| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | histone deacetylase 2|This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010] (NCBI Entrez Gene Database, 3066) |
| External Link | https://ncbi.nlm.nih.gov/gene/3066 |
| Similar Terms | |
| Downloads & Tools |
497 genes differentially expressed following the HDAC2 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| S100P | S100 calcium binding protein P | 0.0152807 |
| C8ORF4 | chromosome 8 open reading frame 4 | 0.0132608 |
| CLEC11A | C-type lectin domain family 11, member A | 0.0120022 |
| PROM1 | prominin 1 | 0.0118766 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.011747 |
| CNTN1 | contactin 1 | 0.0116176 |
| ANXA1 | annexin A1 | 0.0113876 |
| LGALS13 | lectin, galactoside-binding, soluble, 13 | 0.0111254 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 0.0107464 |
| RGS4 | regulator of G-protein signaling 4 | 0.0106768 |
| SLC2A5 | solute carrier family 2 (facilitated glucose/fructose transporter), member 5 | 0.010488 |
| ID3 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein | 0.0104646 |
| CYP4B1 | cytochrome P450, family 4, subfamily B, polypeptide 1 | 0.0103877 |
| MGLL | monoglyceride lipase | 0.0102753 |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) | 0.0101667 |
| ANXA3 | annexin A3 | 0.00996232 |
| LDB2 | LIM domain binding 2 | 0.00993033 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.00988658 |
| CRABP2 | cellular retinoic acid binding protein 2 | 0.00988148 |
| CYBA | cytochrome b-245, alpha polypeptide | 0.00986275 |
| MRPS16 | mitochondrial ribosomal protein S16 | 0.0096938 |
| UCP2 | uncoupling protein 2 (mitochondrial, proton carrier) | 0.00962937 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | 0.00943267 |
| MDK | midkine (neurite growth-promoting factor 2) | 0.00913324 |
| LMO2 | LIM domain only 2 (rhombotin-like 1) | 0.00903276 |
| SLC4A4 | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 | 0.00891041 |
| PLK1 | polo-like kinase 1 | 0.00873466 |
| ICAM2 | intercellular adhesion molecule 2 | 0.00871803 |
| NME4 | NME/NM23 nucleoside diphosphate kinase 4 | 0.00871415 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.00862895 |
| IGFBP4 | insulin-like growth factor binding protein 4 | 0.00850491 |
| POU2AF1 | POU class 2 associating factor 1 | 0.00850308 |
| SYT1 | synaptotagmin I | 0.00832687 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.00832162 |
| LAMP3 | lysosomal-associated membrane protein 3 | 0.00830837 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.00824155 |
| NEBL | nebulette | 0.00822381 |
| CHN1 | chimerin 1 | 0.00819728 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.00816535 |
| HERC5 | HECT and RLD domain containing E3 ubiquitin protein ligase 5 | 0.00816352 |
| CDC25B | cell division cycle 25B | 0.00814457 |
| C7 | complement component 7 | 0.00812048 |
| FKBP11 | FK506 binding protein 11, 19 kDa | 0.00804108 |
| DAXX | death-domain associated protein | 0.00798118 |
| SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 | 0.00791728 |
| TPBG | trophoblast glycoprotein | 0.00786532 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 0.00786403 |
| JPT1 | Jupiter microtubule associated homolog 1 | 0.00784784 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | 0.00781339 |
| HSPA1A | heat shock 70kDa protein 1A | 0.00777178 |
| ARID4A | AT rich interactive domain 4A (RBP1-like) | 0.00776765 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.00769472 |
| CXCL6 | chemokine (C-X-C motif) ligand 6 | 0.00769362 |
| TSPYL5 | TSPY-like 5 | 0.00764102 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.00763053 |
| GALNT6 | polypeptide N-acetylgalactosaminyltransferase 6 | 0.00762922 |
