Gynecomastia Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
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Genes

253 genes co-occuring with the disease Gynecomastia in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
PRL prolactin 2.928
AR androgen receptor 2.823
NR3C2 nuclear receptor subfamily 3, group C, member 2 2.784
SHBG sex hormone-binding globulin 2.7
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 2.679
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 2.513
ESR1 estrogen receptor 1 2.507
KLK3 kallikrein-related peptidase 3 2.47
POMC proopiomelanocortin 2.455
SRY sex determining region Y 2.407
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 2.329
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 2.313
REN renin 2.296
IGF1 insulin-like growth factor 1 (somatomedin C) 2.285
AMH anti-Mullerian hormone 2.193
AFP alpha-fetoprotein 2.174
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 2.171
PGR progesterone receptor 2.164
ACE angiotensin I converting enzyme 2.151
BRCA2 breast cancer 2, early onset 2.109
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 2.072
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 2.071
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 2.068
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1 2.034
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.999
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 1.991
PROKR2 prokineticin receptor 2 1.983
ALB albumin 1.982
INSL3 insulin-like 3 (Leydig cell) 1.967
INS insulin 1.952
ANOS1 anosmin 1 1.945
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 1.897
DHRS11 dehydrogenase/reductase (SDR family) member 11 1.87
ESR2 estrogen receptor 2 (ER beta) 1.856
PHF6 PHD finger protein 6 1.856
BRCA1 breast cancer 1, early onset 1.855
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 1.849
GNRHR gonadotropin-releasing hormone receptor 1.844
NR5A1 nuclear receptor subfamily 5, group A, member 1 1.826
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 1.821
CALB2 calbindin 2 1.816
NR0B1 nuclear receptor subfamily 0, group B, member 1 1.816
KISS1 KiSS-1 metastasis-suppressor 1.758
CKMT1B creatine kinase, mitochondrial 1B 1.753
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 1.75
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 1.75
CKM creatine kinase, muscle 1.749
CKB creatine kinase, brain 1.746
SHOX short stature homeobox 1.74
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.74
ERBB2 erb-b2 receptor tyrosine kinase 2 1.732
DMXL2 Dmx-like 2 1.731
KISS1R KISS1 receptor 1.711
TRH thyrotropin-releasing hormone 1.709
SOX3 SRY (sex determining region Y)-box 3 1.709
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.703
PPIG peptidylprolyl isomerase G (cyclophilin G) 1.692
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 1.674
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 1.664
TAC3 tachykinin 3 1.653
STAR steroidogenic acute regulatory protein 1.646
PROK2 prokineticin 2 1.638
ZFY zinc finger protein, Y-linked 1.618
GH1 growth hormone 1 1.617
LEP leptin 1.61
LHCGR luteinizing hormone/choriogonadotropin receptor 1.61
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) 1.582
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 1.577
TACR3 tachykinin receptor 3 1.576
HRH2 histamine receptor H2 1.57
GHRH growth hormone releasing hormone 1.548
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 1.547
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 1.543
SOX9 SRY (sex determining region Y)-box 9 1.54
GPER1 G protein-coupled estrogen receptor 1 1.539
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1 1.537
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 1.528
DRD2 dopamine receptor D2 1.527
NPPB natriuretic peptide B 1.524
CRH corticotropin releasing hormone 1.517
TP53 tumor protein p53 1.505
CSH2 chorionic somatomammotropin hormone 2 1.504
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 1.496
CD99 CD99 molecule 1.494
GHRL ghrelin/obestatin prepropeptide 1.482
PRLR prolactin receptor 1.482
MME membrane metallo-endopeptidase 1.479
SST somatostatin 1.473
F2 coagulation factor II (thrombin) 1.472
AVP arginine vasopressin 1.472
IGFBP3 insulin-like growth factor binding protein 3 1.468
PDE5A phosphodiesterase 5A, cGMP-specific 1.46
CD34 CD34 molecule 1.459
PTH parathyroid hormone 1.448
RSPO1 R-spondin 1 1.427
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 1.424
TGFB1 transforming growth factor, beta 1 1.424
IL6 interleukin 6 1.42
GHR growth hormone receptor 1.413
KRT7 keratin 7, type II 1.411
MEN1 multiple endocrine neoplasia I 1.409
CD99L2 CD99 molecule-like 2 1.409
GH2 growth hormone 2 1.397
BPY2 basic charge, Y-linked, 2 1.397
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 1.387
AKR1C3 aldo-keto reductase family 1, member C3 1.386
NF1 neurofibromin 1 1.385
ALPP alkaline phosphatase, placental 1.38
WT1 Wilms tumor 1 1.358
DMRT1 doublesex and mab-3 related transcription factor 1 1.355
MAMLD1 mastermind-like domain containing 1 1.354
DAZ1 deleted in azoospermia 1 1.353
WNT4 wingless-type MMTV integration site family, member 4 1.351
RNF216 ring finger protein 216 1.35
HS6ST1 heparan sulfate 6-O-sulfotransferase 1 1.346
CHD7 chromodomain helicase DNA binding protein 7 1.341
IL17RD interleukin 17 receptor D 1.339
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 1.337
MYOM2 myomesin 2 1.328
LYSMD2 LysM, putative peptidoglycan-binding, domain containing 2 1.326
CHEK2 checkpoint kinase 2 1.324
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.323
MSTN myostatin 1.323
EPO erythropoietin 1.323
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.321
MMEL1 membrane metallo-endopeptidase-like 1 1.321
