HEY1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description hes-related family bHLH transcription factor with YRPW motif 1|This gene encodes a nuclear protein belonging to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcriptional repressors. Expression of this gene is induced by the Notch and c-Jun signal transduction pathways. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 23462)
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Genes

342 genes differentially expressed following the HEY1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
DPRX divergent-paired related homeobox 2.77044
LTBP2 latent transforming growth factor beta binding protein 2 2.77044
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 2.77044
ITGA11 integrin, alpha 11 2.77044
HUS1B HUS1 checkpoint homolog b (S. pombe) 2.77044
H2AC21 H2A clustered histone 21 2.77044
SPDYE6 speedy/RINGO cell cycle regulator family member E6 2.77044
STYXL2 serine/threonine/tyrosine interacting like 2 2.77044
TMPRSS12 transmembrane (C-terminal) protease, serine 12 2.77044
LRRTM1 leucine rich repeat transmembrane neuronal 1 2.77044
FOXN4 forkhead box N4 2.77044
LOC114841035 uncharacterized LOC114841035 2.77044
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) 2.77044
ADGRG3 adhesion G protein-coupled receptor G3 2.77044
ANKRD34A ankyrin repeat domain 34A 2.77044
ANKRD61 ankyrin repeat domain 61 2.77044
LOC107985101 uncharacterized LOC107985101 2.77044
GJC2 gap junction protein, gamma 2, 47kDa 2.77044
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 2.77044
VCX3A variable charge, X-linked 3A 2.77044
TENT5D terminal nucleotidyltransferase 5D 2.77044
FRMPD2 FERM and PDZ domain containing 2 2.77044
CYP26C1 cytochrome P450, family 26, subfamily C, polypeptide 1 2.75274
FPR1 formyl peptide receptor 1 2.75274
GPR6 G protein-coupled receptor 6 2.75274
RS1 retinoschisin 1 2.75274
DMP1 dentin matrix acidic phosphoprotein 1 2.75274
PCDHB12 protocadherin beta 12 2.75274
VSX2 visual system homeobox 2 2.75274
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 2.75274
CALCA calcitonin-related polypeptide alpha 2.75274
DMBX1 diencephalon/mesencephalon homeobox 1 2.75274
TLR4 toll-like receptor 4 2.75274
ADGRG1 adhesion G protein-coupled receptor G1 2.75274
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 2.75274
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 2.75274
NOTUM notum pectinacetylesterase homolog (Drosophila) 2.75274
ARSF arylsulfatase F 2.75274
TUBB8 tubulin, beta 8 class VIII 2.75274
XCL1 chemokine (C motif) ligand 1 2.75274
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 2.75274
SSMEM1 serine-rich single-pass membrane protein 1 2.75274
TYRP1 tyrosinase-related protein 1 2.75274
SLC15A5 solute carrier family 15, member 5 2.75274
PTH2 parathyroid hormone 2 2.75274
IQCJ IQ motif containing J 2.75274
CCNB3 cyclin B3 2.75274
DNASE1L2 deoxyribonuclease I-like 2 2.75274
RCL1 RNA terminal phosphate cyclase-like 1 2.75274
WDR87 WD repeat domain 87 2.75274
GPR26 G protein-coupled receptor 26 2.75274
ASB15 ankyrin repeat and SOCS box containing 15 2.75274
CLEC12A C-type lectin domain family 12, member A 2.75274
KHDC3L KH domain containing 3-like, subcortical maternal complex member 2.75274
TBX3 T-box 3 2.75274
ZNF257 zinc finger protein 257 2.75274
CCN5 cellular communication network factor 5 2.75274
TENT5C terminal nucleotidyltransferase 5C 2.75274
ALPG alkaline phosphatase, germ cell 2.75274
MISP3 MISP family member 3 2.75274
SQOR sulfide quinone oxidoreductase 2.75274
NECTIN4 nectin cell adhesion molecule 4 2.75274
