HDAC4 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description histone deacetylase 4|Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 9759)
Similar Terms
Downloads & Tools

Genes

291 genes differentially expressed following the HDAC4 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
DGCR6 DiGeorge syndrome critical region gene 6 2.93755
GCSAM germinal center-associated, signaling and motility 2.93755
RGPD3 RANBP2-like and GRIP domain containing 3 2.93755
TMIGD3 transmembrane and immunoglobulin domain containing 3 2.93755
SACK1A scaffolding CK1 anchoring protein A 2.93755
ADGRE3 adhesion G protein-coupled receptor E3 2.93755
C17ORF78 chromosome 17 open reading frame 78 2.93755
GJA5 gap junction protein, alpha 5, 40kDa 2.93755
NKX3-1 NK3 homeobox 1 2.93755
KCTD4 potassium channel tetramerization domain containing 4 2.93755
EFCAB9 EF-hand calcium binding domain 9 2.93755
FCGBP Fc fragment of IgG binding protein 2.93755
C1ORF167 chromosome 1 open reading frame 167 2.93755
PON1 paraoxonase 1 2.93755
WDHD1 WD repeat and HMG-box DNA binding protein 1 2.93755
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.93755
ZNF441 zinc finger protein 441 2.93755
GC group-specific component (vitamin D binding protein) 2.93755
APOL1 apolipoprotein L, 1 2.93755
FGF10 fibroblast growth factor 10 2.93755
CLEC4A C-type lectin domain family 4, member A 2.93755
CCN3 cellular communication network factor 3 2.93755
VSIR V-set immunoregulatory receptor 2.93755
HLF hepatic leukemia factor 2.93755
TNNI1 troponin I type 1 (skeletal, slow) 2.93755
TWIST1 twist family bHLH transcription factor 1 2.93755
C10ORF90 chromosome 10 open reading frame 90 2.93755
SELPLG selectin P ligand 2.86667
TREM1 triggering receptor expressed on myeloid cells 1 2.86667
RASL10A RAS-like, family 10, member A 2.86667
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 2.86667
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 2.86667
GJA9 gap junction protein, alpha 9, 59kDa 2.86667
CLEC12A C-type lectin domain family 12, member A 2.86667
HCRTR1 hypocretin (orexin) receptor 1 2.86667
TMEM176B transmembrane protein 176B 2.86667
KNG1 kininogen 1 2.86667
C3ORF22 chromosome 3 open reading frame 22 2.86667
HYAL4 hyaluronoglucosaminidase 4 2.86667
CELA1 chymotrypsin-like elastase family, member 1 2.86667
MAGED4 melanoma antigen family D4 2.86667
SHE Src homology 2 domain containing E 2.86667
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) 2.86667
TREML1 triggering receptor expressed on myeloid cells-like 1 2.86667
SLC37A2 solute carrier family 37 (glucose-6-phosphate transporter), member 2 2.86667
TAS2R19 taste receptor, type 2, member 19 2.86667
ACOT12 acyl-CoA thioesterase 12 2.86667
TRPC5OS TRPC5 opposite strand 2.86667
MROH2B maestro heat-like repeat family member 2B 2.86667
ZNF556 zinc finger protein 556 2.86667
OR10A2 olfactory receptor, family 10, subfamily A, member 2 2.86667
SLC25A45 solute carrier family 25, member 45 2.86667
CCL5 chemokine (C-C motif) ligand 5 2.86667
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 2.86667
DSG3 desmoglein 3 2.86667
GYPB glycophorin B (MNS blood group) 2.86667
PBOV1 prostate and breast cancer overexpressed 1 2.86667
FAM221B family with sequence similarity 221, member B 2.86667
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 2.86667
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 2.86667
LRTM3 leucine rich repeat transmembrane protein 3 2.86667
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 2.86667
TUBA4B tubulin, alpha 4b 2.86667
LTB lymphotoxin beta (TNF superfamily, member 3) 2.86667
DLK2 delta-like 2 homolog (Drosophila) 2.86667
MOV10L1 Mov10 RISC complex RNA helicase like 1 2.86667
