Goserelin (acetate)_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Goserelin (acetate) perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

187 genes differentially expressed following the Goserelin (acetate)_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.248271
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.244902
FN1 fibronectin 1 0.171137
SPTBN1 spectrin, beta, non-erythrocytic 1 0.140211
COL6A3 collagen, type VI, alpha 3 0.138026
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.12585
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.117385
TTC3 tetratricopeptide repeat domain 3 0.112782
PABPC1 poly(A) binding protein, cytoplasmic 1 0.11102
NAV2 neuron navigator 2 0.107287
RPS3 ribosomal protein S3 0.103779
MYO10 myosin X 0.0955929
DST dystonin 0.0931431
GOLGA4 golgin A4 0.0914693
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0835442
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.082684
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.081488
GOLGB1 golgin B1 0.081384
EIF1 eukaryotic translation initiation factor 1 0.08019
DSCAM Down syndrome cell adhesion molecule 0.0797044
INHBA inhibin, beta A 0.0796506
NKD1 naked cuticle homolog 1 (Drosophila) 0.0790793
PRKG1 protein kinase, cGMP-dependent, type I 0.0748215
B2M beta-2-microglobulin 0.0692436
MT2A metallothionein 2A 0.0660628
RPS19 ribosomal protein S19 0.0654655
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0648388
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0643529
PCBP2 poly(rC) binding protein 2 0.0636438
NALF1 NALCN channel auxiliary factor 1 0.0626262
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0625259
CD44 CD44 molecule (Indian blood group) 0.0612005
TM4SF1 transmembrane 4 L six family member 1 0.05997
RPL31 ribosomal protein L31 0.0591566
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.058142
PCBP3 poly(rC) binding protein 3 0.0561345
RPS8 ribosomal protein S8 0.0555841
COL6A2 collagen, type VI, alpha 2 0.0544127
OXR1 oxidation resistance 1 0.0540141
LMAN1 lectin, mannose-binding, 1 0.0534812
JARID2 jumonji, AT rich interactive domain 2 0.0520475
AHNAK AHNAK nucleoprotein 0.0512414
VIM vimentin 0.0496889
RPL35A ribosomal protein L35a 0.0485823
LIMS1 LIM and senescent cell antigen-like domains 1 0.0479232
BRD2 bromodomain containing 2 0.0456303
JMJD1C jumonji domain containing 1C 0.0450463
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0443092
RPL26 ribosomal protein L26 0.0439957
RPS6 ribosomal protein S6 0.0430807
EFNA5 ephrin-A5 0.0426384
HSPA8 heat shock 70kDa protein 8 0.0413713
ENO1 enolase 1, (alpha) 0.0404895
UBC ubiquitin C 0.0371994
EPS8 epidermal growth factor receptor pathway substrate 8 0.0361352
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.036051
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0355025
ATP13A3 ATPase type 13A3 0.0347632
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0332876
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0320298
EZR ezrin 0.0307481
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0296598
MYOF myoferlin 0.0278053
RPL23 ribosomal protein L23 0.0263982
AKAP13 A kinase (PRKA) anchor protein 13 0.0263635
FLNB filamin B, beta 0.0258994
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0228896
TAS2R14 taste receptor, type 2, member 14 0.021163
RTN4 reticulon 4 0.0210777
TPT1 tumor protein, translationally-controlled 1 0.0209972
SMAD3 SMAD family member 3 0.0208718
NDRG1 N-myc downstream regulated 1 0.0208662
SEC31A SEC31 homolog A (S. cerevisiae) 0.0206392
ANXA2 annexin A2 0.0201898
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0189083
NAMPT nicotinamide phosphoribosyltransferase 0.0144975
GLIS3 GLIS family zinc finger 3 0.0142364
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0138171
NPAS2 neuronal PAS domain protein 2 0.0137769
RPS27A ribosomal protein S27a 0.013296
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0116363
ZSWIM6 zinc finger, SWIM-type containing 6 0.0103924
ATM ATM serine/threonine kinase 0.0100876
HMGA2 high mobility group AT-hook 2 0.00852231
ARID1B AT rich interactive domain 1B (SWI1-like) 0.00758964
ANKRD11 ankyrin repeat domain 11 0.00693387
PTMA prothymosin, alpha 0.00487125
NIPBL Nipped-B homolog (Drosophila) 0.00460843
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.00317081
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.00128281

