Guanethidine Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/3518
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Genes

199 proteins with high or low expression in Guanethidine relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
IER2 immediate early response 2 2.05
UHMK1 U2AF homology motif (UHM) kinase 1 1.74
GIGYF1 GRB10 interacting GYF protein 1 1.53
BAHCC1 BAH domain and coiled-coil containing 1 1.35
PIP prolactin-induced protein 1.03
TTC27 tetratricopeptide repeat domain 27 0.88
SBSN suprabasin 0.77
TSPAN14 tetraspanin 14 0.72
TMEM132A transmembrane protein 132A 0.7
NAP1L1 nucleosome assembly protein 1-like 1 0.65
CBR3 carbonyl reductase 3 0.65
ZNF581 zinc finger protein 581 0.62
ZNF286B zinc finger protein 286B 0.6
C12ORF60 chromosome 12 open reading frame 60 0.56
SOX4 SRY (sex determining region Y)-box 4 0.54
GRAMD4 GRAM domain containing 4 0.53
PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 0.51
OMA1 OMA1 zinc metallopeptidase 0.51
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit 0.5
CRY2 cryptochrome circadian clock 2 0.44
PWWP3A PWWP domain containing 3A, DNA repair factor 0.44
SLC25A19 solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19 0.43
CCDC32 coiled-coil domain containing 32 0.42
UBXN2A UBX domain protein 2A 0.41
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.41
AZGP1 alpha-2-glycoprotein 1, zinc-binding 0.41
VPS37C vacuolar protein sorting 37 homolog C (S. cerevisiae) 0.4
RIN3 Ras and Rab interactor 3 0.4
FOXD2 forkhead box D2 0.38
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.38
CRYBG2 crystallin beta-gamma domain containing 2 0.38
ZNF428 zinc finger protein 428 0.37
FZD1 frizzled class receptor 1 0.37
ETV6 ets variant 6 0.36
CERCAM cerebral endothelial cell adhesion molecule 0.36
ABRACL ABRA C-terminal like 0.36
NPM3 nucleophosmin/nucleoplasmin 3 0.36
VWA5B2 von Willebrand factor A domain containing 5B2 0.36
DST dystonin 0.36
EYS eyes shut homolog (Drosophila) 0.36
RPL31 ribosomal protein L31 0.35
ENKD1 enkurin domain containing 1 0.34
ABLIM2 actin binding LIM protein family, member 2 0.34
WWC3 WWC family member 3 0.33
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow 0.33
USP43 ubiquitin specific peptidase 43 0.33
DENND3 DENN/MADD domain containing 3 0.33
MIEN1 migration and invasion enhancer 1 0.33
EPOP elongin BC and polycomb repressive complex 2 associated protein 0.33
PTGES prostaglandin E synthase 0.32
FGFR1OP2 FGFR1 oncogene partner 2 0.32
RPUSD1 RNA pseudouridylate synthase domain containing 1 0.32
INPP5J inositol polyphosphate-5-phosphatase J 0.32
PROS1 protein S (alpha) 0.31
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 0.31
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa 0.31
ANKRD46 ankyrin repeat domain 46 0.31
GPRC5B G protein-coupled receptor, class C, group 5, member B 0.3
BCORL1 BCL6 corepressor-like 1 0.3
GPBP1L1 GC-rich promoter binding protein 1-like 1 0.3
PMFBP1 polyamine modulated factor 1 binding protein 1 0.3
ZNF777 zinc finger protein 777 0.3
IFT43 intraflagellar transport 43 0.29
FHIT fragile histidine triad 0.29
DMD dystrophin 0.29
POLQ polymerase (DNA directed), theta 0.29
UBTD1 ubiquitin domain containing 1 0.28
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 0.28
RWDD2A RWD domain containing 2A 0.28
MTX2 metaxin 2 0.28
BOD1 biorientation of chromosomes in cell division 1 0.28
PCNX1 pecanex 1 0.28
FGD6 FYVE, RhoGEF and PH domain containing 6 0.27
ZKSCAN8 zinc finger with KRAB and SCAN domains 8 0.27
OVCA2 ovarian tumor suppressor candidate 2 0.27
TMEM102 transmembrane protein 102 0.27
DPYD dihydropyrimidine dehydrogenase 0.27
RBP7 retinol binding protein 7, cellular 0.27
CIB1 calcium and integrin binding 1 (calmyrin) 0.27
SRD5A3 steroid 5 alpha-reductase 3 0.26
TMEM64 transmembrane protein 64 0.26
JPT1 Jupiter microtubule associated homolog 1 0.26
RFLNB refilin B 0.26
CLUH clustered mitochondria (cluA/CLU1) homolog 0.26
HLA-F major histocompatibility complex, class I, F 0.26
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10 0.26
CNOT8 CCR4-NOT transcription complex, subunit 8 0.26
PDZD11 PDZ domain containing 11 0.26
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.26
ARSB arylsulfatase B 0.26
COA7 cytochrome c oxidase assembly factor 7 (putative) 0.26
ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 0.26
OTUD7A OTU deubiquitinase 7A 0.25
CHRD chordin 0.25
LRRC49 leucine rich repeat containing 49 0.25
DNAH1 dynein, axonemal, heavy chain 1 0.25
C15ORF61 chromosome 15 open reading frame 61 0.25
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.25
SIKE1 suppressor of IKBKE 1 0.25
RMI2 RecQ mediated genome instability 2 0.25

