HDAC5 Gene Set

Dataset LINCS L1000 CMAP CRISPR Knockout Consensus Signatures
Category transcriptomics
Type gene perturbation
Description histone deacetylase 5|Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 10014)
External Link https://ncbi.nlm.nih.gov/gene/10014
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Genes

499 genes differentially expressed following the HDAC5 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
KRT14 keratin 14, type I 0.0125445
G0S2 G0/G1 switch 2 0.012421
GPX3 glutathione peroxidase 3 0.0123022
ECM1 extracellular matrix protein 1 0.0121087
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0112892
MT1E metallothionein 1E 0.0108129
CRYAB crystallin, alpha B 0.0105754
PLAAT3 phospholipase A and acyltransferase 3 0.0105717
FSTL1 follistatin-like 1 0.0100899
PGGHG protein-glucosylgalactosylhydroxylysine glucosidase 0.010011
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 0.0096365
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 0.00954571
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.00952763
C1S complement component 1, s subcomponent 0.00941919
FABP4 fatty acid binding protein 4, adipocyte 0.00932426
MMP1 matrix metallopeptidase 1 0.00929829
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 0.00921695
IL32 interleukin 32 0.00920733
CCNA2 cyclin A2 0.00919537
IGFBP6 insulin-like growth factor binding protein 6 0.00912191
IFI27 interferon, alpha-inducible protein 27 0.00906412
MMP7 matrix metallopeptidase 7 0.00903538
COQ8A coenzyme Q8A 0.00900844
CXCL14 chemokine (C-X-C motif) ligand 14 0.00896209
AMOTL2 angiomotin like 2 0.00889703
KRT18 keratin 18, type I 0.0087766
ADIPOQ adiponectin, C1Q and collagen domain containing 0.00864557
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.00849001
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.00829063
DUSP5 dual specificity phosphatase 5 0.00828877
AZGP1 alpha-2-glycoprotein 1, zinc-binding 0.00827373
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3 0.00824882
ASS1 argininosuccinate synthase 1 0.00824271
C1R complement component 1, r subcomponent 0.00823314
RARRES2 retinoic acid receptor responder (tazarotene induced) 2 0.00821954
CAV1 caveolin 1, caveolae protein, 22kDa 0.00821933
COL6A2 collagen, type VI, alpha 2 0.00804835
TMEM176B transmembrane protein 176B 0.00803603
EMP1 epithelial membrane protein 1 0.00799702
KRT7 keratin 7, type II 0.00786193
GATA3 GATA binding protein 3 0.00786023
KRT16 keratin 16, type I 0.00783031
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 0.0077237
TGFBI transforming growth factor, beta-induced, 68kDa 0.0075119
PSAP prosaposin 0.00748194
CHRDL1 chordin-like 1 0.00741908
GABRP gamma-aminobutyric acid (GABA) A receptor, pi 0.00741669
HSPA1A heat shock 70kDa protein 1A 0.00738077
FLNA filamin A, alpha 0.00733922
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.00730841
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 0.0073033
IRF7 interferon regulatory factor 7 0.00728885
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 0.00723689
NRCAM neuronal cell adhesion molecule 0.00708238
CHIC2 cysteine-rich hydrophobic domain 2 0.00706462
NUCB1 nucleobindin 1 0.00706154
PGAM1 phosphoglycerate mutase 1 (brain) 0.00705493
CCN2 cellular communication network factor 2 0.00705178
KDM5D lysine (K)-specific demethylase 5D 0.0070474
CD70 CD70 molecule 0.00703141
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.00700476
EPHA2 EPH receptor A2 0.00698859
NMB neuromedin B 0.00696511
GNAS GNAS complex locus 0.00693761
HSPB1 heat shock 27kDa protein 1 0.00691525
CRCT1 cysteine-rich C-terminal 1 0.00689393
