HCT-15 Gene Set

Dataset GDSC Cell Line Gene Expression Profiles
Category transcriptomics
Type cell line
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Genes

303 genes with high or low expression in HCT-15 relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.

high expression

Symbol Name Standardized Value
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 3.02353
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 2.73118
CAPN7 calpain 7 2.67741
SUPT4H1 suppressor of Ty 4 homolog 1 (S. cerevisiae) 2.40436
ASCL2 achaete-scute family bHLH transcription factor 2 2.37476
CDH7 cadherin 7, type 2 2.3569
HOXB6 homeobox B6 2.33814
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF 2.32464
MGEA5 meningioma expressed antigen 5 (hyaluronidase) 2.31677
ARSD arylsulfatase D 2.31639
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 2.28842
HIPK3 homeodomain interacting protein kinase 3 2.27955
HOXB9 homeobox B9 2.26792
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1 2.26279
PITX2 paired-like homeodomain 2 2.24817
SMU1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) 2.24272
AHSA2 AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast) 2.23321
ZNF33B zinc finger protein 33B 2.2097
ZNF91 zinc finger protein 91 2.15735
WAC WW domain containing adaptor with coiled-coil 2.15638
PIGL phosphatidylinositol glycan anchor biosynthesis, class L 2.14787
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 2.1402
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) 2.14
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2 2.07609
MAN1A2 mannosidase, alpha, class 1A, member 2 2.04668
FBXW4 F-box and WD repeat domain containing 4 2.04091
SH3GLB2 SH3-domain GRB2-like endophilin B2 2.03262
CAB39L calcium binding protein 39-like 2.03059
ZNF236 zinc finger protein 236 1.97715
SLC41A3 solute carrier family 41, member 3 1.94786
NEK4 NIMA-related kinase 4 1.94215
NPY4R neuropeptide Y receptor Y4 1.9342
TSGA10 testis specific, 10 1.91507
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) 1.89505
KAT5 K(lysine) acetyltransferase 5 1.89444
UBFD1 ubiquitin family domain containing 1 1.88972
TSN translin 1.86719
GPBP1L1 GC-rich promoter binding protein 1-like 1 1.85355
ZNF460 zinc finger protein 460 1.83862
DCTN4 dynactin 4 (p62) 1.82626
NDP Norrie disease (pseudoglioma) 1.82565
PPARA peroxisome proliferator-activated receptor alpha 1.8252
DCAKD dephospho-CoA kinase domain containing 1.81523
SBNO1 strawberry notch homolog 1 (Drosophila) 1.80692
ZNF286A zinc finger protein 286A 1.79568
GRSF1 G-rich RNA sequence binding factor 1 1.7944
EXD2 exonuclease 3'-5' domain containing 2 1.79284
IFT38 intraflagellar transport 38 1.78772
RRAGB Ras-related GTP binding B 1.78109
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 1.77323
USP6NL USP6 N-terminal like 1.76668
THRAP3 thyroid hormone receptor associated protein 3 1.76526
ZBTB1 zinc finger and BTB domain containing 1 1.76499
OSBP oxysterol binding protein 1.76401
ODAM odontogenic, ameloblast asssociated 1.76336
TMCO3 transmembrane and coiled-coil domains 3 1.76039
USP9Y ubiquitin specific peptidase 9, Y-linked 1.74618
UTRN utrophin 1.74601
GCC2 GRIP and coiled-coil domain containing 2 1.74329
SDAD1 SDA1 domain containing 1 1.73891
WBP4 WW domain binding protein 4 1.72253
MGC4859 uncharacterized LOC79150 1.71526
DENND4C DENN/MADD domain containing 4C 1.7125
MAN2B2 mannosidase, alpha, class 2B, member 2 1.70911
CHD8 chromodomain helicase DNA binding protein 8 1.70226
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 1.7017
LMAN1 lectin, mannose-binding, 1 1.69702
TEX13B testis expressed 13B 1.68431
CARF calcium responsive transcription factor 1.68339
HIST1H3E histone cluster 1, H3e 1.68016
DOCK1 dedicator of cytokinesis 1 1.67854
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 1.67687
