HCC827 Gene Set

Dataset DepMap CRISPR Gene Dependency
Category disease or phenotype associations
Type cell line
External Link https://depmap.org/portal/cell_line/ACH-000012
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Genes

332 gene knockdowns changing fitness of HCC827 relative to other cell lines from the DepMap CRISPR Gene Dependency Dataset.

Symbol Name Standardized Value
BAALC brain and acute leukemia, cytoplasmic 16.1295
ADTRP androgen-dependent TFPI-regulating protein 15.8054
SUMF2 sulfatase modifying factor 2 13.5452
LRRC6 leucine rich repeat containing 6 11.8123
CALM1 calmodulin 1 (phosphorylase kinase, delta) 10.6872
HMGA2 high mobility group AT-hook 2 9.60407
CCDC159 coiled-coil domain containing 159 8.59869
CYRIB CYFIP related Rac1 interactor B 8.00847
FAM193A family with sequence similarity 193, member A 7.49503
SACK1H scaffolding CK1 anchoring protein H 7.31939
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 7.01645
LRRC57 leucine rich repeat containing 57 7.01107
GPR84 G protein-coupled receptor 84 6.67795
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F 6.65427
ZNF385A zinc finger protein 385A 6.43402
PEX2 peroxisomal biogenesis factor 2 6.40888
PEX14 peroxisomal biogenesis factor 14 5.98039
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 5.9153
ESRP1 epithelial splicing regulatory protein 1 5.85213
STK35 serine/threonine kinase 35 5.83652
RRAS related RAS viral (r-ras) oncogene homolog 5.83011
P2RY11 purinergic receptor P2Y, G-protein coupled, 11 5.75459
EDRF1 erythroid differentiation regulatory factor 1 5.66848
FKBP9 FK506 binding protein 9, 63 kDa 5.633
CD46 CD46 molecule, complement regulatory protein 5.55467
RASAL2 RAS protein activator like 2 5.51998
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 5.4951
TLCD3A TLC domain containing 3A 5.47221
CORO1C coronin, actin binding protein, 1C 5.35829
ING2 inhibitor of growth family, member 2 5.17749
DUSP10 dual specificity phosphatase 10 5.10366
FOXD4L5 forkhead box D4-like 5 5.099
ZNF679 zinc finger protein 679 5.09124
PEX10 peroxisomal biogenesis factor 10 5.08659
POC5 POC5 centriolar protein 5.04748
C2CD3 C2 calcium-dependent domain containing 3 5.04502
AMOTL2 angiomotin like 2 5.00831
FUS FUS RNA binding protein 4.84886
CDK8 cyclin-dependent kinase 8 4.79516
LRRTM2 leucine rich repeat transmembrane neuronal 2 4.78253
ANAPC7 anaphase promoting complex subunit 7 4.72807
SPAG17 sperm associated antigen 17 4.65126
MCTS1 malignant T cell amplified sequence 1 4.57855
CEP41 centrosomal protein 41kDa 4.5543
TOR4A torsin family 4, member A 4.47373
CAPNS1 calpain, small subunit 1 4.34877
JSRP1 junctional sarcoplasmic reticulum protein 1 4.26765
CEP120 centrosomal protein 120kDa 4.2469
USF2 upstream transcription factor 2, c-fos interacting 4.23533
IL6R interleukin 6 receptor 4.16067
HMGXB3 HMG box domain containing 3 4.10884
ACOX1 acyl-CoA oxidase 1, palmitoyl 4.05878
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1 4.05817
GNL1 guanine nucleotide binding protein-like 1 4.02372
KANK2 KN motif and ankyrin repeat domains 2 3.99217
FITM2 fat storage-inducing transmembrane protein 2 3.95505
USF1 upstream transcription factor 1 3.94452
RBBP7 retinoblastoma binding protein 7 3.93766
PEX12 peroxisomal biogenesis factor 12 3.93713