PGA5 pepsinogen 5, group I (pepsinogen A) 2.86667
C7ORF57 chromosome 7 open reading frame 57 2.86667
GLIPR1L2 GLI pathogenesis-related 1 like 2 2.86667
SELL selectin L 2.86667
TTR transthyretin 2.86667
SPRR2F small proline-rich protein 2F 2.86667
SPATA31F3 SPATA31 subfamily F member 3 2.86667
NHERF4 NHERF family PDZ scaffold protein 4 2.86667
CFAP97D2 CFAP97 domain containing 2 2.86667
CLEC20A C-type lectin domain containing 20A 2.86667
G6PC1 glucose-6-phosphatase catalytic subunit 1 2.86667
CES4A carboxylesterase 4A 2.86667
MCHR1 melanin-concentrating hormone receptor 1 2.86667
RBL2 retinoblastoma-like 2 2.86667
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 2.86667
TLR6 toll-like receptor 6 2.86667
PDILT protein disulfide isomerase-like, testis expressed 2.86667
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 2.86667
PLVAP plasmalemma vesicle associated protein 2.86667
CFHR3 complement factor H-related 3 2.86667
SCEL sciellin 2.86667
FAM187B family with sequence similarity 187, member B 2.86667
COL7A1 collagen, type VII, alpha 1 2.86667
UPK3A uroplakin 3A 2.86667
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 2.86667
FPR3 formyl peptide receptor 3 2.86667
PTEN phosphatase and tensin homolog 2.86667
DMBX1 diencephalon/mesencephalon homeobox 1 2.86667
ZNF638 zinc finger protein 638 2.86667
TMEM235 transmembrane protein 235 2.86667
HPR haptoglobin-related protein 2.86667
IRF5 interferon regulatory factor 5 2.86667
CLDN9 claudin 9 2.86667
FOXD1 forkhead box D1 2.86667
RS1 retinoschisin 1 2.86667
CD274 CD274 molecule 2.86667
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 2.86667
CRTAM cytotoxic and regulatory T cell molecule 2.86667
CPO carboxypeptidase O 2.86667
TBPL2 TATA box binding protein like 2 2.86667
ZP1 zona pellucida glycoprotein 1 (sperm receptor) 2.86667
MAGEA2B melanoma antigen family A2B 2.86667
AKR1B15 aldo-keto reductase family 1, member B15 2.86667
NIM1K NIM1 serine/threonine protein kinase 2.86667
RGS11 regulator of G-protein signaling 11 2.86667
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6 2.86667
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 2.86667
WDFY4 WDFY family member 4 2.86667
TEX36 testis expressed 36 2.86667
GRAPL GRB2-related adaptor protein-like 2.86667
CD86 CD86 molecule 2.86667
NPAS4 neuronal PAS domain protein 4 2.86667
FITM1 fat storage-inducing transmembrane protein 1 2.86667
EPO erythropoietin 2.86667
NUTM2B NUT family member 2B 2.86667
LPAR5 lysophosphatidic acid receptor 5 2.86667
SV2B synaptic vesicle glycoprotein 2B 2.86667
SERPINB11 serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene) 2.86667
CHIT1 chitinase 1 (chitotriosidase) 2.86667
TPPP3 tubulin polymerization-promoting protein family member 3 2.86667
FCRL4 Fc receptor-like 4 2.86667
OTOP2 otopetrin 2 2.86667
UBXN10 UBX domain protein 10 2.86667
ADCY4 adenylate cyclase 4 2.86667
FKBP1C FK506 binding protein 1C 2.86667
SFTA2 surfactant associated 2 2.86667
UTS2R urotensin 2 receptor 2.86667
TTC16 tetratricopeptide repeat domain 16 2.86667
FRK fyn-related Src family tyrosine kinase 2.86667
FAM177B family with sequence similarity 177, member B 2.86667
CBX8 chromobox homolog 8 2.86667
EMP1 epithelial membrane protein 1 2.86667
WNT7A wingless-type MMTV integration site family, member 7A 2.86667
VWA7 von Willebrand factor A domain containing 7 2.86667
C8ORF89 chromosome 8 open reading frame 89 2.86667
CATIP ciliogenesis associated TTC17 interacting protein 2.86667
TTC36 tetratricopeptide repeat domain 36 2.86667
PADI1 peptidyl arginine deiminase, type I 2.86667
PADI4 peptidyl arginine deiminase, type IV 2.86667
IL17B interleukin 17B 2.86667
POPDC2 popeye domain containing 2 2.86667