| PDZD2 | PDZ domain containing 2 | 0.00762827 |
| FGF13 | fibroblast growth factor 13 | 0.00757286 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | 0.00755213 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.00753932 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | 0.00753707 |
| TMEM100 | transmembrane protein 100 | 0.00751176 |
| GPM6B | glycoprotein M6B | 0.00747449 |
| CDS1 | CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 | 0.00742713 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 0.00741717 |
| CAV2 | caveolin 2 | 0.00741014 |
| GSTP1 | glutathione S-transferase pi 1 | 0.00733513 |
| IMPDH2 | IMP (inosine 5'-monophosphate) dehydrogenase 2 | 0.00725088 |
| C1ORF54 | chromosome 1 open reading frame 54 | 0.00718209 |
| GAD1 | glutamate decarboxylase 1 (brain, 67kDa) | 0.00717406 |
| TAC1 | tachykinin, precursor 1 | 0.00712231 |
| MPO | myeloperoxidase | 0.00711933 |
| HSPA8 | heat shock 70kDa protein 8 | 0.00709578 |
| CLDN5 | claudin 5 | 0.00708405 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | 0.00707505 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.00704324 |
| GAP43 | growth associated protein 43 | 0.00700594 |
| RBM34 | RNA binding motif protein 34 | 0.00699002 |
| SHCBP1 | SHC SH2-domain binding protein 1 | 0.00698667 |
| ASRGL1 | asparaginase like 1 | 0.00698079 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | 0.00696794 |
| P2RX5 | purinergic receptor P2X, ligand gated ion channel, 5 | 0.00695931 |
| MID1IP1 | MID1 interacting protein 1 | 0.00695245 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.00692021 |
| TP53I3 | tumor protein p53 inducible protein 3 | 0.00691179 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.00686405 |
| LILRA2 | leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 | 0.00685003 |
| ABCG2 | ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) | 0.00682568 |
| PIP5K1B | phosphatidylinositol-4-phosphate 5-kinase, type I, beta | 0.00679423 |
| SLC35A3 | solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 | 0.00678675 |
| METTL7A | methyltransferase like 7A | 0.00678455 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | 0.00677814 |
| BAALC | brain and acute leukemia, cytoplasmic | 0.00673175 |
| SRGN | serglycin | 0.00672981 |
| CAPN6 | calpain 6 | 0.00670839 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.00668211 |
| STK10 | serine/threonine kinase 10 | 0.00665499 |
| TMEM243 | transmembrane protein 243, mitochondrial | 0.00663355 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.00660974 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | 0.00660198 |
| PENK | proenkephalin | 0.00652527 |
| ATP5G2 | ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9) | 0.00652318 |
| CD81 | CD81 molecule | 0.00650938 |
| ALDH5A1 | aldehyde dehydrogenase 5 family, member A1 | 0.00650084 |
| LY86 | lymphocyte antigen 86 | 0.00649789 |
| C1ORF115 | chromosome 1 open reading frame 115 | 0.00647823 |
| RGS1 | regulator of G-protein signaling 1 | 0.00647333 |
| PTEN | phosphatase and tensin homolog | 0.0064683 |
| CXCL12 | chemokine (C-X-C motif) ligand 12 | 0.00646634 |
| LXN | latexin | 0.00646501 |
| HAUS4 | HAUS augmin-like complex, subunit 4 | 0.00646174 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.00645907 |
| KCNJ16 | potassium channel, inwardly rectifying subfamily J, member 16 | 0.00645862 |
| KRT81 | keratin 81, type II | 0.0064576 |
| LTF | lactotransferrin | 0.00644634 |
| ELOVL2 | ELOVL fatty acid elongase 2 | 0.00644134 |
| AZIN1 | antizyme inhibitor 1 | 0.006437 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | 0.00640964 |