TNNC1 troponin C type 1 (slow) 1.67495
CDX2 caudal type homeobox 2 1.66857
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6 1.65977
B3GALNT1 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) 1.65375
ZNF200 zinc finger protein 200 1.65004
RAD50 RAD50 homolog (S. cerevisiae) 1.63997
RNF170 ring finger protein 170 1.63811
GIGYF2 GRB10 interacting GYF protein 2 1.63555
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 1.63283
WDR13 WD repeat domain 13 1.62383
SCARB2 scavenger receptor class B, member 2 1.61014
MCOLN3 mucolipin 3 1.60617
HNF4G hepatocyte nuclear factor 4, gamma 1.60413
TRIM10 tripartite motif containing 10 1.59896
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1 1.59353
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 1.59349
REV1 REV1, polymerase (DNA directed) 1.59101
FZD3 frizzled class receptor 3 1.58509
TMEM39A transmembrane protein 39A 1.5842
C4BPB complement component 4 binding protein, beta 1.57886
TWSG1 twisted gastrulation BMP signaling modulator 1 1.57749
RBM4B RNA binding motif protein 4B 1.5741
AKTIP AKT interacting protein 1.56852
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 1.56834
ZCCHC14 zinc finger, CCHC domain containing 14 1.56726
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 1.55204
PKP2 plakophilin 2 1.54983
FAM63B family with sequence similarity 63, member B 1.54467
ZNF84 zinc finger protein 84 1.54451
LIPT1 lipoyltransferase 1 1.54328
CNOT6 CCR4-NOT transcription complex, subunit 6 1.54253
CNOT8 CCR4-NOT transcription complex, subunit 8 1.53727
RCC1 regulator of chromosome condensation 1 1.5354
GLYAT glycine-N-acyltransferase 1.53511
SGPP1 sphingosine-1-phosphate phosphatase 1 1.53435
SLC39A9 solute carrier family 39, member 9 1.53383
FPGT fucose-1-phosphate guanylyltransferase 1.52955
PTER phosphotriesterase related 1.52469
MINPP1 multiple inositol-polyphosphate phosphatase 1 1.52301
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5 1.52092
CRK v-crk avian sarcoma virus CT10 oncogene homolog 1.51828
OTUD4 OTU deubiquitinase 4 1.51754
SP1 Sp1 transcription factor 1.51539
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 1.51444
LMBRD1 LMBR1 domain containing 1 1.51416
KDM3B lysine (K)-specific demethylase 3B 1.50909
RNF146 ring finger protein 146 1.50888
FAM215A family with sequence similarity 215, member A (non-protein coding) 1.5065
TMED7 transmembrane emp24 protein transport domain containing 7 1.50292
RNF41 ring finger protein 41, E3 ubiquitin protein ligase 1.49445
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 1.49379
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 1.4912
UBXN8 UBX domain protein 8 1.48526
MSH4 mutS homolog 4 1.48338
ZFY zinc finger protein, Y-linked 1.48061
SH3BP4 SH3-domain binding protein 4 1.4784
TTC26 tetratricopeptide repeat domain 26 1.47778
HOXA6 homeobox A6 1.47725
LGALS8 lectin, galactoside-binding, soluble, 8 1.47375
SLC35E2 solute carrier family 35, member E2 1.47192
ULBP1 UL16 binding protein 1 1.4708
TOM1L1 target of myb1 (chicken)-like 1 1.47007
TBC1D4 TBC1 domain family, member 4 1.46849
ULK2 unc-51 like autophagy activating kinase 2 1.45966
MAP3K2 mitogen-activated protein kinase kinase kinase 2 1.45937
SATB2 SATB homeobox 2 1.45906
TMEM59 transmembrane protein 59 1.45768
TRIM52 tripartite motif containing 52 1.45626
LATS1 large tumor suppressor kinase 1 1.45625
ZBTB3 zinc finger and BTB domain containing 3 1.454
SCRN3 secernin 3 1.45376
COQ7 coenzyme Q7 homolog, ubiquinone (yeast) 1.44985
EFCAB14 EF-hand calcium binding domain 14 1.4495
PTBP3 polypyrimidine tract binding protein 3 1.44597
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 1.44359
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 1.44036
ARHGAP5 Rho GTPase activating protein 5 1.4399
NR2C1 nuclear receptor subfamily 2, group C, member 1 1.43792
