HDAC4 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description histone deacetylase 4|Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 9759)
External Link http://www.ncbi.nlm.nih.gov/gene/9759
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354 interacting proteins for HDAC4 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABLIM1 actin binding LIM protein 1
ACTA1 actin, alpha 1, skeletal muscle
AGAP3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
AHRR aryl-hydrocarbon receptor repressor
AKT1S1 AKT1 substrate 1 (proline-rich)
AMPD2 adenosine monophosphate deaminase 2
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
ANKRD11 ankyrin repeat domain 11
APP amyloid beta (A4) precursor protein
AR androgen receptor
ARAF A-Raf proto-oncogene, serine/threonine kinase
ARHGAP35 Rho GTPase activating protein 35
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARID1A AT rich interactive domain 1A (SWI-like)
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ATF2 activating transcription factor 2
ATF3 activating transcription factor 3
ATF7 activating transcription factor 7
ATRX alpha thalassemia/mental retardation syndrome X-linked
ATXN1 ataxin 1
BAD BCL2-associated agonist of cell death
BAIAP2 BAI1-associated protein 2
BCAR1 breast cancer anti-estrogen resistance 1
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL6 B-cell CLL/lymphoma 6
BCOR BCL6 corepressor
BCORL1 BCL6 corepressor-like 1
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRMS1 breast cancer metastasis suppressor 1
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
C1QBP complement component 1, q subcomponent binding protein
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CAMK1 calcium/calmodulin-dependent protein kinase I
CAMK2D calcium/calmodulin-dependent protein kinase II delta
CAMK4 calcium/calmodulin-dependent protein kinase IV
CAMKK1 calcium/calmodulin-dependent protein kinase kinase 1, alpha
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBX5 chromobox homolog 5
CCDC6 coiled-coil domain containing 6
CCND1 cyclin D1
CDC25C cell division cycle 25C
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDK16 cyclin-dependent kinase 16
CDK17 cyclin-dependent kinase 17
CDK18 cyclin-dependent kinase 18
CDK5 cyclin-dependent kinase 5
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CEP170 centrosomal protein 170kDa
CEP170B centrosomal protein 170B
CEP250 centrosomal protein 250kDa
CGN cingulin
CIITA class II, major histocompatibility complex, transactivator
CLASP1 cytoplasmic linker associated protein 1
CLASP2 cytoplasmic linker associated protein 2
CRTC1 CREB regulated transcription coactivator 1
CRTC2 CREB regulated transcription coactivator 2
CRTC3 CREB regulated transcription coactivator 3
CSMD1 CUB and Sushi multiple domains 1
CSNK1A1 casein kinase 1, alpha 1
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein)
CTBP1 C-terminal binding protein 1
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYLD cylindromatosis (turban tumor syndrome)
DCAF7 DDB1 and CUL4 associated factor 7
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DENND1A DENN/MADD domain containing 1A
DENND4A DENN/MADD domain containing 4A
DENND4C DENN/MADD domain containing 4C
DMTN dematin actin binding protein
DNAH9 dynein, axonemal, heavy chain 9
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DNAJB8 DnaJ (Hsp40) homolog, subfamily B, member 8
DOCK11 dedicator of cytokinesis 11
DROSHA drosha, ribonuclease type III
E2F3 E2F transcription factor 3
EBF1 early B-cell factor 1
EDC3 enhancer of mRNA decapping 3
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF4E2 eukaryotic translation initiation factor 4E family member 2
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1
ELAVL1 ELAV like RNA binding protein 1
ELF1 E74-like factor 1 (ets domain transcription factor)
EP300 E1A binding protein p300
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EPHB6 EPH receptor B6
ERCC5 excision repair cross-complementation group 5
ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2
ESR1 estrogen receptor 1
EXO1 exonuclease 1
FAM53C family with sequence similarity 53, member C
FOXO3 forkhead box O3
FOXP3 forkhead box P3
GAPVD1 GTPase activating protein and VPS9 domains 1
GATA1 GATA binding protein 1 (globin transcription factor 1)
GATA3 GATA binding protein 3
GCM1 glial cells missing homolog 1 (Drosophila)
GIGYF1 GRB10 interacting GYF protein 1
GIGYF2 GRB10 interacting GYF protein 2
