HDAC1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description histone deacetylase 1|Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3065)
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Genes

345 genes differentially expressed following the HDAC1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
FAM153A family with sequence similarity 153, member A 3.52744
SDR9C7 short chain dehydrogenase/reductase family 9C, member 7 3.52744
SLC46A3 solute carrier family 46, member 3 3.52744
CD160 CD160 molecule 3.52744
PCDHB7 protocadherin beta 7 3.52744
NCF4 neutrophil cytosolic factor 4, 40kDa 3.52744
SLC25A41 solute carrier family 25, member 41 3.52744
PAX7 paired box 7 3.52744
SLC15A5 solute carrier family 15, member 5 3.52744
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 3.52744
SSTR5 somatostatin receptor 5 3.52744
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E 3.52744
USP26 ubiquitin specific peptidase 26 3.52744
ACR acrosin 3.52744
SLCO1B3 solute carrier organic anion transporter family, member 1B3 3.52744
SRL sarcalumenin 3.52744
CFHR4 complement factor H-related 4 3.52744
ZNF780A zinc finger protein 780A 3.52744
MYO7B myosin VIIB 3.52744
LRRD1 leucine-rich repeats and death domain containing 1 3.52744
CARD18 caspase recruitment domain family, member 18 3.52744
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 3.52744
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 3.52744
TAS2R1 taste receptor, type 2, member 1 3.52744
ADAD1 adenosine deaminase domain containing 1 (testis-specific) 3.52744
USP50 ubiquitin specific peptidase 50 3.52744
EDDM3A epididymal protein 3A 3.52744
CRH corticotropin releasing hormone 3.52744
WNT8B wingless-type MMTV integration site family, member 8B 3.52744
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 3.52744
SETSIP SET-like protein 3.52744
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 3.52744
CRYGA crystallin, gamma A 3.52744
MMP20 matrix metallopeptidase 20 3.52744
RASSF9 Ras association (RalGDS/AF-6) domain family (N-terminal) member 9 3.52744
GNAT3 guanine nucleotide binding protein, alpha transducing 3 3.52744
CACNG1 calcium channel, voltage-dependent, gamma subunit 1 3.52744
MYCT1 myc target 1 3.52744
FBLN7 fibulin 7 3.52744
ADGB androglobin 3.52744
THRSP thyroid hormone responsive 3.52744
POSTN periostin, osteoblast specific factor 3.52744
TRPV5 transient receptor potential cation channel, subfamily V, member 5 3.52744
ADAMTSL5 ADAMTS-like 5 3.52744
F7 coagulation factor VII (serum prothrombin conversion accelerator) 3.52744
C3ORF22 chromosome 3 open reading frame 22 3.52744
IMPG2 interphotoreceptor matrix proteoglycan 2 3.52744
ACY3 aminoacylase 3 3.52744
LRTM3 leucine rich repeat transmembrane protein 3 3.52744
TMOD4 tropomodulin 4 (muscle) 3.52744
MCHR1 melanin-concentrating hormone receptor 1 3.52744
ALX4 ALX homeobox 4 3.52744
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 3.52744
FMO3 flavin containing monooxygenase 3 3.52744
PROC protein C (inactivator of coagulation factors Va and VIIIa) 3.52744
SAG S-antigen; retina and pineal gland (arrestin) 3.52744
FCMR Fc fragment of IgM receptor 3.52744
SMTNL1 smoothelin-like 1 3.52744
OR8G5 olfactory receptor, family 8, subfamily G, member 5 3.52744
VSIR V-set immunoregulatory receptor 3.52744
PLAAT4 phospholipase A and acyltransferase 4 3.52744
COXFA4L2 cytochrome c oxidase hypoxia associated subunit FA4L2 3.52744