PHF24 PHD finger protein 24 2.75274
GBP4 guanylate binding protein 4 2.75274
G6PC1 glucose-6-phosphatase catalytic subunit 1 2.75274
CABCOCO1 ciliary associated calcium binding coiled-coil 1 2.75274
CIMIP7 ciliary microtubule inner protein 7 2.75274
TEX53 testis expressed 53 2.75274
PNMA6E PNMA family member 6E 2.75274
LY6S-AS1 LY6S antisense RNA 1 2.75274
SMIM43 small integral membrane protein 43 2.75274
CHCT1 CHD1 helical C-terminal domain containing 1 2.75274
ALKAL1 ALK and LTK ligand 1 2.75274
CCDC190 coiled-coil domain containing 190 2.75274
GBP1 guanylate binding protein 1, interferon-inducible 2.75274
GBP3 guanylate binding protein 3 2.75274
SRPK3 SRSF protein kinase 3 2.75274
GC group-specific component (vitamin D binding protein) 2.75274
GRAP GRB2-related adaptor protein 2.75274
DUSP8 dual specificity phosphatase 8 2.75274
LY6H lymphocyte antigen 6 complex, locus H 2.75274
BEST3 bestrophin 3 2.75274
PIWIL1 piwi-like RNA-mediated gene silencing 1 2.75274
C1QTNF1 C1q and tumor necrosis factor related protein 1 2.75274
ASB9 ankyrin repeat and SOCS box containing 9 2.75274
WDR64 WD repeat domain 64 2.75274
MCHR2 melanin-concentrating hormone receptor 2 2.75274
ROPN1L rhophilin associated tail protein 1-like 2.75274
RCVRN recoverin 2.75274
HTRA4 HtrA serine peptidase 4 2.75274
TMIGD1 transmembrane and immunoglobulin domain containing 1 2.75274
FRG2C FSHD region gene 2 family, member C 2.75274
SPRR2G small proline-rich protein 2G 2.75274
APOBEC3H apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H 2.75274
CIMIP2C ciliary microtubule inner protein 2C 2.75274
WNT8B wingless-type MMTV integration site family, member 8B 2.75274
KRT12 keratin 12, type I 2.75274
CETP cholesteryl ester transfer protein, plasma 2.75274
CRYBB3 crystallin, beta B3 2.75274
SLITRK1 SLIT and NTRK-like family, member 1 2.75274
LRRC31 leucine rich repeat containing 31 2.75274
CYSLTR1 cysteinyl leukotriene receptor 1 2.75274
GLOD5 glyoxalase domain containing 5 2.75274
LMAN1L lectin, mannose-binding, 1 like 2.75274
MC5R melanocortin 5 receptor 2.75274
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 2.75274
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1 2.75274
TEX35 testis expressed 35 2.75274
TTC36 tetratricopeptide repeat domain 36 2.75274
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 2.75274
CDC20B cell division cycle 20B 2.75274
ITPKA inositol-trisphosphate 3-kinase A 2.75274
OR56A4 olfactory receptor, family 56, subfamily A, member 4 2.75274
CIDEA cell death-inducing DFFA-like effector a 2.75274
DYTN dystrotelin 2.75274
LRRC32 leucine rich repeat containing 32 2.75274
SCN3A sodium channel, voltage gated, type III alpha subunit 2.75274
SH2D1B SH2 domain containing 1B 2.75274
ORM2 orosomucoid 2 2.75274
GP1BB glycoprotein Ib (platelet), beta polypeptide 2.75274
POTEJ POTE ankyrin domain family, member J 2.75274
POTEI POTE ankyrin domain family, member I 2.75274
RPA4 replication protein A4, 30kDa 2.75274
CNTF ciliary neurotrophic factor 2.75274
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 2.75274
RERGL RERG/RAS-like 2.75274
PPP1R3C protein phosphatase 1, regulatory subunit 3C 2.75274
CLEC4M C-type lectin domain family 4, member M 2.75274
VWC2L von Willebrand factor C domain containing protein 2-like 2.75274
KLK15 kallikrein-related peptidase 15 2.75274
NMUR2 neuromedin U receptor 2 2.75274
ETV7 ets variant 7 2.75274
BEGAIN brain-enriched guanylate kinase-associated 2.75274
TMC2 transmembrane channel-like 2 2.75274
SLC39A12 solute carrier family 39 (zinc transporter), member 12 2.75274
ZFP92 ZFP92 zinc finger protein 2.75274
