| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/655457 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in HFI-142 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VPS37B | vacuolar protein sorting 37 homolog B (S. cerevisiae) | 0.9 |
| PAQR7 | progestin and adipoQ receptor family member VII | 0.65 |
| TMEM131L | transmembrane 131 like | 0.64 |
| SCAND1 | SCAN domain containing 1 | 0.57 |
| OTUD5 | OTU deubiquitinase 5 | 0.56 |
| ATF3 | activating transcription factor 3 | 0.55 |
| FAM133B | family with sequence similarity 133, member B | 0.52 |
| PUS3 | pseudouridylate synthase 3 | 0.5 |
| ZNF503 | zinc finger protein 503 | 0.49 |
| TRAK2 | trafficking protein, kinesin binding 2 | 0.45 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.45 |
| LAMA5 | laminin, alpha 5 | 0.44 |
| CEP112 | centrosomal protein 112kDa | 0.44 |
| TPM4 | tropomyosin 4 | 0.41 |
| SPATA2L | spermatogenesis associated 2-like | 0.41 |
| ZNF169 | zinc finger protein 169 | 0.4 |
| BTG3 | BTG family, member 3 | 0.4 |
| DNAH6 | dynein, axonemal, heavy chain 6 | 0.38 |
| SEMA4C | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C | 0.38 |
| GATC | glutamyl-tRNA(Gln) amidotransferase, subunit C | 0.37 |
| CDK2AP1 | cyclin-dependent kinase 2 associated protein 1 | 0.37 |
| TUFT1 | tuftelin 1 | 0.36 |
| EBAG9 | estrogen receptor binding site associated, antigen, 9 | 0.36 |
| SERAC1 | serine active site containing 1 | 0.35 |
| STX1A | syntaxin 1A (brain) | 0.35 |
| GPSM2 | G-protein signaling modulator 2 | 0.35 |
| CALU | calumenin | 0.35 |
| SHROOM1 | shroom family member 1 | 0.34 |
| ANTKMT | adenine nucleotide translocase lysine methyltransferase | 0.33 |
| FXN | frataxin | 0.33 |
| TROAP | trophinin associated protein | 0.33 |
| CCDC71 | coiled-coil domain containing 71 | 0.32 |
| NUDT18 | nudix (nucleoside diphosphate linked moiety X)-type motif 18 | 0.32 |
| KLHL21 | kelch-like family member 21 | 0.31 |
| IFT52 | intraflagellar transport 52 | 0.31 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.31 |
| ZNF440 | zinc finger protein 440 | 0.31 |
| CUX1 | cut-like homeobox 1 | 0.31 |
| LAGE3 | L antigen family, member 3 | 0.31 |
| PICK1 | protein interacting with PRKCA 1 | 0.31 |
| MPV17 | MpV17 mitochondrial inner membrane protein | 0.3 |
| TNFAIP1 | tumor necrosis factor, alpha-induced protein 1 (endothelial) | 0.3 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.3 |
| ZBTB2 | zinc finger and BTB domain containing 2 | 0.3 |
| MTFR1L | mitochondrial fission regulator 1-like | 0.3 |
| SRR | serine racemase | 0.29 |
| C5ORF30 | chromosome 5 open reading frame 30 | 0.29 |
| CALD1 | caldesmon 1 | 0.29 |
| RETREG3 | reticulophagy regulator family member 3 | 0.29 |
| UPP1 | uridine phosphorylase 1 | 0.29 |
| SERINC1 | serine incorporator 1 | 0.28 |
| ARL6IP6 | ADP-ribosylation factor-like 6 interacting protein 6 | 0.28 |
| MT2A | metallothionein 2A | 0.28 |
| FCHSD2 | FCH and double SH3 domains 2 | 0.28 |
| SELENOF | selenoprotein F | 0.28 |
| NECTIN2 | nectin cell adhesion molecule 2 | 0.27 |
| POP5 | processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) | 0.27 |
| DNASE1L1 | deoxyribonuclease I-like 1 | 0.27 |
| CLOCK | clock circadian regulator | 0.27 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.27 |
