HAP1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description huntingtin-associated protein 1|Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 9001)
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Genes

343 genes differentially expressed following the HAP1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
OR2A12 olfactory receptor, family 2, subfamily A, member 12 2.56416
FLRT3 fibronectin leucine rich transmembrane protein 3 2.56416
MYBPC1 myosin binding protein C, slow type 2.56416
SPATA3 spermatogenesis associated 3 2.56416
LPIN3 lipin 3 2.56416
TMPRSS7 transmembrane protease, serine 7 2.56416
ENKUR enkurin, TRPC channel interacting protein 2.56416
C1QL3 complement component 1, q subcomponent-like 3 2.56416
TNNI1 troponin I type 1 (skeletal, slow) 2.56416
C9ORF64 chromosome 9 open reading frame 64 2.56416
C6ORF118 chromosome 6 open reading frame 118 2.56416
NBPF8 neuroblastoma breakpoint family, member 8 2.56416
MAGEA6 melanoma antigen family A6 2.56416
HEATR9 HEAT repeat containing 9 2.56416
PLEK2 pleckstrin 2 2.56416
MMP19 matrix metallopeptidase 19 2.56416
CXORF65 chromosome X open reading frame 65 2.56416
LRRC56 leucine rich repeat containing 56 2.56416
TPSD1 tryptase delta 1 2.56416
RFPL2 ret finger protein-like 2 2.56416
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 2.56416
LAMB4 laminin, beta 4 2.56416
MPZ myelin protein zero 2.56416
ADGRG1 adhesion G protein-coupled receptor G1 2.56416
WNT4 wingless-type MMTV integration site family, member 4 2.56416
RNF39 ring finger protein 39 2.56416
NUTM2F NUT family member 2F 2.56416
CPLX1 complexin 1 2.56416
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit 2.56416
SDR9C7 short chain dehydrogenase/reductase family 9C, member 7 2.40105
SLFN11 schlafen family member 11 2.40105
ADGRE1 adhesion G protein-coupled receptor E1 2.40105
MS4A6E membrane-spanning 4-domains, subfamily A, member 6E 2.40105
GPR21 G protein-coupled receptor 21 2.40105
ALB albumin 2.40105
ZNF99 zinc finger protein 99 2.40105
MYBPHL myosin binding protein H-like 2.40105
SRPX2 sushi-repeat containing protein, X-linked 2 2.40105
OR2A25 olfactory receptor, family 2, subfamily A, member 25 2.40105
BPIFA2 BPI fold containing family A, member 2 2.40105
DNM1L dynamin 1-like 2.40105
HHEX hematopoietically expressed homeobox 2.40105
SLC46A2 solute carrier family 46, member 2 2.40105
MYOM3 myomesin 3 2.40105
MYCT1 myc target 1 2.40105
SIGLEC5 sialic acid binding Ig-like lectin 5 2.40105
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 2.40105
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 2.40105
NCOR2 nuclear receptor corepressor 2 2.40105
OR10A2 olfactory receptor, family 10, subfamily A, member 2 2.40105
RIMBP2 RIMS binding protein 2 2.40105
UPB1 ureidopropionase, beta 2.40105
HES7 hes family bHLH transcription factor 7 2.40105
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 2.40105
PCDHB6 protocadherin beta 6 2.40105
PON1 paraoxonase 1 2.40105
CELA3A chymotrypsin-like elastase family, member 3A 2.40105
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans) 2.40105
PLIN1 perilipin 1 2.40105
KLRK1 killer cell lectin-like receptor subfamily K, member 1 2.40105
PTGFR prostaglandin F receptor (FP) 2.40105
WASL-DT WASL divergent transcript 2.40105
SQOR sulfide quinone oxidoreductase 2.40105
GIPC3 GIPC PDZ domain containing family, member 3 2.40105
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 2.40105
TAS2R60 taste receptor, type 2, member 60 2.40105
ALX3 ALX homeobox 3 2.40105
