Goserelin (acetate)_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Goserelin (acetate) perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Goserelin (acetate)_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.150601
NKD1 naked cuticle homolog 1 (Drosophila) 0.149673
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.123767
HSPA8 heat shock 70kDa protein 8 0.0962879
EZR ezrin 0.0747091
MYH9 myosin, heavy chain 9, non-muscle 0.0622587
DSPP dentin sialophosphoprotein 0.0602351
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0602109
INTS6 integrator complex subunit 6 0.0580332
VMP1 vacuole membrane protein 1 0.0574837
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0537059
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.053508
LMO7 LIM domain 7 0.0499613
AHNAK AHNAK nucleoprotein 0.0489109
SAMD4A sterile alpha motif domain containing 4A 0.0483921
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0477683
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.047394
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0470936
APLP2 amyloid beta (A4) precursor-like protein 2 0.0470433
YAP1 Yes-associated protein 1 0.0463454
ASPH aspartate beta-hydroxylase 0.0438522
VCL vinculin 0.0431701
MACF1 microtubule-actin crosslinking factor 1 0.0423586
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0420599
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0402161
SMAD3 SMAD family member 3 0.0382957
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0378511
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0373137
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0366815
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0361078
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0358675
BCL2L1 BCL2-like 1 0.0357947
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0355441
RAD51B RAD51 paralog B 0.035461
MSN moesin 0.0333742
LRMDA leucine rich melanocyte differentiation associated 0.0329032
PDLIM5 PDZ and LIM domain 5 0.0328415
LOC102724023 ES1 protein homolog, mitochondrial 0.0327864
ZBTB38 zinc finger and BTB domain containing 38 0.0326336
SPATA13 spermatogenesis associated 13 0.0326134
EIF4A2 eukaryotic translation initiation factor 4A2 0.032327
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0320794
NCEH1 neutral cholesterol ester hydrolase 1 0.0318311
EGFR epidermal growth factor receptor 0.0315486
AXIN2 axin 2 0.0312572
GLI3 GLI family zinc finger 3 0.0308459
BCAR3 breast cancer anti-estrogen resistance 3 0.0294278
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.029315
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0288885
CD44 CD44 molecule (Indian blood group) 0.0286403
DOCK5 dedicator of cytokinesis 5 0.0284669
CTSB cathepsin B 0.0284054
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0283292
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0282617
TJP1 tight junction protein 1 0.0279619
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0278133
DSCAM Down syndrome cell adhesion molecule 0.0274951
TNS3 tensin 3 0.0274545
ACTN1 actinin, alpha 1 0.0271823
RPS3 ribosomal protein S3 0.0264704
SEPTIN9 septin 9 0.0263097
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0260534
CENPF centromere protein F, 350/400kDa 0.0258503
ANO6 anoctamin 6 0.0256831
EXOC4 exocyst complex component 4 0.0256304
SFPQ splicing factor proline/glutamine-rich 0.0256176
RPL14 ribosomal protein L14 0.0255825
CORO1C coronin, actin binding protein, 1C 0.0254943
MCC mutated in colorectal cancers 0.0250288
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0245198
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0243485
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0243342
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0242121
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0241911
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0239698
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0236288
DOCK4 dedicator of cytokinesis 4 0.0234108
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.023323
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0233207
SET SET nuclear proto-oncogene 0.0230975
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0230307
RCOR1 REST corepressor 1 0.0225672
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0225302
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0224748
FAT1 FAT atypical cadherin 1 0.0222918
RPS2 ribosomal protein S2 0.022201
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0219335
AATF apoptosis antagonizing transcription factor 0.0218479
YBX3 Y box binding protein 3 0.0218476
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0215931
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0215659
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0215591
OSBPL10 oxysterol binding protein-like 10 0.0215205
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0214694