| OSR2 | odd-skipped related transciption factor 2 | 0.00640292 |
| FZD6 | frizzled class receptor 6 | 0.00638897 |
| MSLN | mesothelin | 0.00636817 |
| MICB | MHC class I polypeptide-related sequence B | 0.00635705 |
| CALB1 | calbindin 1, 28kDa | 0.00633644 |
| C9ORF91 | chromosome 9 open reading frame 91 | 0.006325 |
| HIST1H2BD | histone cluster 1, H2bd | 0.00632467 |
| CLIC5 | chloride intracellular channel 5 | 0.00631653 |
| MED1 | mediator complex subunit 1 | 0.00630643 |
| IL15 | interleukin 15 | 0.00629851 |
| SAP30 | Sin3A-associated protein, 30kDa | 0.00629561 |
| NFATC3 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 | 0.00627341 |
| CLDN10 | claudin 10 | 0.00625478 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.00625082 |
| OLFML3 | olfactomedin-like 3 | 0.00624696 |
| GYPC | glycophorin C (Gerbich blood group) | 0.00622114 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | 0.00621935 |
| AQP4 | aquaporin 4 | 0.00620808 |
| FXYD6 | FXYD domain containing ion transport regulator 6 | 0.0061879 |
| TGM2 | transglutaminase 2 | 0.00615442 |
| HMGA1 | high mobility group AT-hook 1 | 0.00615026 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.00613632 |
| GOLM1 | golgi membrane protein 1 | 0.00613047 |
| MGP | matrix Gla protein | 0.00611224 |
| CADPS2 | Ca++-dependent secretion activator 2 | 0.00611119 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | 0.00608689 |
| HACD2 | 3-hydroxyacyl-CoA dehydratase 2 | 0.00605921 |
| PEG3 | paternally expressed 3 | 0.00604738 |
| CCK | cholecystokinin | 0.00603537 |
| ARHGDIB | Rho GDP dissociation inhibitor (GDI) beta | 0.00603291 |
| OAT | ornithine aminotransferase | 0.00600704 |
| EDN3 | endothelin 3 | 0.00597865 |
| CPM | carboxypeptidase M | 0.00595868 |
| DEFA5 | defensin, alpha 5, Paneth cell-specific | 0.0059549 |
| MEOX2 | mesenchyme homeobox 2 | 0.00594382 |
| GINS2 | GINS complex subunit 2 (Psf2 homolog) | 0.00593426 |
| ACAA1 | acetyl-CoA acyltransferase 1 | 0.00593028 |
| RASSF2 | Ras association (RalGDS/AF-6) domain family member 2 | 0.00588613 |
| CD302 | CD302 molecule | 0.00588479 |
| C3ORF14 | chromosome 3 open reading frame 14 | 0.00588104 |
| MAPKAPK5-AS1 | MAPKAPK5 antisense RNA 1 | 0.00587913 |
| FBXO11 | F-box protein 11 | 0.00586549 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | 0.00586411 |
| SELL | selectin L | 0.00586106 |
| GPD1L | glycerol-3-phosphate dehydrogenase 1-like | 0.00585372 |
| BRINP3 | bone morphogenetic protein/retinoic acid inducible neural-specific 3 | 0.00584983 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | 0.005849 |
| HIST1H2BH | histone cluster 1, H2bh | 0.00584697 |
| COTL1 | coactosin-like F-actin binding protein 1 | 0.00582007 |
| TCTN1 | tectonic family member 1 | 0.0058156 |
| CYRIA | CYFIP related Rac1 interactor A | 0.0058151 |
| CFDP1 | craniofacial development protein 1 | 0.00580918 |
| DPYD | dihydropyrimidine dehydrogenase | 0.00580716 |
| IRS2 | insulin receptor substrate 2 | 0.00579011 |
| ADD3 | adducin 3 (gamma) | 0.0057699 |
| RGCC | regulator of cell cycle | 0.00574586 |
| CRYBG1 | crystallin beta-gamma domain containing 1 | 0.00573828 |
| CYP2B6 | cytochrome P450, family 2, subfamily B, polypeptide 6 | 0.00572639 |
| EVI2A | ecotropic viral integration site 2A | 0.00572601 |
| DDX11 | DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 | 0.00570615 |
| C6ORF48 | chromosome 6 open reading frame 48 | 0.00569737 |
| TFRC | transferrin receptor | 0.00569477 |
| C1QB | complement component 1, q subcomponent, B chain | 0.00566714 |
| HSD17B6 | hydroxysteroid (17-beta) dehydrogenase 6 | 0.00565636 |
| CENPX | centromere protein X | 0.00562609 |
| ELF1 | E74-like factor 1 (ets domain transcription factor) | 0.00562118 |