CFAP97 cilia and flagella associated protein 97 2.40105
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.40105
PCP4L1 Purkinje cell protein 4 like 1 2.40105
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough 2.40105
CCDC9B coiled-coil domain containing 9B 2.40105
FAM237B family with sequence similarity 237 member B 2.40105
CPHXL2 cytoplasmic polyadenylated homeobox like 2 2.40105
CIMAP1D CIMAP1 family member D 2.40105
INSYN1 inhibitory synaptic factor 1 2.40105
SMIM45 small integral membrane protein 45 2.40105
C20ORF204 chromosome 20 open reading frame 204 2.40105
H2AC19 H2A clustered histone 19 2.40105
ACP4 acid phosphatase 4 2.40105
CCDC197 coiled-coil domain containing 197 2.40105
ODAPH odontogenesis associated phosphoprotein 2.40105
SPDYE9 speedy/RINGO cell cycle regulator family member E9 2.40105
GAPT GRB2-binding adaptor protein, transmembrane 2.40105
C15ORF62 chromosome 15 open reading frame 62 2.40105
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 2.40105
EPCIP exosomal polycystin 1 interacting protein 2.40105
SLC45A2 solute carrier family 45, member 2 2.40105
SCIMP SLP adaptor and CSK interacting membrane protein 2.40105
AWAT2 acyl-CoA wax alcohol acyltransferase 2 2.40105
THOC3 THO complex 3 2.40105
PTP4A1 protein tyrosine phosphatase type IVA, member 1 2.40105
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 2.40105
MAG myelin associated glycoprotein 2.40105
PCDHA8 protocadherin alpha 8 2.40105
CDKN2A cyclin-dependent kinase inhibitor 2A 2.40105
S100G S100 calcium binding protein G 2.40105
OVOL1 ovo-like zinc finger 1 2.40105
GATA2 GATA binding protein 2 2.40105
OR7D2 olfactory receptor, family 7, subfamily D, member 2 2.40105
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 2.40105
PRDM7 PR domain containing 7 2.40105
LTF lactotransferrin 2.40105
LRRC72 leucine rich repeat containing 72 2.40105
FAM131C family with sequence similarity 131, member C 2.40105
SAA4 serum amyloid A4, constitutive 2.40105
RGS21 regulator of G-protein signaling 21 2.40105
ATP13A5 ATPase type 13A5 2.40105
RTN4RL1 reticulon 4 receptor-like 1 2.40105
GP1BB glycoprotein Ib (platelet), beta polypeptide 2.40105
PCDHGB2 protocadherin gamma subfamily B, 2 2.40105
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 2.40105
LRRC46 leucine rich repeat containing 46 2.40105
CAPSL calcyphosine-like 2.40105
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) 2.40105
EFCAB9 EF-hand calcium binding domain 9 2.40105
CTAGE1 cutaneous T-cell lymphoma-associated antigen 1 2.40105
ADCY4 adenylate cyclase 4 2.40105
KRT17 keratin 17, type I 2.40105
TRPM5 transient receptor potential cation channel, subfamily M, member 5 2.40105
COL22A1 collagen, type XXII, alpha 1 2.40105
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) 2.40105
CHRM4 cholinergic receptor, muscarinic 4 2.40105
PRSS55 protease, serine, 55 2.40105
SPRN shadow of prion protein homolog (zebrafish) 2.40105
WNT7B wingless-type MMTV integration site family, member 7B 2.40105
ZNF479 zinc finger protein 479 2.40105
NXF2B nuclear RNA export factor 2B 2.40105
PRM1 protamine 1 2.40105
GML glycosylphosphatidylinositol anchored molecule like 2.40105
PRDM9 PR domain containing 9 2.40105
IGF2 insulin-like growth factor 2 2.40105
C8G complement component 8, gamma polypeptide 2.40105
ZC3H12D zinc finger CCCH-type containing 12D 2.40105
F13B coagulation factor XIII, B polypeptide 2.40105
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 2.40105
DND1 DND microRNA-mediated repression inhibitor 1 2.40105
