HESX1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description HESX homeobox 1|This gene encodes a conserved homeobox protein that is a transcriptional repressor in the developing forebrain and pituitary gland. Mutations in this gene are associated with septooptic dysplasia, HESX1-related growth hormone deficiency, and combined pituitary hormone deficiency. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 8820)
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Genes

355 genes differentially expressed following the HESX1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SPMAP2L sperm microtubule associated protein 2 like 2.36492
EFCC1 EF-hand and coiled-coil domain containing 1 2.36492
NOD2 nucleotide-binding oligomerization domain containing 2 2.36492
UPK3B uroplakin 3B 2.36492
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 2.36492
ITLN2 intelectin 2 2.36492
FNDC1 fibronectin type III domain containing 1 2.36492
CTXN2 cortexin 2 2.36492
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 2.36492
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 2.36492
GCM2 glial cells missing homolog 2 (Drosophila) 2.36492
SCG2 secretogranin II 2.36492
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 2.36492
OR52N2 olfactory receptor, family 52, subfamily N, member 2 2.36492
CCDC170 coiled-coil domain containing 170 2.36492
USP50 ubiquitin specific peptidase 50 2.36492
ZFP92 ZFP92 zinc finger protein 2.36492
EPX eosinophil peroxidase 2.36492
CLEC12A C-type lectin domain family 12, member A 2.36492
GOLGA6C golgin A6 family, member C 2.36492
FCN1 ficolin (collagen/fibrinogen domain containing) 1 2.36492
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 2.3511
WEE2 WEE1 homolog 2 (S. pombe) 2.3511
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 2.3511
IL11RA interleukin 11 receptor, alpha 2.3511
LURAP1L leucine rich adaptor protein 1-like 2.3511
COL19A1 collagen, type XIX, alpha 1 2.3511
OR2A25 olfactory receptor, family 2, subfamily A, member 25 2.3511
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 2.3511
CATSPER2 cation channel, sperm associated 2 2.3511
CD48 CD48 molecule 2.3511
VSX2 visual system homeobox 2 2.3511
TUBA3D tubulin, alpha 3d 2.3511
PRB4 proline-rich protein BstNI subfamily 4 2.3511
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.3511
PCDHA3 protocadherin alpha 3 2.3511
CPNE9 copine family member IX 2.3511
NKX3-1 NK3 homeobox 1 2.3511
ACTRT1 actin-related protein T1 2.3511
RASL10A RAS-like, family 10, member A 2.3511
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 2.3511
SLC15A5 solute carrier family 15, member 5 2.3511
CEP295NL CEP295 N-terminal like 2.3511
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae) 2.3511
ASB17 ankyrin repeat and SOCS box containing 17 2.3511
NUGGC nuclear GTPase, germinal center associated 2.3511
KCNMB4 potassium channel subfamily M regulatory beta subunit 4 2.3511
SELPLG selectin P ligand 2.3511
FHL5 four and a half LIM domains 5 2.3511
ANKRD34A ankyrin repeat domain 34A 2.3511
POSTN periostin, osteoblast specific factor 2.3511
PAX7 paired box 7 2.3511
OR10A3 olfactory receptor, family 10, subfamily A, member 3 2.3511
DERPC DERPC proline and glycine rich nuclear protein 2.3511
NKAPL NFKB activating protein-like 2.3511
GPR52 G protein-coupled receptor 52 2.3511
ADGRE1 adhesion G protein-coupled receptor E1 2.3511
KNG1 kininogen 1 2.3511
KLRK1 killer cell lectin-like receptor subfamily K, member 1 2.3511
CELF6 CUGBP, Elav-like family member 6 2.3511
PLIN1 perilipin 1 2.3511
SPINK6 serine peptidase inhibitor, Kazal type 6 2.3511