TMEM184A transmembrane protein 184A 2.86667
ANXA2R annexin A2 receptor 2.86667
KRTAP13-4 keratin associated protein 13-4 2.86667
CD3E CD3e molecule, epsilon (CD3-TCR complex) 2.86667
DDAH1 dimethylarginine dimethylaminohydrolase 1 2.86667
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 2.86667
MNX1 motor neuron and pancreas homeobox 1 2.86667
ANKRD30B ankyrin repeat domain 30B 2.86667
PASD1 PAS domain containing 1 2.86667
SMCO1 single-pass membrane protein with coiled-coil domains 1 2.86667
FOXG1 forkhead box G1 2.86667
ADAM20 ADAM metallopeptidase domain 20 2.86667
GRP gastrin-releasing peptide 2.86667
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 2.86667
ANXA1 annexin A1 2.86667
NLRP3 NLR family, pyrin domain containing 3 2.86667
HIC1 hypermethylated in cancer 1 2.86667
KIAA1755 KIAA1755 2.86667
TMC2 transmembrane channel-like 2 2.86667
TAS2R40 taste receptor, type 2, member 40 2.86667
IFITM10 interferon induced transmembrane protein 10 2.86667
LEP leptin 2.86667
CDK5RAP2 CDK5 regulatory subunit associated protein 2 2.82442
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 2.8075
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 2.76997
KCNK10 potassium channel, two pore domain subfamily K, member 10 2.76997
VSTM2L V-set and transmembrane domain containing 2 like 2.76997
SOX2 SRY (sex determining region Y)-box 2 2.74904
ZC3HAV1 zinc finger CCCH-type, antiviral 1 2.69587
UQCC2 ubiquinol-cytochrome c reductase complex assembly factor 2 2.68914
FAM227A family with sequence similarity 227, member A 2.68458
ACLY ATP citrate lyase 2.66227
C14ORF93 chromosome 14 open reading frame 93 2.53037
RALGPS1 Ral GEF with PH domain and SH3 binding motif 1 2.52388
JSRP1 junctional sarcoplasmic reticulum protein 1 2.51533
CTNNA3 catenin (cadherin-associated protein), alpha 3 2.45455
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 2.38758
CTIF CBP80/20-dependent translation initiation factor 2.37499
THSD7B thrombospondin, type I, domain containing 7B 2.34674
IL17RD interleukin 17 receptor D 2.31023
PITPNB phosphatidylinositol transfer protein, beta 2.31023
SCYL2 SCY1-like 2 (S. cerevisiae) 2.30599
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein 2.30257
AUH AU RNA binding protein/enoyl-CoA hydratase 2.29717
RNF112 ring finger protein 112 2.2938
NT5M 5',3'-nucleotidase, mitochondrial 2.29053
PTCD2 pentatricopeptide repeat domain 2 2.2712
ADCY8 adenylate cyclase 8 (brain) 2.27012
AP1M2 adaptor-related protein complex 1, mu 2 subunit 2.2567
ZFAND6 zinc finger, AN1-type domain 6 2.24743
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 2.23558
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 2.21062
FTSJ3 FtsJ homolog 3 (E. coli) 2.19427
TGFBR3L transforming growth factor, beta receptor III-like 2.1645
CEACAM19 carcinoembryonic antigen-related cell adhesion molecule 19 2.13038
ARV1 ARV1 homolog (S. cerevisiae) 2.128
DCAKD dephospho-CoA kinase domain containing 2.10505
ZNF724 zinc finger protein 724 2.08504
UBE2Q2 ubiquitin-conjugating enzyme E2Q family member 2 2.06381
RASL12 RAS-like, family 12 2.05949
FLOT1 flotillin 1 2.05949
DMWD dystrophia myotonica, WD repeat containing 2.05644
CCDC159 coiled-coil domain containing 159 2.04863
NUMB numb homolog (Drosophila) 2.01695
TRIM6 tripartite motif containing 6 2.01444
WDR70 WD repeat domain 70 2.01415
CD1D CD1d molecule 2.00532
CHURC1 churchill domain containing 1 2.00532

decreased expression

Symbol Name Standardized Value
CCT7 chaperonin containing TCP1, subunit 7 (eta) -2.86667
RAB40B RAB40B, member RAS oncogene family -2.86667
ACE angiotensin I converting enzyme -2.86667
MMD2 monocyte to macrophage differentiation-associated 2 -2.86667