| CORO1A | coronin, actin binding protein, 1A | 0.00560698 |
| GALC | galactosylceramidase | 0.0056017 |
| B3GALNT1 | beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) | 0.00558671 |
| GRB7 | growth factor receptor-bound protein 7 | 0.00558616 |
| KIF18A | kinesin family member 18A | 0.00557909 |
| SGCG | sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) | 0.00557853 |
| TCN1 | transcobalamin I (vitamin B12 binding protein, R binder family) | 0.00557767 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | 0.00557072 |
| MAGEA12 | melanoma antigen family A12 | 0.00556396 |
| TARP | TCR gamma alternate reading frame protein | 0.00556351 |
| SLC15A2 | solute carrier family 15 (oligopeptide transporter), member 2 | 0.00556195 |
| ARL4A | ADP-ribosylation factor-like 4A | 0.00555516 |
| GLIPR1 | GLI pathogenesis-related 1 | 0.00554182 |
| EPCAM | epithelial cell adhesion molecule | 0.0055372 |
| SELENOW | selenoprotein W | 0.00552856 |
| NCAN | neurocan | 0.00551422 |
| PAQR3 | progestin and adipoQ receptor family member III | 0.00550764 |
| ACTA2 | actin, alpha 2, smooth muscle, aorta | 0.00550291 |
| PMP2 | peripheral myelin protein 2 | 0.00548762 |
| CYTIP | cytohesin 1 interacting protein | 0.00548674 |
| NUDT4 | nudix (nucleoside diphosphate linked moiety X)-type motif 4 | 0.00548664 |
| KRT7 | keratin 7, type II | 0.00548481 |
| MYO1C | myosin IC | 0.00548057 |
| ISG20 | interferon stimulated exonuclease gene 20kDa | 0.00547747 |
| PTDSS1 | phosphatidylserine synthase 1 | 0.005475 |
| BCAS1 | breast carcinoma amplified sequence 1 | 0.00545412 |
| FAM169A | family with sequence similarity 169, member A | 0.00545275 |
| MSMB | microseminoprotein, beta- | 0.00543402 |
| TSPAN13 | tetraspanin 13 | 0.00542181 |
| PDE8B | phosphodiesterase 8B | 0.00541992 |
| YAF2 | YY1 associated factor 2 | 0.00541861 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.00541569 |
| FLNA | filamin A, alpha | 0.00541244 |
| CREB3L1 | cAMP responsive element binding protein 3-like 1 | 0.00540181 |
| ERAP2 | endoplasmic reticulum aminopeptidase 2 | 0.00539679 |
| LAMP5 | lysosomal-associated membrane protein family, member 5 | 0.00538262 |
| TCF12 | transcription factor 12 | 0.00537415 |
| PCTP | phosphatidylcholine transfer protein | 0.00536909 |
| CD27 | CD27 molecule | 0.00536017 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 0.00535117 |
| CSRP2 | cysteine and glycine-rich protein 2 | 0.00534431 |
| GNPTAB | N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits | 0.00534378 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | 0.00533745 |
| ZFP36L2 | ZFP36 ring finger protein-like 2 | 0.00529918 |
| S100A12 | S100 calcium binding protein A12 | 0.00528654 |
| PAPSS2 | 3'-phosphoadenosine 5'-phosphosulfate synthase 2 | 0.00528585 |
| JAM2 | junctional adhesion molecule 2 | 0.00528379 |
| CCNB2 | cyclin B2 | 0.00527886 |
| CHP1 | calcineurin-like EF-hand protein 1 | 0.0052709 |
| PAX5 | paired box 5 | 0.00526858 |
| OLR1 | oxidized low density lipoprotein (lectin-like) receptor 1 | 0.00526617 |
| ARMCX2 | armadillo repeat containing, X-linked 2 | 0.005264 |
| FCGR3B | Fc fragment of IgG, low affinity IIIb, receptor (CD16b) | 0.00525851 |
| ARAP2 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 | 0.00525049 |
| NEK2 | NIMA-related kinase 2 | 0.00523768 |
| SERPINB9 | serpin peptidase inhibitor, clade B (ovalbumin), member 9 | 0.00523609 |
| TRAPPC2 | trafficking protein particle complex 2 | 0.00523361 |
| CCN2 | cellular communication network factor 2 | 0.00523222 |
| IFI44 | interferon-induced protein 44 | 0.00522046 |
| PRKCA | protein kinase C, alpha | 0.00517984 |
| CCNE2 | cyclin E2 | 0.00517899 |
