HDR through Homologous Recombination (HRR) Gene Set

Dataset Reactome Pathways 2024
Category structural or functional annotations
Type pathway
External Link https://reactome.org/PathwayBrowser/#/R-HSA-5685942
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Genes

69 proteins participating in the HDR through Homologous Recombination (HRR) pathway from the Reactome Pathways 2024 dataset.

Symbol Name
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
ATRIP ATR interacting protein
BARD1 BRCA1 associated RING domain 1
BLM Bloom syndrome, RecQ helicase-like
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BRIP1 BRCA1 interacting protein C-terminal helicase 1
CHEK1 checkpoint kinase 1
DNA2 DNA replication helicase/nuclease 2
EME1 essential meiotic structure-specific endonuclease 1
EME2 essential meiotic structure-specific endonuclease subunit 2
EXO1 exonuclease 1
FIGNL1 fidgetin-like 1
FIRRM FIGNL1 interacting regulator of recombination and mitosis
GEN1 GEN1 Holliday junction 5' flap endonuclease
HUS1 HUS1 checkpoint homolog (S. pombe)
KAT5 K(lysine) acetyltransferase 5
MRE11 MRE11 homolog, double strand break repair nuclease
MUS81 MUS81 structure-specific endonuclease subunit
NBN nibrin
PALB2 partner and localizer of BRCA2
PCNA proliferating cell nuclear antigen
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POLD2 polymerase (DNA directed), delta 2, accessory subunit
POLD3 polymerase (DNA-directed), delta 3, accessory subunit
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POLE polymerase (DNA directed), epsilon, catalytic subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
POLE4 polymerase (DNA-directed), epsilon 4, accessory subunit
POLH polymerase (DNA directed), eta
POLK polymerase (DNA directed) kappa
RAD1 RAD1 checkpoint DNA exonuclease
RAD17 RAD17 homolog (S. pombe)
RAD50 RAD50 homolog (S. cerevisiae)
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RAD51B RAD51 paralog B
RAD51C RAD51 paralog C
RAD51D RAD51 paralog D
RAD9A RAD9 homolog A (S. pombe)
RAD9B RAD9 homolog B (S. pombe)
RBBP8 retinoblastoma binding protein 8
RFC1 replication factor C (activator 1) 1, 145kDa
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RHNO1 RAD9-HUS1-RAD1 interacting nuclear orphan 1
RMI1 RecQ mediated genome instability 1
RMI2 RecQ mediated genome instability 2
RPA1 replication protein A1, 70kDa
RPA2 replication protein A2, 32kDa
RPA3 replication protein A3, 14kDa
RPS27A ribosomal protein S27a
RTEL1 regulator of telomere elongation helicase 1
SEM1 SEM1 26S proteasome subunit
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae)
SLX4 SLX4 structure-specific endonuclease subunit
SPIDR scaffolding protein involved in DNA repair
TOP3A topoisomerase (DNA) III alpha
TOPBP1 topoisomerase (DNA) II binding protein 1
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBB ubiquitin B
UBC ubiquitin C
WRN Werner syndrome, RecQ helicase-like
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3