UBXN10 UBX domain protein 10 2.40105
TEX19 testis expressed 19 2.40105
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 2.40105
GOLGA6B golgin A6 family, member B 2.40105
ADAM7 ADAM metallopeptidase domain 7 2.40105
SEL1L2 sel-1 suppressor of lin-12-like 2 (C. elegans) 2.40105
HPX hemopexin 2.40105
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 2.40105
NIPAL4 NIPA-like domain containing 4 2.40105
RGS8 regulator of G-protein signaling 8 2.40105
CDH10 cadherin 10, type 2 (T2-cadherin) 2.40105
PGR progesterone receptor 2.40105
CACNG1 calcium channel, voltage-dependent, gamma subunit 1 2.40105
OR56A3 olfactory receptor, family 56, subfamily A, member 3 2.40105
GALNTL5 polypeptide N-acetylgalactosaminyltransferase-like 5 2.40105
CNDP1 carnosine dipeptidase 1 (metallopeptidase M20 family) 2.40105
PRSS21 protease, serine, 21 (testisin) 2.40105
EBI3 Epstein-Barr virus induced 3 2.40105
SLC36A3 solute carrier family 36, member 3 2.40105
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 2.40105
ANXA2R annexin A2 receptor 2.40105
GYS2 glycogen synthase 2 (liver) 2.40105
HMX3 H6 family homeobox 3 2.40105
PRR29 proline rich 29 2.40105
IL17REL interleukin 17 receptor E-like 2.40105
OR1L8 olfactory receptor, family 1, subfamily L, member 8 2.40105
CRH corticotropin releasing hormone 2.40105
TTLL2 tubulin tyrosine ligase-like family member 2 2.40105
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 2.40105
RFX6 regulatory factor X, 6 2.40105
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.40105
GALR3 galanin receptor 3 2.40105
OR51A4 olfactory receptor, family 51, subfamily A, member 4 2.40105
TSSK1B testis-specific serine kinase 1B 2.40105
ASCL1 achaete-scute family bHLH transcription factor 1 2.40105
NLRP5 NLR family, pyrin domain containing 5 2.40105
CHRDL2 chordin-like 2 2.40105
ZNF831 zinc finger protein 831 2.40105
ZSCAN2 zinc finger and SCAN domain containing 2 2.40105
C10ORF90 chromosome 10 open reading frame 90 2.40105
FKBP1C FK506 binding protein 1C 2.40105
LY6G5C lymphocyte antigen 6 complex, locus G5C 2.40105
CIB4 calcium and integrin binding family member 4 2.40105
C5ORF46 chromosome 5 open reading frame 46 2.40105
IRX5 iroquois homeobox 5 2.40105
PITX1 paired-like homeodomain 1 2.40105
CD38 CD38 molecule 2.40105
FIZ1 FLT3-interacting zinc finger 1 2.39658
MAP7D2 MAP7 domain containing 2 2.39463
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) 2.38961
BCL2L14 BCL2-like 14 (apoptosis facilitator) 2.37694
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 2.37694
ZNF792 zinc finger protein 792 2.37694
USP9X ubiquitin specific peptidase 9, X-linked 2.36799
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled 2.3651
RGS7 regulator of G-protein signaling 7 2.34856
MAP3K19 mitogen-activated protein kinase kinase kinase 19 2.33905
TEKTIP1 tektin bundle interacting protein 1 2.2923
RCSD1 RCSD domain containing 1 2.2923
TTC29 tetratricopeptide repeat domain 29 2.2923
LPCAT3 lysophosphatidylcholine acyltransferase 3 2.2923
WNK4 WNK lysine deficient protein kinase 4 2.2923
JADE1 jade family PHD finger 1 2.2923
YIPF1 Yip1 domain family, member 1 2.26058
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) 2.25746
IGF2R insulin-like growth factor 2 receptor 2.24534
EOLA2 endothelium and lymphocyte associated ASCH domain 2 2.24403
MSRB1 methionine sulfoxide reductase B1 2.23297
E2F5 E2F transcription factor 5, p130-binding 2.22783
TUBB2B tubulin, beta 2B class IIb 2.22196