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 2.75274
ASTL astacin-like metallo-endopeptidase (M12 family) 2.75274
NLRP14 NLR family, pyrin domain containing 14 2.75274
FAM135B family with sequence similarity 135, member B 2.75274
ATOH1 atonal homolog 1 (Drosophila) 2.75274
HEPHL1 hephaestin-like 1 2.75274
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 2.75274
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 2.75274
SNAI2 snail family zinc finger 2 2.75274
KIF12 kinesin family member 12 2.75274
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 2.75274
NLRP3 NLR family, pyrin domain containing 3 2.75274
IRX4 iroquois homeobox 4 2.75274
CLEC2B C-type lectin domain family 2, member B 2.75274
PCDHGA3 protocadherin gamma subfamily A, 3 2.75274
VWA7 von Willebrand factor A domain containing 7 2.75274
TMEM52B transmembrane protein 52B 2.75274
CD3D CD3d molecule, delta (CD3-TCR complex) 2.75274
FXYD3 FXYD domain containing ion transport regulator 3 2.75274
TP63 tumor protein p63 2.75274
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D 2.75274
MAGED4B melanoma antigen family D4B 2.75274
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 2.75274
ZNF521 zinc finger protein 521 2.71858
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2 2.71858
AHSP alpha hemoglobin stabilizing protein 2.71858
RPL13 ribosomal protein L13 2.71858
ARMCX6 armadillo repeat containing, X-linked 6 2.71858
ADAM12 ADAM metallopeptidase domain 12 2.44557
LAMP3 lysosomal-associated membrane protein 3 2.44557
ZNF684 zinc finger protein 684 2.439
TEX19 testis expressed 19 2.42183
PRR4 proline rich 4 (lacrimal) 2.41277
KLHL36 kelch-like family member 36 2.36616
CWC22 CWC22 spliceosome-associated protein 2.35895
LRRC70 leucine rich repeat containing 70 2.35334
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4 2.34494
DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2 2.34334
SLC39A5 solute carrier family 39 (zinc transporter), member 5 2.33434
DCUN1D5 DCN1, defective in cullin neddylation 1, domain containing 5 2.32914
NUP88 nucleoporin 88kDa 2.32914
RND3 Rho family GTPase 3 2.3078
CCDC74A coiled-coil domain containing 74A 2.30167
EOLA2 endothelium and lymphocyte associated ASCH domain 2 2.28846
LPCAT4 lysophosphatidylcholine acyltransferase 4 2.28218
UBE2K ubiquitin-conjugating enzyme E2K 2.28051
NDUFAF1 NADH dehydrogenase (ubiquinone) complex I, assembly factor 1 2.26568
DPEP3 dipeptidase 3 2.25778
ACAP1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 2.25613
MBOAT1 membrane bound O-acyltransferase domain containing 1 2.23012
CLPTM1L CLPTM1-like 2.2158
PLAAT1 phospholipase A and acyltransferase 1 2.21486
SNRNP48 small nuclear ribonucleoprotein 48kDa (U11/U12) 2.20967
TMEM184C transmembrane protein 184C 2.20863
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 2.1995
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 2.15957
ERF Ets2 repressor factor 2.15887
ASB1 ankyrin repeat and SOCS box containing 1 2.15883
CCNI cyclin I 2.14875
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 2.13245
TUT7 terminal uridylyl transferase 7 2.12367
CD2AP CD2-associated protein 2.12367
TYW1 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) 2.12152
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae) 2.11408
COPS7A COP9 signalosome subunit 7A 2.11408
ADAT1 adenosine deaminase, tRNA-specific 1 2.10755
SLF1 SMC5-SMC6 complex localization factor 1 2.09429
CCDC6 coiled-coil domain containing 6 2.08935
NPC1 Niemann-Pick disease, type C1 2.08372
HOMER2 homer scaffolding protein 2 2.07407
CLTC clathrin, heavy chain (Hc) 2.07173
