Goserelin (acetate)_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Goserelin (acetate) perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Goserelin (acetate)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.321339
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.1245
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.106492
YBX3 Y box binding protein 3 0.103651
RPS3 ribosomal protein S3 0.0987537
GOLGB1 golgin B1 0.0630601
HSPA8 heat shock 70kDa protein 8 0.0537584
INTS6 integrator complex subunit 6 0.0527929
RPS21 ribosomal protein S21 0.0491934
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0474025
RPL37 ribosomal protein L37 0.0451892
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0419636
HOMER1 homer scaffolding protein 1 0.0396325
TPM2 tropomyosin 2 (beta) 0.0395044
RPL37A ribosomal protein L37a 0.0385476
RPS12 ribosomal protein S12 0.037567
AEBP2 AE binding protein 2 0.0354589
MCL1 myeloid cell leukemia 1 0.0350851
RPL26 ribosomal protein L26 0.0349076
MYH9 myosin, heavy chain 9, non-muscle 0.0342996
TRA2A transformer 2 alpha homolog (Drosophila) 0.0329834
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0329069
BRD2 bromodomain containing 2 0.032038
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.030371
TPM3 tropomyosin 3 0.0297663
PTMA prothymosin, alpha 0.0294564
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0291547
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0288949
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0286104
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0280715
APLP2 amyloid beta (A4) precursor-like protein 2 0.027076
DST dystonin 0.0270633
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.026686
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0261878
KTN1 kinectin 1 (kinesin receptor) 0.0260809
RPS4X ribosomal protein S4, X-linked 0.0260232
MACF1 microtubule-actin crosslinking factor 1 0.025685
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0256661
RPS2 ribosomal protein S2 0.025111
RPL35A ribosomal protein L35a 0.0249393
IFI6 interferon, alpha-inducible protein 6 0.0249285
EIF5B eukaryotic translation initiation factor 5B 0.0247983
RPS29 ribosomal protein S29 0.024747
SND1 staphylococcal nuclease and tudor domain containing 1 0.024687
RBM39 RNA binding motif protein 39 0.0246859
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0245338
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.024228
PRELID2 PRELI domain containing 2 0.0241275
MBD5 methyl-CpG binding domain protein 5 0.0241088
RPL36 ribosomal protein L36 0.0238972
TPT1 tumor protein, translationally-controlled 1 0.0238408
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0238199
VCP valosin containing protein 0.0238177
ZSWIM6 zinc finger, SWIM-type containing 6 0.0236943
AKAP9 A kinase (PRKA) anchor protein 9 0.022798
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0227837
RPS17 ribosomal protein S17 0.0227054
RPS10 ribosomal protein S10 0.0226427
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0220224
PMM2 phosphomannomutase 2 0.0218783
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0213008
RABGAP1L RAB GTPase activating protein 1-like 0.021188
NFE2L1 nuclear factor, erythroid 2-like 1 0.0210763
DSPP dentin sialophosphoprotein 0.0209383
PABPN1 poly(A) binding protein, nuclear 1 0.0209121
TTC3 tetratricopeptide repeat domain 3 0.0208828
ASPH aspartate beta-hydroxylase 0.0206612
GPATCH2L G patch domain containing 2-like 0.0205566
RAB7A RAB7A, member RAS oncogene family 0.0204149
SFTPA2 surfactant protein A2 0.0203648
ATP5F1E ATP synthase F1 subunit epsilon 0.020298
FUS FUS RNA binding protein 0.0199249
SERINC1 serine incorporator 1 0.019901
ASXL1 additional sex combs like transcriptional regulator 1 0.0197644
TLN1 talin 1 0.0195937
TMEM263 transmembrane protein 263 0.0195733
RPS8 ribosomal protein S8 0.0191154
CUL3 cullin 3 0.0190858
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0190635
CCSER1 coiled-coil serine-rich protein 1 0.0189948
ZC3H13 zinc finger CCCH-type containing 13 0.0186906
ZCCHC7 zinc finger, CCHC domain containing 7 0.0186532
RPS19 ribosomal protein S19 0.0184129
TOP1 topoisomerase (DNA) I 0.0182015
SET SET nuclear proto-oncogene 0.0178152
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.017705
PDLIM5 PDZ and LIM domain 5 0.0177003
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0176775
PRPF4B pre-mRNA processing factor 4B 0.0176463
PDIA4 protein disulfide isomerase family A, member 4 0.0175631
TPI1 triosephosphate isomerase 1 0.017449
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0173336
CAPRIN2 caprin family member 2 0.017129
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0170911
SH3GL1 SH3-domain GRB2-like 1 0.0167791
RPL14 ribosomal protein L14 0.0166255
TRIM59 tripartite motif containing 59 0.0166188
MYO6 myosin VI 0.0165103
SAMD4A sterile alpha motif domain containing 4A 0.0164615
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0164116

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.278349