GLUD2 glutamate dehydrogenase 2 2.3511
SSTR1 somatostatin receptor 1 2.3511
TRPV3 transient receptor potential cation channel, subfamily V, member 3 2.3511
EXOC1L exocyst complex component 1 like 2.3511
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 2.3511
SLC7A13 solute carrier family 7 (anionic amino acid transporter), member 13 2.3511
ERVW-1 endogenous retrovirus group W, member 1 2.3511
GBP4 guanylate binding protein 4 2.3511
GBP6 guanylate binding protein family, member 6 2.3511
SOHLH1 spermatogenesis and oogenesis specific basic helix-loop-helix 1 2.3511
SPI1 Spi-1 proto-oncogene 2.3511
ELOVL6 ELOVL fatty acid elongase 6 2.3511
PKD2L1 polycystic kidney disease 2-like 1 2.3511
FOXN4 forkhead box N4 2.3511
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.3511
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 2.3511
MRTFA myocardin related transcription factor A 2.3511
NOTCH2NLB notch 2 N-terminal like B 2.3511
LOC124906010 uncharacterized LOC124906010 2.3511
FAM246C family with sequence similarity 246 member C (gene/pseudogene) 2.3511
RHEX regulator of hemoglobinization and erythroid cell expansion 2.3511
SMIM43 small integral membrane protein 43 2.3511
AKAIN1 A-kinase anchor inhibitor 1 2.3511
CPHXL cytoplasmic polyadenylated homeobox like 2.3511
FAM236D family with sequence similarity 236 member D 2.3511
PLAAT2 phospholipase A and acyltransferase 2 2.3511
BICDL2 BICD family like cargo adaptor 2 2.3511
KYAT1 kynurenine aminotransferase 1 2.3511
KLB klotho beta 2.3511
ADRB3 adrenoceptor beta 3 2.3511
ZAR1L zygote arrest 1-like 2.3511
STARD6 StAR-related lipid transfer (START) domain containing 6 2.3511
VCX3A variable charge, X-linked 3A 2.3511
GLIPR1L2 GLI pathogenesis-related 1 like 2 2.3511
GSC goosecoid homeobox 2.3511
S100G S100 calcium binding protein G 2.3511
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 2.3511
CCR8 chemokine (C-C motif) receptor 8 2.3511
MYO6 myosin VI 2.3511
CCDC92 coiled-coil domain containing 92 2.3511
C10ORF67 chromosome 10 open reading frame 67 2.3511
BEST3 bestrophin 3 2.3511
MOV10L1 Mov10 RISC complex RNA helicase like 1 2.3511
GC group-specific component (vitamin D binding protein) 2.3511
C10ORF53 chromosome 10 open reading frame 53 2.3511
FCMR Fc fragment of IgM receptor 2.3511
TSPAN8 tetraspanin 8 2.3511
VSIG8 V-set and immunoglobulin domain containing 8 2.3511
GATA6 GATA binding protein 6 2.3511
PARVG parvin, gamma 2.3511
MS4A5 membrane-spanning 4-domains, subfamily A, member 5 2.3511
CNTN6 contactin 6 2.3511
DYNAP dynactin associated protein 2.3511
DLK1 delta-like 1 homolog (Drosophila) 2.3511
TRHDE thyrotropin-releasing hormone degrading enzyme 2.3511
ARGFX arginine-fifty homeobox 2.3511
VAX2 ventral anterior homeobox 2 2.3511
NACA2 nascent polypeptide-associated complex alpha subunit 2 2.3511
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 2.3511
CCL25 chemokine (C-C motif) ligand 25 2.3511
KCNK7 potassium channel, two pore domain subfamily K, member 7 2.3511
NIM1K NIM1 serine/threonine protein kinase 2.3511
EDA2R ectodysplasin A2 receptor 2.3511
ADCY7 adenylate cyclase 7 2.3511
EFCAB3 EF-hand calcium binding domain 3 2.3511
THTPA thiamine triphosphatase 2.3511
LRRC32 leucine rich repeat containing 32 2.3511
PMP2 peripheral myelin protein 2 2.3511
CLCNKB chloride channel, voltage-sensitive Kb 2.3511
LY6G5C lymphocyte antigen 6 complex, locus G5C 2.3511
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1 2.3511
CLCA1 chloride channel accessory 1 2.3511
CHRM1 cholinergic receptor, muscarinic 1 2.3511
NUTM2A NUT family member 2A 2.3511