| TBC1D31 | TBC1 domain family, member 31 | 0.00517623 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.00517588 |
| SMS | spermine synthase | 0.00517237 |
| MKI67 | marker of proliferation Ki-67 | 0.00517209 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MAP7 | microtubule-associated protein 7 | -0.0174117 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -0.0148043 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0147469 |
| PSIP1 | PC4 and SFRS1 interacting protein 1 | -0.0137797 |
| S100A2 | S100 calcium binding protein A2 | -0.0116413 |
| PPL | periplakin | -0.0112862 |
| FN1 | fibronectin 1 | -0.0111427 |
| CXCL9 | chemokine (C-X-C motif) ligand 9 | -0.0108609 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | -0.0107353 |
| DCT | dopachrome tautomerase | -0.0106599 |
| CCN3 | cellular communication network factor 3 | -0.0105091 |
| PERP | PERP, TP53 apoptosis effector | -0.010337 |
| KRT14 | keratin 14, type I | -0.0102854 |
| KRT5 | keratin 5, type II | -0.0102834 |
| KRT17 | keratin 17, type I | -0.00986026 |
| NVL | nuclear VCP-like | -0.00974591 |
| IDO1 | indoleamine 2,3-dioxygenase 1 | -0.00968602 |
| RIPK4 | receptor-interacting serine-threonine kinase 4 | -0.00955927 |
| ELN | elastin | -0.00949065 |
| CXCL10 | chemokine (C-X-C motif) ligand 10 | -0.00919091 |
| ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 | -0.00916964 |
| SIRT3 | sirtuin 3 | -0.00901088 |
| PMEL | premelanosome protein | -0.00900342 |
| MMP1 | matrix metallopeptidase 1 | -0.0089545 |
| HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 | -0.00872694 |
| DSP | desmoplakin | -0.00863271 |
| CD9 | CD9 molecule | -0.00852689 |
| SKIV2L | superkiller viralicidic activity 2-like (S. cerevisiae) | -0.00845025 |
| CTSK | cathepsin K | -0.00844007 |
| SERPING1 | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 | -0.00841334 |
| WISP2 | WNT1 inducible signaling pathway protein 2 | -0.00819447 |
| KRT23 | keratin 23, type I | -0.00800368 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.00800208 |
| CNPY3 | canopy FGF signaling regulator 3 | -0.00790924 |
| TGFBR3 | transforming growth factor, beta receptor III | -0.00781644 |
| GAL | galanin/GMAP prepropeptide | -0.00777325 |
| DNM1L | dynamin 1-like | -0.00776633 |
| LGALS2 | lectin, galactoside-binding, soluble, 2 | -0.00771413 |
| CP | ceruloplasmin (ferroxidase) | -0.00769555 |
| MBL2 | mannose-binding lectin (protein C) 2, soluble | -0.0076509 |
| KIF1B | kinesin family member 1B | -0.00763305 |
| FST | follistatin | -0.00751 |
| GBP1 | guanylate binding protein 1, interferon-inducible | -0.00741352 |
| LRRC15 | leucine rich repeat containing 15 | -0.0073517 |
| MFGE8 | milk fat globule-EGF factor 8 protein | -0.00732254 |
| TPSAB1 | tryptase alpha/beta 1 | -0.00722002 |
| PGGHG | protein-glucosylgalactosylhydroxylysine glucosidase | -0.00721281 |
| FBLN1 | fibulin 1 | -0.00716748 |
| SUPV3L1 | suppressor of var1, 3-like 1 (S. cerevisiae) | -0.00709171 |
| TXNIP | thioredoxin interacting protein | -0.00694626 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | -0.00694074 |
| SERPINF1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | -0.0069181 |
| NDRG1 | N-myc downstream regulated 1 | -0.00689428 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | -0.00677928 |
| HK2 | hexokinase 2 | -0.00675258 |
| DSC1 | desmocollin 1 | -0.00670937 |
| BCAT2 | branched chain amino-acid transaminase 2, mitochondrial | -0.00664309 |
| PLIN1 | perilipin 1 | -0.00659704 |
| CGA | glycoprotein hormones, alpha polypeptide | -0.00657802 |
| FCER1A | Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide | -0.00655731 |
