H-7-5968 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the H-7-5968 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ACSL5 acyl-CoA synthetase long-chain family member 5
ACTG2 actin, gamma 2, smooth muscle, enteric
ADGRG2 adhesion G protein-coupled receptor G2
AKR1C2 aldo-keto reductase family 1, member C2
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AMT aminomethyltransferase
ANXA10 annexin A10
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa
ASTN2 astrotactin 2
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
C16ORF58 chromosome 16 open reading frame 58
CALML3 calmodulin-like 3
CD4 CD4 molecule
CDHR2 cadherin-related family member 2
CEMP1 cementum protein 1
CNTD2 cyclin N-terminal domain containing 2
CNTNAP2 contactin associated protein-like 2
COL6A1 collagen, type VI, alpha 1
CORO1B coronin, actin binding protein, 1B
CPQ carboxypeptidase Q
CYB561 cytochrome b561
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
EGFR epidermal growth factor receptor
ELK1 ELK1, member of ETS oncogene family
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)
ENG endoglin
FGF4 fibroblast growth factor 4
FGF6 fibroblast growth factor 6
FLT1 fms-related tyrosine kinase 1
GALK1 galactokinase 1
GBP1 guanylate binding protein 1, interferon-inducible
GDAP1 ganglioside induced differentiation associated protein 1
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GK2 glycerol kinase 2
GLP1R glucagon-like peptide 1 receptor
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GNG7 guanine nucleotide binding protein (G protein), gamma 7
HAUS5 HAUS augmin-like complex, subunit 5
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H1E histone cluster 1, H1e
HIST1H2AJ histone cluster 1, H2aj
HIST1H3C histone cluster 1, H3c
HOXA7 homeobox A7
HOXA9 homeobox A9
HOXB2 homeobox B2
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
IDUA iduronidase, alpha-L-
IFNA2 interferon, alpha 2
ISYNA1 inositol-3-phosphate synthase 1
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KANK1 KN motif and ankyrin repeat domains 1
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KLHL35 kelch-like family member 35
KRT19P2 keratin 19 pseudogene 2
L3MBTL1 l(3)mbt-like 1 (Drosophila)
LMAN1 lectin, mannose-binding, 1
LOC100286895 cell division cycle 27 homolog pseudogene
LPCAT3 lysophosphatidylcholine acyltransferase 3
LRRC61 leucine rich repeat containing 61
LST1 leukocyte specific transcript 1
LY6D lymphocyte antigen 6 complex, locus D
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MOXD1 monooxygenase, DBH-like 1
MR1 major histocompatibility complex, class I-related
NADK NAD kinase
NEO1 neogenin 1
NXPH4 neurexophilin 4
PADI1 peptidyl arginine deiminase, type I
PALM paralemmin
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PIN1P1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 pseudogene 1
PLCH1 phospholipase C, eta 1
PTN pleiotrophin
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTRF polymerase I and transcript release factor
RAB26 RAB26, member RAS oncogene family
RPL10L ribosomal protein L10-like
RPL7 ribosomal protein L7
RUNX1 runt-related transcription factor 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC22A18 solute carrier family 22, member 18
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SMC1A structural maintenance of chromosomes 1A
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
SRRT serrate, RNA effector molecule
TBCD tubulin folding cofactor D
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TESPA1 thymocyte expressed, positive selection associated 1
TGFB2 transforming growth factor, beta 2
TMEM180 transmembrane protein 180
TMEM209 transmembrane protein 209
TP53I11 tumor protein p53 inducible protein 11
TPMT thiopurine S-methyltransferase
UNC13A unc-13 homolog A (C. elegans)
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
VCL vinculin
ZMYND11 zinc finger, MYND-type containing 11