OAF OAF homolog (Drosophila) -2.86667
CLPSL1 colipase-like 1 -2.86667
SAMD14 sterile alpha motif domain containing 14 -2.86667
GLIS1 GLIS family zinc finger 1 -2.86667
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4 -2.86667
CLDN19 claudin 19 -2.86667
LAT linker for activation of T cells -2.86667
GDAP1 ganglioside induced differentiation associated protein 1 -2.86667
VSTM5 V-set and transmembrane domain containing 5 -2.86667
BSPRY B-box and SPRY domain containing -2.86402
CYBA cytochrome b-245, alpha polypeptide -2.75977
CFAP90 cilia and flagella associated protein 90 -2.72886
RIN1 Ras and Rab interactor 1 -2.72886
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 -2.72886
CIITA class II, major histocompatibility complex, transactivator -2.72886
OR2A42 olfactory receptor, family 2, subfamily A, member 42 -2.72886
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 -2.72886
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 -2.72886
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 -2.72886
CLCNKA chloride channel, voltage-sensitive Ka -2.72886
TMEM151A transmembrane protein 151A -2.72886
PENK proenkephalin -2.72886
FIBIN fin bud initiation factor homolog (zebrafish) -2.72886
SH2D4B SH2 domain containing 4B -2.72886
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -2.72886
CRYBA1 crystallin, beta A1 -2.72886
PLCZ1 phospholipase C, zeta 1 -2.72886
SMIM17 small integral membrane protein 17 -2.72886
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 -2.72886
STMND1 stathmin domain containing 1 -2.72886
AMER2 APC membrane recruitment protein 2 -2.72886
GH2 growth hormone 2 -2.72886
OTOF otoferlin -2.72886
SAMD10 sterile alpha motif domain containing 10 -2.56763
IGSF10 immunoglobulin superfamily, member 10 -2.56763
C11ORF52 chromosome 11 open reading frame 52 -2.56273
LRRC59 leucine rich repeat containing 59 -2.55213
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae) -2.53114
SLC24A2 solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 -2.53037
TBC1D7-LOC100130357 TBC1D7-LOC100130357 readthrough -2.50261
ZNF280C zinc finger protein 280C -2.4099
ROGDI rogdi homolog (Drosophila) -2.37499
STK17B serine/threonine kinase 17b -2.36261
TOX3 TOX high mobility group box family member 3 -2.31217
PHF8 PHD finger protein 8 -2.31217
GPR137C G protein-coupled receptor 137C -2.30309
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) -2.2938
COL4A2 collagen, type IV, alpha 2 -2.29053
ARMC8 armadillo repeat containing 8 -2.26525
RAB32 RAB32, member RAS oncogene family -2.21062
CPT1B carnitine palmitoyltransferase 1B (muscle) -2.19748
ERLEC1 endoplasmic reticulum lectin 1 -2.19748
TMX4 thioredoxin-related transmembrane protein 4 -2.17214
SEZ6L seizure related 6 homolog (mouse)-like -2.16589
SFRP4 secreted frizzled-related protein 4 -2.16589
TCF15 transcription factor 15 (basic helix-loop-helix) -2.13233
DTX3 deltex 3, E3 ubiquitin ligase -2.12509
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit -2.12441
CA4 carbonic anhydrase IV -2.09812
FAM24B family with sequence similarity 24, member B -2.0921
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 -2.0921
CFAP70 cilia and flagella associated protein 70 -2.0921
ZNF563 zinc finger protein 563 -2.0921
WDR83 WD repeat domain 83 -2.09099
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit -2.09099
GPR161 G protein-coupled receptor 161 -2.06396
PTGES3L prostaglandin E synthase 3 (cytosolic)-like -2.05949
CDC16 cell division cycle 16 -2.04354
GPR173 G protein-coupled receptor 173 -2.04172
CDC6 cell division cycle 6 -2.03175
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase -2.01068
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 -2.00099