
ANO1 anoctamin 1, calcium activated chloride channel -0.0290961
GMDS GDP-mannose 4,6-dehydratase -0.0288964
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0287042
ZFP36L2 ZFP36 ring finger protein-like 2 -0.0286641
XAF1 XIAP associated factor 1 -0.0284459
CCND1 cyclin D1 -0.0282142
MAML2 mastermind-like 2 (Drosophila) -0.0281668
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.0280225
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0279875
RPS25 ribosomal protein S25 -0.0279103
ACTN4 actinin, alpha 4 -0.0276006
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0265706
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0262688
LARP1 La ribonucleoprotein domain family, member 1 -0.0262328
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 -0.0261019
MX2 MX dynamin-like GTPase 2 -0.0260658
RNF213 ring finger protein 213 -0.0260355
EGFR epidermal growth factor receptor -0.0260139
AGR2 anterior gradient 2 -0.0259923
RPLP2 ribosomal protein, large, P2 -0.0258365
COG5 component of oligomeric golgi complex 5 -0.025669
SREBF2 sterol regulatory element binding transcription factor 2 -0.0254443
OSBPL3 oxysterol binding protein-like 3 -0.0253857
COL17A1 collagen, type XVII, alpha 1 -0.0252964
SUGCT succinyl-CoA:glutarate-CoA transferase -0.02522
RPS24 ribosomal protein S24 -0.0250938
VDAC1 voltage-dependent anion channel 1 -0.0249246
FGD4 FYVE, RhoGEF and PH domain containing 4 -0.0249226
COBL cordon-bleu WH2 repeat protein -0.0248982
RIN2 Ras and Rab interactor 2 -0.024772
DNM2 dynamin 2 -0.0244141
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0243324
PTPRK protein tyrosine phosphatase, receptor type, K -0.0242713
SEC31A SEC31 homolog A (S. cerevisiae) -0.024262
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) -0.0242295
ETFA electron-transfer-flavoprotein, alpha polypeptide -0.0242236
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0242078
BIRC6 baculoviral IAP repeat containing 6 -0.0241356
MUC2 mucin 2, oligomeric mucus/gel-forming -0.0239263
IARS1 isoleucyl-tRNA synthetase 1 -0.0236109
TAS2R14 taste receptor, type 2, member 14 -0.0235359
UBE3C ubiquitin protein ligase E3C -0.023472
TJP2 tight junction protein 2 -0.0234352
IFI6 interferon, alpha-inducible protein 6 -0.0233928
NPEPPS aminopeptidase puromycin sensitive -0.0228668
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0228212
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0225582
ALCAM activated leukocyte cell adhesion molecule -0.0224012
ZFAND3 zinc finger, AN1-type domain 3 -0.0223285
PIAS1 protein inhibitor of activated STAT, 1 -0.0221311