PLIN1 perilipin 1 0.00688219
ACADVL acyl-CoA dehydrogenase, very long chain 0.00687771
LCN2 lipocalin 2 0.00684891
S100A11 S100 calcium binding protein A11 0.0068155
BSG basigin (Ok blood group) 0.00679664
HMOX1 heme oxygenase 1 0.0067862
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 0.00678299
CRYBG1 crystallin beta-gamma domain containing 1 0.00678118
MET MET proto-oncogene, receptor tyrosine kinase 0.00672884
FOSL1 FOS-like antigen 1 0.00670234
HSPB8 heat shock 22kDa protein 8 0.00665467
NNMT nicotinamide N-methyltransferase 0.00663814
CX3CR1 chemokine (C-X3-C motif) receptor 1 0.00663054
CFI complement factor I 0.00662566
IGFBP4 insulin-like growth factor binding protein 4 0.0066174
TM4SF1 transmembrane 4 L six family member 1 0.00657324
SCD5 stearoyl-CoA desaturase 5 0.00656522
C1QA complement component 1, q subcomponent, A chain 0.0065648
IFI44L interferon-induced protein 44-like 0.00655782
TIMP4 TIMP metallopeptidase inhibitor 4 0.00655605
KRT6A keratin 6A, type II 0.00647584
AOX1 aldehyde oxidase 1 0.006434
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 0.0064181
PNMA2 paraneoplastic Ma antigen 2 0.00639328
FHL1 four and a half LIM domains 1 0.00637819
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.00634689
CTSL cathepsin L 0.0063358
EMP3 epithelial membrane protein 3 0.00633513
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.00632201
FMO2 flavin containing monooxygenase 2 (non-functional) 0.00630789
AKAP12 A kinase (PRKA) anchor protein 12 0.00624353
SPP1 secreted phosphoprotein 1 0.00623818
LGALS13 lectin, galactoside-binding, soluble, 13 0.00623782
LY6E lymphocyte antigen 6 complex, locus E 0.00623232
CTSD cathepsin D 0.00620541
BHMT2 betaine--homocysteine S-methyltransferase 2 0.00618248
MXRA7 matrix-remodelling associated 7 0.00616596
ACSL1 acyl-CoA synthetase long-chain family member 1 0.00616573
LYZ lysozyme 0.00615824
MVP major vault protein 0.0061474
TRIP6 thyroid hormone receptor interactor 6 0.00612437
RETREG1 reticulophagy regulator 1 0.00610819
S100A10 S100 calcium binding protein A10 0.00610155
TBX3 T-box 3 0.00609708
CDO1 cysteine dioxygenase type 1 0.00606156
RND3 Rho family GTPase 3 0.00605571
NID1 nidogen 1 0.00604718
JUND jun D proto-oncogene 0.00602765
SFN stratifin 0.00602261
CSK c-src tyrosine kinase 0.00600778
PERP PERP, TP53 apoptosis effector 0.00600358
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 0.005955
LY6D lymphocyte antigen 6 complex, locus D 0.00595074
OPHN1 oligophrenin 1 0.00593649
GEM GTP binding protein overexpressed in skeletal muscle 0.00593203
LPAR6 lysophosphatidic acid receptor 6 0.00592662
HLA-C major histocompatibility complex, class I, C 0.00592094
HLA-F major histocompatibility complex, class I, F 0.00591704
FXYD5 FXYD domain containing ion transport regulator 5 0.00591343
CTSB cathepsin B 0.00591003
ACTN4 actinin, alpha 4 0.00589012
G6PD glucose-6-phosphate dehydrogenase 0.00587769
BCL2L1 BCL2-like 1 0.00586607
ABHD4 abhydrolase domain containing 4 0.00586182
CST3 cystatin C 0.00585952
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 0.00585034
UPP1 uridine phosphorylase 1 0.00583213
MARCKSL1 MARCKS-like 1 0.00583212
IFITM1 interferon induced transmembrane protein 1 0.00583104
TUBB6 tubulin, beta 6 class V 0.00582639
HIST1H2BK histone cluster 1, H2bk 0.00582563
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 0.00582555
CKM creatine kinase, muscle 0.00582505
RHOBTB3 Rho-related BTB domain containing 3 0.00582184
MX2 MX dynamin-like GTPase 2 0.00577814
DYNLL1 dynein, light chain, LC8-type 1 0.00577753
HLA-B major histocompatibility complex, class I, B 0.00577416