CIMIP2C ciliary microtubule inner protein 2C 3.52744
TMEM238L transmembrane protein 238 like 3.52744
LHFPL7 LHFPL tetraspan subfamily member 7 3.52744
H2AC1 H2A clustered histone 1 3.52744
CBY2 chibby family member 2 3.52744
SPACDR sperm acrosome developmental regulator 3.52744
CABCOCO1 ciliary associated calcium binding coiled-coil 1 3.52744
CCN5 cellular communication network factor 5 3.52744
VEGFD vascular endothelial growth factor D 3.52744
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 3.52744
GATA3 GATA binding protein 3 3.52744
CD48 CD48 molecule 3.52744
DAO D-amino-acid oxidase 3.52744
BIK BCL2-interacting killer (apoptosis-inducing) 3.52744
MAGEB3 melanoma antigen family B3 3.52744
CLDN9 claudin 9 3.52744
CFAP99 cilia and flagella associated protein 99 3.52744
PRB4 proline-rich protein BstNI subfamily 4 3.52744
PCDHA5 protocadherin alpha 5 3.52744
RS1 retinoschisin 1 3.52744
LBHD1 LBH domain containing 1 3.52744
CBLN3 cerebellin 3 precursor 3.52744
SLC45A2 solute carrier family 45, member 2 3.52744
PRDM7 PR domain containing 7 3.52744
IL16 interleukin 16 3.52744
GPR83 G protein-coupled receptor 83 3.52744
PABPC1L2A poly(A) binding protein, cytoplasmic 1-like 2A 3.52744
IL7R interleukin 7 receptor 3.52744
OOSP1 oocyte secreted protein 1, pseudogene 3.52744
SAA4 serum amyloid A4, constitutive 3.52744
CLDN22 claudin 22 3.52744
PIWIL3 piwi-like RNA-mediated gene silencing 3 3.52744
C1QL3 complement component 1, q subcomponent-like 3 3.52744
CD300E CD300e molecule 3.52744
SPACA4 sperm acrosome associated 4 3.52744
PLGLB1 plasminogen-like B1 3.52744
OR56A3 olfactory receptor, family 56, subfamily A, member 3 3.52744
EDN3 endothelin 3 3.52744
RSPH10B2 radial spoke head 10 homolog B2 (Chlamydomonas) 3.52744
THTPA thiamine triphosphatase 3.52744
CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18 3.52744
CLRN1 clarin 1 3.52744
IL21R interleukin 21 receptor 3.52744
JSRP1 junctional sarcoplasmic reticulum protein 1 3.52744
ADAM2 ADAM metallopeptidase domain 2 3.52744
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 3.52744
ERICH4 glutamate-rich 4 3.52744
CROCC2 ciliary rootlet coiled-coil, rootletin family member 2 3.52744
PRRX1 paired related homeobox 1 3.52744
TDRD10 tudor domain containing 10 3.52744
SMYD1 SET and MYND domain containing 1 3.52744
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 3.52744
KRT13 keratin 13, type I 3.52744
APOH apolipoprotein H (beta-2-glycoprotein I) 3.52744
PCDHGB2 protocadherin gamma subfamily B, 2 3.52744
TMEM132D transmembrane protein 132D 3.52744
PLET1 placenta expressed transcript 1 3.52744
CPA2 carboxypeptidase A2 (pancreatic) 3.52744
CTXN3 cortexin 3 3.52744
OR4D2 olfactory receptor, family 4, subfamily D, member 2 3.52744
PLCD4 phospholipase C, delta 4 3.52744
RGS8 regulator of G-protein signaling 8 3.52744
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 3.52744
CCNI2 cyclin I family, member 2 3.52744
NYX nyctalopin 3.52744
RASA4 RAS p21 protein activator 4 3.52744
PCDHAC2 protocadherin alpha subfamily C, 2 3.52744
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 3.52744
EPHA10 EPH receptor A10 3.52744
CDH10 cadherin 10, type 2 (T2-cadherin) 3.52744
TRIM50 tripartite motif containing 50 3.52744
TRIM55 tripartite motif containing 55 3.52744
RANBP3L RAN binding protein 3-like 3.52744
EVPLL envoplakin-like 3.52744
TEKT1 tektin 1 3.52744
