Goserelin (acetate)_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Goserelin (acetate) perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Goserelin (acetate)_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.152703
DST dystonin 0.120924
CAPRIN2 caprin family member 2 0.108205
ERRFI1 ERBB receptor feedback inhibitor 1 0.102536
WWTR1 WW domain containing transcription regulator 1 0.0855481
PSD3 pleckstrin and Sec7 domain containing 3 0.0743701
BCAR3 breast cancer anti-estrogen resistance 3 0.0739445
FMNL2 formin-like 2 0.0588118
RPS3 ribosomal protein S3 0.0583783
RPS12 ribosomal protein S12 0.0527626
EZR ezrin 0.049555
RPS6 ribosomal protein S6 0.0475097
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0446697
KTN1 kinectin 1 (kinesin receptor) 0.0440025
AREG amphiregulin 0.0430212
TM4SF1 transmembrane 4 L six family member 1 0.0414649
HLA-B major histocompatibility complex, class I, B 0.0410272
ZFP36L1 ZFP36 ring finger protein-like 1 0.0401632
MT1X metallothionein 1X 0.0401606
TTC3 tetratricopeptide repeat domain 3 0.0386108
RPL26 ribosomal protein L26 0.0381983
RPL36 ribosomal protein L36 0.0378378
KMT2E lysine (K)-specific methyltransferase 2E 0.0364887
VMP1 vacuole membrane protein 1 0.0361993
RUNX1 runt-related transcription factor 1 0.0361517
SQSTM1 sequestosome 1 0.0360948
MACF1 microtubule-actin crosslinking factor 1 0.0359556
MT1E metallothionein 1E 0.0353895
BIRC3 baculoviral IAP repeat containing 3 0.0348371
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0343046
ANGPTL4 angiopoietin-like 4 0.0342516
ARHGAP5 Rho GTPase activating protein 5 0.0330367
B2M beta-2-microglobulin 0.0312508
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0311865
IFI6 interferon, alpha-inducible protein 6 0.0309609
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0308501
APLP2 amyloid beta (A4) precursor-like protein 2 0.0308004
PRELID2 PRELI domain containing 2 0.0305668
GOLGB1 golgin B1 0.030284
TXNIP thioredoxin interacting protein 0.0301551
HSPA8 heat shock 70kDa protein 8 0.0300449
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0299798
AKAP9 A kinase (PRKA) anchor protein 9 0.0298483
JUN jun proto-oncogene 0.029642
KLF6 Kruppel-like factor 6 0.0295878
JMJD1C jumonji domain containing 1C 0.0291708
HOMER1 homer scaffolding protein 1 0.0287927
TMF1 TATA element modulatory factor 1 0.0277592
PDE10A phosphodiesterase 10A 0.0273564
CAMTA1 calmodulin binding transcription activator 1 0.0262348
EIF4A2 eukaryotic translation initiation factor 4A2 0.0260762
BIRC2 baculoviral IAP repeat containing 2 0.0259916
CXCL8 chemokine (C-X-C motif) ligand 8 0.0257195
PLK2 polo-like kinase 2 0.0257108
ADARB1 adenosine deaminase, RNA-specific, B1 0.0250865
CEP290 centrosomal protein 290kDa 0.024998
AKAP12 A kinase (PRKA) anchor protein 12 0.0235351
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0231957
RPL12 ribosomal protein L12 0.0231537
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0230088
FNIP1 folliculin interacting protein 1 0.0226819
RPL37A ribosomal protein L37a 0.0222904
RPS8 ribosomal protein S8 0.0222344
ZBTB38 zinc finger and BTB domain containing 38 0.022184
EEF1G eukaryotic translation elongation factor 1 gamma 0.0221686
HLA-A major histocompatibility complex, class I, A 0.0220474
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0218625
NAP1L1 nucleosome assembly protein 1-like 1 0.0217267
EXOC6B exocyst complex component 6B 0.0217251
RPS19 ribosomal protein S19 0.0215275
RPS17 ribosomal protein S17 0.021068
TPT1 tumor protein, translationally-controlled 1 0.021044
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0207886
PDE4D phosphodiesterase 4D, cAMP-specific 0.0207298
ANKRD36 ankyrin repeat domain 36 0.0204302
LOC102724023 ES1 protein homolog, mitochondrial 0.0204187
RPLP2 ribosomal protein, large, P2 0.0201882
SOX9 SRY (sex determining region Y)-box 9 0.0200039
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0198822
RPS27 ribosomal protein S27 0.0197732
NT5E 5'-nucleotidase, ecto (CD73) 0.0197729
EREG epiregulin 0.0196136
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0195355
RPL37 ribosomal protein L37 0.0193872
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0192948
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0192513
LPIN1 lipin 1 0.0192234
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0188928
ZNF638 zinc finger protein 638 0.0185615
ARL4C ADP-ribosylation factor-like 4C 0.0185585
RCOR1 REST corepressor 1 0.0183918
RAB7A RAB7A, member RAS oncogene family 0.0183693
ASPH aspartate beta-hydroxylase 0.018321
SLK STE20-like kinase 0.0182551
SGMS2 sphingomyelin synthase 2 0.0181247
FN1 fibronectin 1 0.0180573
TAPBP TAP binding protein (tapasin) 0.0179974
GYS1 glycogen synthase 1 (muscle) 0.0177529
RPL27 ribosomal protein L27 0.0175955
AMPD3 adenosine monophosphate deaminase 3 0.0175072

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.142576
