| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/3519 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in Guanfacine relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HBB | hemoglobin, beta | 1.24 |
| CD63 | CD63 molecule | 0.69 |
| PIP | prolactin-induced protein | 0.65 |
| TSPAN3 | tetraspanin 3 | 0.6 |
| ZKSCAN2 | zinc finger with KRAB and SCAN domains 2 | 0.55 |
| ALDH1L2 | aldehyde dehydrogenase 1 family, member L2 | 0.54 |
| SH3D19 | SH3 domain containing 19 | 0.49 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.48 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.47 |
| CLN3 | ceroid-lipofuscinosis, neuronal 3 | 0.46 |
| JOSD1 | Josephin domain containing 1 | 0.46 |
| DHFR | dihydrofolate reductase | 0.46 |
| DNPH1 | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | 0.45 |
| PLEKHA3 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3 | 0.43 |
| JAK2 | Janus kinase 2 | 0.42 |
| KIAA0513 | KIAA0513 | 0.41 |
| ZKSCAN3 | zinc finger with KRAB and SCAN domains 3 | 0.41 |
| DCLRE1A | DNA cross-link repair 1A | 0.41 |
| HFE | hemochromatosis | 0.4 |
| PCGF1 | polycomb group ring finger 1 | 0.38 |
| MPV17L2 | MPV17 mitochondrial membrane protein-like 2 | 0.38 |
| TFAP4 | transcription factor AP-4 (activating enhancer binding protein 4) | 0.38 |
| CTNND2 | catenin (cadherin-associated protein), delta 2 | 0.36 |
| ACY1 | aminoacylase 1 | 0.36 |
| DNAAF3 | dynein, axonemal, assembly factor 3 | 0.34 |
| PWWP2B | PWWP domain containing 2B | 0.32 |
| CCPG1 | cell cycle progression 1 | 0.32 |
| IGFBP6 | insulin-like growth factor binding protein 6 | 0.31 |
| MIIP | migration and invasion inhibitory protein | 0.31 |
| C15ORF40 | chromosome 15 open reading frame 40 | 0.3 |
| DMTF1 | cyclin D binding myb-like transcription factor 1 | 0.29 |
| VAMP8 | vesicle-associated membrane protein 8 | 0.29 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.29 |
| RCAN1 | regulator of calcineurin 1 | 0.29 |
| KLF4 | Kruppel-like factor 4 (gut) | 0.29 |
| RITA1 | RBPJ interacting and tubulin associated 1 | 0.28 |
| HSPA1L | heat shock 70kDa protein 1-like | 0.28 |
| MIDN | midnolin | 0.28 |
| SLC38A2 | solute carrier family 38, member 2 | 0.28 |
| GTF2IRD1 | GTF2I repeat domain containing 1 | 0.28 |
| ING4 | inhibitor of growth family, member 4 | 0.27 |
| MISO1 | mitochondrial inner membrane subdomain organizer 1 | 0.27 |
| CDC42EP1 | CDC42 effector protein (Rho GTPase binding) 1 | 0.26 |
| ZSCAN26 | zinc finger and SCAN domain containing 26 | 0.26 |
| MLXIPL | MLX interacting protein-like | 0.25 |
| TNK2 | tyrosine kinase, non-receptor, 2 | 0.25 |
| PLEKHG3 | pleckstrin homology domain containing, family G (with RhoGef domain) member 3 | 0.25 |
| STC2 | stanniocalcin 2 | 0.25 |
| ZNF485 | zinc finger protein 485 | 0.25 |
| IRX4 | iroquois homeobox 4 | 0.25 |
| PKD2 | polycystic kidney disease 2 (autosomal dominant) | 0.25 |
| KRT222 | keratin 222, type II | 0.25 |
| SYNE3 | spectrin repeat containing, nuclear envelope family member 3 | 0.25 |
| PUM2 | pumilio RNA-binding family member 2 | 0.25 |
| CHCHD2P9 | coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 9 | 0.25 |
| EXPH5 | exophilin 5 | 0.24 |
| CNNM1 | cyclin and CBS domain divalent metal cation transport mediator 1 | 0.24 |
| H1-2 | H1.2 linker histone, cluster member | 0.24 |
| PRR36 | proline rich 36 | 0.24 |
| RAB5IF | RAB5 interacting factor | 0.24 |
| ZNF362 | zinc finger protein 362 | 0.24 |
| TM7SF3 | transmembrane 7 superfamily member 3 | 0.24 |
| ZNF623 | zinc finger protein 623 | 0.23 |
| PCSK9 | proprotein convertase subtilisin/kexin type 9 | 0.23 |
| AP4S1 | adaptor-related protein complex 4, sigma 1 subunit | 0.23 |
| GSE1 | Gse1 coiled-coil protein | 0.23 |
| CEBPB | CCAAT/enhancer binding protein (C/EBP), beta | 0.23 |
| ZNF771 | zinc finger protein 771 | 0.23 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.23 |
