HAP1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description huntingtin-associated protein 1|Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 9001)
External Link http://www.ncbi.nlm.nih.gov/gene/9001
Similar Terms
Downloads & Tools

Genes

76 interacting proteins for HAP1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
APLP1 amyloid beta (A4) precursor-like protein 1
ATP5J2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2
ATXN3 ataxin 3
BARD1 BRCA1 associated RING domain 1
BRD7 bromodomain containing 7
C7ORF25 chromosome 7 open reading frame 25
C8ORF33 chromosome 8 open reading frame 33
CBX8 chromobox homolog 8
CCDC113 coiled-coil domain containing 113
CDC73 cell division cycle 73
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CEP126 centrosomal protein 126kDa
COL9A2 collagen, type IX, alpha 2
CRIP1 cysteine-rich protein 1 (intestinal)
DCTN1 dynactin 1
DDX49 DEAD (Asp-Glu-Ala-Asp) box polypeptide 49
DEFB1 defensin, beta 1
EIF3E eukaryotic translation initiation factor 3, subunit E
FAM173A family with sequence similarity 173, member A
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
GADD45G growth arrest and DNA-damage-inducible, gamma
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GLTSCR2 glioma tumor suppressor candidate region gene 2
GPRASP2 G protein-coupled receptor associated sorting protein 2
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
HMOX2 heme oxygenase 2
HSPA4 heat shock 70kDa protein 4
HTT huntingtin
IMMT inner membrane protein, mitochondrial
ING5 inhibitor of growth family, member 5
KAT5 K(lysine) acetyltransferase 5
KAT7 K(lysine) acetyltransferase 7
KATNBL1 katanin p80 subunit B-like 1
KBTBD7 kelch repeat and BTB (POZ) domain containing 7
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LRIF1 ligand dependent nuclear receptor interacting factor 1
LUC7L2 LUC7-like 2 (S. cerevisiae)
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MRPS9 mitochondrial ribosomal protein S9
NAP1L5 nucleosome assembly protein 1-like 5
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa
NEUROD1 neuronal differentiation 1
NIPSNAP3A nipsnap homolog 3A (C. elegans)
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form)
PCM1 pericentriolar material 1
PDCD7 programmed cell death 7
PFDN1 prefoldin subunit 1
PPID peptidylprolyl isomerase D
PPOX protoporphyrinogen oxidase
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RER1 retention in endoplasmic reticulum sorting receptor 1
RHOG ras homolog family member G
RHOJ ras homolog family member J
RHOQ ras homolog family member Q
RIF1 replication timing regulatory factor 1
RPS10 ribosomal protein S10
RPS25 ribosomal protein S25
SNAPIN SNAP-associated protein
SRSF4 serine/arginine-rich splicing factor 4
STX5 syntaxin 5
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TBP TATA box binding protein
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast)
TNNT1 troponin T type 1 (skeletal, slow)
TNNT3 troponin T type 3 (skeletal, fast)
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TSPYL1 TSPY-like 1
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
VIM vimentin
ZNF20 zinc finger protein 20
ZNF24 zinc finger protein 24
ZNF33B zinc finger protein 33B
ZNF691 zinc finger protein 691