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GNG2 guanine nucleotide binding protein (G protein), gamma 2
GRIP1 glutamate receptor interacting protein 1
GSK3B glycogen synthase kinase 3 beta
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HDAC3 histone deacetylase 3
HDAC5 histone deacetylase 5
HDAC7 histone deacetylase 7
HDAC8 histone deacetylase 8
HDAC9 histone deacetylase 9
HELZ2 helicase with zinc finger 2, transcriptional coactivator
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
HIC1 hypermethylated in cancer 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIST1H4F histone cluster 1, H4f
HNF1A HNF1 homeobox A
HNF4A hepatocyte nuclear factor 4, alpha
HSF4 heat shock transcription factor 4
HSPA8 heat shock 70kDa protein 8
IDI2 isopentenyl-diphosphate delta isomerase 2
IFRD1 interferon-related developmental regulator 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IKZF2 IKAROS family zinc finger 2 (Helios)
IKZF3 IKAROS family zinc finger 3 (Aiolos)
IKZF4 IKAROS family zinc finger 4 (Eos)
IRS2 insulin receptor substrate 2
IRS4 insulin receptor substrate 4
JDP2 Jun dimerization protein 2
KDM2A lysine (K)-specific demethylase 2A
KDM5B lysine (K)-specific demethylase 5B
KIAA0355 KIAA0355
KIAA0930 KIAA0930
KIAA1671 KIAA1671
KIF13B kinesin family member 13B
KIF1B kinesin family member 1B
KIF1C kinesin family member 1C
KIF23 kinesin family member 23
KIF5B kinesin family member 5B
KLC1 kinesin light chain 1
KLC2 kinesin light chain 2
KLC3 kinesin light chain 3
KLC4 kinesin light chain 4
KMT2B lysine (K)-specific methyltransferase 2B
KSR1 kinase suppressor of ras 1
LARP1 La ribonucleoprotein domain family, member 1
LCOR ligand dependent nuclear receptor corepressor
LIMA1 LIM domain and actin binding 1
LMO7 LIM domain 7
LPAR2 lysophosphatidic acid receptor 2
LPAR4 lysophosphatidic acid receptor 4
LSM1 LSM1, U6 small nuclear RNA associated
LSR lipolysis stimulated lipoprotein receptor
LUZP1 leucine zipper protein 1
LZTR1 leucine-zipper-like transcription regulator 1
MAP1S microtubule-associated protein 1S
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MARK1 MAP/microtubule affinity-regulating kinase 1
MARK2 MAP/microtubule affinity-regulating kinase 2
MARK3 MAP/microtubule affinity-regulating kinase 3
MAST2 microtubule associated serine/threonine kinase 2
MAST3 microtubule associated serine/threonine kinase 3
MECOM MDS1 and EVI1 complex locus
MED23 mediator complex subunit 23
MEF2A myocyte enhancer factor 2A
MEF2B myocyte enhancer factor 2B
MEF2C myocyte enhancer factor 2C
MEF2D myocyte enhancer factor 2D
MEGF10 multiple EGF-like-domains 10
MIF4GD MIF4G domain containing
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MORC2 MORC family CW-type zinc finger 2
MTMR12 myotubularin related protein 12
MTMR6 myotubularin related protein 6
NACC1 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
NADK NAD kinase
NAV1 neuron navigator 1
NCKAP1 NCK-associated protein 1
NCKIPSD NCK interacting protein with SH3 domain
NCOR1 nuclear receptor corepressor 1
NCOR2 nuclear receptor corepressor 2
NELFA negative elongation factor complex member A
NELFB negative elongation factor complex member B
NF1 neurofibromin 1
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NKRF NFKB repressing factor
NPPB natriuretic peptide B
NR1H2 nuclear receptor subfamily 1, group H, member 2
NR2C1 nuclear receptor subfamily 2, group C, member 1
NR2C2 nuclear receptor subfamily 2, group C, member 2
NRF1 nuclear respiratory factor 1
NUP153 nucleoporin 153kDa
NUP155 nucleoporin 155kDa
NUP210 nucleoporin 210kDa
NUP214 nucleoporin 214kDa
NUP62 nucleoporin 62kDa
OLA1 Obg-like ATPase 1
OSBPL1A oxysterol binding protein-like 1A
OSBPL3 oxysterol binding protein-like 3
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PANX3 pannexin 3
PARD3 par-3 family cell polarity regulator
PARK2 parkin RBR E3 ubiquitin protein ligase
PARP12 poly (ADP-ribose) polymerase family, member 12
PARP8 poly (ADP-ribose) polymerase family, member 8
PCDH9 protocadherin 9
PDZD11 PDZ domain containing 11
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
PHLDB2 pleckstrin homology-like domain, family B, member 2
PI4KB phosphatidylinositol 4-kinase, catalytic, beta
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PKP2 plakophilin 2
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLEKHA7 pleckstrin homology domain containing, family A member 7
POU2F3 POU class 2 homeobox 3