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.321
FGFR1 fibroblast growth factor receptor 1 1.317
USP9Y ubiquitin specific peptidase 9, Y-linked 1.316
GCG glucagon 1.316
PALB2 partner and localizer of BRCA2 1.313
IGF2 insulin-like growth factor 2 1.313
AMELX amelogenin, X-linked 1.31
DAZ3 deleted in azoospermia 3 1.309
SYP synaptophysin 1.302
SALL4 spalt-like transcription factor 4 1.3
CRP C-reactive protein, pentraxin-related 1.298
STK11 serine/threonine kinase 11 1.293
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.288
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 1.286
TNF tumor necrosis factor 1.285
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 1.284
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.283
PIP prolactin-induced protein 1.278
BPY2C basic charge, Y-linked, 2C 1.268
BPY2B basic charge, Y-linked, 2B 1.268
ARMC5 armadillo repeat containing 5 1.267
SOX10 SRY (sex determining region Y)-box 10 1.265
IL1B interleukin 1, beta 1.261
DHH desert hedgehog 1.257
DAZ2 deleted in azoospermia 2 1.253
BGLAP bone gamma-carboxyglutamate (gla) protein 1.252
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.248
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5 1.248
AMELY amelogenin, Y-linked 1.248
FGF8 fibroblast growth factor 8 (androgen-induced) 1.241
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 1.239
GLDN gliomedin 1.238
KRT5 keratin 5, type II 1.234
HESX1 HESX homeobox 1 1.231
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3 1.225
PRKACG protein kinase, cAMP-dependent, catalytic, gamma 1.221
TEX11 testis expressed 11 1.215
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 1.213
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 1.213
EGFR epidermal growth factor receptor 1.211
PRKACB protein kinase, cAMP-dependent, catalytic, beta 1.211
GAST gastrin 1.209
DNAH8 dynein, axonemal, heavy chain 8 1.209
BCL2 B-cell CLL/lymphoma 2 1.207
MC2R melanocortin 2 receptor (adrenocorticotropic hormone) 1.202
AMHR2 anti-Mullerian hormone receptor, type II 1.201
PROP1 PROP paired-like homeobox 1 1.201
FGF9 fibroblast growth factor 9 1.2
NPPA natriuretic peptide A 1.198
FLRT3 fibronectin leucine rich transmembrane protein 3 1.193
OXT oxytocin/neurophysin I prepropeptide 1.192
ZFX zinc finger protein, X-linked 1.192
GNAS GNAS complex locus 1.178
EDN1 endothelin 1 1.174
GTPBP6 GTP binding protein 6 (putative) 1.171
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 1.166
PTEN phosphatase and tensin homolog 1.161
PXDNL peroxidasin-like 1.157
PXDN peroxidasin 1.156
MAOA monoamine oxidase A 1.155
FSHB follicle stimulating hormone, beta polypeptide 1.15
PPARG peroxisome proliferator-activated receptor gamma 1.148
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 1.144
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 1.138
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 1.138
ADIPOQ adiponectin, C1Q and collagen domain containing 1.136
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 1.134
MYH14 myosin, heavy chain 14, non-muscle 1.132
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 1.129
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 1.129
MAOB monoamine oxidase B 1.128
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 1.124
CYB5A cytochrome b5 type A (microsomal) 1.121
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 1.12
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor 1.115
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 1.115
LHX4 LIM homeobox 4 1.113
FST follistatin 1.111
CD4 CD4 molecule 1.111
RPGRIP1L RPGRIP1-like 1.109
ESX1 ESX homeobox 1 1.107
CD68 CD68 molecule 1.102
YIPF1 Yip1 domain family, member 1 1.101
FOXL2 forkhead box L2 1.101
USP26 ubiquitin specific peptidase 26 1.1
KNG1 kininogen 1 1.097
SMN2 survival of motor neuron 2, centromeric 1.093
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 1.089
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.086
GATA3 GATA binding protein 3 1.082
POR P450 (cytochrome) oxidoreductase 1.08
RXFP2 relaxin/insulin-like family peptide receptor 2 1.08
PRPH2 peripherin 2 (retinal degeneration, slow) 1.075
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.075
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 1.07
ALMS1 Alstrom syndrome protein 1 1.066
TMOD3 tropomodulin 3 (ubiquitous) 1.065
CHCHD5 coiled-coil-helix-coiled-coil-helix domain containing 5 1.065
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 1.063
SMN1 survival of motor neuron 1, telomeric 1.061
HSPA4 heat shock 70kDa protein 4 1.059
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.057
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 1.05
STS steroid sulfatase (microsomal), isozyme S 1.05
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1 1.049
KRT20 keratin 20, type I 1.042
NCAM1 neural cell adhesion molecule 1 1.041
ACR acrosin 1.04
FGF17 fibroblast growth factor 17 1.033
UGT1A4 UDP glucuronosyltransferase 1 family, polypeptide A4 1.032
GLP1R glucagon-like peptide 1 receptor 1.031
DAZ4 deleted in azoospermia 4 1.029
ATM ATM serine/threonine kinase 1.027
EGF epidermal growth factor 1.024
ADRA1A adrenoceptor alpha 1A 1.023
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 1.022
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 1.021
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 1.019
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 1.019
GPX5 glutathione peroxidase 5 1.018
HSFY1 heat shock transcription factor, Y-linked 1 1.014
TSPY1 testis specific protein, Y-linked 1 1.011
NCOA1 nuclear receptor coactivator 1 1.011
SSTR5 somatostatin receptor 5 1.01
AKR1C4 aldo-keto reductase family 1, member C4 1.007
OTUD4 OTU deubiquitinase 4 1.0
FBXO32 F-box protein 32 1.0