DKFZP434C153 DKFZP434C153 protein 1.43494
TTC19 tetratricopeptide repeat domain 19 1.43341
FUT2 fucosyltransferase 2 (secretor status included) 1.43335
KCNQ1DN KCNQ1 downstream neighbor (non-protein coding) 1.43208
FRAS1 Fraser extracellular matrix complex subunit 1 1.43193
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 1.43089
UST uronyl-2-sulfotransferase 1.42327
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 1.41754
ZKSCAN8 zinc finger with KRAB and SCAN domains 8 1.41735
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 1.41688

low expression

Symbol Name Standardized Value
FTSJ1 FtsJ RNA methyltransferase homolog 1 (E. coli) -3.53649
SOX5 SRY (sex determining region Y)-box 5 -3.44985
HDGF hepatoma-derived growth factor -3.37244
GBX2 gastrulation brain homeobox 2 -3.17756
SMG7-AS1 SMG7 antisense RNA 1 -3.05973
TUBG1 tubulin, gamma 1 -3.05209
TCEA2 transcription elongation factor A (SII), 2 -3.04082
ADRA1D adrenoceptor alpha 1D -2.97664
GYPB glycophorin B (MNS blood group) -2.83973
SEC31A SEC31 homolog A (S. cerevisiae) -2.82643
GBP1 guanylate binding protein 1, interferon-inducible -2.70166
OASL 2'-5'-oligoadenylate synthetase-like -2.58477
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1 -2.4495
IFI16 interferon, gamma-inducible protein 16 -2.39847
TFRC transferrin receptor -2.369
SH3PXD2A SH3 and PX domains 2A -2.31804
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) -2.29913
FSD1 fibronectin type III and SPRY domain containing 1 -2.28399
FNBP1 formin binding protein 1 -2.22568
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 -2.19296
MSH6 mutS homolog 6 -2.17822
FAM127A family with sequence similarity 127, member A -2.17721
CALR calreticulin -2.1449
RAD54L RAD54-like (S. cerevisiae) -2.09441
MAP7D1 MAP7 domain containing 1 -2.09013
DIAPH2-AS1 DIAPH2 antisense RNA 1 -2.08163
CIDEB cell death-inducing DFFA-like effector b -2.02741
THAP11 THAP domain containing 11 -2.00479
CTNNA2 catenin (cadherin-associated protein), alpha 2 -1.99151
DTNA dystrobrevin, alpha -1.96879
USP20 ubiquitin specific peptidase 20 -1.96753
CXCR2 chemokine (C-X-C motif) receptor 2 -1.95446
SF3A3 splicing factor 3a, subunit 3, 60kDa -1.94659
PTCRA pre T-cell antigen receptor alpha -1.9204
MYO19 myosin XIX -1.91219
FUZ fuzzy planar cell polarity protein -1.89618
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2 -1.89162
MGAT4C MGAT4 family, member C -1.88778
DOK5 docking protein 5 -1.87695
PAOX polyamine oxidase (exo-N4-amino) -1.87555
VCAN versican -1.86641
TPTE transmembrane phosphatase with tensin homology -1.86434
OBSL1 obscurin-like 1 -1.85874
MSN moesin -1.84904
GP2 glycoprotein 2 (zymogen granule membrane) -1.83016
TWIST1 twist family bHLH transcription factor 1 -1.81195
ZNF22 zinc finger protein 22 -1.81129
ZNF512B zinc finger protein 512B -1.80645
CORO2B coronin, actin binding protein, 2B -1.80129
MTCH1 mitochondrial carrier 1 -1.78879
NDUFS5 NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) -1.78528
SCGN secretagogin, EF-hand calcium binding protein -1.78413
SNRPA1 small nuclear ribonucleoprotein polypeptide A' -1.78086
HSPB6 heat shock protein, alpha-crystallin-related, B6 -1.77282
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) -1.76967
ZNF304 zinc finger protein 304 -1.76804
SPHK1 sphingosine kinase 1 -1.75113
PCDH11Y protocadherin 11 Y-linked -1.74569
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 -1.72328
DMP1 dentin matrix acidic phosphoprotein 1 -1.72313
TMED9 transmembrane emp24 protein transport domain containing 9 -1.72254
PPP1R3C protein phosphatase 1, regulatory subunit 3C -1.70041
EHD3 EH-domain containing 3 -1.69126
GRPR gastrin-releasing peptide receptor -1.69039
EPHB1 EPH receptor B1 -1.68539
SEZ6L seizure related 6 homolog (mouse)-like -1.67492
ANKRD28 ankyrin repeat domain 28 -1.67274