TNIP1 TNFAIP3 interacting protein 1 0.00576671
TAGLN transgelin 0.00576443
GSTA4 glutathione S-transferase alpha 4 0.00573218
TSPAN13 tetraspanin 13 0.00572251
PLBD1 phospholipase B domain containing 1 0.00570703
PROCR protein C receptor, endothelial 0.00570347
RRBP1 ribosome binding protein 1 0.00565808
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 0.00561661
IL1RN interleukin 1 receptor antagonist 0.00561036
PLIN2 perilipin 2 0.00560422
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.00556682
MMP2 matrix metallopeptidase 2 0.00556625
TGM1 transglutaminase 1 0.00555007
ANXA5 annexin A5 0.00553562
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.00552216
PITX3 paired-like homeodomain 3 0.00548207
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 0.0054711
ANXA2 annexin A2 0.00545267
PROM1 prominin 1 0.00544457
CES1 carboxylesterase 1 0.00544299
MT1G metallothionein 1G 0.00543143
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding) 0.00539114
MFGE8 milk fat globule-EGF factor 8 protein 0.00539036
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.00538443
NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha 0.00537992
RHOB ras homolog family member B 0.00537927
MX1 MX dynamin-like GTPase 1 0.00537803
FAM50A family with sequence similarity 50, member A 0.00537462
PITX1 paired-like homeodomain 1 0.00537323
KRT17 keratin 17, type I 0.00537139
HOPX HOP homeobox 0.00535023
RNF167 ring finger protein 167 0.00533661
FABP7 fatty acid binding protein 7, brain 0.00533516
TIMP3 TIMP metallopeptidase inhibitor 3 0.00532307
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.00529828
CD151 CD151 molecule (Raph blood group) 0.00529455
PXDN peroxidasin 0.00528137
C3 complement component 3 0.0052725
GSAP gamma-secretase activating protein 0.00527007
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 0.00525237
SPON2 spondin 2, extracellular matrix protein 0.00524627
LIPG lipase, endothelial 0.00523871
OASL 2'-5'-oligoadenylate synthetase-like 0.00523836
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 0.005235
AK1 adenylate kinase 1 0.00523173
AXL AXL receptor tyrosine kinase 0.00522932
STAB1 stabilin 1 0.00522459
TGM2 transglutaminase 2 0.00522142
ZEB2 zinc finger E-box binding homeobox 2 0.00520627
ACSS3 acyl-CoA synthetase short-chain family member 3 0.00520547
BCL3 B-cell CLL/lymphoma 3 0.00519904
FBLN2 fibulin 2 0.00519838
HIST1H2AC histone cluster 1, H2ac 0.00519428
PRSS23 protease, serine, 23 0.00518351
MEOX2 mesenchyme homeobox 2 0.00518188
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.00517157
PDZK1IP1 PDZK1 interacting protein 1 0.00516115
FDXR ferredoxin reductase 0.00515395
RIN2 Ras and Rab interactor 2 0.00515392
ACTB actin, beta 0.00513923
MT1H metallothionein 1H 0.00511039
U2AF2 U2 small nuclear RNA auxiliary factor 2 0.00510596
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.00510141
CAPNS1 calpain, small subunit 1 0.00509966
GPX1 glutathione peroxidase 1 0.00507203
CD14 CD14 molecule 0.00503998
TXLNA taxilin alpha 0.00502377
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa 0.00502334
IFI6 interferon, alpha-inducible protein 6 0.00502005
IER2 immediate early response 2 0.00501679
TYROBP TYRO protein tyrosine kinase binding protein 0.00500643
DSG3 desmoglein 3 0.00500101
MSX1 msh homeobox 1 0.00500087
POLR2D polymerase (RNA) II (DNA directed) polypeptide D 0.00498045
TGFB1 transforming growth factor, beta 1 0.0049719
TYMS thymidylate synthetase 0.00497066
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.00496538
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 0.00496206