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 2.3511
PRND prion protein 2 (dublet) 2.3511
ZMYND15 zinc finger, MYND-type containing 15 2.3511
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 2.3511
CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18 2.3511
HSPA1L heat shock 70kDa protein 1-like 2.3511
VAV1 vav 1 guanine nucleotide exchange factor 2.3511
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 2.3511
C1ORF105 chromosome 1 open reading frame 105 2.3511
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) 2.3511
CNR2 cannabinoid receptor 2 (macrophage) 2.3511
PPP1R27 protein phosphatase 1, regulatory subunit 27 2.3511
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 2.3511
GOLGA8M golgin A8 family, member M 2.3511
PHOX2A paired-like homeobox 2a 2.3511
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 2.3511
PLA2G12B phospholipase A2, group XIIB 2.3511
FCRLB Fc receptor-like B 2.3511
NOX1 NADPH oxidase 1 2.3511
SPO11 SPO11 meiotic protein covalently bound to DSB 2.3511
DRD2 dopamine receptor D2 2.3511
IFNL4 interferon, lambda 4 (gene/pseudogene) 2.3511
WNT7A wingless-type MMTV integration site family, member 7A 2.3511
CHI3L2 chitinase 3-like 2 2.3511
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A 2.3511
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 2.3511
STIM2 stromal interaction molecule 2 2.3511
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1 2.3511
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 2.3511
C22ORF23 chromosome 22 open reading frame 23 2.3511
IRX5 iroquois homeobox 5 2.3511
MYO1A myosin IA 2.3511
LCN15 lipocalin 15 2.3511
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 2.3511
TECTB tectorin beta 2.3511
DGKQ diacylglycerol kinase, theta 110kDa 2.3511
RNASE6 ribonuclease, RNase A family, k6 2.3511
FXYD3 FXYD domain containing ion transport regulator 3 2.3511
WFDC13 WAP four-disulfide core domain 13 2.3511
SPINT4 serine peptidase inhibitor, Kunitz type 4 2.3511
AVP arginine vasopressin 2.3511
TAS2R10 taste receptor, type 2, member 10 2.3511
DIO3 deiodinase, iodothyronine, type III 2.3511
ADAMTSL5 ADAMTS-like 5 2.3511
OR1L8 olfactory receptor, family 1, subfamily L, member 8 2.3511
UBA7 ubiquitin-like modifier activating enzyme 7 2.3511
RGPD3 RANBP2-like and GRIP domain containing 3 2.3511
GNG13 guanine nucleotide binding protein (G protein), gamma 13 2.3511
LRRIQ4 leucine-rich repeats and IQ motif containing 4 2.3511
ABI3BP ABI family, member 3 (NESH) binding protein 2.3511
HBM hemoglobin, mu 2.3511
CRYGC crystallin, gamma C 2.3511
ICAM2 intercellular adhesion molecule 2 2.3511
NLRP3 NLR family, pyrin domain containing 3 2.3511
DCAF16 DDB1 and CUL4 associated factor 16 2.3511
IL17C interleukin 17C 2.3511
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 2.3511
PGM5 phosphoglucomutase 5 2.3511
SERPINE3 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3 2.35092
AFF3 AF4/FMR2 family, member 3 2.33378
TMEM150C transmembrane protein 150C 2.33378
H4C5 H4 clustered histone 5 2.33378
CRHR1 corticotropin releasing hormone receptor 1 2.33378
KCTD4 potassium channel tetramerization domain containing 4 2.33073
MTARC1 mitochondrial amidoxime reducing component 1 2.3244
SDHAF4 succinate dehydrogenase complex assembly factor 4 2.31866
AP1M1 adaptor-related protein complex 1, mu 1 subunit 2.30267
ZNF525 zinc finger protein 525 2.30267
GOLGA8R golgin A8 family, member R 2.29236
IDO1 indoleamine 2,3-dioxygenase 1 2.29236
CELA2B chymotrypsin-like elastase family, member 2B 2.29236
RGL2 ral guanine nucleotide dissociation stimulator-like 2 2.29236