decreased expression

Symbol Name Standardized Value
PDE10A phosphodiesterase 10A -0.182258
DOCK4 dedicator of cytokinesis 4 -0.148894
FNDC3A fibronectin type III domain containing 3A -0.132961
THSD4 thrombospondin, type I, domain containing 4 -0.124936
EGFR epidermal growth factor receptor -0.112522
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.107451
SLTM SAFB-like, transcription modulator -0.096726
AOPEP aminopeptidase O (putative) -0.095845
TCF12 transcription factor 12 -0.0951071
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0924037
GRB10 growth factor receptor-bound protein 10 -0.0870214
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0864515
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0854201
ALCAM activated leukocyte cell adhesion molecule -0.0823916
KMT2C lysine (K)-specific methyltransferase 2C -0.0822027
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0812279
PKM pyruvate kinase, muscle -0.0801182
NF1 neurofibromin 1 -0.0694109
SETD5 SET domain containing 5 -0.0684063
ELOVL5 ELOVL fatty acid elongase 5 -0.0671665
ATP9B ATPase, class II, type 9B -0.0670227
PDLIM5 PDZ and LIM domain 5 -0.066054
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0659586
CALU calumenin -0.0641243
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0632745
FNDC3B fibronectin type III domain containing 3B -0.06059
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0597913
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0587108
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.0577773
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0574384
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0566306
NUP58 nucleoporin 58 -0.0540956
VCL vinculin -0.0530118
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0529663
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0511825
PARD3 par-3 family cell polarity regulator -0.0505503
IGF2 insulin-like growth factor 2 -0.0493139
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0474242
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0468881
ESYT2 extended synaptotagmin-like protein 2 -0.0452355
PRRC2C proline-rich coiled-coil 2C -0.0444041
SAMD4A sterile alpha motif domain containing 4A -0.044038
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0435651
EEF2 eukaryotic translation elongation factor 2 -0.0418484
RIGI RNA sensor RIG-I -0.0416833
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.041477
RORA RAR-related orphan receptor A -0.0402074
KDM2A lysine (K)-specific demethylase 2A -0.0394116
DTNA dystrobrevin, alpha -0.03663
PSD3 pleckstrin and Sec7 domain containing 3 -0.035356
ADAM10 ADAM metallopeptidase domain 10 -0.0352212
CTIF CBP80/20-dependent translation initiation factor -0.0347695
TMSB10 thymosin beta 10 -0.0344965
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0331095
MARCHF7 membrane associated ring-CH-type finger 7 -0.0324792
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma -0.0321498
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0315735
EXT1 exostosin glycosyltransferase 1 -0.030477
LDHA lactate dehydrogenase A -0.0304003
SRPK2 SRSF protein kinase 2 -0.0300354
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0288771
RLF rearranged L-myc fusion -0.0286676
ZBTB20 zinc finger and BTB domain containing 20 -0.02839
MYH9 myosin, heavy chain 9, non-muscle -0.0274755
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0268715
GPC6 glypican 6 -0.0265684
NBEAL1 neurobeachin-like 1 -0.0265007
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0232587
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0222289
WAC WW domain containing adaptor with coiled-coil -0.0221023
PTK2 protein tyrosine kinase 2 -0.0219685
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0217663
CERS6 ceramide synthase 6 -0.021441
PRKD3 protein kinase D3 -0.0209034
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0208592
BBX bobby sox homolog (Drosophila) -0.0188361
CDH13 cadherin 13 -0.0185076
TRIO trio Rho guanine nucleotide exchange factor -0.0183645
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0178535
MBD5 methyl-CpG binding domain protein 5 -0.0177424
GMDS GDP-mannose 4,6-dehydratase -0.017406
MYO1E myosin IE -0.0166624
TXNRD1 thioredoxin reductase 1 -0.0163979
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0149505
COL5A2 collagen, type V, alpha 2 -0.0132421
ASPH aspartate beta-hydroxylase -0.0128482
CCNI cyclin I -0.0120952
ZNF292 zinc finger protein 292 -0.0113697
ACTN4 actinin, alpha 4 -0.010469
LMO7 LIM domain 7 -0.00941908
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.00734156
APP amyloid beta (A4) precursor protein -0.00718809
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.00567995
PDE4D phosphodiesterase 4D, cAMP-specific -0.00534066
SMYD3 SET and MYND domain containing 3 -0.00366459
PGK1 phosphoglycerate kinase 1 -0.00360127
COL8A1 collagen, type VIII, alpha 1 -4.01915E-5