CAMK1 calcium/calmodulin-dependent protein kinase I 0.00495169
ZBTB20 zinc finger and BTB domain containing 20 0.00494604
XAF1 XIAP associated factor 1 0.00494524
HBEGF heparin-binding EGF-like growth factor 0.00494339
LSP1 lymphocyte-specific protein 1 0.00494055
IL13RA2 interleukin 13 receptor, alpha 2 0.00493584
SMAGP small cell adhesion glycoprotein 0.0049131
PDLIM2 PDZ and LIM domain 2 (mystique) 0.00490991
CTH cystathionine gamma-lyase 0.0049043
PRDX2 peroxiredoxin 2 0.00489885
CDC37 cell division cycle 37 0.00489317
TMPRSS11E transmembrane protease, serine 11E 0.00488959
SMAD7 SMAD family member 7 0.00488901
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 0.00488277
PDGFA platelet-derived growth factor alpha polypeptide 0.00483632
S100A4 S100 calcium binding protein A4 0.00483217
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 0.00481771
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.00481202
S100A12 S100 calcium binding protein A12 0.00480681
PTPRE protein tyrosine phosphatase, receptor type, E 0.00479768
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 0.00479436
IFITM3 interferon induced transmembrane protein 3 0.0047918
CRNN cornulin 0.00478921
KRT1 keratin 1, type II 0.00478746
GABARAPL1 GABA(A) receptor-associated protein like 1 0.00478417
MLPH melanophilin 0.00478386
MIA melanoma inhibitory activity 0.00478225
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2 0.0047819
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 0.00477563

decreased expression

Symbol Name Standardized Value
MAP7 microtubule-associated protein 7 -0.0108758
FGFR3 fibroblast growth factor receptor 3 -0.0102327
CHN1 chimerin 1 -0.00957924
PPP1R13B protein phosphatase 1, regulatory subunit 13B -0.00931496
PCCB propionyl CoA carboxylase, beta polypeptide -0.00925126
PBK PDZ binding kinase -0.00859103
MPO myeloperoxidase -0.00835447
ODC1 ornithine decarboxylase 1 -0.00833703
FKBP5 FK506 binding protein 5 -0.0083266
ZNF395 zinc finger protein 395 -0.00817855
IDE insulin-degrading enzyme -0.008119
ADD3 adducin 3 (gamma) -0.008012
CLC Charcot-Leyden crystal galectin -0.00777138
NTS neurotensin -0.00763155
HAT1 histone acetyltransferase 1 -0.00755881
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 -0.00752629
SORL1 sortilin-related receptor, L(DLR class) A repeats containing -0.00747128
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) -0.00737426
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 -0.00732384
CCNB2 cyclin B2 -0.00729244
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 -0.00729063
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.00690387
MYB v-myb avian myeloblastosis viral oncogene homolog -0.00684626
GCA grancalcin, EF-hand calcium binding protein -0.00681193
GPD1L glycerol-3-phosphate dehydrogenase 1-like -0.00678403
RRM2 ribonucleotide reductase M2 -0.00674395
RGCC regulator of cell cycle -0.00659357
NME5 NME/NM23 family member 5 -0.00658227
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.00654927
WT1 Wilms tumor 1 -0.00648426
BPHL biphenyl hydrolase-like (serine hydrolase) -0.00643472
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 -0.00641433
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) -0.00637597
RPRD1A regulation of nuclear pre-mRNA domain containing 1A -0.00635326
CLGN calmegin -0.00628938
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.00627453
MSMB microseminoprotein, beta- -0.00621339
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 -0.00618662
FGFR2 fibroblast growth factor receptor 2 -0.00618392
EPCAM epithelial cell adhesion molecule -0.00615848