EVI2A ecotropic viral integration site 2A 3.52744
IGF2 insulin-like growth factor 2 3.52744
ZC3H11D zinc finger CCCH-type containing 11D 3.52744
PPP1R27 protein phosphatase 1, regulatory subunit 27 3.52744
OR51I2 olfactory receptor, family 51, subfamily I, member 2 3.52744
TGM3 transglutaminase 3 3.52744
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 3.52744
FXYD3 FXYD domain containing ion transport regulator 3 3.52744
IFNK interferon, kappa 3.52744
RERGL RERG/RAS-like 3.52744
ALLC allantoicase 3.52744
PATE2 prostate and testis expressed 2 3.52744
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 3.52744
THEMIS thymocyte selection associated 3.52744
TMEM86A transmembrane protein 86A 3.52744
BTBD19 BTB (POZ) domain containing 19 3.52744
IRX5 iroquois homeobox 5 3.52744
PLGLB2 plasminogen-like B2 3.52744
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 3.52744
ADGRF5 adhesion G protein-coupled receptor F5 3.52744
TXNDC2 thioredoxin domain containing 2 (spermatozoa) 3.52744
AMIGO3 adhesion molecule with Ig-like domain 3 3.52744
LAMP3 lysosomal-associated membrane protein 3 3.52744
POTEI POTE ankyrin domain family, member I 3.52744
CD8B CD8b molecule 3.52744
OR56B1 olfactory receptor, family 56, subfamily B, member 1 3.52744
EBF2 early B-cell factor 2 3.48307
CDH24 cadherin 24, type 2 3.38594
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 3.20344
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 3.00534
MAML1 mastermind-like 1 (Drosophila) 2.98667
MEX3D mex-3 RNA binding family member D 2.83604
RPL35 ribosomal protein L35 2.82525
FER fer (fps/fes related) tyrosine kinase 2.81629
ZNF362 zinc finger protein 362 2.7374
SFT2D3 SFT2 domain containing 3 2.72884
HELQ helicase, POLQ-like 2.70599
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 2.54137
CD70 CD70 molecule 2.49473
PPEF1 protein phosphatase, EF-hand calcium binding domain 1 2.49473
PEX12 peroxisomal biogenesis factor 12 2.49473
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2.49473
ZNF517 zinc finger protein 517 2.49473
STARD5 StAR-related lipid transfer (START) domain containing 5 2.49473
ARL2 ADP-ribosylation factor-like 2 2.49473
PMM2 phosphomannomutase 2 2.49473
GIPR gastric inhibitory polypeptide receptor 2.49473
TRPM2 transient receptor potential cation channel, subfamily M, member 2 2.49473
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 2.47659
MEI1 meiosis inhibitor 1 2.45573
AVEN apoptosis, caspase activation inhibitor 2.45573
SLC7A6OS solute carrier family 7, member 6 opposite strand 2.43528
SSUH2 ssu-2 homolog (C. elegans) 2.42479
SERPINE3 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3 2.42479
POLR1F RNA polymerase I subunit F 2.42479
LYPLA1 lysophospholipase I 2.39766
ZNF324B zinc finger protein 324B 2.39387
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 2.39387
CA5A carbonic anhydrase VA, mitochondrial 2.39387
NLRC4 NLR family, CARD domain containing 4 2.39387
GFRA1 GDNF family receptor alpha 1 2.38747
KHNYN KH and NYN domain containing 2.35372
MRPL46 mitochondrial ribosomal protein L46 2.33839
TMEM234 transmembrane protein 234 2.32117
DNAAF2 dynein, axonemal, assembly factor 2 2.30255
ALG3 ALG3, alpha-1,3- mannosyltransferase 2.28042
AFG1L AFG1 like ATPase 2.2715
UNG uracil-DNA glycosylase 2.24955
IST1 increased sodium tolerance 1 homolog (yeast) 2.23793
TAB3 TGF-beta activated kinase 1/MAP3K7 binding protein 3 2.23484