DLG1 discs, large homolog 1 (Drosophila) -0.1171
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.111878
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0923959
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.085133
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0828415
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0649688
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0590406
CADM2 cell adhesion molecule 2 -0.0584397
EEF2 eukaryotic translation elongation factor 2 -0.055848
EHBP1 EH domain binding protein 1 -0.0554798
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0544464
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0504723
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0494644
APP amyloid beta (A4) precursor protein -0.0478991
CFAP299 cilia and flagella associated protein 299 -0.0471013
WARS1 tryptophanyl-tRNA synthetase 1 -0.0467867
TMEM123 transmembrane protein 123 -0.045749
TNS3 tensin 3 -0.0453014
TP63 tumor protein p63 -0.0434612
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0428752
RAI1 retinoic acid induced 1 -0.039212
CENPF centromere protein F, 350/400kDa -0.0387839
ZMYND8 zinc finger, MYND-type containing 8 -0.0383666
ADGRG6 adhesion G protein-coupled receptor G6 -0.0373235
ACTG1 actin gamma 1 -0.0360637
SBF2 SET binding factor 2 -0.0360628
HMGA1 high mobility group AT-hook 1 -0.0351671
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0350785
ZNF292 zinc finger protein 292 -0.0350122
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -0.0328044
EFNA5 ephrin-A5 -0.0322572
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0318822
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0313732
PTK2 protein tyrosine kinase 2 -0.030472
LMAN1 lectin, mannose-binding, 1 -0.0295519
LOC112694756 uncharaterized LOC112694756 -0.0292709
DOCK11 dedicator of cytokinesis 11 -0.0291145
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0285109
HSPG2 heparan sulfate proteoglycan 2 -0.0284166
PKM pyruvate kinase, muscle -0.0281559
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0277027
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0275068
USP34 ubiquitin specific peptidase 34 -0.0273253
OLA1 Obg-like ATPase 1 -0.0270278
VDAC1 voltage-dependent anion channel 1 -0.0267569
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0265492
ACACA acetyl-CoA carboxylase alpha -0.0261446
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0259118
FTH1 ferritin, heavy polypeptide 1 -0.0257678
PODXL podocalyxin-like -0.0251617
ZNF207 zinc finger protein 207 -0.0250925
ANKRD17 ankyrin repeat domain 17 -0.0250125
POTEF POTE ankyrin domain family, member F -0.024972
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0247813
EPHA4 EPH receptor A4 -0.0247635
WSB1 WD repeat and SOCS box containing 1 -0.0246563
CSMD3 CUB and Sushi multiple domains 3 -0.0245072
SMC4 structural maintenance of chromosomes 4 -0.0240941
PDIA3 protein disulfide isomerase family A, member 3 -0.0237949
NF1 neurofibromin 1 -0.0236145
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0234613
TSC22D1 TSC22 domain family, member 1 -0.0233304
EXOC4 exocyst complex component 4 -0.0233299
TTC28 tetratricopeptide repeat domain 28 -0.0232897
CD44 CD44 molecule (Indian blood group) -0.0230651
MYO10 myosin X -0.0227693
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0226653
MBNL2 muscleblind-like splicing regulator 2 -0.0225895
ZNF217 zinc finger protein 217 -0.0225864
ANKRD28 ankyrin repeat domain 28 -0.0224458
LPP LIM domain containing preferred translocation partner in lipoma -0.0224108
ITGB4 integrin, beta 4 -0.0222599
KPNB1 karyopherin (importin) beta 1 -0.0221267
TMSB10 thymosin beta 10 -0.0218659
FLNB filamin B, beta -0.0215524
PGAP1 post-GPI attachment to proteins 1 -0.0214597
GARS1 glycyl-tRNA synthetase 1 -0.0209743
PTPRF protein tyrosine phosphatase, receptor type, F -0.0209362
ANLN anillin, actin binding protein -0.0208828
NUP58 nucleoporin 58 -0.0208223
DENND5B DENN/MADD domain containing 5B -0.020721
ANXA1 annexin A1 -0.0207169
ANKRD11 ankyrin repeat domain 11 -0.0207141
CFDP1 craniofacial development protein 1 -0.0206257
RAP2B RAP2B, member of RAS oncogene family -0.0204949
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0204854
BRWD1 bromodomain and WD repeat domain containing 1 -0.020176
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.0201204
MIS18BP1 MIS18 binding protein 1 -0.0200584
LDHA lactate dehydrogenase A -0.019953
BSG basigin (Ok blood group) -0.0199138
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0197805
OSBPL3 oxysterol binding protein-like 3 -0.0196921
FOXK1 forkhead box K1 -0.0196182
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0195269
WDR45B WD repeat domain 45B -0.0194344
RNF213 ring finger protein 213 -0.0193904
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0193721
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0193383