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -0.0061369
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.00606623
MRTFB myocardin related transcription factor B -0.00606476
PDE9A phosphodiesterase 9A -0.00603033
ZBTB16 zinc finger and BTB domain containing 16 -0.00601955
NVL nuclear VCP-like -0.00601008
LTBP1 latent transforming growth factor beta binding protein 1 -0.00600186
TCF21 transcription factor 21 -0.00598251
CLDN8 claudin 8 -0.00589461
MSH2 mutS homolog 2 -0.00584427
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 -0.00584128
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.00582831
EAF2 ELL associated factor 2 -0.00582662
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial -0.00582372
DOCK1 dedicator of cytokinesis 1 -0.00580402
LAMP5 lysosomal-associated membrane protein family, member 5 -0.00577311
RAD51AP1 RAD51 associated protein 1 -0.00576732
ATP5MJ ATP synthase membrane subunit j -0.00576535
TYRP1 tyrosinase-related protein 1 -0.00576054
CXADR coxsackie virus and adenovirus receptor -0.00572759
SYT1 synaptotagmin I -0.00568762
SCGB2A1 secretoglobin, family 2A, member 1 -0.00567746
PER2 period circadian clock 2 -0.00567519
KLHL23 kelch-like family member 23 -0.00564956
IQCK IQ motif containing K -0.00558986
EAPP E2F-associated phosphoprotein -0.00557131
MUC16 mucin 16, cell surface associated -0.00554628
CDKN3 cyclin-dependent kinase inhibitor 3 -0.00551371
GREB1 growth regulation by estrogen in breast cancer 1 -0.00550278
ATAD2 ATPase family, AAA domain containing 2 -0.00549645
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -0.00543576
MEIS1 Meis homeobox 1 -0.00543133
ALCAM activated leukocyte cell adhesion molecule -0.00542633
GSTM3 glutathione S-transferase mu 3 (brain) -0.00541312
PBX3 pre-B-cell leukemia homeobox 3 -0.0054127
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.00541216
TFF3 trefoil factor 3 (intestinal) -0.00540915
SGMS1 sphingomyelin synthase 1 -0.00538648
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 -0.00537521
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 -0.00535844
PRKACB protein kinase, cAMP-dependent, catalytic, beta -0.00534622
TFRC transferrin receptor -0.0053414
CLDN10 claudin 10 -0.00533472
ADO 2-aminoethanethiol (cysteamine) dioxygenase -0.00532639
HAL histidine ammonia-lyase -0.00532507
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 -0.00532034
OXA1L oxidase (cytochrome c) assembly 1-like -0.00532013
NRGN neurogranin (protein kinase C substrate, RC3) -0.00530025
KDM3A lysine (K)-specific demethylase 3A -0.00529707
KIF11 kinesin family member 11 -0.00529615
BID BH3 interacting domain death agonist -0.00529588
ACAT2 acetyl-CoA acetyltransferase 2 -0.00528733
ARL3 ADP-ribosylation factor-like 3 -0.00525955
PAX5 paired box 5 -0.00525476
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) -0.00523175
CPE carboxypeptidase E -0.00522654
CDC25B cell division cycle 25B -0.00521813
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b -0.0052113
UGP2 UDP-glucose pyrophosphorylase 2 -0.0052044
EPAS1 endothelial PAS domain protein 1 -0.00520234
EFCAB11 EF-hand calcium binding domain 11 -0.00519019
IFT27 intraflagellar transport 27 -0.00516634
MKI67 marker of proliferation Ki-67 -0.00515102
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.00515013
PKP4 plakophilin 4 -0.00514739
UBE2J1 ubiquitin-conjugating enzyme E2, J1 -0.00514172
SC5D sterol-C5-desaturase -0.00510661
CRYM crystallin, mu -0.00509611
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.00508572
DEFA4 defensin, alpha 4, corticostatin -0.0050839
TDP1 tyrosyl-DNA phosphodiesterase 1 -0.00505096