low expression

Symbol Name Standardized Value
VGF VGF nerve growth factor inducible -1.85
GSKIP GSK3B interacting protein -0.71
TIMP2 TIMP metallopeptidase inhibitor 2 -0.7
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -0.67
LIPH lipase, member H -0.59
NR1H2 nuclear receptor subfamily 1, group H, member 2 -0.55
PPP4R4 protein phosphatase 4, regulatory subunit 4 -0.52
SH3YL1 SH3 and SYLF domain containing 1 -0.44
PCLO piccolo presynaptic cytomatrix protein -0.41
ISOC2 isochorismatase domain containing 2 -0.4
DCBLD1 discoidin, CUB and LCCL domain containing 1 -0.38
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.37
MTRF1L mitochondrial translational release factor 1-like -0.36
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B -0.36
MT1F metallothionein 1F -0.34
ZBED2 zinc finger, BED-type containing 2 -0.34
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) -0.33
MADD MAP-kinase activating death domain -0.32
ZBTB4 zinc finger and BTB domain containing 4 -0.32
CERS4 ceramide synthase 4 -0.32
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3 -0.31
DXO decapping exoribonuclease -0.31
CCDC15 coiled-coil domain containing 15 -0.31
MAST3 microtubule associated serine/threonine kinase 3 -0.29
CLCN5 chloride channel, voltage-sensitive 5 -0.29
ABHD18 abhydrolase domain containing 18 -0.29
UNC13D unc-13 homolog D (C. elegans) -0.28
FUNDC1 FUN14 domain containing 1 -0.28
LGALSL lectin, galactoside-binding-like -0.28
RAB11FIP4 RAB11 family interacting protein 4 (class II) -0.27
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.27
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.26
GID8 GID complex subunit 8 -0.26
PDIA4 protein disulfide isomerase family A, member 4 -0.26
RNF111 ring finger protein 111 -0.25
COX10 COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor -0.25
ATMIN ATM interactor -0.24
RUFY3 RUN and FYVE domain containing 3 -0.24
SLC44A2 solute carrier family 44 (choline transporter), member 2 -0.23
TMEM106B transmembrane protein 106B -0.23
TTLL7 tubulin tyrosine ligase-like family member 7 -0.23
UQCRH ubiquinol-cytochrome c reductase hinge protein -0.23
SYTL2 synaptotagmin-like 2 -0.23
UBQLN1 ubiquilin 1 -0.23
C1QTNF3 C1q and tumor necrosis factor related protein 3 -0.22
WDR48 WD repeat domain 48 -0.22
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 -0.22
OSBPL1A oxysterol binding protein-like 1A -0.22
FAM86B2 family with sequence similarity 86, member B2 -0.22
C5ORF34 chromosome 5 open reading frame 34 -0.22
DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1 -0.22
KRT222 keratin 222, type II -0.22
MTUS2 microtubule associated tumor suppressor candidate 2 -0.22
CLASP1 cytoplasmic linker associated protein 1 -0.22
TSPAN3 tetraspanin 3 -0.21
TMEM101 transmembrane protein 101 -0.21
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 -0.21
CEP104 centrosomal protein 104kDa -0.21
HIPK2 homeodomain interacting protein kinase 2 -0.21
LRRC8B leucine rich repeat containing 8 family, member B -0.21
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1 -0.21
ASB7 ankyrin repeat and SOCS box containing 7 -0.21
PARP16 poly (ADP-ribose) polymerase family, member 16 -0.21
RNF26 ring finger protein 26 -0.21
CMC4 C-x(9)-C motif containing 4 -0.2
UVSSA UV-stimulated scaffold protein A -0.2
DESI1 desumoylating isopeptidase 1 -0.2
ZMAT3 zinc finger, matrin-type 3 -0.2
SLC35F6 solute carrier family 35, member F6 -0.2
F2RL1 coagulation factor II (thrombin) receptor-like 1 -0.2
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha -0.2
SAYSD1 SAYSVFN motif domain containing 1 -0.2
SLC25A40 solute carrier family 25, member 40 -0.2
XPR1 xenotropic and polytropic retrovirus receptor 1 -0.2
RAB12 RAB12, member RAS oncogene family -0.2
LETMD1 LETM1 domain containing 1 -0.2
PPP2R2B protein phosphatase 2, regulatory subunit B, beta -0.19
MROH6 maestro heat-like repeat family member 6 -0.19
PIP4P1 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 -0.19
LRRC46 leucine rich repeat containing 46 -0.19
APOB apolipoprotein B -0.19
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa -0.19
SLC30A7 solute carrier family 30 (zinc transporter), member 7 -0.19
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 -0.19
SIRPA signal-regulatory protein alpha -0.19
WDFY3 WD repeat and FYVE domain containing 3 -0.19
ZNF746 zinc finger protein 746 -0.19
ZNF92 zinc finger protein 92 -0.19
ISG20 interferon stimulated exonuclease gene 20kDa -0.19
POLR3F polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa -0.19
MKRN1 makorin ring finger protein 1 -0.19
NAIF1 nuclear apoptosis inducing factor 1 -0.19
LARGE2 LARGE xylosyl- and glucuronyltransferase 2 -0.18
CEBPZOS CEBPZ opposite strand -0.18
GTF2A1 general transcription factor IIA, 1, 19/37kDa -0.18
ALKBH5 AlkB family member 5, RNA demethylase -0.18
MYH15 myosin, heavy chain 15 -0.18
MYPOP Myb-related transcription factor, partner of profilin -0.18
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6 -0.18