ECSIT ECSIT signalling integrator 2.05282
SNRPN small nuclear ribonucleoprotein polypeptide N 2.04187
WRNIP1 Werner helicase interacting protein 1 2.03459
DSC3 desmocollin 3 2.00957
PPA2 pyrophosphatase (inorganic) 2 2.00933

decreased expression

Symbol Name Standardized Value
ADAM21 ADAM metallopeptidase domain 21 -2.77044
SH2D4B SH2 domain containing 4B -2.77044
NBPF14 neuroblastoma breakpoint family, member 14 -2.77044
CBX4 chromobox homolog 4 -2.77044
APOA1 apolipoprotein A-I -2.77044
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial -2.77044
CARMIL3 capping protein regulator and myosin 1 linker 3 -2.77044
MPZL2 myelin protein zero-like 2 -2.77044
NCBP2 nuclear cap binding protein subunit 2, 20kDa -2.77044
GID4 GID complex subunit 4 -2.75274
ONECUT2 one cut homeobox 2 -2.75274
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa -2.75274
ZNF10 zinc finger protein 10 -2.75274
CCS copper chaperone for superoxide dismutase -2.75274
ATRX alpha thalassemia/mental retardation syndrome X-linked -2.75274
IKZF1 IKAROS family zinc finger 1 (Ikaros) -2.75274
SYNPO2L synaptopodin 2-like -2.75274
H2AC12 H2A clustered histone 12 -2.75274
PSRC1 proline/serine-rich coiled-coil 1 -2.75274
OVCH2 ovochymase 2 (gene/pseudogene) -2.71858
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 -2.71858
SLC37A2 solute carrier family 37 (glucose-6-phosphate transporter), member 2 -2.71858
LHX1 LIM homeobox 1 -2.71858
CBX8 chromobox homolog 8 -2.71858
NWD1 NACHT and WD repeat domain containing 1 -2.71858
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 -2.71858
C2ORF80 chromosome 2 open reading frame 80 -2.71858
TRIM72 tripartite motif containing 72, E3 ubiquitin protein ligase -2.71858
ACP7 acid phosphatase 7, tartrate resistant (putative) -2.71858
MATCAP2 microtubule associated tyrosine carboxypeptidase 2 -2.71858
EPOP elongin BC and polycomb repressive complex 2 associated protein -2.71858
STRIT1 small transmembrane regulator of ion transport 1 -2.71858
GATA3 GATA binding protein 3 -2.71858
WDR93 WD repeat domain 93 -2.71858
FAM131C family with sequence similarity 131, member C -2.71858
PGLYRP1 peptidoglycan recognition protein 1 -2.71858
TMEM179 transmembrane protein 179 -2.71858
LEF1 lymphoid enhancer-binding factor 1 -2.71858
OR2A14 olfactory receptor, family 2, subfamily A, member 14 -2.71858
SUMO4 small ubiquitin-like modifier 4 -2.71858
CATSPERD catsper channel auxiliary subunit delta -2.71858
C1ORF202 chromosome 1 open reading frame 202 -2.71858
DNAJB7 DnaJ (Hsp40) homolog, subfamily B, member 7 -2.71858
TTC29 tetratricopeptide repeat domain 29 -2.71858
C6ORF163 chromosome 6 open reading frame 163 -2.71858
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 -2.71858
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 -2.71858
DRD3 dopamine receptor D3 -2.71858
EGR2 early growth response 2 -2.71858
WBP2NL WBP2 N-terminal like -2.71858
LYPD3 LY6/PLAUR domain containing 3 -2.71858
GNG8 guanine nucleotide binding protein (G protein), gamma 8 -2.71858
NBPF20 neuroblastoma breakpoint family, member 20 -2.71858
AARS1 alanyl-tRNA synthetase 1 -2.65286
MMD monocyte to macrophage differentiation-associated -2.646
RAMAC RNA guanine-7 methyltransferase activating subunit -2.60655
CCDC196 coiled-coil domain containing 196 -2.5966
DNASE2 deoxyribonuclease II, lysosomal -2.57393
FLT4 fms-related tyrosine kinase 4 -2.56399
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2 -2.56399
FLNC filamin C, gamma -2.56399
ZNF597 zinc finger protein 597 -2.56399
ZMAT4 zinc finger, matrin-type 4 -2.55923