TIMM29 translocase of inner mitochondrial membrane 29 2.21883
STON1 stonin 1 2.21432
CCDC154 coiled-coil domain containing 154 2.21391
NELL1 NEL-like 1 (chicken) 2.21391
RBM19 RNA binding motif protein 19 2.20336
NOP14 NOP14 nucleolar protein 2.20336
DDHD1 DDHD domain containing 1 2.18918
NYNRIN NYN domain and retroviral integrase containing 2.18585
SLC10A7 solute carrier family 10, member 7 2.18585
ACSS3 acyl-CoA synthetase short-chain family member 3 2.16341
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) 2.08476
LUC7L2 LUC7-like 2 (S. cerevisiae) 2.08476
TNIK TRAF2 and NCK interacting kinase 2.0821
CEP131 centrosomal protein 131kDa 2.06293
INA internexin neuronal intermediate filament protein, alpha 2.0628
DNAH5 dynein, axonemal, heavy chain 5 2.05328
RAB34 RAB34, member RAS oncogene family 2.03985
OMD osteomodulin 2.03509
SPIN2A spindlin family, member 2A 2.03281
ERVMER34-1 endogenous retrovirus group MER34, member 1 2.02224
TOR1AIP2 torsin A interacting protein 2 2.01647
ATF2 activating transcription factor 2 2.01647
SF3B3 splicing factor 3b, subunit 3, 130kDa 2.01422
ABHD12 abhydrolase domain containing 12 2.01422

decreased expression

Symbol Name Standardized Value
ZNF843 zinc finger protein 843 -2.56416
FDXACB1 ferredoxin-fold anticodon binding domain containing 1 -2.56416
ARL8A ADP-ribosylation factor-like 8A -2.56416
TRPC6 transient receptor potential cation channel, subfamily C, member 6 -2.56416
HMGB1 high mobility group box 1 -2.56416
NCMAP noncompact myelin associated protein -2.56416
CATSPERD catsper channel auxiliary subunit delta -2.56416
WSCD2 WSC domain containing 2 -2.56416
GFY golgi-associated, olfactory signaling regulator -2.56416
FICD FIC domain containing -2.56416
LINGO1 leucine rich repeat and Ig domain containing 1 -2.51672
WDR55 WD repeat domain 55 -2.40105
ZSCAN22 zinc finger and SCAN domain containing 22 -2.40105
GTF2I general transcription factor IIi -2.40105
PDGFD platelet derived growth factor D -2.40105
DUSP7 dual specificity phosphatase 7 -2.40105
GRIK3 glutamate receptor, ionotropic, kainate 3 -2.40105
FZD7 frizzled class receptor 7 -2.40105
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -2.40105
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 -2.40105
IGSF23 immunoglobulin superfamily, member 23 -2.40105
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 -2.40105
SERTAD4 SERTA domain containing 4 -2.40105
ZNF436 zinc finger protein 436 -2.40105
ANGPT4 angiopoietin 4 -2.40105
STKLD1 serine/threonine kinase-like domain containing 1 -2.40105
NECAB1 N-terminal EF-hand calcium binding protein 1 -2.40105
PGA5 pepsinogen 5, group I (pepsinogen A) -2.40105
AADACL3 arylacetamide deacetylase-like 3 -2.40105
DCUN1D5 DCN1, defective in cullin neddylation 1, domain containing 5 -2.40105
STAC2 SH3 and cysteine rich domain 2 -2.40105
MEI1 meiosis inhibitor 1 -2.40105
BCL7A B-cell CLL/lymphoma 7A -2.40105
XKRX XK, Kell blood group complex subunit-related, X-linked -2.40105
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 -2.40105
MGST3 microsomal glutathione S-transferase 3 -2.40105
CMTM2 CKLF-like MARVEL transmembrane domain containing 2 -2.40105
HELB helicase (DNA) B -2.40105
C2ORF72 chromosome 2 open reading frame 72 -2.40105
MUC19 mucin 19, oligomeric -2.40105
TENT5D terminal nucleotidyltransferase 5D -2.40105
EFCAB3 EF-hand calcium binding domain 3 -2.40105
SPOP speckle-type POZ protein -2.40105
UHRF2 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase -2.40105
NOX1 NADPH oxidase 1 -2.40105
