HEY2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description hes-related family bHLH transcription factor with YRPW motif 2|This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 23493)
Similar Terms
Downloads & Tools

Genes

322 genes differentially expressed following the HEY2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
IL6 interleukin 6 3.26964
PCDHB7 protocadherin beta 7 3.26964
PCDHB9 protocadherin beta 9 3.26964
DGAT2L6 diacylglycerol O-acyltransferase 2-like 6 3.26964
TM4SF20 transmembrane 4 L six family member 20 3.26964
GJA10 gap junction protein, alpha 10, 62kDa 3.26964
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 3.26964
PAX9 paired box 9 3.26964
FOLR3 folate receptor 3 (gamma) 3.26964
GDNF glial cell derived neurotrophic factor 3.26964
SIGLECL1 SIGLEC family like 1 3.26964
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 3.26964
CFHR3 complement factor H-related 3 3.26964
LRIT3 leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 3.26964
CATSPER3 cation channel, sperm associated 3 3.26964
OLAH oleoyl-ACP hydrolase 3.26964
C1ORF87 chromosome 1 open reading frame 87 3.26964
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 3.26964
TMEM229A transmembrane protein 229A 3.26964
SLC22A14 solute carrier family 22, member 14 3.26964
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 3.26964
TAS2R9 taste receptor, type 2, member 9 3.26964
ASB14 ankyrin repeat and SOCS box containing 14 3.26964
OLFM4 olfactomedin 4 3.26964
MUC20 mucin 20, cell surface associated 3.26964
OXT oxytocin/neurophysin I prepropeptide 3.26964
ATOH7 atonal homolog 7 (Drosophila) 3.26964
CORO6 coronin 6 3.26964
TMC8 transmembrane channel-like 8 3.26964
RNF39 ring finger protein 39 3.26964
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 3.26964
NWD2 NACHT and WD repeat domain containing 2 3.26964
SPAG6 sperm associated antigen 6 3.26964
SETSIP SET-like protein 3.26964
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 3.26964
LRRC63 leucine rich repeat containing 63 3.26964
LYNX1 Ly6/neurotoxin 1 3.26964
REN renin 3.26964
SLC9C2 solute carrier family 9, member C2 (putative) 3.26964
C1ORF146 chromosome 1 open reading frame 146 3.26964
SPNS2 spinster homolog 2 (Drosophila) 3.26964
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 3.26964
PRSS36 protease, serine, 36 3.26964
LACTBL1 lactamase, beta-like 1 3.26964
TCP11 t-complex 11, testis-specific 3.26964
SPAG8 sperm associated antigen 8 3.26964
TMEM276-ZFTRAF1 TMEM276-ZFTRAF1 readthrough 3.26964
H2BC3 H2B clustered histone 3 3.26964
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 3.26964
CFAP157 cilia and flagella associated protein 157 3.26964
TEKTIP1 tektin bundle interacting protein 1 3.26964
CLXN calaxin 3.26964
ANKRD40CL ANKRD40 C-terminal like 3.26964
ANGPTL8 angiopoietin like 8 3.26964
ERVW-1 endogenous retrovirus group W, member 1 3.26964
GBP6 guanylate binding protein family, member 6 3.26964
CLEC20A C-type lectin domain containing 20A 3.26964
MYMK myomaker, myoblast fusion factor 3.26964
TMEM238L transmembrane protein 238 like 3.26964
COXFA4L3 cytochrome c oxidase associated subunit FA4L3 3.26964
CATSPERH catsper channel auxiliary subunit eta 3.26964
SPMAP2L sperm microtubule associated protein 2 like 3.26964
HSFX3 heat shock transcription factor family, X-linked member 3 3.26964
TBC1D3I TBC1 domain family member 3I 3.26964
ANKRD42-DT ANKRD42 divergent transcript 3.26964
REELD1 reeler domain containing 1 3.26964
ZNF593OS ZNF593 opposite strand 3.26964
H4C12 H4 clustered histone 12 3.26964
ROPN1B rhophilin associated tail protein 1B 3.26964
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 3.26964
GATA1 GATA binding protein 1 (globin transcription factor 1) 3.26964
KL klotho 3.26964
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 3.26964
STARD6 StAR-related lipid transfer (START) domain containing 6 3.26964
BLNK B-cell linker 3.26964
C7 complement component 7 3.26964
SBSN suprabasin 3.26964
SLC45A2 solute carrier family 45, member 2 3.26964