NKIRAS2 NFKB inhibitor interacting Ras-like 2 3.89246
PLEC plectin 3.866
HSPB9 heat shock protein, alpha-crystallin-related, B9 3.86344
TSPAN31 tetraspanin 31 3.85049
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4 3.84284
MARCHF6 membrane associated ring-CH-type finger 6 3.83862
PHF23 PHD finger protein 23 3.78233
SLC30A3 solute carrier family 30 (zinc transporter), member 3 3.71644
PEX26 peroxisomal biogenesis factor 26 3.70937
RAB40C RAB40C, member RAS oncogene family 3.68002
NUPR1L nuclear protein, transcriptional regulator, 1-like 3.66051
ZNF727 zinc finger protein 727 3.64979
MTCH2 mitochondrial carrier 2 3.63799
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 3.59396
ZBTB44 zinc finger and BTB domain containing 44 3.57375
KLHDC8B kelch domain containing 8B 3.5666
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 3.55378
SHB Src homology 2 domain containing adaptor protein B 3.55194
PICALM phosphatidylinositol binding clathrin assembly protein 3.51887
TSPYL6 TSPY-like 6 3.48035
SEPTIN14 septin 14 3.47327
EPN2 epsin 2 3.46269
NRIP1 nuclear receptor interacting protein 1 3.43844
GTPBP8 GTP-binding protein 8 (putative) 3.41416
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic) 3.39177
PEX5 peroxisomal biogenesis factor 5 3.37436
FCHO2 FCH domain only 2 3.33611
PMEL premelanosome protein 3.32778
ACSL4 acyl-CoA synthetase long-chain family member 4 3.29277
SCRN2 secernin 2 3.28232
RMDN3 regulator of microtubule dynamics 3 3.2475
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant 3.23022
PEX6 peroxisomal biogenesis factor 6 3.17503
ZNF622 zinc finger protein 622 3.17093
VENTX VENT homeobox 3.14609
RAD23B RAD23 homolog B (S. cerevisiae) 3.13904
CCR7 chemokine (C-C motif) receptor 7 3.13594
KRT31 keratin 31, type I 3.13545
ATXN2L ataxin 2-like 3.13497
AURKC aurora kinase C 3.13376
ARHGAP12 Rho GTPase activating protein 12 3.13039
CYB5R4 cytochrome b5 reductase 4 3.12955
FBXL8 F-box and leucine-rich repeat protein 8 3.12691
GDAP1 ganglioside induced differentiation associated protein 1 3.12435
USP15 ubiquitin specific peptidase 15 3.11113
POTEM POTE ankyrin domain family, member M 3.09867
CXCR6 chemokine (C-X-C motif) receptor 6 3.07934
PEX19 peroxisomal biogenesis factor 19 3.04637
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 3.0373
RDH8 retinol dehydrogenase 8 (all-trans) 3.03695
DSTN destrin (actin depolymerizing factor) 3.02856
MLEC malectin 3.02092
ZCCHC7 zinc finger, CCHC domain containing 7 2.9986
PEX3 peroxisomal biogenesis factor 3 2.98802
CNOT4 CCR4-NOT transcription complex, subunit 4 2.98223
HEATR6 HEAT repeat containing 6 2.97726
SPTBN1 spectrin, beta, non-erythrocytic 1 2.97586
TMEM170B transmembrane protein 170B 2.97546
COQ7 coenzyme Q7 homolog, ubiquinone (yeast) 2.95373
NRDC nardilysin convertase 2.94672
RAP2B RAP2B, member of RAS oncogene family 2.93067
MRPL13 mitochondrial ribosomal protein L13 2.91056
ZNF680 zinc finger protein 680 2.90367
PSRC1 proline/serine-rich coiled-coil 1 2.88768
ARL10 ADP-ribosylation factor-like 10 2.88056
ANKRD17 ankyrin repeat domain 17 2.87685
TENT4B terminal nucleotidyltransferase 4B 2.87249
ODF1 outer dense fiber of sperm tails 1 2.87109
FHL5 four and a half LIM domains 5 2.86345
TOR3A torsin family 3, member A 2.85939
RTN4 reticulon 4 2.85307