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.00504254
WASF1 WAS protein family, member 1 -0.00503793
GUCY2C guanylate cyclase 2C -0.00502478
MAOA monoamine oxidase A -0.00501059
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like -0.00500535
ZNF467 zinc finger protein 467 -0.00499885
EXOC5 exocyst complex component 5 -0.00499298
CCL14 chemokine (C-C motif) ligand 14 -0.00497817
NUP85 nucleoporin 85kDa -0.00497343
MAP2K6 mitogen-activated protein kinase kinase 6 -0.0049724
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.00495893
ESD esterase D -0.00494814
UMOD uromodulin -0.00493834
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -0.00493736
DEPTOR DEP domain containing MTOR-interacting protein -0.00492962
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 -0.00492213
REXO5 RNA exonuclease 5 -0.00492203
ARMCX2 armadillo repeat containing, X-linked 2 -0.00491766
HCRT hypocretin (orexin) neuropeptide precursor -0.00490127
FAM107A family with sequence similarity 107, member A -0.00489841
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.00489225
ST14 suppression of tumorigenicity 14 (colon carcinoma) -0.00489072
FABP1 fatty acid binding protein 1, liver -0.00488119
DAZAP2 DAZ associated protein 2 -0.00485499
MBNL1 muscleblind-like splicing regulator 1 -0.00483657
ARG1 arginase 1 -0.00483644
NGRN neugrin, neurite outgrowth associated -0.0048356
TFCP2L1 transcription factor CP2-like 1 -0.00483435
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -0.00481713
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein -0.00481638
EMP2 epithelial membrane protein 2 -0.00481015
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.00480572
MATN2 matrilin 2 -0.00479466
ALDH5A1 aldehyde dehydrogenase 5 family, member A1 -0.00479451
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) -0.00478707
ADAM28 ADAM metallopeptidase domain 28 -0.00474428
SOSTDC1 sclerostin domain containing 1 -0.00474269
OLFM1 olfactomedin 1 -0.00473392
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2 -0.00472528
ACOX2 acyl-CoA oxidase 2, branched chain -0.00472191
ECT2 epithelial cell transforming 2 -0.00471287
CREB3L2 cAMP responsive element binding protein 3-like 2 -0.00470801
TREM1 triggering receptor expressed on myeloid cells 1 -0.00469418
WDR61 WD repeat domain 61 -0.00469125
TCFL5 transcription factor-like 5 (basic helix-loop-helix) -0.00468319
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.00467165
GLUD2 glutamate dehydrogenase 2 -0.00465575
APLP1 amyloid beta (A4) precursor-like protein 1 -0.0046509
PBX1 pre-B-cell leukemia homeobox 1 -0.00464456
RAB40B RAB40B, member RAS oncogene family -0.00464075
COL4A5 collagen, type IV, alpha 5 -0.00463636
TGIF2 TGFB-induced factor homeobox 2 -0.00463525
EML4 echinoderm microtubule associated protein like 4 -0.00463241
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) -0.00463117
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator -0.00463056
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 -0.00461939
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12 -0.00461161
CCNE2 cyclin E2 -0.00461004
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 -0.00459244
CALB1 calbindin 1, 28kDa -0.00458633
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.00457911
SCN3B sodium channel, voltage gated, type III beta subunit -0.00456305
IL1R1 interleukin 1 receptor, type I -0.00455928
TWSG1 twisted gastrulation BMP signaling modulator 1 -0.00455113
WDR7 WD repeat domain 7 -0.00454847
AUTS2 autism susceptibility candidate 2 -0.00453457
ATXN1 ataxin 1 -0.0045279
CCP110 centriolar coiled coil protein 110kDa -0.00452124
