Gout Gene Set

Dataset DISEASES Experimental Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description Hereditary metabolic disorder characterized by recurrent acute arthritis, hyperuricemia and deposition of sodium urate in and around the joints, sometimes with formation of uric acid calculi. (Experimental Factor Ontology, EFO_0004274)
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Genes

174 genes associated with the disease Gout in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 2.069
PKD2 polycystic kidney disease 2 (autosomal dominant) 2.069
SPP1 secreted phosphoprotein 1 2.062
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 2.05
WDR1 WD repeat domain 1 2.046
SLC17A3 solute carrier family 17 (organic anion transporter), member 3 2.044
SLC17A1 solute carrier family 17 (organic anion transporter), member 1 2.044
SLC17A4 solute carrier family 17, member 4 2.044
ACAD10 acyl-CoA dehydrogenase family, member 10 2.043
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 2.043
IFT172 intraflagellar transport 172 2.033
NRBP1 nuclear receptor binding protein 1 2.033
KRTCAP3 keratinocyte associated protein 3 2.033
GCKR glucokinase (hexokinase 4) regulator 2.033
ZNF512 zinc finger protein 512 2.033
FNDC4 fibronectin type III domain containing 4 2.033
H2BC1 H2B clustered histone 1 2.032
H2AC1 H2A clustered histone 1 2.032
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 2.026
NRXN2 neurexin 2 2.026
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.024
TBX4 T-box 4 2.022
TBX2 T-box 2 2.022
BCAS3 breast carcinoma amplified sequence 3 2.022
SLC22A12 solute carrier family 22 (organic anion/urate transporter), member 12 2.014
PPM1K protein phosphatase, Mg2+/Mn2+ dependent, 1K 1.989
CUX2 cut-like homeobox 2 1.974
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G 1.97
SHLD2 shieldin complex subunit 2 1.966
GLUD1 glutamate dehydrogenase 1 1.966
SLC17A2 solute carrier family 17, member 2 1.965
NUTM2A NUT family member 2A 1.956
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 1.945
TRAFD1 TRAF-type zinc finger domain containing 1 1.945
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit 1.945
MUC1 mucin 1, cell surface associated 1.928
TRIM46 tripartite motif containing 46 1.928
EFNA3 ephrin-A3 1.928
EFNA1 ephrin-A1 1.928
CLK2 CDC-like kinase 2 1.928
THBS3 thrombospondin 3 1.928
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1 1.928
KRTCAP2 keratinocyte associated protein 2 1.928
SCAMP3 secretory carrier membrane protein 3 1.928
MTX1 metaxin 1 1.928
HCN3 hyperpolarization activated cyclic nucleotide gated potassium channel 3 1.928
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3 1.928
PNPLA3 patatin-like phospholipase domain containing 3 1.918
SULT4A1 sulfotransferase family 4A, member 1 1.918
PARVB parvin, beta 1.918
SAMM50 SAMM50 sorting and assembly machinery component 1.918
PNPLA5 patatin-like phospholipase domain containing 5 1.918
INHBE inhibin, beta E 1.874
R3HDM2 R3H domain containing 2 1.874
GLI1 GLI family zinc finger 1 1.874
INHBC inhibin, beta C 1.874
ARHGAP9 Rho GTPase activating protein 9 1.874
MARS1 methionyl-tRNA synthetase 1 1.874
MLXIPL MLX interacting protein-like 1.873
TBL2 transducin (beta)-like 2 1.873
VPS37D vacuolar protein sorting 37 homolog D (S. cerevisiae) 1.873
STX1A syntaxin 1A (brain) 1.873
DNAJC30 DnaJ (Hsp40) homolog, subfamily C, member 30 1.873
BCL7B B-cell CLL/lymphoma 7B 1.873
BUD23 BUD23 rRNA methyltransferase and ribosome maturation factor 1.873
BAZ1B bromodomain adjacent to zinc finger domain, 1B 1.873
SLC16A9 solute carrier family 16, member 9 1.871
CCDC6 coiled-coil domain containing 6 1.871
MRLN myoregulin 1.871
MYL2 myosin, light chain 2, regulatory, cardiac, slow 1.86
CCDC63 coiled-coil domain containing 63 1.86
PHETA1 PH domain containing endocytic trafficking adaptor 1 1.82
TMEM116 transmembrane protein 116 1.801
ERP29 endoplasmic reticulum protein 29 1.801
SFMBT1 Scm-like with four mbt domains 1 1.779
STIMATE STIM activating enhancer 1.779
RFT1 RFT1 homolog (S. cerevisiae) 1.779
PDZK1 PDZ domain containing 1 1.77
CD160 CD160 molecule 1.77
RNF115 ring finger protein 115 1.77
GPHRA golgi pH regulator A 1.77