decreased expression

Symbol Name
AAR2 AAR2 splicing factor homolog (S. cerevisiae)
AMOTL2 angiomotin like 2
ANKRD49 ankyrin repeat domain 49
ARF6 ADP-ribosylation factor 6
BAMBI BMP and activin membrane-bound inhibitor
BRPF1 bromodomain and PHD finger containing, 1
C10ORF2 chromosome 10 open reading frame 2
C14ORF169 chromosome 14 open reading frame 169
C1ORF106 chromosome 1 open reading frame 106
CASP8AP2 caspase 8 associated protein 2
CDCA4 cell division cycle associated 4
CDR2 cerebellar degeneration-related protein 2, 62kDa
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEP72 centrosomal protein 72kDa
CEP76 centrosomal protein 76kDa
CHD1 chromodomain helicase DNA binding protein 1
CLDN4 claudin 4
CLP1 cleavage and polyadenylation factor I subunit 1
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAAF2 dynein, axonemal, assembly factor 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DOLK dolichol kinase
DPF2 D4, zinc and double PHD fingers family 2
E2F6 E2F transcription factor 6
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1
ETAA1 Ewing tumor-associated antigen 1
FADD Fas (TNFRSF6)-associated via death domain
FASTKD5 FAST kinase domains 5
FBXW12 F-box and WD repeat domain containing 12
FOSL1 FOS-like antigen 1
FZD8 frizzled class receptor 8
GCC1 GRIP and coiled-coil domain containing 1
GEMIN4 gem (nuclear organelle) associated protein 4
GPR87 G protein-coupled receptor 87
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa
HAUS3 HAUS augmin-like complex, subunit 3
HILPDA hypoxia inducible lipid droplet-associated
HJURP Holliday junction recognition protein
IER5 immediate early response 5
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
JMJD1C jumonji domain containing 1C
JRKL JRK-like
LEMD3 LEM domain containing 3
LIPT1 lipoyltransferase 1
LRRC37A3 leucine rich repeat containing 37, member A3
MED17 mediator complex subunit 17
MEPCE methylphosphate capping enzyme
MFSD5 major facilitator superfamily domain containing 5
MGA MGA, MAX dimerization protein
MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)
NXT1 nuclear transport factor 2-like export factor 1
OXSM 3-oxoacyl-ACP synthase, mitochondrial
PEX12 peroxisomal biogenesis factor 12
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
POP7 processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae)
PPAN peter pan homolog (Drosophila)
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R10 protein phosphatase 1, regulatory subunit 10
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PTCD1 pentatricopeptide repeat domain 1
RAB20 RAB20, member RAS oncogene family
RDH14 retinol dehydrogenase 14 (all-trans/9-cis/11-cis)
RGS2 regulator of G-protein signaling 2
RIOK2 RIO kinase 2
RND3 Rho family GTPase 3
RNF113A ring finger protein 113A
RNF139 ring finger protein 139
RNMTL1 RNA methyltransferase like 1
RPP38 ribonuclease P/MRP 38kDa subunit
SCO2 SCO2 cytochrome c oxidase assembly protein
SGK1 serum/glucocorticoid regulated kinase 1
SMG8 SMG8 nonsense mediated mRNA decay factor
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
TBCC tubulin folding cofactor C
TBK1 TANK-binding kinase 1
TBP TATA box binding protein
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TOB1 transducer of ERBB2, 1
TRIM13 tripartite motif containing 13
TRIM26 tripartite motif containing 26
TRIM32 tripartite motif containing 32
TRMT12 tRNA methyltransferase 12 homolog (S. cerevisiae)
XBP1 X-box binding protein 1
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZBED5 zinc finger, BED-type containing 5
ZBTB24 zinc finger and BTB domain containing 24
ZC3H4 zinc finger CCCH-type containing 4
ZCCHC8 zinc finger, CCHC domain containing 8
ZNF133 zinc finger protein 133
ZNF14 zinc finger protein 14
ZNF165 zinc finger protein 165
ZNF184 zinc finger protein 184
ZNF217 zinc finger protein 217
ZNF274 zinc finger protein 274
ZNF443 zinc finger protein 443
ZNF7 zinc finger protein 7