HFE Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description hemochromatosis|The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene. At least nine alternatively spliced variants have been described for this gene. Additional variants have been found but their full-length nature has not been determined. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3077)
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Genes

260 genes differentially expressed following the HFE gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ZNF431 zinc finger protein 431 2.00487
PLIN1 perilipin 1 2.00487
CABP4 calcium binding protein 4 2.00487
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 2.00487
CD160 CD160 molecule 2.00487
PDIA2 protein disulfide isomerase family A, member 2 2.00487
ELMO3 engulfment and cell motility 3 2.00487
PSD3 pleckstrin and Sec7 domain containing 3 2.00487
AZGP1 alpha-2-glycoprotein 1, zinc-binding 2.00487
OR10A2 olfactory receptor, family 10, subfamily A, member 2 2.00487
APLN apelin 2.00487
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 2.00487
SLC46A3 solute carrier family 46, member 3 2.00487
RXFP3 relaxin/insulin-like family peptide receptor 3 2.00487
NKX3-1 NK3 homeobox 1 2.00487
RRP36 ribosomal RNA processing 36 homolog (S. cerevisiae) 2.00487
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 2.00487
PHRF1 PHD and ring finger domains 1 2.00487
GJA5 gap junction protein, alpha 5, 40kDa 2.00487
ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 2.00487
CD99 CD99 molecule 2.00487
FAM167B family with sequence similarity 167, member B 2.00487
TNRC6C trinucleotide repeat containing 6C 2.00487
ZNF492 zinc finger protein 492 2.00487
WT1 Wilms tumor 1 2.00487
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 2.00487
GUCY2F guanylate cyclase 2F, retinal 2.00487
GUCY2D guanylate cyclase 2D, membrane (retina-specific) 2.00487
FAM120AOS family with sequence similarity 120A opposite strand 2.00487
UBA7 ubiquitin-like modifier activating enzyme 7 2.00487
TTLL8 tubulin tyrosine ligase-like family member 8 2.00487
OCSTAMP osteoclast stimulatory transmembrane protein 2.00487
DLX4 distal-less homeobox 4 2.00487
CX3CR1 chemokine (C-X3-C motif) receptor 1 2.00487
ZNF343 zinc finger protein 343 2.00487
TMEM121 transmembrane protein 121 2.00487
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 2.00487
ADAMTSL2 ADAMTS-like 2 2.00487
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 2.00487
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 2.00487
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 2.00487
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 2.00487
SLC15A4 solute carrier family 15 (oligopeptide transporter), member 4 2.00487
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 2.00487
GPR21 G protein-coupled receptor 21 2.00487
GIMAP4 GTPase, IMAP family member 4 2.00487
VAMP4 vesicle-associated membrane protein 4 2.00487
HCRTR2 hypocretin (orexin) receptor 2 2.00487
THRSP thyroid hormone responsive 2.00487
MMP28 matrix metallopeptidase 28 2.00487
OR56B2 olfactory receptor family 56 subfamily B member 2 2.00487
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 2.00487
CES4A carboxylesterase 4A 2.00487
YIPF7 Yip1 domain family, member 7 2.00487
CLDN16 claudin 16 2.00487
GPR33 G protein-coupled receptor 33 (gene/pseudogene) 2.00487