RBM12 RNA binding motif protein 12 0.0214518
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0213988
ZSWIM6 zinc finger, SWIM-type containing 6 0.0213958
GOLGB1 golgin B1 0.0212897
DST dystonin 0.0211414
TRIM44 tripartite motif containing 44 0.0208363

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.23318
TMSB10 thymosin beta 10 -0.138126
RPLP1 ribosomal protein, large, P1 -0.0999719
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0892221
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0871849
RPL35A ribosomal protein L35a -0.0811084
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0797233
HMGA1 high mobility group AT-hook 1 -0.0764506
RPS24 ribosomal protein S24 -0.0689405
EEF2 eukaryotic translation elongation factor 2 -0.0685466
VIM vimentin -0.0604322
TPT1 tumor protein, translationally-controlled 1 -0.0600621
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0561912
RPLP2 ribosomal protein, large, P2 -0.0552835
RPS13 ribosomal protein S13 -0.052868
KRT18 keratin 18, type I -0.052358
CDH13 cadherin 13 -0.0495002
ACTG1 actin gamma 1 -0.0492737
RPL36A ribosomal protein L36a -0.0486872
RPL7A ribosomal protein L7a -0.0481822
RPS19 ribosomal protein S19 -0.046887
RPS25 ribosomal protein S25 -0.0463202
RPL27A ribosomal protein L27a -0.0456147
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.045287
EIF1 eukaryotic translation initiation factor 1 -0.0442335
PERP PERP, TP53 apoptosis effector -0.0437986
RPL32 ribosomal protein L32 -0.0428945
RPS23 ribosomal protein S23 -0.042848
MAML2 mastermind-like 2 (Drosophila) -0.0421884
KPNB1 karyopherin (importin) beta 1 -0.0419061
RPL23 ribosomal protein L23 -0.0418528
TMEM123 transmembrane protein 123 -0.0407711
PKM pyruvate kinase, muscle -0.0406243
RPL19 ribosomal protein L19 -0.0396128
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0392083
RPLP0 ribosomal protein, large, P0 -0.0384403
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0383962
KRT8 keratin 8, type II -0.0380551
RPS16 ribosomal protein S16 -0.0378423
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa -0.0377815
RPL31 ribosomal protein L31 -0.0377083
ITGB4 integrin, beta 4 -0.0374232
RPL12 ribosomal protein L12 -0.0369112
RPS5 ribosomal protein S5 -0.0365093
RPL11 ribosomal protein L11 -0.0357492
GNAS GNAS complex locus -0.0355747
RPL8 ribosomal protein L8 -0.0355635
ESYT2 extended synaptotagmin-like protein 2 -0.0355514
ZMYND8 zinc finger, MYND-type containing 8 -0.03473
RPS11 ribosomal protein S11 -0.0345576
RPL28 ribosomal protein L28 -0.0344252
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0343642
TPM4 tropomyosin 4 -0.0338419
BIRC6 baculoviral IAP repeat containing 6 -0.0336083
PFN1 profilin 1 -0.0331868
AKAP12 A kinase (PRKA) anchor protein 12 -0.0326468
GLG1 golgi glycoprotein 1 -0.0326258
VDAC1 voltage-dependent anion channel 1 -0.0324931
DLG1 discs, large homolog 1 (Drosophila) -0.0323039
ZBTB20 zinc finger and BTB domain containing 20 -0.0316783
RPL37 ribosomal protein L37 -0.0314715
HMGB1 high mobility group box 1 -0.0314173
RPL5 ribosomal protein L5 -0.0313614
RPL38 ribosomal protein L38 -0.0310174
RPS15 ribosomal protein S15 -0.0309176
RPS20 ribosomal protein S20 -0.030633
CCND1 cyclin D1 -0.0305169
TUBA1B tubulin, alpha 1b -0.0301405
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0298961
S100A6 S100 calcium binding protein A6 -0.02974
ANO1 anoctamin 1, calcium activated chloride channel -0.0297073
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0295349
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.0292799
WDFY2 WD repeat and FYVE domain containing 2 -0.0290734
THOC2 THO complex 2 -0.0290077
CANX calnexin -0.0289754
SKAP1 src kinase associated phosphoprotein 1 -0.028791
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0287274
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0286905
IARS1 isoleucyl-tRNA synthetase 1 -0.0286614
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0285361
MORF4L2 mortality factor 4 like 2 -0.0284897
PGK1 phosphoglycerate kinase 1 -0.0281457
RPS29 ribosomal protein S29 -0.0279981
FTH1 ferritin, heavy polypeptide 1 -0.0277903
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0275253
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0269513
EPB41 erythrocyte membrane protein band 4.1 -0.0268015
MON2 MON2 homolog (S. cerevisiae) -0.0267271
RPS6 ribosomal protein S6 -0.0266843
DEK DEK proto-oncogene -0.0263751
NIPSNAP2 nipsnap homolog 2 -0.0262542
WASF2 WAS protein family, member 2 -0.0261914
PIBF1 progesterone immunomodulatory binding factor 1 -0.0255057
TUBB tubulin, beta class I -0.0255022
FTL ferritin, light polypeptide -0.0249768
GARS1 glycyl-tRNA synthetase 1 -0.0247062
RPS27A ribosomal protein S27a -0.0246736
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0243232
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0242067