IFT70B intraflagellar transport 70B -2.40105
GPHA2 glycoprotein hormone alpha 2 -2.40105
OGFRL1 opioid growth factor receptor-like 1 -2.40105
IRF2-DT IRF2 divergent transcript -2.40105
FAM240C family with sequence similarity 240 member C -2.40105
TTYH2 tweety family member 2 -2.40105
TTC22 tetratricopeptide repeat domain 22 -2.40105
FBXO30 F-box protein 30 -2.40105
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.40105
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -2.40105
EBF3 early B-cell factor 3 -2.40105
ICMT isoprenylcysteine carboxyl methyltransferase -2.40105
CPXM1 carboxypeptidase X (M14 family), member 1 -2.40105
RSAD2 radical S-adenosyl methionine domain containing 2 -2.40105
DNAAF8 dynein axonemal assembly factor 8 -2.40105
SMYD5 SMYD family member 5 -2.39683
HSPD1 heat shock 60kDa protein 1 (chaperonin) -2.38961
FZD4 frizzled class receptor 4 -2.37694
STARD13 StAR-related lipid transfer (START) domain containing 13 -2.3442
SLC31A1 solute carrier family 31 (copper transporter), member 1 -2.34326
SPEG SPEG complex locus -2.33958
SHANK3 SH3 and multiple ankyrin repeat domains 3 -2.33958
KYAT3 kynurenine aminotransferase 3 -2.33958
TIPE3 TNF alpha induced protein 8 like 3 -2.31362
PHKG1 phosphorylase kinase, gamma 1 (muscle) -2.31362
ACADL acyl-CoA dehydrogenase, long chain -2.30181
PDCL2 phosducin-like 2 -2.30181
EMP2 epithelial membrane protein 2 -2.29723
SUMO2 small ubiquitin-like modifier 2 -2.29498
FKTN fukutin -2.27589
DLEU7 deleted in lymphocytic leukemia, 7 -2.25547
EXOC3 exocyst complex component 3 -2.25536
EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa -2.25488
AMBP alpha-1-microglobulin/bikunin precursor -2.21826
NDUFA6 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa -2.21432
CNTD1 cyclin N-terminal domain containing 1 -2.20336
AKAP19 A-kinase anchoring protein 19 -2.16792
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial -2.15279
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -2.15139
SHPRH SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase -2.14855
UGCG UDP-glucose ceramide glucosyltransferase -2.1454
KDM4D lysine (K)-specific demethylase 4D -2.14048
KDM7A lysine (K)-specific demethylase 7A -2.12971
ZNF586 zinc finger protein 586 -2.12381
GRID1 glutamate receptor, ionotropic, delta 1 -2.11376
SPRYD3 SPRY domain containing 3 -2.11376
PRPF40B PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae) -2.11376
NEU1 sialidase 1 (lysosomal sialidase) -2.11226
PKD1 polycystic kidney disease 1 (autosomal dominant) -2.10716
RABL2B RAB, member of RAS oncogene family-like 2B -2.1007
AKAP10 A kinase (PRKA) anchor protein 10 -2.09774
KLHL4 kelch-like family member 4 -2.0821
ARHGAP45 Rho GTPase activating protein 45 -2.0628
CACNB3 calcium channel, voltage-dependent, beta 3 subunit -2.06076
MPC2 mitochondrial pyruvate carrier 2 -2.05608
YOD1 YOD1 deubiquitinase -2.05586
TIMM10 translocase of inner mitochondrial membrane 10 homolog (yeast) -2.03585
ADNP activity-dependent neuroprotector homeobox -2.03509
PHIP pleckstrin homology domain interacting protein -2.03509
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase -2.02278
MCM10 minichromosome maintenance complex component 10 -2.02031
CATSPER2 cation channel, sperm associated 2 -2.01647
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) -2.01647
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 -2.01422
VASH1 vasohibin 1 -2.01422
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa -2.00506
CCDC28B coiled-coil domain containing 28B -2.00347