Gout Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description Hereditary metabolic disorder characterized by recurrent acute arthritis, hyperuricemia and deposition of sodium urate in and around the joints, sometimes with formation of uric acid calculi. (Experimental Factor Ontology, EFO_0004274)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D006073
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Genes

59 genes/proteins associated with the disease Gout from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
ALDH16A1 aldehyde dehydrogenase 16 family, member A1 2.88009
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 2.88009
CAT catalase 1.61248
IL1B interleukin 1, beta 1.54086
TNF tumor necrosis factor 1.53941
CCL2 chemokine (C-C motif) ligand 2 1.46648
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.45194
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 1.43591
IL6 interleukin 6 1.41091
SLC22A12 solute carrier family 22 (organic anion/urate transporter), member 12 1.38441
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 1.36418
PPARG peroxisome proliferator-activated receptor gamma 1.33553
NOS3 nitric oxide synthase 3 (endothelial cell) 1.30758
VEGFA vascular endothelial growth factor A 1.30329
JUN jun proto-oncogene 1.30269
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 1.26052
REN renin 1.25776
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.254
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.25152
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 1.23648
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.23392
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.22209
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.21823
IL1A interleukin 1, alpha 1.20913
TGFB1 transforming growth factor, beta 1 1.20751
ADIPOQ adiponectin, C1Q and collagen domain containing 1.20328
EDN1 endothelin 1 1.2013
MPO myeloperoxidase 1.19639
PPARD peroxisome proliferator-activated receptor delta 1.19477
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.19279
TP53 tumor protein p53 1.18981
HMOX1 heme oxygenase 1 1.18915
PPARA peroxisome proliferator-activated receptor alpha 1.18685
NOS2 nitric oxide synthase 2, inducible 1.17695
CCND1 cyclin D1 1.17563
IL12B interleukin 12B 1.16335
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.14954
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.14575
IFNG interferon, gamma 1.14541
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.13381
FOS FBJ murine osteosarcoma viral oncogene homolog 1.12564
ICAM1 intercellular adhesion molecule 1 1.11775
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.08833
PCNA proliferating cell nuclear antigen 1.08055
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.07804
FAS Fas cell surface death receptor 1.07199
GDF15 growth differentiation factor 15 1.07057
BAX BCL2-associated X protein 1.05535
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 1.05052
DDIT3 DNA-damage-inducible transcript 3 1.04904
SOD2 superoxide dismutase 2, mitochondrial 1.04201
FASN fatty acid synthase 1.04051
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 1.04051
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 1.03641
TJP1 tight junction protein 1 1.02933
CDK2 cyclin-dependent kinase 2 1.01324
CASP6 caspase 6, apoptosis-related cysteine peptidase 1.01212
CA2 carbonic anhydrase II 1.01062
BCL2 B-cell CLL/lymphoma 2 1.01025