Goserelin (acetate)_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Goserelin (acetate) perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Goserelin (acetate)_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AHNAK AHNAK nucleoprotein 0.0971223
ADAM10 ADAM metallopeptidase domain 10 0.083804
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.07243
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0554024
TMSB4X thymosin beta 4, X-linked 0.0516162
FLNB filamin B, beta 0.0481334
PDE4D phosphodiesterase 4D, cAMP-specific 0.0467609
ZEB1 zinc finger E-box binding homeobox 1 0.0438296
PRELID2 PRELI domain containing 2 0.0434207
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0429987
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.04238
HSPA8 heat shock 70kDa protein 8 0.0406079
EZR ezrin 0.0394678
VCL vinculin 0.0386012
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0384024
PYGB phosphorylase, glycogen; brain 0.0369334
TGFBR3 transforming growth factor, beta receptor III 0.0369051
YEATS2 YEATS domain containing 2 0.0343517
DSCAM Down syndrome cell adhesion molecule 0.033487
EIF4A2 eukaryotic translation initiation factor 4A2 0.030736
ZNF608 zinc finger protein 608 0.0305507
ANXA1 annexin A1 0.0303082
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0301009
NCKAP1 NCK-associated protein 1 0.0299506
KDM3A lysine (K)-specific demethylase 3A 0.029521
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0292873
TOP2B topoisomerase (DNA) II beta 180kDa 0.0292477
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0290554
CAMTA1 calmodulin binding transcription activator 1 0.0290484
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0288661
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0288193
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.028421
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0281264
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0278177
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0277481
MACF1 microtubule-actin crosslinking factor 1 0.0276777
NAMPT nicotinamide phosphoribosyltransferase 0.0276449
CD47 CD47 molecule 0.0271092
ANKRD36 ankyrin repeat domain 36 0.0268616
HDAC9 histone deacetylase 9 0.0264849
BMP2K BMP2 inducible kinase 0.026062
PICALM phosphatidylinositol binding clathrin assembly protein 0.0259073
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0256568
MATR3 matrin 3 0.0255951
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0252684
DST dystonin 0.0251793
TPM4 tropomyosin 4 0.0247362
PGK1 phosphoglycerate kinase 1 0.0243978
CORO1C coronin, actin binding protein, 1C 0.0242476
FAT1 FAT atypical cadherin 1 0.0242246
MYOF myoferlin 0.0235426
LPP LIM domain containing preferred translocation partner in lipoma 0.0229386
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0226802
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.022657
EIF4B eukaryotic translation initiation factor 4B 0.0226331
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0220311
RLF rearranged L-myc fusion 0.0218868
MACROD2 MACRO domain containing 2 0.0217113
H1-4 H1.4 linker histone, cluster member 0.02168
RAB27B RAB27B, member RAS oncogene family 0.0216248
XRN2 5'-3' exoribonuclease 2 0.0212922
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0208627
SOX6 SRY (sex determining region Y)-box 6 0.0206243
EP300 E1A binding protein p300 0.020242
DENND5A DENN/MADD domain containing 5A 0.0201154
RPL14 ribosomal protein L14 0.0200651
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0199011
TMEM65 transmembrane protein 65 0.0198843
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0196467
XPO6 exportin 6 0.0196094
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0193822
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.0193542
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0191729
MEF2A myocyte enhancer factor 2A 0.0191109
CRY1 cryptochrome circadian clock 1 0.0188454
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0187581
CDC73 cell division cycle 73 0.0187337
TPR translocated promoter region, nuclear basket protein 0.0186987
WAC WW domain containing adaptor with coiled-coil 0.01867
CHD1 chromodomain helicase DNA binding protein 1 0.0186645
APP amyloid beta (A4) precursor protein 0.0186312
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0184758
TXNRD1 thioredoxin reductase 1 0.0184393
PHF21A PHD finger protein 21A 0.0184265
IQGAP1 IQ motif containing GTPase activating protein 1 0.0183569
RPL4 ribosomal protein L4 0.018331
YAP1 Yes-associated protein 1 0.0182966
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.018155
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0181521
PTBP2 polypyrimidine tract binding protein 2 0.0181156
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0180593
SAMD4A sterile alpha motif domain containing 4A 0.0180346
TLK1 tousled-like kinase 1 0.0178735