VN1R1 vomeronasal 1 receptor 1 2.00487
ZG16 zymogen granule protein 16 2.00487
RHCG Rh family, C glycoprotein 2.00487
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 2.00487
FMO1 flavin containing monooxygenase 1 2.00487
SPART spartin 2.00487
H3-5 H3.5 histone 2.00487
PMIS2 PMIS2 transmembrane protein 2.00487
CIMIP4 ciliary microtubule inner protein 4 2.00487
AGA-DT AGA divergent transcript 2.00487
C20ORF204 chromosome 20 open reading frame 204 2.00487
TEX13D TEX13 family member D 2.00487
MEIOSIN meiosis initiator 2.00487
ITPRID1 ITPR interacting domain containing 1 2.00487
FLACC1 flagellum associated containing coiled-coil domains 1 2.00487
JAML junction adhesion molecule like 2.00487
DELE1 DAP3 binding cell death enhancer 1 2.00487
GPRASP3 G protein-coupled receptor associated sorting protein family member 3 2.00487
SLC2A7 solute carrier family 2 (facilitated glucose transporter), member 7 2.00487
TREX2 three prime repair exonuclease 2 2.00487
MSX2 msh homeobox 2 2.00487
CD79A CD79a molecule, immunoglobulin-associated alpha 2.00487
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 2.00487
FYN FYN proto-oncogene, Src family tyrosine kinase 2.00487
OR8D4 olfactory receptor, family 8, subfamily D, member 4 2.00487
BBS5 Bardet-Biedl syndrome 5 2.00487
NXPE1 neurexophilin and PC-esterase domain family, member 1 2.00487
MAGEB1 melanoma antigen family B1 2.00487
DMP1 dentin matrix acidic phosphoprotein 1 2.00487
PCDHA8 protocadherin alpha 8 2.00487
IL4 interleukin 4 2.00487
ZNF777 zinc finger protein 777 2.00487
TBX3 T-box 3 2.00487
TTR transthyretin 2.00487
DOK2 docking protein 2, 56kDa 2.00487
LY6K lymphocyte antigen 6 complex, locus K 2.00487
FAM228A family with sequence similarity 228, member A 2.00487
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like 2.00487
GPHN gephyrin 2.00487
CNTN6 contactin 6 2.00487
HNF1A HNF1 homeobox A 2.00487
LTF lactotransferrin 2.00487
OPN5 opsin 5 2.00487
FEZ1 fasciculation and elongation protein zeta 1 (zygin I) 2.00487
FAM216B family with sequence similarity 216, member B 2.00487
TIGIT T cell immunoreceptor with Ig and ITIM domains 2.00487
HHATL hedgehog acyltransferase-like 2.00487
CRYBB2 crystallin, beta B2 2.00487
DCLK2 doublecortin-like kinase 2 2.00487
KLF5 Kruppel-like factor 5 (intestinal) 2.00487
EMX2 empty spiracles homeobox 2 2.00487
SERINC4 serine incorporator 4 2.00487
SPATA6 spermatogenesis associated 6 2.00487
APOC2 apolipoprotein C-II 2.00487
SNX31 sorting nexin 31 2.00487
C2CD4D C2 calcium-dependent domain containing 4D 2.00487
RETNLB resistin like beta 2.00487
RSPH10B2 radial spoke head 10 homolog B2 (Chlamydomonas) 2.00487
SYNE3 spectrin repeat containing, nuclear envelope family member 3 2.00487
PCDHGB1 protocadherin gamma subfamily B, 1 2.00487
LRRC4C leucine rich repeat containing 4C 2.00487
CCL27 chemokine (C-C motif) ligand 27 2.00487
ARHGAP23 Rho GTPase activating protein 23 2.00487
OR56A3 olfactory receptor, family 56, subfamily A, member 3 2.00487
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 2.00487
LCNL1 lipocalin-like 1 2.00487
CERKL ceramide kinase-like 2.00487
SIT1 signaling threshold regulating transmembrane adaptor 1 2.00487
HCRT hypocretin (orexin) neuropeptide precursor 2.00487
TCP10L t-complex 10-like 2.00487
VWA3A von Willebrand factor A domain containing 3A 2.00487
CHIC2 cysteine-rich hydrophobic domain 2 2.00487