FGD5 FYVE, RhoGEF and PH domain containing 5 -2.49683
CTTNBP2NL CTTNBP2 N-terminal like -2.48967
EMC8 ER membrane protein complex subunit 8 -2.46285
TBC1D15 TBC1 domain family, member 15 -2.44255
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa -2.44245
CNTNAP5 contactin associated protein-like 5 -2.36049
HSH2D hematopoietic SH2 domain containing -2.36049
ZNF433 zinc finger protein 433 -2.34224
CCNP cyclin P -2.33811
AXDND1 axonemal dynein light chain domain containing 1 -2.33811
CIITA class II, major histocompatibility complex, transactivator -2.33811
KCNK12 potassium channel, two pore domain subfamily K, member 12 -2.33811
MPZ myelin protein zero -2.33666
OTUD4 OTU deubiquitinase 4 -2.33666
SLC25A46 solute carrier family 25, member 46 -2.33666
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -2.31487
SAMD3 sterile alpha motif domain containing 3 -2.30931
ZNF592 zinc finger protein 592 -2.3078
LDOC1 leucine zipper, down-regulated in cancer 1 -2.28846
FBXL5 F-box and leucine-rich repeat protein 5 -2.25613
SIN3A SIN3 transcription regulator family member A -2.23757
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit -2.23757
FASN fatty acid synthase -2.23561
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2 -2.21861
LHFPL6 LHFPL tetraspan subfamily member 6 -2.21225
GUF1 GUF1 GTPase homolog (S. cerevisiae) -2.21101
B3GNT7 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 -2.20967
OSGIN2 oxidative stress induced growth inhibitor family member 2 -2.20967
ARFRP1 ADP-ribosylation factor related protein 1 -2.20967
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -2.19572
NXT1 nuclear transport factor 2-like export factor 1 -2.19243
OXNAD1 oxidoreductase NAD-binding domain containing 1 -2.18896
TRAPPC4 trafficking protein particle complex 4 -2.18098
CMTM1 CKLF-like MARVEL transmembrane domain containing 1 -2.15997
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 -2.15997
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled -2.15997
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila) -2.14728
TIMP2 TIMP metallopeptidase inhibitor 2 -2.13966
P2RY14 purinergic receptor P2Y, G-protein coupled, 14 -2.12878
POMT2 protein-O-mannosyltransferase 2 -2.12367
FKBP7 FK506 binding protein 7 -2.12152
TMEM183A transmembrane protein 183A -2.11408
ARFGAP2 ADP-ribosylation factor GTPase activating protein 2 -2.11408
ATG2B autophagy related 2B -2.11408
NXN nucleoredoxin -2.1133
RDH12 retinol dehydrogenase 12 (all-trans/9-cis/11-cis) -2.10545
LARP1B La ribonucleoprotein domain family, member 1B -2.09715
GEMIN8 gem (nuclear organelle) associated protein 8 -2.09627
RGS17 regulator of G-protein signaling 17 -2.09621
TUB tubby bipartite transcription factor -2.09621
TMSB4X thymosin beta 4, X-linked -2.09621
MARCHF6 membrane associated ring-CH-type finger 6 -2.09429
SEC61G Sec61 gamma subunit -2.09322
MESP2 mesoderm posterior basic helix-loop-helix transcription factor 2 -2.08935
PYGM phosphorylase, glycogen, muscle -2.08935
DOC2B double C2-like domains, beta -2.08935
PADI2 peptidyl arginine deiminase, type II -2.08935
MECOM MDS1 and EVI1 complex locus -2.08935
NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 -2.07541
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 -2.05041
RBBP4 retinoblastoma binding protein 4 -2.05041
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) -2.05041
REEP3 receptor accessory protein 3 -2.04253
PPP6R2 protein phosphatase 6, regulatory subunit 2 -2.0196
TIPE3 TNF alpha induced protein 8 like 3 -2.0196
FBXL3 F-box and leucine-rich repeat protein 3 -2.0196
ACACB acetyl-CoA carboxylase beta -2.01564