COA5 cytochrome c oxidase assembly factor 5 2.20588
ERCC3 excision repair cross-complementation group 3 2.18828
PRRC2A proline-rich coiled-coil 2A 2.17937
DNAH9 dynein, axonemal, heavy chain 9 2.1759
SIRT5 sirtuin 5 2.16621
CA8 carbonic anhydrase VIII 2.14738
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 2.14738
KIAA1217 KIAA1217 2.14738
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) 2.1348
TOR1AIP2 torsin A interacting protein 2 2.13275
DZIP1 DAZ interacting zinc finger protein 1 2.12042
ANKRD31 ankyrin repeat domain 31 2.11338
PTGR2 prostaglandin reductase 2 2.08205
AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2.07026
METTL4 methyltransferase like 4 2.05506
LGALS8 lectin, galactoside-binding, soluble, 8 2.02788
TEN1 TEN1 CST complex subunit 2.02105
SPAG7 sperm associated antigen 7 2.02105
BCAR1 breast cancer anti-estrogen resistance 1 2.01232

decreased expression

Symbol Name Standardized Value
INSYN1 inhibitory synaptic factor 1 -3.52744
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -3.52744
MOGAT3 monoacylglycerol O-acyltransferase 3 -3.52744
F2 coagulation factor II (thrombin) -3.52744
LRRC61 leucine rich repeat containing 61 -3.52744
AVP arginine vasopressin -3.52744
OVCH1 ovochymase 1 -3.52744
WNK4 WNK lysine deficient protein kinase 4 -3.52744
LKAAEAR1 LKAAEAR motif containing 1 -3.52744
ANGPTL7 angiopoietin-like 7 -3.52744
CBR3 carbonyl reductase 3 -3.52744
MSANTD1 Myb/SANT-like DNA-binding domain containing 1 -3.52744
ACAN aggrecan -3.52744
FLI1 Fli-1 proto-oncogene, ETS transcription factor -3.52744
BCAS1 breast carcinoma amplified sequence 1 -3.52744
EPN3 epsin 3 -3.52744
SYCP3 synaptonemal complex protein 3 -3.52744
LTC4S leukotriene C4 synthase -3.52744
LIPT2-AS1 LIPT2 antisense RNA 1 -3.52744
GGTA1 glycoprotein alpha-galactosyltransferase 1 (inactive) -3.52744
ALDOB aldolase B, fructose-bisphosphate -3.52744
TBC1D3L TBC1 domain family, member 3L -3.52744
SMPX small muscle protein, X-linked -3.52744
SMTNL2 smoothelin-like 2 -3.52744
LEKR1 leucine, glutamate and lysine rich 1 -3.52744
WNT9B wingless-type MMTV integration site family, member 9B -3.52744
NPIPB7 nuclear pore complex interacting protein family, member B7 -3.52744
TACR2 tachykinin receptor 2 -3.52744
OVOL1 ovo-like zinc finger 1 -3.52744
ZNF575 zinc finger protein 575 -3.52744
CXCL17 chemokine (C-X-C motif) ligand 17 -3.52744
BBS5 Bardet-Biedl syndrome 5 -3.52744
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 -3.52744
PTPRN protein tyrosine phosphatase, receptor type, N -3.52744
ACKR4 atypical chemokine receptor 4 -3.52744
DES desmin -3.52744
ACOX2 acyl-CoA oxidase 2, branched chain -3.52744
HCLS1 hematopoietic cell-specific Lyn substrate 1 -3.52744
GAB3 GRB2-associated binding protein 3 -3.52744
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 -3.52744
ITGA10 integrin, alpha 10 -3.52744
CRYBA4 crystallin, beta A4 -3.52744
INCA1 inhibitor of CDK, cyclin A1 interacting protein 1 -3.52744
INSL6 insulin-like 6 -3.52744
RSPH9 radial spoke head 9 homolog (Chlamydomonas) -3.52744
BTG4 B-cell translocation gene 4 -3.52744
MYO3A myosin IIIA -3.49928
USP18 ubiquitin specific peptidase 18 -3.46445
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta -3.0683
CMTM7 CKLF-like MARVEL transmembrane domain containing 7 -3.05548
SRGAP2C SLIT-ROBO Rho GTPase activating protein 2C -2.88883