TXNRD1 thioredoxin reductase 1 -0.153947
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.130803
EEF2 eukaryotic translation elongation factor 2 -0.0866123
TFPI2 tissue factor pathway inhibitor 2 -0.0842883
VIM vimentin -0.0744698
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0715746
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0658897
RAD51B RAD51 paralog B -0.0629516
EGR1 early growth response 1 -0.0620609
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0595689
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0586683
THSD4 thrombospondin, type I, domain containing 4 -0.0561747
IGF1R insulin-like growth factor 1 receptor -0.0514487
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0498082
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0425388
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0415351
KDM2A lysine (K)-specific demethylase 2A -0.0411991
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0410709
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0406597
STC1 stanniocalcin 1 -0.0400736
LATS2 large tumor suppressor kinase 2 -0.038852
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0379059
PKM pyruvate kinase, muscle -0.0378555
TOP2A topoisomerase (DNA) II alpha 170kDa -0.037846
HMGA2 high mobility group AT-hook 2 -0.0374494
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0369542
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0357222
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0354258
NUP155 nucleoporin 155kDa -0.0346209
OSMR oncostatin M receptor -0.0340806
PHIP pleckstrin homology domain interacting protein -0.0335378
EML4 echinoderm microtubule associated protein like 4 -0.0334072
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0331447
ADGRG6 adhesion G protein-coupled receptor G6 -0.0330383
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0326626
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0312652
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0310007
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.030576
KPNB1 karyopherin (importin) beta 1 -0.0305563
NF1 neurofibromin 1 -0.0304312
MIS18BP1 MIS18 binding protein 1 -0.0304164
HMGA1 high mobility group AT-hook 1 -0.0302162
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0300156
BBX bobby sox homolog (Drosophila) -0.0295174
PCNX1 pecanex 1 -0.0293607
GATAD2B GATA zinc finger domain containing 2B -0.0290862
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0290699
GPHN gephyrin -0.0290122
ADAM9 ADAM metallopeptidase domain 9 -0.0289212
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0288648
VDAC1 voltage-dependent anion channel 1 -0.0288268
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0281714
ZFR zinc finger RNA binding protein -0.0281623
XPO1 exportin 1 -0.0281225
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0281182
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0279713
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0279019
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0275975
SENP6 SUMO1/sentrin specific peptidase 6 -0.0274667
ATP5F1B ATP synthase F1 subunit beta -0.0273723
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -0.0271918
KMT2A lysine (K)-specific methyltransferase 2A -0.0270728
MELK maternal embryonic leucine zipper kinase -0.0269324
NABP1 nucleic acid binding protein 1 -0.0268004
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0264733
PHF21A PHD finger protein 21A -0.0260696
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.026021
DIAPH3 diaphanous-related formin 3 -0.0259167
DOCK3 dedicator of cytokinesis 3 -0.0254205
NUP153 nucleoporin 153kDa -0.0254097
MMP12 matrix metallopeptidase 12 -0.0251995
PDE10A phosphodiesterase 10A -0.0251537
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0251066
SLC38A2 solute carrier family 38, member 2 -0.0250707
PGK1 phosphoglycerate kinase 1 -0.0250314
TMEM165 transmembrane protein 165 -0.0250065
RUSC2 RUN and SH3 domain containing 2 -0.0249062
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0247465
RNF38 ring finger protein 38 -0.0246419
BPTF bromodomain PHD finger transcription factor -0.024559
BCAS3 breast carcinoma amplified sequence 3 -0.0243293
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0241715
TWF1 twinfilin actin binding protein 1 -0.0241592
WASF2 WAS protein family, member 2 -0.0241042
MATR3 matrin 3 -0.0240729
SMAD3 SMAD family member 3 -0.0240377
IL6ST interleukin 6 signal transducer -0.0239597
KCMF1 potassium channel modulatory factor 1 -0.0238904
CLDN1 claudin 1 -0.0238794
TUBB tubulin, beta class I -0.0238641
DENND5B DENN/MADD domain containing 5B -0.0238376
ZNFX1 zinc finger, NFX1-type containing 1 -0.0237416
BSG basigin (Ok blood group) -0.0235798
NUP58 nucleoporin 58 -0.0235175
BLTP2 bridge-like lipid transfer protein family member 2 -0.023509
TMPO thymopoietin -0.0233886
ANXA5 annexin A5 -0.0232629
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.0231864
ZBTB20 zinc finger and BTB domain containing 20 -0.0229149