| RNF128 | ring finger protein 128, E3 ubiquitin protein ligase | -0.00655551 |
| THBS2 | thrombospondin 2 | -0.00654106 |
| RXRA | retinoid X receptor, alpha | -0.00651467 |
| CELP | carboxyl ester lipase pseudogene | -0.00650467 |
| ANGPTL2 | angiopoietin-like 2 | -0.00649741 |
| PMP22 | peripheral myelin protein 22 | -0.00646362 |
| SCGN | secretagogin, EF-hand calcium binding protein | -0.00643651 |
| CTSZ | cathepsin Z | -0.00639258 |
| ALDH3A2 | aldehyde dehydrogenase 3 family, member A2 | -0.00638871 |
| FGFR1 | fibroblast growth factor receptor 1 | -0.00638178 |
| LIF | leukemia inhibitory factor | -0.00636875 |
| VTCN1 | V-set domain containing T cell activation inhibitor 1 | -0.00635198 |
| LDOC1 | leucine zipper, down-regulated in cancer 1 | -0.00634527 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0063257 |
| GLO1 | glyoxalase I | -0.00631781 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | -0.00631654 |
| KRT1 | keratin 1, type II | -0.00631594 |
| HDAC2 | histone deacetylase 2 | -0.00631489 |
| CHKB | choline kinase beta | -0.00630359 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.00628267 |
| HLA-B | major histocompatibility complex, class I, B | -0.00626728 |
| ERBB3 | erb-b2 receptor tyrosine kinase 3 | -0.00625061 |
| EPHB6 | EPH receptor B6 | -0.00622551 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.00621631 |
| PTP4A3 | protein tyrosine phosphatase type IVA, member 3 | -0.00621058 |
| HMGN3 | high mobility group nucleosomal binding domain 3 | -0.00620842 |
| TYRP1 | tyrosinase-related protein 1 | -0.00620813 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.00619971 |
| DDR2 | discoidin domain receptor tyrosine kinase 2 | -0.00618958 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.00618777 |
| RBM47 | RNA binding motif protein 47 | -0.00617112 |
| LOR | loricrin | -0.00614851 |
| DEGS1 | delta(4)-desaturase, sphingolipid 1 | -0.00614823 |
| CPB1 | carboxypeptidase B1 (tissue) | -0.00614751 |
| S100A7 | S100 calcium binding protein A7 | -0.00610995 |
| MMP2 | matrix metallopeptidase 2 | -0.0061035 |
| PHACTR2 | phosphatase and actin regulator 2 | -0.00608136 |
| PKM | pyruvate kinase, muscle | -0.00606937 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | -0.00603568 |
| SPINK1 | serine peptidase inhibitor, Kazal type 1 | -0.00601472 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.00601161 |
| SLC27A2 | solute carrier family 27 (fatty acid transporter), member 2 | -0.00599093 |
| CYP17A1 | cytochrome P450, family 17, subfamily A, polypeptide 1 | -0.0059804 |
| NAV2 | neuron navigator 2 | -0.00597904 |
| LGALS8 | lectin, galactoside-binding, soluble, 8 | -0.0059734 |
| PHF10 | PHD finger protein 10 | -0.0059437 |
| TYR | tyrosinase | -0.00593615 |
| CSK | c-src tyrosine kinase | -0.00592681 |
| KCTD14 | potassium channel tetramerization domain containing 14 | -0.00592495 |
| SCGB1D2 | secretoglobin, family 1D, member 2 | -0.00591613 |
| NDUFA4L2 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 | -0.00591543 |
| CIDEA | cell death-inducing DFFA-like effector a | -0.00588148 |
| KANK1 | KN motif and ankyrin repeat domains 1 | -0.00582612 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.00581464 |
| TMEM45A | transmembrane protein 45A | -0.00580946 |
| FRS2 | fibroblast growth factor receptor substrate 2 | -0.00578648 |
| NOP2 | NOP2 nucleolar protein | -0.00573781 |
| PER3 | period circadian clock 3 | -0.00573459 |
| STAP2 | signal transducing adaptor family member 2 | -0.00572969 |
| SPRR1B | small proline-rich protein 1B | -0.00571266 |
| SDC4 | syndecan 4 | -0.00569117 |
| STX3 | syntaxin 3 | -0.00568043 |
| SNAI2 | snail family zinc finger 2 | -0.00567471 |