MYL10 myosin, light chain 10, regulatory -1.66608
FAM214B family with sequence similarity 214, member B -1.6581
TBX10 T-box 10 -1.65411
PEA15 phosphoprotein enriched in astrocytes 15 -1.65392
MCM10 minichromosome maintenance complex component 10 -1.6538
IQCA1 IQ motif containing with AAA domain 1 -1.65155
CCDC71 coiled-coil domain containing 71 -1.6405
PMF1 polyamine-modulated factor 1 -1.6338
RSPH14 radial spoke head 14 homolog (Chlamydomonas) -1.63223
RIPPLY3 ripply transcriptional repressor 3 -1.62815
HDAC9 histone deacetylase 9 -1.62745
VN1R1 vomeronasal 1 receptor 1 -1.62503
PRKACA protein kinase, cAMP-dependent, catalytic, alpha -1.62344
WNT5A wingless-type MMTV integration site family, member 5A -1.61847
VKORC1 vitamin K epoxide reductase complex, subunit 1 -1.61824
COL14A1 collagen, type XIV, alpha 1 -1.61094
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 -1.61039
LTBP2 latent transforming growth factor beta binding protein 2 -1.60682
HAUS5 HAUS augmin-like complex, subunit 5 -1.60098
CFL1 cofilin 1 (non-muscle) -1.58457
GMEB1 glucocorticoid modulatory element binding protein 1 -1.58052
ATAD3A ATPase family, AAA domain containing 3A -1.57134
FRMD4A FERM domain containing 4A -1.56835
GRIK1 glutamate receptor, ionotropic, kainate 1 -1.56759
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa -1.56261
PAX1 paired box 1 -1.56066
PDE4A phosphodiesterase 4A, cAMP-specific -1.5574
GJC2 gap junction protein, gamma 2, 47kDa -1.5541
NEIL3 nei endonuclease VIII-like 3 (E. coli) -1.55316
PRMT8 protein arginine methyltransferase 8 -1.54811
RNMTL1 RNA methyltransferase like 1 -1.54557
GPR27 G protein-coupled receptor 27 -1.54539
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene -1.5447
PTTG1 pituitary tumor-transforming 1 -1.54135
COL8A1 collagen, type VIII, alpha 1 -1.54128
PLTP phospholipid transfer protein -1.53499
C3AR1 complement component 3a receptor 1 -1.52923
TMCC2 transmembrane and coiled-coil domain family 2 -1.52809
ELOVL5 ELOVL fatty acid elongase 5 -1.52595
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -1.52591
PHEX phosphate regulating endopeptidase homolog, X-linked -1.5231
EPYC epiphycan -1.5171
SAA1 serum amyloid A1 -1.51173
KDM5C lysine (K)-specific demethylase 5C -1.5076
RAB31 RAB31, member RAS oncogene family -1.50744
FBN1 fibrillin 1 -1.5049
POU3F1 POU class 3 homeobox 1 -1.50353
NRSN2 neurensin 2 -1.50248
CRADD CASP2 and RIPK1 domain containing adaptor with death domain -1.50177
AMIGO2 adhesion molecule with Ig-like domain 2 -1.50159
SARS2 seryl-tRNA synthetase 2, mitochondrial -1.49634
PACS1 phosphofurin acidic cluster sorting protein 1 -1.4929
FGF16 fibroblast growth factor 16 -1.48727
ALDOC aldolase C, fructose-bisphosphate -1.48677
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) -1.47984
GEMIN4 gem (nuclear organelle) associated protein 4 -1.4789
PRR11 proline rich 11 -1.475
CLCA3P chloride channel accessory 3, pseudogene -1.47348
MTERF1 mitochondrial transcription termination factor 1 -1.47046
SPACA1 sperm acrosome associated 1 -1.46649
GUCY1A2 guanylate cyclase 1, soluble, alpha 2 -1.4664
RELN reelin -1.46194
SELL selectin L -1.46186
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 -1.46142
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -1.45966
CIB2 calcium and integrin binding family member 2 -1.45857
NAA10 N(alpha)-acetyltransferase 10, NatA catalytic subunit -1.4578
ESRRG estrogen-related receptor gamma -1.43862
TUBA1B tubulin, alpha 1b -1.43472
AURKB aurora kinase B -1.43407
POLDIP2 polymerase (DNA-directed), delta interacting protein 2 -1.43381
CORIN corin, serine peptidase -1.43192
CAMK4 calcium/calmodulin-dependent protein kinase IV -1.43168
SNRPN small nuclear ribonucleoprotein polypeptide N -1.42272
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 -1.42053
TGFB2 transforming growth factor, beta 2 -1.41626