DCN decorin 2.00487
CLEC1A C-type lectin domain family 1, member A 2.00487
LAMB4 laminin, beta 4 2.00487
OPALIN oligodendrocytic myelin paranodal and inner loop protein 2.00487
BHLHA15 basic helix-loop-helix family, member a15 2.00487
VMO1 vitelline membrane outer layer 1 homolog (chicken) 2.00487
GOLGA8O golgin A8 family, member O 2.00487
TDG thymine-DNA glycosylase 2.00487
MZB1 marginal zone B and B1 cell-specific protein 2.00487
PGR progesterone receptor 2.00487
FANCA Fanconi anemia, complementation group A 2.00487
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 2.00487
THNSL2 threonine synthase-like 2 (S. cerevisiae) 2.00487
SORCS2 sortilin-related VPS10 domain containing receptor 2 2.00487
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 2.00487
IGF2 insulin-like growth factor 2 2.00487
SVOP SV2 related protein homolog (rat) 2.00487
SAMD7 sterile alpha motif domain containing 7 2.00487
UTS2B urotensin 2B 2.00487
LRP4 low density lipoprotein receptor-related protein 4 2.00487
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 2.00487
DMRT2 doublesex and mab-3 related transcription factor 2 2.00487
CFB complement factor B 2.00487
BHMT2 betaine--homocysteine S-methyltransferase 2 2.00487
CD22 CD22 molecule 2.00487
TSSK1B testis-specific serine kinase 1B 2.00487
CSTB cystatin B (stefin B) 2.00487
AFP alpha-fetoprotein 2.00487
NRGN neurogranin (protein kinase C substrate, RC3) 2.00487
NLRP6 NLR family, pyrin domain containing 6 2.00487
IL17B interleukin 17B 2.00487
NKPD1 NTPase, KAP family P-loop domain containing 1 2.00487
PPP1R3G protein phosphatase 1, regulatory subunit 3G 2.00487
BPIFC BPI fold containing family C 2.00487
ZNF485 zinc finger protein 485 2.00487
PPP4R1 protein phosphatase 4, regulatory subunit 1 2.00487
ABRACL ABRA C-terminal like 2.00487
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 2.00487
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 2.00487
OVCH1 ovochymase 1 2.00487
HMX2 H6 family homeobox 2 2.00487
PHOSPHO2-KLHL23 PHOSPHO2-KLHL23 readthrough 2.00487
FAM181B family with sequence similarity 181, member B 2.00487
ITIH6 inter-alpha-trypsin inhibitor heavy chain family, member 6 2.00487
TENM2 teneurin transmembrane protein 2 2.00487
NWD2 NACHT and WD repeat domain containing 2 2.00487
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 2.00487
IFNK interferon, kappa 2.00487
CCNO cyclin O 2.00487
FAM25A family with sequence similarity 25, member A 2.00487
SUN3 Sad1 and UNC84 domain containing 3 2.00487
STMND1 stathmin domain containing 1 2.00487
MAPK11 mitogen-activated protein kinase 11 2.00487
PDGFRB platelet-derived growth factor receptor, beta polypeptide 2.00487
ZMYND10 zinc finger, MYND-type containing 10 2.00487
GPR50 G protein-coupled receptor 50 2.00487
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 2.00487
KRT15 keratin 15, type I 2.00487
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) 2.00487
POU3F3 POU class 3 homeobox 3 2.00487
FAM53B family with sequence similarity 53, member B 2.00487
PAGE2B P antigen family, member 2B 2.00487
SZT2 seizure threshold 2 homolog (mouse) 2.00487
TRAM1L1 translocation associated membrane protein 1-like 1 2.00487
DUOXA1 dual oxidase maturation factor 1 2.00487
ZBED5 zinc finger, BED-type containing 5 2.00487
NAT10 N-acetyltransferase 10 (GCN5-related) 2.00487