TRIM41 tripartite motif containing 41 2.29236
OTX2 orthodenticle homeobox 2 2.27166
LTN1 listerin E3 ubiquitin protein ligase 1 2.25907
LIN52 lin-52 DREAM MuvB core complex component 2.25395
GSK3B glycogen synthase kinase 3 beta 2.2172
AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2.20426
MCTS1 malignant T cell amplified sequence 1 2.20324
GARS1 glycyl-tRNA synthetase 1 2.20324
PPM1N protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative) 2.19448
H4C6 H4 clustered histone 6 2.19263
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 2.14129
SELENOT selenoprotein T 2.13959
COQ3 coenzyme Q3 methyltransferase 2.13535
WHAMM WAS protein homolog associated with actin, golgi membranes and microtubules 2.13394
HACL2 2-hydroxyacyl-CoA lyase 2 2.10631
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 2.10212
ADAMTSL1 ADAMTS-like 1 2.09925
MALL mal, T-cell differentiation protein-like 2.08316
DNM3 dynamin 3 2.08316
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 2.07556
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 2.06749
KCNV2 potassium channel, voltage gated modifier subfamily V, member 2 2.06649
NLK nemo-like kinase 2.05634
INSIG1 insulin induced gene 1 2.05084
SP1 Sp1 transcription factor 2.04785
PRKCH protein kinase C, eta 2.04692
SNX11 sorting nexin 11 2.04573
OTUD7B OTU deubiquitinase 7B 2.04573
ZBTB18 zinc finger and BTB domain containing 18 2.03131
EDNRB endothelin receptor type B 2.03131
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 2.02384
CATSPERT catsper channel auxiliary subunit tau 2.02384
AIG1 androgen-induced 1 2.01645
C12ORF60 chromosome 12 open reading frame 60 2.01645
OBI1 ORC ubiquitin ligase 1 2.0118
RNF146 ring finger protein 146 2.00413

decreased expression

Symbol Name Standardized Value
MROH8 maestro heat-like repeat family member 8 -2.36492
AQP3 aquaporin 3 (Gill blood group) -2.36492
MRGPRF MAS-related GPR, member F -2.36492
PCDH10 protocadherin 10 -2.36492
ILF2 interleukin enhancer binding factor 2 -2.36492
ECEL1 endothelin converting enzyme-like 1 -2.36492
TRIM17 tripartite motif containing 17 -2.36492
PCDHGA11 protocadherin gamma subfamily A, 11 -2.3511
CD37 CD37 molecule -2.3511
ELF1 E74-like factor 1 (ets domain transcription factor) -2.3511
RBX1 ring-box 1, E3 ubiquitin protein ligase -2.3511
LOC124904542 uncharacterized LOC124904542 -2.3511
FSTL3 follistatin-like 3 (secreted glycoprotein) -2.3511
TCP11L2 t-complex 11, testis-specific-like 2 -2.3511
PSORS1C2 psoriasis susceptibility 1 candidate 2 -2.3511
CES3 carboxylesterase 3 -2.3511
ZNF470 zinc finger protein 470 -2.3511
ZNF471 zinc finger protein 471 -2.3511
SPDYE6 speedy/RINGO cell cycle regulator family member E6 -2.3511
DCAF12L2 DDB1 and CUL4 associated factor 12-like 2 -2.3511
GOLGA7 golgin A7 -2.3511
INHBC inhibin, beta C -2.3511
NME5 NME/NM23 family member 5 -2.3511
CACNG5 calcium channel, voltage-dependent, gamma subunit 5 -2.3511
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 -2.3511
SSTR5 somatostatin receptor 5 -2.3511
ASPN asporin -2.3511
CDNF cerebral dopamine neurotrophic factor -2.3511
CORO1C coronin, actin binding protein, 1C -2.3511
HGD homogentisate 1,2-dioxygenase -2.3511
CRY2 cryptochrome circadian clock 2 -2.3511
PFDN1 prefoldin subunit 1 -2.3511
TMEM82 transmembrane protein 82 -2.3511
NXPH3 neurexophilin 3 -2.3511
CYTIP cytohesin 1 interacting protein -2.3511
NACAD NAC alpha domain containing -2.3511
LBHD1 LBH domain containing 1 -2.3511
AMIGO1 adhesion molecule with Ig-like domain 1 -2.3511
NRIP2 nuclear receptor interacting protein 2 -2.3511