HDAC1 histone deacetylase 1 -2.87439
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 -2.82416
APP amyloid beta (A4) precursor protein -2.80086
LMBRD2 LMBR1 domain containing 2 -2.7998
UPP1 uridine phosphorylase 1 -2.79028
RNF20 ring finger protein 20, E3 ubiquitin protein ligase -2.78451
DAAM2 dishevelled associated activator of morphogenesis 2 -2.71533
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 -2.69726
TPK1 thiamin pyrophosphokinase 1 -2.69444
PPTC7 PTC7 protein phosphatase homolog (S. cerevisiae) -2.68626
WASF1 WAS protein family, member 1 -2.64914
SPIN2B spindlin family, member 2B -2.64364
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) -2.60542
KLF7 Kruppel-like factor 7 (ubiquitous) -2.58492
SCAND3 SCAN domain containing 3 -2.58492
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) -2.58492
AKIRIN1 akirin 1 -2.58492
RPP40 ribonuclease P/MRP 40kDa subunit -2.5375
C4ORF36 chromosome 4 open reading frame 36 -2.5317
CCDC106 coiled-coil domain containing 106 -2.5317
SAXO2 stabilizer of axonemal microtubules 2 -2.5317
CALHM2 calcium homeostasis modulator 2 -2.50463
SQSTM1 sequestosome 1 -2.49889
ASB18 ankyrin repeat and SOCS box containing 18 -2.49473
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 -2.4824
FNDC5 fibronectin type III domain containing 5 -2.44994
C17ORF75 chromosome 17 open reading frame 75 -2.44969
SUSD1 sushi domain containing 1 -2.42815
RNF14 ring finger protein 14 -2.42808
BUD31 BUD31 homolog (S. cerevisiae) -2.4237
DBF4 DBF4 zinc finger -2.4076
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1 -2.40479
MRPS14 mitochondrial ribosomal protein S14 -2.39516
PARP16 poly (ADP-ribose) polymerase family, member 16 -2.39387
MYORG myogenesis regulating glycosidase (putative) -2.39387
TET3 tet methylcytosine dioxygenase 3 -2.39387
NRBP2 nuclear receptor binding protein 2 -2.39077
CLASRP CLK4-associating serine/arginine rich protein -2.38747
RAD54L2 RAD54-like 2 (S. cerevisiae) -2.38706
INTS10 integrator complex subunit 10 -2.34009
GRHL3 grainyhead-like 3 (Drosophila) -2.28971
RNF152 ring finger protein 152 -2.28161
FRMD1 FERM domain containing 1 -2.27178
FNBP1L formin binding protein 1-like -2.23027
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.22363
SFN stratifin -2.21993
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 -2.21993
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2 -2.21447
ZXDB zinc finger, X-linked, duplicated B -2.13832
RUBCN rubicon autophagy regulator -2.13434
ZSWIM6 zinc finger, SWIM-type containing 6 -2.13275
AGO3 argonaute RISC catalytic component 3 -2.12042
FANCL Fanconi anemia, complementation group L -2.11743
LDAH lipid droplet associated hydrolase -2.11338
USP54 ubiquitin specific peptidase 54 -2.10632
SKIC8 SKI8 subunit of superkiller complex -2.07641
SF1 splicing factor 1 -2.07612
UBAP2 ubiquitin associated protein 2 -2.07026
ANKRD46 ankyrin repeat domain 46 -2.06691
PASK PAS domain containing serine/threonine kinase -2.06691
SWT1 SWT1 RNA endoribonuclease homolog (S. cerevisiae) -2.06691
CCDC88C coiled-coil domain containing 88C -2.059
ZMYND11 zinc finger, MYND-type containing 11 -2.04376
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 -2.04009
TNRC18 trinucleotide repeat containing 18 -2.01996
FBXO2 F-box protein 2 -2.01823
NNT nicotinamide nucleotide transhydrogenase -2.01138
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) -2.01095