ADCY7 adenylate cyclase 7 2.83663
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 2.83321
CNOT7 CCR4-NOT transcription complex, subunit 7 2.83256
NONO non-POU domain containing, octamer-binding 2.82975
CPPED1 calcineurin-like phosphoesterase domain containing 1 2.82638
MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase 2.82574
KHDC4 KH domain containing 4, pre-mRNA splicing factor 2.82129
WDR4 WD repeat domain 4 2.82096
WWC1 WW and C2 domain containing 1 2.81157
OXSM 3-oxoacyl-ACP synthase, mitochondrial 2.80583
OLFM2 olfactomedin 2 2.80126
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 2.80057
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 2.79827
ENDOG endonuclease G 2.79058
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide 2.79056
NPHS1 nephrosis 1, congenital, Finnish type (nephrin) 2.7872
PPP1R26 protein phosphatase 1, regulatory subunit 26 2.78716
OR1M1 olfactory receptor, family 1, subfamily M, member 1 2.78678
THAP7 THAP domain containing 7 2.78387
BCAP31 B-cell receptor-associated protein 31 2.78361
SZT2 seizure threshold 2 homolog (mouse) 2.78247
LIPT2 lipoyl(octanoyl) transferase 2 (putative) 2.78194
GSDMC gasdermin C 2.78156
TOGARAM1 TOG array regulator of axonemal microtubules 1 2.77624
UBE2G2 ubiquitin-conjugating enzyme E2G 2 2.76407
NCOR1 nuclear receptor corepressor 1 2.76296
RAD52 RAD52 homolog (S. cerevisiae) 2.75797
VPS36 vacuolar protein sorting 36 homolog (S. cerevisiae) 2.73793
BTBD17 BTB (POZ) domain containing 17 2.73477
OC90 otoconin 90 2.73103
LEO1 Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 2.72
DUSP23 dual specificity phosphatase 23 2.71769
ZBTB20 zinc finger and BTB domain containing 20 2.70367
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 2.69076
RPRD2 regulation of nuclear pre-mRNA domain containing 2 2.68361
PEX13 peroxisomal biogenesis factor 13 2.67956
RAB3D RAB3D, member RAS oncogene family 2.67563
KRT33B keratin 33B, type I 2.66574
MT1G metallothionein 1G 2.66527
DNAJC19 DnaJ (Hsp40) homolog, subfamily C, member 19 2.66045
CLDN12 claudin 12 2.65328
EXOC7 exocyst complex component 7 2.65129
NOSIP nitric oxide synthase interacting protein 2.65067
INAFM1 InaF-motif containing 1 2.64584
COL8A2 collagen, type VIII, alpha 2 2.64564
LIN54 lin-54 DREAM MuvB core complex component 2.63504
ADAT2 adenosine deaminase, tRNA-specific 2 2.63377
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35 2.6264
DOCK6 dedicator of cytokinesis 6 2.61662
MOV10 Mov10 RISC complex RNA helicase 2.59967
ZWILCH zwilch kinetochore protein 2.59447
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) 2.57966
CNOT11 CCR4-NOT transcription complex, subunit 11 2.57813
RASIP1 Ras interacting protein 1 2.57405
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 2.56606
SLFNL1 schlafen-like 1 2.56313
LRRC45 leucine rich repeat containing 45 2.56097
MAGEE2 melanoma antigen family E2 2.55287
ANKRD24 ankyrin repeat domain 24 2.54831
METTL12 methyltransferase like 12 2.54154
RPRML reprimo-like 2.53344
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 2.52753
CPNE7 copine VII 2.52627
MIGA2 mitoguardin 2 2.52511
MGLL monoglyceride lipase 2.5243
NBEAL2 neurobeachin-like 2 2.52186
GOT1 glutamic-oxaloacetic transaminase 1, soluble 2.51899
C12ORF49 chromosome 12 open reading frame 49 2.50991