SPRED3 sprouty-related, EVH1 domain containing 3 -2.3511
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -2.3511
EPOP elongin BC and polycomb repressive complex 2 associated protein -2.3511
SMIM17 small integral membrane protein 17 -2.3511
FLACC1 flagellum associated containing coiled-coil domains 1 -2.3511
FNDC11 fibronectin type III domain containing 11 -2.3511
DOCK2 dedicator of cytokinesis 2 -2.3511
WDR18 WD repeat domain 18 -2.3511
H3C4 H3 clustered histone 4 -2.3511
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 -2.3511
H3-7 H3.7 histone (putative) -2.3511
GOLGA8K golgin A8 family, member K -2.3511
RCAN3 RCAN family member 3 -2.3511
LSMEM1 leucine-rich single-pass membrane protein 1 -2.3511
CERKL ceramide kinase-like -2.3511
RAD51AP1 RAD51 associated protein 1 -2.3511
DEPDC7 DEP domain containing 7 -2.3511
GHRHR growth hormone releasing hormone receptor -2.3511
HAL histidine ammonia-lyase -2.3511
HTR3E 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic -2.3511
NPHS1 nephrosis 1, congenital, Finnish type (nephrin) -2.3511
IFIT1B interferon-induced protein with tetratricopeptide repeats 1B -2.3511
ENTPD8 ectonucleoside triphosphate diphosphohydrolase 8 -2.3511
KIF5C kinesin family member 5C -2.34914
LTB4R leukotriene B4 receptor -2.33902
IL15RA interleukin 15 receptor, alpha -2.33902
RUMY3 RUMY family member 3 -2.33902
LRRC23 leucine rich repeat containing 23 -2.33765
RNF113A ring finger protein 113A -2.33378
SCN1A sodium channel, voltage gated, type I alpha subunit -2.32294
WDR62 WD repeat domain 62 -2.30833
PPARG peroxisome proliferator-activated receptor gamma -2.30597
CLIC1 chloride intracellular channel 1 -2.29337
AGGF1 angiogenic factor with G patch and FHA domains 1 -2.28146
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -2.22924
IQANK1 IQ motif and ankyrin repeat containing 1 -2.20554
PURB purine-rich element binding protein B -2.20324
CZIB CXXC motif containing zinc binding protein -2.20324
PYGO1 pygopus family PHD finger 1 -2.20324
FBXO5 F-box protein 5 -2.19448
SHOC2 soc-2 suppressor of clear homolog (C. elegans) -2.19429
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha -2.19
BOLA1 bolA family member 1 -2.16626
MFAP1 microfibrillar-associated protein 1 -2.16246
ATF6B activating transcription factor 6 beta -2.14175
TINAGL1 tubulointerstitial nephritis antigen-like 1 -2.13535
ELN elastin -2.13535
EHD1 EH-domain containing 1 -2.12448
THRAP3 thyroid hormone receptor associated protein 3 -2.11596
IRAK1 interleukin-1 receptor-associated kinase 1 -2.10499
FMO5 flavin containing monooxygenase 5 -2.10212
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 -2.10182
PRKCSH protein kinase C substrate 80K-H -2.09535
ZDHHC24 zinc finger, DHHC-type containing 24 -2.0779
THEM6 thioesterase superfamily member 6 -2.06749
SEC22C SEC22 vesicle trafficking protein homolog C (S. cerevisiae) -2.06649
HESX1 HESX homeobox 1 -2.06649
KIF23 kinesin family member 23 -2.05805
PKD1L3 polycystic kidney disease 1-like 3 -2.04414
SALL2 spalt-like transcription factor 2 -2.03577
POMP proteasome maturation protein -2.03577
EEF1AKMT3 EEF1A lysine methyltransferase 3 -2.03131
ECH1 enoyl CoA hydratase 1, peroxisomal -2.03131
SRR serine racemase -2.03131
MLH3 mutL homolog 3 -2.02951
ATF6 activating transcription factor 6 -2.01976
LEMD2 LEM domain containing 2 -2.01645
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -2.01503
ZNF786 zinc finger protein 786 -2.00227
TMEM37 transmembrane protein 37 -2.00227
SLC35F6 solute carrier family 35, member F6 -2.00227
SBSPON somatomedin B and thrombospondin, type 1 domain containing -2.00227