PPAP2B phosphatidic acid phosphatase type 2B
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4
PPP2R5D protein phosphatase 2, regulatory subunit B', delta
PRKCI protein kinase C, iota
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PTPN14 protein tyrosine phosphatase, non-receptor type 14
PUM1 pumilio RNA-binding family member 1
R3HDM1 R3H domain containing 1
R3HDM2 R3H domain containing 2
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RABEP1 rabaptin, RAB GTPase binding effector protein 1
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RANBP2 RAN binding protein 2
RANGAP1 Ran GTPase activating protein 1
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6
RARA retinoic acid receptor, alpha
RASAL2 RAS protein activator like 2
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RBBP4 retinoblastoma binding protein 4
REEP1 receptor accessory protein 1
REEP4 receptor accessory protein 4
REST RE1-silencing transcription factor
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RFXANK regulatory factor X-associated ankyrin-containing protein
RFXAP regulatory factor X-associated protein
RICTOR RPTOR independent companion of MTOR, complex 2
RTKN rhotekin
RUNX2 runt-related transcription factor 2
RUNX3 runt-related transcription factor 3
RUVBL2 RuvB-like AAA ATPase 2
RXRA retinoid X receptor, alpha
SACK1B scaffolding CK1 anchoring protein B
SAE1 SUMO1 activating enzyme subunit 1
SAMD4A sterile alpha motif domain containing 4A
SAMD4B sterile alpha motif domain containing 4B
SENP1 SUMO1/sentrin specific peptidase 1
SENP7 SUMO1/sentrin specific peptidase 7
SF1 splicing factor 1
SFN stratifin
SH3PXD2A SH3 and PX domains 2A
SH3RF1 SH3 domain containing ring finger 1
SH3RF3 SH3 domain containing ring finger 3
SHKBP1 SH3KBP1 binding protein 1
SHROOM2 shroom family member 2
SHROOM3 shroom family member 3
SIN3A SIN3 transcription regulator family member A
SIPA1L3 signal-induced proliferation-associated 1 like 3
SIRT1 sirtuin 1
SKIV2L2 superkiller viralicidic activity 2-like 2 (S. cerevisiae)
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SMAD3 SMAD family member 3
SMO smoothened, frizzled class receptor
SORBS1 sorbin and SH3 domain containing 1
SORBS2 sorbin and SH3 domain containing 2
SP1 Sp1 transcription factor
SPEN spen family transcriptional repressor
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SRF serum response factor (c-fos serum response element-binding transcription factor)
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2
SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STK3 serine/threonine kinase 3
SUMO1 small ubiquitin-like modifier 1
SUMO2 small ubiquitin-like modifier 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYK spleen tyrosine kinase
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TBC1D22A TBC1 domain family, member 22A
TBC1D22B TBC1 domain family, member 22B
TBC1D4 TBC1 domain family, member 4
TBC1D5 TBC1 domain family, member 5
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TIAM1 T-cell lymphoma invasion and metastasis 1
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TP53BP1 tumor protein p53 binding protein 1
TP53BP2 tumor protein p53 binding protein 2
TPD52L1 tumor protein D52-like 1
TRAF3IP3 TRAF3 interacting protein 3
TRIB3 tribbles pseudokinase 3
TRIM32 tripartite motif containing 32
TRIP11 thyroid hormone receptor interactor 11
TSC1 tuberous sclerosis 1
TSC2 tuberous sclerosis 2
TTC28 tetratricopeptide repeat domain 28
UBE2I ubiquitin-conjugating enzyme E2I
UHRF1BP1L UHRF1 binding protein 1-like
USP54 ubiquitin specific peptidase 54
USP8 ubiquitin specific peptidase 8
UTP6 UTP6, small subunit (SSU) processome component, homolog (yeast)
VAMP8 vesicle-associated membrane protein 8
VIPAS39 VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog
VPS33B vacuolar protein sorting 33 homolog B (yeast)
WDR35 WD repeat domain 35
WNK1 WNK lysine deficient protein kinase 1
WNK4 WNK lysine deficient protein kinase 4
WNT16 wingless-type MMTV integration site family, member 16
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
YY1 YY1 transcription factor
ZBTB16 zinc finger and BTB domain containing 16
ZBTB7B zinc finger and BTB domain containing 7B
ZCCHC8 zinc finger, CCHC domain containing 8
ZEB2 zinc finger E-box binding homeobox 2
ZFP36L2 ZFP36 ring finger protein-like 2
ZMYND8 zinc finger, MYND-type containing 8
ZNF148 zinc finger protein 148
ZNF354A zinc finger protein 354A
ZNF443 zinc finger protein 443