| DDX4 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 | 0.23 |
| ANTKMT | adenine nucleotide translocase lysine methyltransferase | 0.23 |
| ZNF512B | zinc finger protein 512B | 0.23 |
| RHBDD1 | rhomboid domain containing 1 | 0.23 |
| PPIL2 | peptidylprolyl isomerase (cyclophilin)-like 2 | 0.22 |
| SLC25A39 | solute carrier family 25, member 39 | 0.22 |
| ACIN1 | apoptotic chromatin condensation inducer 1 | 0.22 |
| RGS19 | regulator of G-protein signaling 19 | 0.22 |
| COQ10B | coenzyme Q10 homolog B (S. cerevisiae) | 0.22 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.22 |
| HKDC1 | hexokinase domain containing 1 | 0.22 |
| TMEM219 | transmembrane protein 219 | 0.22 |
| ANTXR1 | anthrax toxin receptor 1 | 0.22 |
| FBXW4 | F-box and WD repeat domain containing 4 | 0.21 |
| RNF170 | ring finger protein 170 | 0.21 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | 0.21 |
| PAQR7 | progestin and adipoQ receptor family member VII | 0.21 |
| SLC12A5 | solute carrier family 12 (potassium/chloride transporter), member 5 | 0.21 |
| GHITM | growth hormone inducible transmembrane protein | 0.21 |
| IKZF5 | IKAROS family zinc finger 5 (Pegasus) | 0.21 |
| RBMS2 | RNA binding motif, single stranded interacting protein 2 | 0.2 |
| MTERF1 | mitochondrial transcription termination factor 1 | 0.2 |
| BCL2L1 | BCL2-like 1 | 0.2 |
| NUDT1 | nudix (nucleoside diphosphate linked moiety X)-type motif 1 | 0.2 |
| ARL2BP | ADP-ribosylation factor-like 2 binding protein | 0.2 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.2 |
| PLEKHA2 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 | 0.2 |
| SCARB2 | scavenger receptor class B, member 2 | 0.2 |
| SLC1A4 | solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 | 0.2 |
| CELSR1 | cadherin, EGF LAG seven-pass G-type receptor 1 | 0.2 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.2 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MCOLN2 | mucolipin 2 | -1.6 |
| ZNF12 | zinc finger protein 12 | -1.51 |
| ALPK3 | alpha-kinase 3 | -1.44 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | -0.89 |
| MT-CO2 | cytochrome c oxidase subunit II | -0.83 |
| MRPL13 | mitochondrial ribosomal protein L13 | -0.83 |
| MRPS21 | mitochondrial ribosomal protein S21 | -0.81 |
| COA5 | cytochrome c oxidase assembly factor 5 | -0.8 |
| MT-ND5 | NADH dehydrogenase, subunit 5 (complex I) | -0.8 |
| MRPL30 | mitochondrial ribosomal protein L30 | -0.79 |
| MRPL51 | mitochondrial ribosomal protein L51 | -0.77 |
| MRPL37 | mitochondrial ribosomal protein L37 | -0.76 |
| CLTA | clathrin, light chain A | -0.76 |
| MT-CO1 | cytochrome c oxidase subunit I | -0.75 |
| CHCHD1 | coiled-coil-helix-coiled-coil-helix domain containing 1 | -0.74 |
| SLC26A11 | solute carrier family 26 (anion exchanger), member 11 | -0.73 |
| MRPL50 | mitochondrial ribosomal protein L50 | -0.73 |
| MT-ND1 | NADH dehydrogenase, subunit 1 (complex I) | -0.72 |
| MRPS12 | mitochondrial ribosomal protein S12 | -0.69 |
| NDUFS5 | NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) | -0.67 |
| MRPS18A | mitochondrial ribosomal protein S18A | -0.67 |
| NDUFA7 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa | -0.66 |
| ABCB11 | ATP-binding cassette, sub-family B (MDR/TAP), member 11 | -0.66 |
| TP53 | tumor protein p53 | -0.65 |
| MRPL57 | mitochondrial ribosomal protein L57 | -0.65 |
| MRPS14 | mitochondrial ribosomal protein S14 | -0.65 |
| MRPL35 | mitochondrial ribosomal protein L35 | -0.64 |
| NDUFC2 | NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa | -0.64 |
| METRNL | meteorin, glial cell differentiation regulator-like | -0.62 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.6 |
| MT-ATP6 | ATP synthase F0 subunit 6 | -0.6 |
| MRPL16 | mitochondrial ribosomal protein L16 | -0.59 |
| MRPS30 | mitochondrial ribosomal protein S30 | -0.59 |