TLR1 toll-like receptor 1 3.26964
HTR3C 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic 3.26964
TBX10 T-box 10 3.26964
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 3.26964
TAS2R60 taste receptor, type 2, member 60 3.26964
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 3.26964
MYH8 myosin, heavy chain 8, skeletal muscle, perinatal 3.26964
BNC1 basonuclin 1 3.26964
TMIGD1 transmembrane and immunoglobulin domain containing 1 3.26964
TMPRSS7 transmembrane protease, serine 7 3.26964
TMEM40 transmembrane protein 40 3.26964
GC group-specific component (vitamin D binding protein) 3.26964
MAGIX MAGI family member, X-linked 3.26964
OVOL3 ovo-like zinc finger 3 3.26964
UTS2B urotensin 2B 3.26964
ASTL astacin-like metallo-endopeptidase (M12 family) 3.26964
FBXO47 F-box protein 47 3.26964
OPTC opticin 3.26964
NPBWR1 neuropeptides B/W receptor 1 3.26964
NGF nerve growth factor (beta polypeptide) 3.26964
IL26 interleukin 26 3.26964
CATIP ciliogenesis associated TTC17 interacting protein 3.26964
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 3.26964
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 3.26964
UNCX UNC homeobox 3.26964
ZMYND12 zinc finger, MYND-type containing 12 3.26964
GBX2 gastrulation brain homeobox 2 3.26964
OR13A1 olfactory receptor, family 13, subfamily A, member 1 3.26964
TTC9B tetratricopeptide repeat domain 9B 3.26964
DAW1 dynein assembly factor with WDR repeat domains 1 3.26964
TIGIT T cell immunoreceptor with Ig and ITIM domains 3.26964
C8G complement component 8, gamma polypeptide 3.26964
CTAGE4 CTAGE family, member 4 3.26964
KCNS2 potassium voltage-gated channel, modifier subfamily S, member 2 3.26964
PTF1A pancreas specific transcription factor, 1a 3.26964
SLCO2B1 solute carrier organic anion transporter family, member 2B1 3.26964
TBX1 T-box 1 3.26964
ARL13A ADP-ribosylation factor-like 13A 3.26964
ADAM7 ADAM metallopeptidase domain 7 3.26964
CRYBA1 crystallin, beta A1 3.26964
CALHM1 calcium homeostasis modulator 1 3.26964
A3GALT2 alpha 1,3-galactosyltransferase 2 3.26964
NACA2 nascent polypeptide-associated complex alpha subunit 2 3.26964
VAX2 ventral anterior homeobox 2 3.26964
ANKRD55 ankyrin repeat domain 55 3.26964
FOXE3 forkhead box E3 3.26964
NUPR1 nuclear protein, transcriptional regulator, 1 3.26964
EOMES eomesodermin 3.26964
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) 3.26964
PADI6 peptidyl arginine deiminase, type VI 3.26964
MYOZ2 myozenin 2 3.26964
LOXL4 lysyl oxidase-like 4 3.26964
ZNF619 zinc finger protein 619 3.26964
PRR23A proline rich 23A 3.26964
PASD1 PAS domain containing 1 3.26964
GHRH growth hormone releasing hormone 3.26964
GJC2 gap junction protein, gamma 2, 47kDa 3.26964
TEKT5 tektin 5 3.26964
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 3.26964
ZCCHC12 zinc finger, CCHC domain containing 12 3.26964
BTBD16 BTB (POZ) domain containing 16 3.26964
FGF6 fibroblast growth factor 6 3.26964
SHOX short stature homeobox 3.26964
DMRT1 doublesex and mab-3 related transcription factor 1 3.26964
TMPRSS13 transmembrane protease, serine 13 3.26964
NPY2R neuropeptide Y receptor Y2 3.26964
PLGLB2 plasminogen-like B2 3.26964
AMER2 APC membrane recruitment protein 2 3.26964
IFITM5 interferon induced transmembrane protein 5 3.26964
FGF10 fibroblast growth factor 10 3.26964
MUC16 mucin 16, cell surface associated 3.26964
CLCA1 chloride channel accessory 1 3.26964
DRC7 dynein regulatory complex subunit 7 3.26964
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1 3.26964
ALLC allantoicase 3.26964
C4BPA complement component 4 binding protein, alpha 3.26964
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 3.26964
ALOXE3 arachidonate lipoxygenase 3 3.26964
TSKS testis-specific serine kinase substrate 3.26964
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 3.22802
SRSF11 serine/arginine-rich splicing factor 11 3.13061
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 3.12551
POMP proteasome maturation protein 3.03789
TBC1D3L TBC1 domain family, member 3L 2.97063