CNOT4 CCR4-NOT transcription complex, subunit 4 -0.00450555
ATXN10 ataxin 10 -0.00450473
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2 -0.0044959
IQCE IQ motif containing E -0.00448995
EPX eosinophil peroxidase -0.00448499
SUSD4 sushi domain containing 4 -0.00448403
TTC27 tetratricopeptide repeat domain 27 -0.00448109
TXNDC9 thioredoxin domain containing 9 -0.00447972
AFF1 AF4/FMR2 family, member 1 -0.00447528
PDE10A phosphodiesterase 10A -0.00446775
CISH cytokine inducible SH2-containing protein -0.00445626
ASRGL1 asparaginase like 1 -0.0044526
GUCA2A guanylate cyclase activator 2A (guanylin) -0.00443725
TDP2 tyrosyl-DNA phosphodiesterase 2 -0.00443298
DCK deoxycytidine kinase -0.0044228
SCNN1B sodium channel, non voltage gated 1 beta subunit -0.00442275
DNALI1 dynein, axonemal, light intermediate chain 1 -0.00440561
ALPL alkaline phosphatase, liver/bone/kidney -0.00440439
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type -0.00439235
CDH1 cadherin 1, type 1, E-cadherin (epithelial) -0.00439034
KIF14 kinesin family member 14 -0.0043893
DOP1B DOP1 leucine zipper like protein B -0.00437476
ADAMDEC1 ADAM-like, decysin 1 -0.00436215
RAB4A RAB4A, member RAS oncogene family -0.00436092
FABP6 fatty acid binding protein 6, ileal -0.00435797
BHLHE41 basic helix-loop-helix family, member e41 -0.00435363
ALDOB aldolase B, fructose-bisphosphate -0.00433803
SMYD2 SET and MYND domain containing 2 -0.00433254
EXO1 exonuclease 1 -0.00432524
SFTPB surfactant protein B -0.0043057
UFD1 ubiquitin recognition factor in ER associated degradation 1 -0.00429871
FOXJ1 forkhead box J1 -0.00429564
DDHD2 DDHD domain containing 2 -0.00429556
YPEL5 yippee-like 5 (Drosophila) -0.00429547
MAMLD1 mastermind-like domain containing 1 -0.00429298
KLK7 kallikrein-related peptidase 7 -0.0042893
NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21 -0.00428446
STEAP1 six transmembrane epithelial antigen of the prostate 1 -0.00426922
DPYSL3 dihydropyrimidinase-like 3 -0.00426076
LRRC23 leucine rich repeat containing 23 -0.00425826
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa -0.00424975
CYCS cytochrome c, somatic -0.00424483
KAT6B K(lysine) acetyltransferase 6B -0.00424366
CD40 CD40 molecule, TNF receptor superfamily member 5 -0.00424112
ADSL adenylosuccinate lyase -0.00423034
TOB1 transducer of ERBB2, 1 -0.00422394
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.00422209
HSPA4 heat shock 70kDa protein 4 -0.00422121
ANKRD49 ankyrin repeat domain 49 -0.00419986
MTMR4 myotubularin related protein 4 -0.00419083
FANCI Fanconi anemia, complementation group I -0.00418411
SPC25 SPC25, NDC80 kinetochore complex component -0.00418246
PDE2A phosphodiesterase 2A, cGMP-stimulated -0.00417943
UBE2C ubiquitin-conjugating enzyme E2C -0.00417725
EXOSC7 exosome component 7 -0.00417706
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 -0.00417264
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) -0.00417156
TASOR transcription activation suppressor -0.00415527
SPA17 sperm autoantigenic protein 17 -0.00415337
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog -0.00414562
ZFAND1 zinc finger, AN1-type domain 1 -0.00414319
GOLGA7 golgin A7 -0.0041306
NFU1 NFU1 iron-sulfur cluster scaffold -0.00412909
DEFB1 defensin, beta 1 -0.00412417
HOOK1 hook microtubule-tethering protein 1 -0.00412051
BCLAF1 BCL2-associated transcription factor 1 -0.00411971
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) -0.00411542
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 -0.00411503
MAST3 microtubule associated serine/threonine kinase 3 -0.00411122
IRX5 iroquois homeobox 5 -0.00409208