| NDUFB8 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa | -0.59 |
| MRPL22 | mitochondrial ribosomal protein L22 | -0.58 |
| MRPL52 | mitochondrial ribosomal protein L52 | -0.58 |
| COX5B | cytochrome c oxidase subunit Vb | -0.57 |
| DENND3 | DENN/MADD domain containing 3 | -0.57 |
| TMSB10 | thymosin beta 10 | -0.56 |
| NDUFB7 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa | -0.56 |
| COX7A2 | cytochrome c oxidase subunit VIIa polypeptide 2 (liver) | -0.56 |
| BAIAP3 | BAI1-associated protein 3 | -0.55 |
| MRPL34 | mitochondrial ribosomal protein L34 | -0.55 |
| GADD45GIP1 | growth arrest and DNA-damage-inducible, gamma interacting protein 1 | -0.54 |
| ENO1 | enolase 1, (alpha) | -0.54 |
| NEU3 | sialidase 3 (membrane sialidase) | -0.54 |
| MRPL32 | mitochondrial ribosomal protein L32 | -0.54 |
| MRPS11 | mitochondrial ribosomal protein S11 | -0.54 |
| MRPS33 | mitochondrial ribosomal protein S33 | -0.53 |
| MRPS15 | mitochondrial ribosomal protein S15 | -0.53 |
| UBE2C | ubiquitin-conjugating enzyme E2C | -0.53 |
| MRPL58 | mitochondrial ribosomal protein L58 | -0.52 |
| NDUFA12 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12 | -0.52 |
| MRPL9 | mitochondrial ribosomal protein L9 | -0.51 |
| MRPL19 | mitochondrial ribosomal protein L19 | -0.51 |
| METTL17 | methyltransferase like 17 | -0.5 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | -0.5 |
| KIAA1107 | KIAA1107 | -0.5 |
| BBS9 | Bardet-Biedl syndrome 9 | -0.5 |
| MRPL28 | mitochondrial ribosomal protein L28 | -0.5 |
| NDUFS4 | NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) | -0.49 |
| MSL3P1 | male-specific lethal 3 homolog (Drosophila) pseudogene 1 | -0.49 |
| MRPL3 | mitochondrial ribosomal protein L3 | -0.49 |
| ZNF8 | zinc finger protein 8 | -0.49 |
| SLC4A11 | solute carrier family 4, sodium borate transporter, member 11 | -0.48 |
| MRPL17 | mitochondrial ribosomal protein L17 | -0.48 |
| CDC26 | cell division cycle 26 | -0.48 |
| COX6C | cytochrome c oxidase subunit VIc | -0.47 |
| CCT6B | chaperonin containing TCP1, subunit 6B (zeta 2) | -0.47 |
| MYH13 | myosin, heavy chain 13, skeletal muscle | -0.47 |
| MRPL45 | mitochondrial ribosomal protein L45 | -0.47 |
| MRPL27 | mitochondrial ribosomal protein L27 | -0.47 |
| AURKAIP1 | aurora kinase A interacting protein 1 | -0.47 |
| MRPL14 | mitochondrial ribosomal protein L14 | -0.47 |
| HAUS1 | HAUS augmin-like complex, subunit 1 | -0.46 |
| NDUFA13 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 | -0.46 |
| NFE2L3 | nuclear factor, erythroid 2-like 3 | -0.45 |
| MRPL4 | mitochondrial ribosomal protein L4 | -0.45 |
| ATP5PF | ATP synthase peripheral stalk subunit F6 | -0.45 |
| ZGRF1 | zinc finger, GRF-type containing 1 | -0.45 |
| MRPL38 | mitochondrial ribosomal protein L38 | -0.45 |
| MRPL15 | mitochondrial ribosomal protein L15 | -0.44 |
| PTRHD1 | peptidyl-tRNA hydrolase domain containing 1 | -0.44 |
| MRPL23 | mitochondrial ribosomal protein L23 | -0.44 |
| ARHGAP44 | Rho GTPase activating protein 44 | -0.43 |
| FAT4 | FAT atypical cadherin 4 | -0.43 |
| IRF7 | interferon regulatory factor 7 | -0.43 |
| SGK3 | serum/glucocorticoid regulated kinase family, member 3 | -0.43 |
| GTPBP10 | GTP-binding protein 10 (putative) | -0.43 |
| DEF8 | differentially expressed in FDCP 8 homolog (mouse) | -0.43 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.43 |
| NDUFS1 | NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) | -0.43 |
| PET100 | PET100 homolog (S. cerevisiae) | -0.43 |
| NDUFA4 | NDUFA4, mitochondrial complex associated | -0.42 |
| IP6K2 | inositol hexakisphosphate kinase 2 | -0.42 |
| MRPL39 | mitochondrial ribosomal protein L39 | -0.42 |
| ITGA7 | integrin, alpha 7 | -0.42 |
| ZNF808 | zinc finger protein 808 | -0.42 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.41 |
| ADCY9 | adenylate cyclase 9 | -0.41 |