ZNG1E Zn regulated GTPase metalloprotein activator 1E 2.94771
MAP1A microtubule-associated protein 1A 2.89557
SEPTIN2 septin 2 2.85577
CANX calnexin 2.81342
RNF181 ring finger protein 181 2.77011
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 2.70318
RRM2B ribonucleotide reductase M2 B (TP53 inducible) 2.6961
TTC26 tetratricopeptide repeat domain 26 2.62849
PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein 2.55238
USP20 ubiquitin specific peptidase 20 2.49526
FBXO2 F-box protein 2 2.49418
PCBD2 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 2.46288
MCHR1 melanin-concentrating hormone receptor 1 2.44144
CALCA calcitonin-related polypeptide alpha 2.41692
B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 2.40733
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) 2.39806
RND2 Rho family GTPase 2 2.37866
MAPK15 mitogen-activated protein kinase 15 2.37604
COL11A2 collagen, type XI, alpha 2 2.37604
RRP7A ribosomal RNA processing 7 homolog A (S. cerevisiae) 2.33527
METTL8 methyltransferase like 8 2.30583
BBIP1 BBSome interacting protein 1 2.29858
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 2.28536
STXBP5 syntaxin binding protein 5 (tomosyn) 2.25413
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2 2.18648
CHP2 calcineurin-like EF-hand protein 2 2.18648
EDEM2 ER degradation enhancer, mannosidase alpha-like 2 2.1857
DCLK2 doublecortin-like kinase 2 2.17074
SNX31 sorting nexin 31 2.11433
NSMCE3 NSE3 homolog, SMC5-SMC6 complex component 2.11433
C1ORF159 chromosome 1 open reading frame 159 2.09377
IFT140 intraflagellar transport 140 2.09377
TMEM63A transmembrane protein 63A 2.08978
CHD7 chromodomain helicase DNA binding protein 7 2.08978
LIN7A lin-7 homolog A (C. elegans) 2.07341
SLC35D2 solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2 2.07248
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase 2.05205
RAVER2 ribonucleoprotein, PTB-binding 2 2.04894
SPATA7 spermatogenesis associated 7 2.04707
PTBP2 polypyrimidine tract binding protein 2 2.04663
PGPEP1 pyroglutamyl-peptidase I 2.04304
BGLAP bone gamma-carboxyglutamate (gla) protein 2.03912
PTGIS prostaglandin I2 (prostacyclin) synthase 2.03591
CATSPERQ catsper channel auxiliary subunit theta 2.03487
C5 complement component 5 2.03487
CDCA4 cell division cycle associated 4 2.03429
ATP11C ATPase, class VI, type 11C 2.03332
FLNA filamin A, alpha 2.03332
ERVK3-1 endogenous retrovirus group K3, member 1 2.03144
MRPL47 mitochondrial ribosomal protein L47 2.03115
PMPCA peptidase (mitochondrial processing) alpha 2.0262
LIF leukemia inhibitory factor 2.01651
IGF1 insulin-like growth factor 1 (somatomedin C) 2.01651
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13 2.01033
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 2.0008

decreased expression

Symbol Name Standardized Value
ANXA4 annexin A4 -3.26964
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -3.26964
SH2D4B SH2 domain containing 4B -3.26964
ZNF488 zinc finger protein 488 -3.26964
PCDHAC1 protocadherin alpha subfamily C, 1 -3.26964
C1QTNF7 C1q and tumor necrosis factor related protein 7 -3.26964
ANKRD31 ankyrin repeat domain 31 -3.26964
ICAM1 intercellular adhesion molecule 1 -3.26964
SEPHS1 selenophosphate synthetase 1 -3.26964
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2 -3.26964
CER1 cerberus 1, DAN family BMP antagonist -3.26964
QRFPR pyroglutamylated RFamide peptide receptor -3.13982
RTCB RNA 2',3'-cyclic phosphate and 5'-OH ligase -3.1391
REM2 RAS (RAD and GEM)-like GTP binding 2 -2.96064
NMUR1 neuromedin U receptor 1 -2.96064
TWIST1 twist family bHLH transcription factor 1 -2.96064
CCDC92 coiled-coil domain containing 92 -2.96064
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough -2.96064
OTX1 orthodenticle homeobox 1 -2.96064
RAB36 RAB36, member RAS oncogene family -2.96064
UBE2L5 ubiquitin conjugating enzyme E2 L5 -2.96064
CAPS calcyphosine -2.96064
DPPA3 developmental pluripotency associated 3 -2.96064
TTLL9 tubulin tyrosine ligase-like family member 9 -2.96064
