Goserelin (acetate)_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Goserelin (acetate) perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Goserelin (acetate)_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.13097
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.121359
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.108575
TMEM156 transmembrane protein 156 0.101308
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0972425
EXT1 exostosin glycosyltransferase 1 0.0837959
SFTPA2 surfactant protein A2 0.0832198
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0810037
APLP2 amyloid beta (A4) precursor-like protein 2 0.0798748
TPR translocated promoter region, nuclear basket protein 0.0793515
ERRFI1 ERBB receptor feedback inhibitor 1 0.0747093
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0697617
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0690278
PRRC2C proline-rich coiled-coil 2C 0.0686872
NTN4 netrin 4 0.0671607
B2M beta-2-microglobulin 0.065789
CXCL8 chemokine (C-X-C motif) ligand 8 0.0643561
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0640592
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0614456
ASPH aspartate beta-hydroxylase 0.0597086
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0596813
TMED9 transmembrane emp24 protein transport domain containing 9 0.0589194
TOP1 topoisomerase (DNA) I 0.0589082
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.057015
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0569531
LOC102724023 ES1 protein homolog, mitochondrial 0.0551745
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0550529
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0529505
KTN1 kinectin 1 (kinesin receptor) 0.0528815
GOLGA4 golgin A4 0.0524335
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0514448
RND3 Rho family GTPase 3 0.0497424
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0483082
TPM3 tropomyosin 3 0.0476477
BASP1 brain abundant, membrane attached signal protein 1 0.046829
RTN4 reticulon 4 0.0456704
YBX3 Y box binding protein 3 0.0438905
HSPA8 heat shock 70kDa protein 8 0.0437925
TMF1 TATA element modulatory factor 1 0.0430683
SAMD4A sterile alpha motif domain containing 4A 0.042914
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0426822
DUSP6 dual specificity phosphatase 6 0.0423522
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0421049
GPATCH2L G patch domain containing 2-like 0.0409567
DOCK5 dedicator of cytokinesis 5 0.0402163
RSRC2 arginine/serine-rich coiled-coil 2 0.0399914
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.039063
LTBP1 latent transforming growth factor beta binding protein 1 0.0388025
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0377794
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.037653
PDLIM5 PDZ and LIM domain 5 0.0376099
RAI14 retinoic acid induced 14 0.037451
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0374216
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0368157
CENPF centromere protein F, 350/400kDa 0.0367452
ELL2 elongation factor, RNA polymerase II, 2 0.0366835
FAT1 FAT atypical cadherin 1 0.0366633
HIPK2 homeodomain interacting protein kinase 2 0.0362256
BZW1 basic leucine zipper and W2 domains 1 0.0361486
RICTOR RPTOR independent companion of MTOR, complex 2 0.0350014
AKAP9 A kinase (PRKA) anchor protein 9 0.0348355
DSTN destrin (actin depolymerizing factor) 0.0345284
SVIL supervillin 0.0339911
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0337465
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0334072
ITGA1 integrin, alpha 1 0.0330593
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0329272
CHD1 chromodomain helicase DNA binding protein 1 0.0328796
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0328266
SERINC1 serine incorporator 1 0.0326389
STC2 stanniocalcin 2 0.0323942
ENO1 enolase 1, (alpha) 0.0319817
TXNRD1 thioredoxin reductase 1 0.0319415
VMP1 vacuole membrane protein 1 0.0317674
SON SON DNA binding protein 0.0314755
SOX9 SRY (sex determining region Y)-box 9 0.0312255
CTSB cathepsin B 0.0307558
CALR calreticulin 0.0306645
UBXN4 UBX domain protein 4 0.0306538
IFI6 interferon, alpha-inducible protein 6 0.0303366
PALLD palladin, cytoskeletal associated protein 0.030215
CUL3 cullin 3 0.0300461
CLIP2 CAP-GLY domain containing linker protein 2 0.0300235
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.0298977
KIF5B kinesin family member 5B 0.0294134
RASAL2 RAS protein activator like 2 0.0293426
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0293133
IFI27 interferon, alpha-inducible protein 27 0.0292858
NOTCH2 notch 2 0.0288313
WBP11 WW domain binding protein 11 0.0288309
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0286393
BCLAF1 BCL2-associated transcription factor 1 0.028626
LMNA lamin A/C 0.0283271
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0281975
ZSWIM6 zinc finger, SWIM-type containing 6 0.0276574
WWTR1 WW domain containing transcription regulator 1 0.0274726
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0271966
