HAND2 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description heart and neural crest derivatives expressed 2|The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, this transcription factor plays an important role in limb and branchial arch development. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 9464)
External Link http://www.ncbi.nlm.nih.gov/gene/9464
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15 interacting proteins for HAND2 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
CENPB centromere protein B, 80kDa
COPS5 COP9 signalosome subunit 5
EP300 E1A binding protein p300
GATA4 GATA binding protein 4
HAND1 heart and neural crest derivatives expressed 1
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HEYL hes-related family bHLH transcription factor with YRPW motif-like
HOXD13 homeobox D13
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
PHOX2A paired-like homeobox 2a
PPP2R5D protein phosphatase 2, regulatory subunit B', delta
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKCA protein kinase C, alpha
TCF3 transcription factor 3
UBC ubiquitin C