PNMA5 paraneoplastic Ma antigen family member 5 -2.96064
MRPL53 mitochondrial ribosomal protein L53 -2.96064
ACTL10 actin-like 10 -2.96064
PCDHA5 protocadherin alpha 5 -2.96064
SLC5A11 solute carrier family 5 (sodium/inositol cotransporter), member 11 -2.96064
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -2.96064
CA7 carbonic anhydrase VII -2.96064
CPB2 carboxypeptidase B2 (plasma) -2.96064
INSYN1 inhibitory synaptic factor 1 -2.96064
BTNL8 butyrophilin-like 8 -2.96064
PIH1D2 PIH1 domain containing 2 -2.96064
FOSB FBJ murine osteosarcoma viral oncogene homolog B -2.96064
LAMB3 laminin, beta 3 -2.96064
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 -2.96064
FZD9 frizzled class receptor 9 -2.96064
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A -2.96064
FSAF1 40S small subunit processome assembly factor 1 -2.96064
SAMD5 sterile alpha motif domain containing 5 -2.96064
SPAG5 sperm associated antigen 5 -2.81772
PF4 platelet factor 4 -2.80248
ARHGAP35 Rho GTPase activating protein 35 -2.71781
FSBP fibrinogen silencer binding protein -2.62849
C6ORF141 chromosome 6 open reading frame 141 -2.50978
PRPF3 pre-mRNA processing factor 3 -2.47837
TMEM154 transmembrane protein 154 -2.46857
CDK5RAP1 CDK5 regulatory subunit associated protein 1 -2.46288
SFRP4 secreted frizzled-related protein 4 -2.46288
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 -2.46288
PADI3 peptidyl arginine deiminase, type III -2.46288
KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4 -2.46288
VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae) -2.43797
ATXN1 ataxin 1 -2.41692
LMAN1 lectin, mannose-binding, 1 -2.41148
TRIM69 tripartite motif containing 69 -2.39487
IL23A interleukin 23, alpha subunit p19 -2.39015
ZC2HC1A zinc finger, C2HC-type containing 1A -2.38873
ASIP agouti signaling protein -2.37988
MAST3 microtubule associated serine/threonine kinase 3 -2.37866
CD200 CD200 molecule -2.35925
PTPRN protein tyrosine phosphatase, receptor type, N -2.30114
NEURL4 neuralized E3 ubiquitin protein ligase 4 -2.29728
H2BC15 H2B clustered histone 15 -2.28536
BRSK1 BR serine/threonine kinase 1 -2.2641
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta -2.25727
TTC38 tetratricopeptide repeat domain 38 -2.24771
LIFR leukemia inhibitory factor receptor alpha -2.24302
CD7 CD7 molecule -2.23735
MORN1 MORN repeat containing 1 -2.21849
PRTFDC1 phosphoribosyl transferase domain containing 1 -2.21261
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta -2.20417
ENO3 enolase 3 (beta, muscle) -2.18648
C6ORF132 chromosome 6 open reading frame 132 -2.18648
GARIN1B golgi associated RAB2 interactor 1B -2.17334
ZNF99 zinc finger protein 99 -2.16015
ZNF266 zinc finger protein 266 -2.16015
PYM1 PYM homolog 1, exon junction complex associated factor -2.15706
EMC10 ER membrane protein complex subunit 10 -2.15706
NDRG3 NDRG family member 3 -2.15136
GUCY2C guanylate cyclase 2C -2.13768
NEGR1 neuronal growth regulator 1 -2.12735
UBE2S ubiquitin-conjugating enzyme E2S -2.11935
KCNJ13 potassium channel, inwardly rectifying subfamily J, member 13 -2.11935
SAMD4A sterile alpha motif domain containing 4A -2.11433
BROX BRO1 domain and CAAX motif containing -2.11433
TUSC3 tumor suppressor candidate 3 -2.11433
SH3BGRL2 SH3 domain binding glutamate-rich protein like 2 -2.10862
AHCYL2 adenosylhomocysteinase-like 2 -2.10862
SYT1 synaptotagmin I -2.10862
GALR1 galanin receptor 1 -2.10862
ZCRB1 zinc finger CCHC-type and RNA binding motif 1 -2.08978
KRIT1 KRIT1, ankyrin repeat containing -2.05287
SLC8A3 solute carrier family 8 (sodium/calcium exchanger), member 3 -2.04663
COBLL1 cordon-bleu WH2 repeat protein-like 1 -2.04663
CLCF1 cardiotrophin-like cytokine factor 1 -2.04663
HJV hemojuvelin BMP co-receptor -2.04663
NCKAP1 NCK-associated protein 1 -2.04663
CITED4 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 -2.03912
RTRAF RNA transcription, translation and transport factor -2.03487
ZFTRAF1 zinc finger TRAF-type containing 1 -2.01241
ZNF438 zinc finger protein 438 -2.0103
DPEP3 dipeptidase 3 -2.00528