C19ORF35 chromosome 19 open reading frame 35 2.50934
ZFP1 ZFP1 zinc finger protein 2.49453
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 2.49097
DUSP12 dual specificity phosphatase 12 2.49056
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 2.49005
ESRRA estrogen-related receptor alpha 2.48312
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1 2.47963
ARHGAP21 Rho GTPase activating protein 21 2.47872
SCP2 sterol carrier protein 2 2.47777
ZFYVE9 zinc finger, FYVE domain containing 9 2.47361
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) 2.4682
HPDL 4-hydroxyphenylpyruvate dioxygenase-like 2.45851
MYO9B myosin IXB 2.4577
ZNF135 zinc finger protein 135 2.45253
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2.44978
ASPHD2 aspartate beta-hydroxylase domain containing 2 2.44686
POU5F1 POU class 5 homeobox 1 2.44277
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) 2.42674
ANAPC13 anaphase promoting complex subunit 13 2.4199
PEX1 peroxisomal biogenesis factor 1 2.4142
SIRPD signal-regulatory protein delta 2.40928
ZNF556 zinc finger protein 556 2.40866
BRAP BRCA1 associated protein 2.40678
ABHD14B abhydrolase domain containing 14B 2.40592
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2 2.40169
FA2H fatty acid 2-hydroxylase 2.39773
GABRP gamma-aminobutyric acid (GABA) A receptor, pi 2.39696
SVIL supervillin 2.38374
MESDC1 mesoderm development candidate 1 2.38112
P3H1 prolyl 3-hydroxylase 1 2.37775
HNF1B HNF1 homeobox B 2.37551
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 2.37166
IRAK1 interleukin-1 receptor-associated kinase 1 2.36996
RHBDD3 rhomboid domain containing 3 2.36109
POC1A POC1 centriolar protein A 2.35725
CXORF58 chromosome X open reading frame 58 2.35519
RNF212B ring finger protein 212B 2.34665
MLX MLX, MAX dimerization protein 2.34303
KDM4A lysine (K)-specific demethylase 4A 2.33787
TFB1M transcription factor B1, mitochondrial 2.32927
DBNDD2 dysbindin (dystrobrevin binding protein 1) domain containing 2 2.32169
CFAP45 cilia and flagella associated protein 45 2.31688
FOXE3 forkhead box E3 2.31524
IL6ST interleukin 6 signal transducer 2.3038
MARCH2 membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase 2.2985
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 2.29572
GLIS2 GLIS family zinc finger 2 2.29278
ZC3H4 zinc finger CCCH-type containing 4 2.283
FAM46B family with sequence similarity 46, member B 2.2793
WBP4 WW domain binding protein 4 2.2777
FRA10AC1 fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1 2.27176
IER3 immediate early response 3 2.27097
B4GALNT4 beta-1,4-N-acetyl-galactosaminyl transferase 4 2.26852
NEURL4 neuralized E3 ubiquitin protein ligase 4 2.25801
KIRREL2 kin of IRRE like 2 (Drosophila) 2.24951
TCTEX1D1 Tctex1 domain containing 1 2.24702
MBD3L1 methyl-CpG binding domain protein 3-like 1 2.24567
RELCH RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing 2.23884
SYT11 synaptotagmin XI 2.22631
KNCN kinocilin 2.21444
CD151 CD151 molecule (Raph blood group) 2.21373
LEMD2 LEM domain containing 2 2.21336
SUCLG1 succinate-CoA ligase, alpha subunit 2.21088
GOLGA6L6 golgin A6 family-like 6 2.20361
CEP85 centrosomal protein 85kDa 2.19282
MRPL2 mitochondrial ribosomal protein L2 2.18857