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated) 1.462
SF1 splicing factor 1 1.462
PYGM phosphorylase, glycogen, muscle 1.462
BRAP BRCA1 associated protein 1.433
RFX3 regulatory factor X, 3 (influences HLA class II expression) 1.411
GLIS3 GLIS family zinc finger 3 1.411
MBD6 methyl-CpG binding domain protein 6 1.314
DCTN2 dynactin 2 (p50) 1.314
DDIT3 DNA-damage-inducible transcript 3 1.314
KIF5A kinesin family member 5A 1.314
FAM25A family with sequence similarity 25, member A 1.252
ADIRF adipogenesis regulatory factor 1.252
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 1.203
MLXIP MLX interacting protein 1.203
LRRC43 leucine rich repeat containing 43 1.203
BCL7A B-cell CLL/lymphoma 7A 1.203
IL31 interleukin 31 1.203
CNTN5 contactin 5 1.182
YIF1A Yip1 interacting factor homolog A (S. cerevisiae) 1.177
CNIH2 cornichon family AMPA receptor auxiliary protein 2 1.177
CD248 CD248 molecule, endosialin 1.177
PACS1 phosphofurin acidic cluster sorting protein 1 1.177
RIN1 Ras and Rab interactor 1 1.177
TMEM151A transmembrane protein 151A 1.177
RAB1B RAB1B, member RAS oncogene family 1.177
B4GAT1 beta-1,4-glucuronyltransferase 1 1.177
BRMS1 breast cancer metastasis suppressor 1 1.177
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 1.177
KLC2 kinesin light chain 2 1.177
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 1.153
LRP2 low density lipoprotein receptor-related protein 2 1.106
BBS5 Bardet-Biedl syndrome 5 1.106
DHRS9 dehydrogenase/reductase (SDR family) member 9 1.106
CNGA1 cyclic nucleotide gated channel alpha 1 1.06
TXK TXK tyrosine kinase 1.06
NIPAL1 NIPA-like domain containing 1 1.06
ACSM2B acyl-CoA synthetase medium-chain family member 2B 0.923
ACSM2A acyl-CoA synthetase medium-chain family member 2A 0.923
ACSM3 acyl-CoA synthetase medium-chain family member 3 0.923
ACSM1 acyl-CoA synthetase medium-chain family member 1 0.923
ARID1A AT rich interactive domain 1A (SWI-like) 0.894
PIGV phosphatidylinositol glycan anchor biosynthesis, class V 0.894
PIBF1 progesterone immunomodulatory binding factor 1 0.867
KLF5 Kruppel-like factor 5 (intestinal) 0.867
NRG4 neuregulin 4 0.697
UBE2Q2 ubiquitin-conjugating enzyme E2Q family member 2 0.697
FBXO22 F-box protein 22 0.697
CFL1 cofilin 1 (non-muscle) 0.632
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 0.632
AP5B1 adaptor-related protein complex 5, beta 1 subunit 0.632
RNASEH2C ribonuclease H2, subunit C 0.632
SIPA1 signal-induced proliferation-associated 1 0.632
KAT5 K(lysine) acetyltransferase 5 0.632
SNX32 sorting nexin 32 0.632
OVOL1 ovo-like zinc finger 1 0.632
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 0.598
EHD1 EH-domain containing 1 0.598
MEN1 multiple endocrine neoplasia I 0.598
ATG2A autophagy related 2A 0.598
CDC42BPG CDC42 binding protein kinase gamma (DMPK-like) 0.598
ZSCAN12 zinc finger and SCAN domain containing 12 0.582
ZSCAN9 zinc finger and SCAN domain containing 9 0.582
PGBD1 piggyBac transposable element derived 1 0.582
ZSCAN26 zinc finger and SCAN domain containing 26 0.582
ZKSCAN4 zinc finger with KRAB and SCAN domains 4 0.582
ZSCAN31 zinc finger and SCAN domain containing 31 0.582
ZKSCAN3 zinc finger with KRAB and SCAN domains 3 0.582
NKAPL NFKB activating protein-like 0.582
H2BC4 H2B clustered histone 4 0.57
H3C8 H3 clustered histone 8 0.57
H2AC7 H2A clustered histone 7 0.57
H4C6 H4 clustered histone 6 0.57
H3C4 H3 clustered histone 4 0.57
H4C3 H4 clustered histone 3 0.57
H4C4 H4 clustered histone 4 0.57
B4GAT1-DT B4GAT1 divergent transcript 0.57
H4C5 H4 clustered histone 5 0.57
H4C8 H4 clustered histone 8 0.57
H3C6 H3 clustered histone 6 0.57
H2BC8 H2B clustered histone 8 0.57
H3C7 H3 clustered histone 7 0.57
H4C7 H4 clustered histone 7 0.57
HIST1H2BI histone cluster 1, H2bi 0.57
H1-6 H1.6 linker histone, cluster member 0.57
H1-4 H1.4 linker histone, cluster member 0.57
H1-3 H1.3 linker histone, cluster member 0.57
HIST1H2BF histone cluster 1, H2bf 0.57
H2BC5 H2B clustered histone 5 0.57
H2AC6 H2A clustered histone 6 0.57
H2AC8 H2A clustered histone 8 0.57
H2BC9 H2B clustered histone 9 0.57
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 0.508
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 0.508