| KLF9 | Kruppel-like factor 9 | -0.00566987 |
| RALGDS | ral guanine nucleotide dissociation stimulator | -0.00566362 |
| KPNA6 | karyopherin alpha 6 (importin alpha 7) | -0.00566093 |
| FAM162A | family with sequence similarity 162, member A | -0.00565413 |
| PDHX | pyruvate dehydrogenase complex, component X | -0.00564573 |
| NBPF10 | neuroblastoma breakpoint family, member 10 | -0.00562538 |
| KRT16 | keratin 16, type I | -0.00561233 |
| CREBL2 | cAMP responsive element binding protein-like 2 | -0.0056079 |
| LMNA | lamin A/C | -0.00559544 |
| CBX6 | chromobox homolog 6 | -0.00556073 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.00555059 |
| GPX3 | glutathione peroxidase 3 | -0.00554928 |
| HSPB7 | heat shock 27kDa protein family, member 7 (cardiovascular) | -0.0055458 |
| MLLT3 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 | -0.00554468 |
| SOX9 | SRY (sex determining region Y)-box 9 | -0.00554198 |
| VEGFC | vascular endothelial growth factor C | -0.00553722 |
| CXCL11 | chemokine (C-X-C motif) ligand 11 | -0.00553087 |
| TENT4A | terminal nucleotidyltransferase 4A | -0.0055012 |
| PPP1R1A | protein phosphatase 1, regulatory (inhibitor) subunit 1A | -0.00550083 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.00548067 |
| SLC16A6 | solute carrier family 16, member 6 | -0.00547648 |
| PDGFD | platelet derived growth factor D | -0.00544114 |
| SPRR1A | small proline-rich protein 1A | -0.0054368 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.00543111 |
| JUP | junction plakoglobin | -0.00541521 |
| SYNE3 | spectrin repeat containing, nuclear envelope family member 3 | -0.00540101 |
| FSTL1 | follistatin-like 1 | -0.00538753 |
| GRAMD4 | GRAM domain containing 4 | -0.00538466 |
| COMP | cartilage oligomeric matrix protein | -0.00538311 |
| GZMB | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) | -0.00538298 |
| JAG2 | jagged 2 | -0.00535879 |
| PIP | prolactin-induced protein | -0.00534973 |
| GLA | galactosidase, alpha | -0.00534875 |
| ASGR2 | asialoglycoprotein receptor 2 | -0.00533505 |
| COQ8A | coenzyme Q8A | -0.00532653 |
| CLEC3B | C-type lectin domain family 3, member B | -0.00532128 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | -0.005314 |
| NEAT1 | nuclear paraspeckle assembly transcript 1 (non-protein coding) | -0.00530721 |
| GOLIM4 | golgi integral membrane protein 4 | -0.00529653 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.00529388 |
| HOXB13 | homeobox B13 | -0.0052893 |
| PDGFC | platelet derived growth factor C | -0.00528687 |
| RCAN2 | regulator of calcineurin 2 | -0.00527705 |
| CALML3 | calmodulin-like 3 | -0.00525965 |
| WTAP | Wilms tumor 1 associated protein | -0.00525432 |
| ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 | -0.00525333 |
| C10ORF10 | chromosome 10 open reading frame 10 | -0.00524805 |
| ZZEF1 | zinc finger, ZZ-type with EF-hand domain 1 | -0.00524734 |
| AIM2 | absent in melanoma 2 | -0.00523115 |
| GMPR | guanosine monophosphate reductase | -0.00521791 |
| COL9A2 | collagen, type IX, alpha 2 | -0.00519956 |
| PI3 | peptidase inhibitor 3, skin-derived | -0.00519796 |
| FIG4 | FIG4 phosphoinositide 5-phosphatase | -0.00519247 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.00519034 |
| ANKRD11 | ankyrin repeat domain 11 | -0.00517966 |
| C3 | complement component 3 | -0.00515965 |
| IL1RN | interleukin 1 receptor antagonist | -0.00515928 |
| NNAT | neuronatin | -0.0051569 |
| KRT2 | keratin 2, type II | -0.00515013 |
| CCL2 | chemokine (C-C motif) ligand 2 | -0.00514562 |
| IVL | involucrin | -0.0051383 |
| SINHCAF | SIN3-HDAC complex associated factor | -0.0051354 |
| ULK1 | unc-51 like autophagy activating kinase 1 | -0.00512917 |