MACF1 microtubule-actin crosslinking factor 1 0.0271671
AKAP13 A kinase (PRKA) anchor protein 13 0.0269765
BRD2 bromodomain containing 2 0.0268512

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.341775
FN1 fibronectin 1 -0.164201
NRG1 neuregulin 1 -0.145861
TMSB10 thymosin beta 10 -0.0733232
PKM pyruvate kinase, muscle -0.0656193
HMGA2 high mobility group AT-hook 2 -0.065077
RPLP1 ribosomal protein, large, P1 -0.0643367
NDRG1 N-myc downstream regulated 1 -0.0642013
TRIO trio Rho guanine nucleotide exchange factor -0.0623817
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0622865
INTS6 integrator complex subunit 6 -0.0567891
RPS24 ribosomal protein S24 -0.0446311
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0445309
CADM1 cell adhesion molecule 1 -0.0438831
TPT1 tumor protein, translationally-controlled 1 -0.0434219
AEBP2 AE binding protein 2 -0.0426919
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0423518
MBD5 methyl-CpG binding domain protein 5 -0.039549
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0394049
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0384216
FAM20C family with sequence similarity 20, member C -0.0372907
RPS25 ribosomal protein S25 -0.0370032
APOLD1 apolipoprotein L domain containing 1 -0.0360567
LRRC23 leucine rich repeat containing 23 -0.0357479
IER3 immediate early response 3 -0.0352879
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0346091
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0331619
RPS11 ribosomal protein S11 -0.0317772
HLA-B major histocompatibility complex, class I, B -0.0314485
RPS23 ribosomal protein S23 -0.0312692
RPS16 ribosomal protein S16 -0.0306325
RAD51B RAD51 paralog B -0.0305006
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0303217
RPS20 ribosomal protein S20 -0.0302131
GNAS GNAS complex locus -0.0300485
ZBTB20 zinc finger and BTB domain containing 20 -0.0294303
RPS19 ribosomal protein S19 -0.02835
RPS29 ribosomal protein S29 -0.0282981
SOX5 SRY (sex determining region Y)-box 5 -0.0281903
RPL31 ribosomal protein L31 -0.0273653
GLIS3 GLIS family zinc finger 3 -0.0271668
VDAC1 voltage-dependent anion channel 1 -0.0266968
AKAP10 A kinase (PRKA) anchor protein 10 -0.0259415
DPYD dihydropyrimidine dehydrogenase -0.0255543
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.02527
BABAM2 BRISC and BRCA1 A complex member 2 -0.0251945
S100A6 S100 calcium binding protein A6 -0.0250842
RPL28 ribosomal protein L28 -0.0249359
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0247627
LRMDA leucine rich melanocyte differentiation associated -0.0243695
TAS2R14 taste receptor, type 2, member 14 -0.0243217
DNAH5 dynein, axonemal, heavy chain 5 -0.0237734
PRELID2 PRELI domain containing 2 -0.0235672
RPL23 ribosomal protein L23 -0.0233433
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0233307
CTSD cathepsin D -0.0231222
IRAK3 interleukin-1 receptor-associated kinase 3 -0.0229528
ZMYND8 zinc finger, MYND-type containing 8 -0.0228543
SUMF1 sulfatase modifying factor 1 -0.0227417
TTC28 tetratricopeptide repeat domain 28 -0.0223842
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0223075
UGDH UDP-glucose 6-dehydrogenase -0.0219224
GOLPH3L golgi phosphoprotein 3-like -0.0218676
TENM4 teneurin transmembrane protein 4 -0.0217438
RPL19 ribosomal protein L19 -0.0215139
ARF1 ADP-ribosylation factor 1 -0.0214595
RPL38 ribosomal protein L38 -0.0214422
SDK1 sidekick cell adhesion molecule 1 -0.0213848
SOD2 superoxide dismutase 2, mitochondrial -0.0213078
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.021149
PDE4D phosphodiesterase 4D, cAMP-specific -0.0211321
RPLP2 ribosomal protein, large, P2 -0.0207836
AOPEP aminopeptidase O (putative) -0.0205136
ZNF292 zinc finger protein 292 -0.0202531
CD109 CD109 molecule -0.0198569
ACTN4 actinin, alpha 4 -0.0198562
EXOC4 exocyst complex component 4 -0.0196733
EEF2 eukaryotic translation elongation factor 2 -0.0194574
FHIT fragile histidine triad -0.0192164
HMGA1 high mobility group AT-hook 1 -0.0190849
S100A10 S100 calcium binding protein A10 -0.0185328
ATG7 autophagy related 7 -0.0184546
RPS15 ribosomal protein S15 -0.0183401
RPLP0 ribosomal protein, large, P0 -0.018315
GRB10 growth factor receptor-bound protein 10 -0.0182937
COG5 component of oligomeric golgi complex 5 -0.0182926
RPH3AL rabphilin 3A-like (without C2 domains) -0.0180809
TBC1D22A TBC1 domain family, member 22A -0.0180555
AUTS2 autism susceptibility candidate 2 -0.0178202
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A -0.0177762
CNIH3 cornichon family AMPA receptor auxiliary protein 3 -0.0177466
CCND1 cyclin D1 -0.0176705
TBCA tubulin folding cofactor A -0.0173252
PRKCA protein kinase C, alpha -0.0171342
TIAM2 T-cell lymphoma invasion and metastasis 2 -0.0170592
NPC1 Niemann-Pick disease, type C1 -0.0169799
KDM3B lysine (K)-specific demethylase 3B -0.0169611
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0169
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0168412
DENND4C DENN/MADD domain containing 4C -0.0167916