ALDH5A1 aldehyde dehydrogenase 5 family, member A1 2.18396
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 2.16915
ALX3 ALX homeobox 3 2.16695
GON4L gon-4-like (C. elegans) 2.1615
IGSF9 immunoglobulin superfamily, member 9 2.15738
OR5L2 olfactory receptor, family 5, subfamily L, member 2 2.15472
CD48 CD48 molecule 2.15294
TMPO thymopoietin 2.14954
NCOA4 nuclear receptor coactivator 4 2.14526
GRID2IP glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 2.14504
BSG basigin (Ok blood group) 2.13409
FOXRED1 FAD-dependent oxidoreductase domain containing 1 2.13238
GPR62 G protein-coupled receptor 62 2.13004
LAMA2 laminin, alpha 2 2.12686
CCDC137 coiled-coil domain containing 137 2.12648
LCK LCK proto-oncogene, Src family tyrosine kinase 2.12455
RNF40 ring finger protein 40, E3 ubiquitin protein ligase 2.12057
PLA2G12B phospholipase A2, group XIIB 2.11765
MECR mitochondrial trans-2-enoyl-CoA reductase 2.11671
ARMC5 armadillo repeat containing 5 2.11622
TMEM41B transmembrane protein 41B 2.10689
USP1 ubiquitin specific peptidase 1 2.10502
CREB3L3 cAMP responsive element binding protein 3-like 3 2.10074
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 2.09971
FGR FGR proto-oncogene, Src family tyrosine kinase 2.09474
MED25 mediator complex subunit 25 2.09387
XRRA1 X-ray radiation resistance associated 1 2.08843
CETN2 centrin, EF-hand protein, 2 2.08389
SREBF1 sterol regulatory element binding transcription factor 1 2.08344
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 2.0778
ETV3L ets variant 3-like 2.07473
DMRTA2 DMRT-like family A2 2.07427
MOSPD3 motile sperm domain containing 3 2.07423
MATR3 matrin 3 2.07396
EPHA2 EPH receptor A2 2.07316
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 2.06401
SYNPO synaptopodin 2.06355
MRPL11 mitochondrial ribosomal protein L11 2.05637
FMNL1 formin-like 1 2.05463
WAPL WAPL cohesin release factor 2.05096
MIMS1 mitochondrial inner membrane scaffold 1 2.04841
LATS1 large tumor suppressor kinase 1 2.04825
MRPS15 mitochondrial ribosomal protein S15 2.04709
RTRAF RNA transcription, translation and transport factor 2.04395
DNAJC21 DnaJ (Hsp40) homolog, subfamily C, member 21 2.04065
USH1G Usher syndrome 1G (autosomal recessive) 2.0404
TRAP1 TNF receptor-associated protein 1 2.03938
C19ORF24 chromosome 19 open reading frame 24 2.03856
ACAD9 acyl-CoA dehydrogenase family, member 9 2.03691
PPP6C protein phosphatase 6, catalytic subunit 2.02955
HARS2 histidyl-tRNA synthetase 2, mitochondrial 2.02697
DDA1 DET1 and DDB1 associated 1 2.02641
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) 2.02574
SPTAN1 spectrin, alpha, non-erythrocytic 1 2.01995
MEX3A mex-3 RNA binding family member A 2.01878
PRR23B proline rich 23B 2.018
MRPS33 mitochondrial ribosomal protein S33 2.01757
FRY furry homolog (Drosophila) 2.01712
RIOK3 RIO kinase 3 2.01527
GFAP glial fibrillary acidic protein 2.01512
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 2.01104
CHD8 chromodomain helicase DNA binding protein 8 2.01055
LOC391003 PRAME family member-like 2.01025
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 2.00953
CLTA clathrin, light chain A 2.00913
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 2.00755
CCDC17 coiled-coil domain containing 17 2.00478
PPP4R3A protein phosphatase 4 regulatory subunit 3A 2.00351