| ITGA8 | integrin, alpha 8 | -0.00512102 |
| HNRNPL | heterogeneous nuclear ribonucleoprotein L | -0.00511518 |
| HDC | histidine decarboxylase | -0.00510672 |
| LCE2B | late cornified envelope 2B | -0.00509945 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | -0.00509586 |
| DSG1 | desmoglein 1 | -0.00508896 |
| REC8 | REC8 meiotic recombination protein | -0.00508819 |
| TNC | tenascin C | -0.00508614 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | -0.0050585 |
| EPS8L2 | EPS8-like 2 | -0.00505739 |
| TXLNA | taxilin alpha | -0.00504363 |
| PIEZO2 | piezo-type mechanosensitive ion channel component 2 | -0.00503491 |
| ASPH | aspartate beta-hydroxylase | -0.00501734 |
| ZNF91 | zinc finger protein 91 | -0.0049901 |
| HLA-DQB2 | major histocompatibility complex, class II, DQ beta 2 | -0.00498932 |
| CUL7 | cullin 7 | -0.00498224 |
| HOOK2 | hook microtubule-tethering protein 2 | -0.00497849 |
| TSPAN4 | tetraspanin 4 | -0.00497643 |
| DACH1 | dachshund family transcription factor 1 | -0.00496685 |
| WNT11 | wingless-type MMTV integration site family, member 11 | -0.00496625 |
| IGHMBP2 | immunoglobulin mu binding protein 2 | -0.00496104 |
| DHDDS | dehydrodolichyl diphosphate synthase | -0.0049607 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | -0.00495125 |
| ITGA2B | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) | -0.00495023 |
| ACKR3 | atypical chemokine receptor 3 | -0.00493752 |
| RNF43 | ring finger protein 43 | -0.00492055 |
| USP47 | ubiquitin specific peptidase 47 | -0.00491789 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.00491339 |
| CRCT1 | cysteine-rich C-terminal 1 | -0.00490247 |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | -0.00487891 |
| GBP2 | guanylate binding protein 2, interferon-inducible | -0.00487171 |
| IPO13 | importin 13 | -0.00487166 |
| ATP7A | ATPase, Cu++ transporting, alpha polypeptide | -0.00487053 |
| ALDOA | aldolase A, fructose-bisphosphate | -0.00486212 |
| PRKCZ | protein kinase C, zeta | -0.00485316 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.00484707 |
| PLXNC1 | plexin C1 | -0.00482415 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -0.00477167 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.00477114 |
| CDK2AP1 | cyclin-dependent kinase 2 associated protein 1 | -0.00476699 |
| SLC4A3 | solute carrier family 4 (anion exchanger), member 3 | -0.00476437 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | -0.0047378 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | -0.00472763 |
| ZBED5 | zinc finger, BED-type containing 5 | -0.00470904 |
| ACSM3 | acyl-CoA synthetase medium-chain family member 3 | -0.00470207 |
| CD84 | CD84 molecule | -0.00469467 |
| UCHL3 | ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) | -0.00469428 |
| SETBP1 | SET binding protein 1 | -0.00467966 |
| BPHL | biphenyl hydrolase-like (serine hydrolase) | -0.00467075 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | -0.00466934 |
| ENAH | enabled homolog (Drosophila) | -0.00466683 |
| CASD1 | CAS1 domain containing 1 | -0.00466657 |
| CRLF1 | cytokine receptor-like factor 1 | -0.00466194 |
| MYH11 | myosin, heavy chain 11, smooth muscle | -0.00466192 |
| ABCA2 | ATP-binding cassette, sub-family A (ABC1), member 2 | -0.00466191 |
| MYCL | v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog | -0.00465791 |
| PCOLCE2 | procollagen C-endopeptidase enhancer 2 | -0.00465047 |
| APOD | apolipoprotein D | -0.00464656 |
| ACTN4 | actinin, alpha 4 | -0.00464359 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.00464191 |
| FGL2 | fibrinogen-like 2 | -0.00463317 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked | -0.00459156 |