TMEM86A transmembrane protein 86A 2.00487
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 2.00487
RAD1 RAD1 checkpoint DNA exonuclease 2.00487
PATE1 prostate and testis expressed 1 2.00487
ACTR3C ARP3 actin-related protein 3 homolog C (yeast) 2.00487
MCIDAS multiciliate differentiation and DNA synthesis associated cell cycle protein 2.00487

decreased expression

Symbol Name Standardized Value
SLC49A3 solute carrier family 49 member 3 -2.00487
IL4I1 interleukin 4 induced 1 -2.00487
SLCO3A1 solute carrier organic anion transporter family, member 3A1 -2.00487
NECAB1 N-terminal EF-hand calcium binding protein 1 -2.00487
ADCK5 aarF domain containing kinase 5 -2.00487
CELF1 CUGBP, Elav-like family member 1 -2.00487
LYPD6B LY6/PLAUR domain containing 6B -2.00487
MRPL50 mitochondrial ribosomal protein L50 -2.00487
LMO3 LIM domain only 3 (rhombotin-like 2) -2.00487
SNX4 sorting nexin 4 -2.00487
C11ORF86 chromosome 11 open reading frame 86 -2.00487
HDIP1 HDAC and MIER1 interacting protein 1 -2.00487
ASCC2 activating signal cointegrator 1 complex subunit 2 -2.00487
ZDHHC14 zinc finger, DHHC-type containing 14 -2.00487
HDX highly divergent homeobox -2.00487
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -2.00487
SKIC2 SKI2 subunit of superkiller complex -2.00487
CCDC32 coiled-coil domain containing 32 -2.00487
ACP3 acid phosphatase 3 -2.00487
IQUB IQ motif and ubiquitin domain containing -2.00487
ATG7 autophagy related 7 -2.00487
ZSCAN31 zinc finger and SCAN domain containing 31 -2.00487
CDKL2 cyclin-dependent kinase-like 2 (CDC2-related kinase) -2.00487
RPF2 ribosome production factor 2 homolog (S. cerevisiae) -2.00487
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 -2.00487
TCF24 transcription factor 24 -2.00487
PLEKHD1 pleckstrin homology domain containing, family D (with coiled-coil domains) member 1 -2.00487
IRF4 interferon regulatory factor 4 -2.00487
ZNF610 zinc finger protein 610 -2.00487
RAB2B RAB2B, member RAS oncogene family -2.00487
MMP21 matrix metallopeptidase 21 -2.00487
BAG5 BCL2-associated athanogene 5 -2.00487
PLSCR2 phospholipid scramblase 2 -2.00487
STK10 serine/threonine kinase 10 -2.00487
SPOP speckle-type POZ protein -2.00487
PAWR PRKC, apoptosis, WT1, regulator -2.00487
MAGOH mago-nashi homolog, proliferation-associated (Drosophila) -2.00487
MROH7 maestro heat-like repeat family member 7 -2.00487
MARS2 methionyl-tRNA synthetase 2, mitochondrial -2.00487
TRAIP TRAF interacting protein -2.00487
DPH1 diphthamide biosynthesis 1 -2.00487
PCSK9 proprotein convertase subtilisin/kexin type 9 -2.00487
CNR1 cannabinoid receptor 1 (brain) -2.00487
MST1 macrophage stimulating 1 -2.00487
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 -2.00487
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 -2.00487
PMVK phosphomevalonate kinase -2.00487
TMC4 transmembrane channel-like 4 -2.00487
BRPF3 bromodomain and PHD finger containing, 3 -2.00487
FLOT1 flotillin 1 -2.00487
STK32B serine/threonine kinase 32B -2.00487
BRAP BRCA1 associated protein -2.00487
CACNG6 calcium channel, voltage-dependent, gamma subunit 6 -2.00487
ZNF397 zinc finger protein 397 -2.00487
PYGM phosphorylase, glycogen, muscle -2.00487
NOL12 nucleolar protein 12 -2.00487
ACAN aggrecan -2.00487
C10ORF88 chromosome 10 open reading frame 88 -2.00487
TMEM158 transmembrane protein 158 (gene/pseudogene) -2.00069