AFDN afadin, adherens junction formation factor 0.017787
MYO5A myosin VA (heavy chain 12, myoxin) 0.017767
TBC1D5 TBC1 domain family, member 5 0.0177169
ZNF148 zinc finger protein 148 0.0177018
ZNHIT6 zinc finger, HIT-type containing 6 0.0175168
FAM13A family with sequence similarity 13, member A 0.0174934
CEP95 centrosomal protein 95kDa 0.0173679

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.402763
PTMA prothymosin, alpha -0.13709
CPED1 cadherin-like and PC-esterase domain containing 1 -0.132111
PKM pyruvate kinase, muscle -0.109008
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0957039
RPL35A ribosomal protein L35a -0.0889871
PDE4B phosphodiesterase 4B, cAMP-specific -0.0822974
TPT1 tumor protein, translationally-controlled 1 -0.0760169
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0746578
RPLP1 ribosomal protein, large, P1 -0.0734072
ACTG1 actin gamma 1 -0.0732406
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0707043
RPS8 ribosomal protein S8 -0.0705563
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0705099
RPS19 ribosomal protein S19 -0.069784
S100A6 S100 calcium binding protein A6 -0.0626515
RPS23 ribosomal protein S23 -0.0595064
PFN1 profilin 1 -0.0587274
EEF2 eukaryotic translation elongation factor 2 -0.0578933
RPL9 ribosomal protein L9 -0.0554347
RPL31 ribosomal protein L31 -0.0551505
RPS13 ribosomal protein S13 -0.055149
RPS6 ribosomal protein S6 -0.0549779
FOXP1 forkhead box P1 -0.0532577
RPL12 ribosomal protein L12 -0.0531606
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0529251
RPL23 ribosomal protein L23 -0.0515337
RPLP2 ribosomal protein, large, P2 -0.0513079
POTEF POTE ankyrin domain family, member F -0.0506785
RPL11 ribosomal protein L11 -0.050397
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.049811
RPS25 ribosomal protein S25 -0.0487244
EGFR epidermal growth factor receptor -0.0485766
TMSB10 thymosin beta 10 -0.0469233
RPL19 ribosomal protein L19 -0.044362
RPL32 ribosomal protein L32 -0.0433454
INTS6 integrator complex subunit 6 -0.0427048
RPL36 ribosomal protein L36 -0.0421909
S100A9 S100 calcium binding protein A9 -0.0417036
FTL ferritin, light polypeptide -0.0407147
RPS11 ribosomal protein S11 -0.0405942
ENO2 enolase 2 (gamma, neuronal) -0.0402891
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0398014
HSPB1 heat shock 27kDa protein 1 -0.0395459
RPL37A ribosomal protein L37a -0.0395402
EIF1 eukaryotic translation initiation factor 1 -0.0392358
PRDX2 peroxiredoxin 2 -0.0390006
RPL34 ribosomal protein L34 -0.0384963
CCND1 cyclin D1 -0.0382929
RPLP0 ribosomal protein, large, P0 -0.0382244
RPL28 ribosomal protein L28 -0.0380621
RPL5 ribosomal protein L5 -0.0373615
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0368518
RPS16 ribosomal protein S16 -0.0367025
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0366651
RPL13A ribosomal protein L13a -0.0364759
S100A10 S100 calcium binding protein A10 -0.036086
RPS15 ribosomal protein S15 -0.0359201
RPL7A ribosomal protein L7a -0.0347876
RPS14 ribosomal protein S14 -0.0344499
RPS12 ribosomal protein S12 -0.0343547
RPL8 ribosomal protein L8 -0.0333317
RPS27A ribosomal protein S27a -0.0321817
RPL27A ribosomal protein L27a -0.0319952
MT2A metallothionein 2A -0.0317738
RPS24 ribosomal protein S24 -0.0316529
RPS29 ribosomal protein S29 -0.0306545
RPS5 ribosomal protein S5 -0.0301234
RPS21 ribosomal protein S21 -0.0296859
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0290722
IFI16 interferon, gamma-inducible protein 16 -0.0290335
DPYD dihydropyrimidine dehydrogenase -0.0284223
RPS20 ribosomal protein S20 -0.0283726
B2M beta-2-microglobulin -0.0268019
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0265591
RPS17 ribosomal protein S17 -0.0264233
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0262584
RPS10 ribosomal protein S10 -0.0258885
RPL26 ribosomal protein L26 -0.0258166
PDE7B phosphodiesterase 7B -0.0255883
GLI3 GLI family zinc finger 3 -0.0255704
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 -0.0255364
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0253979
RACK1 receptor for activated C kinase 1 -0.0253123
TUBB4B tubulin, beta 4B class IVb -0.025185
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0250759
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0249967
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.024633
RPL27 ribosomal protein L27 -0.0243868
IARS1 isoleucyl-tRNA synthetase 1 -0.0243119
NACA nascent polypeptide-associated complex alpha subunit -0.0240795
HMGA1 high mobility group AT-hook 1 -0.0238404
DLG1 discs, large homolog 1 (Drosophila) -0.0237205
RPL38 ribosomal protein L38 -0.0229242
RPL30 ribosomal protein L30 -0.0228441
RPS27 ribosomal protein S27 -0.0225529
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0224826
ARL4C ADP-ribosylation factor-like 4C -0.0224238
DEK DEK proto-oncogene -0.022379
RPL35 ribosomal protein L35 -0.0223365