| PCBD2 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 | 0.27 |
| AMD1 | adenosylmethionine decarboxylase 1 | 0.27 |
| OGFOD2 | 2-oxoglutarate and iron-dependent oxygenase domain containing 2 | 0.27 |
| ALAS1 | 5'-aminolevulinate synthase 1 | 0.27 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 0.26 |
| MSH5 | mutS homolog 5 | 0.26 |
| ALKBH5 | AlkB family member 5, RNA demethylase | 0.26 |
| PALB2 | partner and localizer of BRCA2 | 0.26 |
| NENF | neudesin neurotrophic factor | 0.26 |
| CEP152 | centrosomal protein 152kDa | 0.26 |
| TPM1 | tropomyosin 1 (alpha) | 0.26 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | 0.25 |
| CDK11A | cyclin-dependent kinase 11A | 0.25 |
| H1-0 | H1.0 linker histone | 0.25 |
| CLDND1 | claudin domain containing 1 | 0.25 |
| DNM1L | dynamin 1-like | 0.25 |
| RAB3IP | RAB3A interacting protein | 0.25 |
| SPATA33 | spermatogenesis associated 33 | 0.25 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | 0.25 |
| GPT2 | glutamic pyruvate transaminase (alanine aminotransferase) 2 | 0.25 |
| TPM3 | tropomyosin 3 | 0.25 |
| SMCR8 | Smith-Magenis syndrome chromosome region, candidate 8 | 0.25 |
| BAHD1 | bromo adjacent homology domain containing 1 | 0.25 |
| GPC4 | glypican 4 | 0.24 |
| PRELID3B | PRELI domain containing 3B | 0.24 |
| CCDC58 | coiled-coil domain containing 58 | 0.24 |
| SELENOI | selenoprotein I | 0.24 |
| COA6 | cytochrome c oxidase assembly factor 6 | 0.24 |
| CERK | ceramide kinase | 0.24 |
| AMZ2 | archaelysin family metallopeptidase 2 | 0.24 |
| GTF3C6 | general transcription factor IIIC, polypeptide 6, alpha 35kDa | 0.24 |
| PES1 | pescadillo ribosomal biogenesis factor 1 | 0.24 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.23 |
| GEMIN8 | gem (nuclear organelle) associated protein 8 | 0.23 |
| CALCOCO2 | calcium binding and coiled-coil domain 2 | 0.23 |
| FKBP7 | FK506 binding protein 7 | 0.23 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | 0.23 |
| CMC1 | C-x(9)-C motif containing 1 | 0.23 |
| CLCN2 | chloride channel, voltage-sensitive 2 | 0.23 |
| DNAH9 | dynein, axonemal, heavy chain 9 | 0.23 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TTLL4 | tubulin tyrosine ligase-like family member 4 | -3.96 |
| VAV1 | vav 1 guanine nucleotide exchange factor | -2.62 |
| MTUS2 | microtubule associated tumor suppressor candidate 2 | -1.29 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -1.27 |
| USP6NL | USP6 N-terminal like | -1.19 |
| MYT1 | myelin transcription factor 1 | -1.13 |
| NEK4 | NIMA-related kinase 4 | -1.01 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | -0.91 |
| ADPRH | ADP-ribosylarginine hydrolase | -0.89 |
| MRPL35 | mitochondrial ribosomal protein L35 | -0.87 |
| IP6K2 | inositol hexakisphosphate kinase 2 | -0.72 |
| RNF5 | ring finger protein 5, E3 ubiquitin protein ligase | -0.71 |
| PIP | prolactin-induced protein | -0.7 |
| SIN3B | SIN3 transcription regulator family member B | -0.68 |
| TINAGL1 | tubulointerstitial nephritis antigen-like 1 | -0.61 |
| HLA-F | major histocompatibility complex, class I, F | -0.55 |
| DEPDC5 | DEP domain containing 5 | -0.55 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.55 |
| CCDC158 | coiled-coil domain containing 158 | -0.51 |
| ZSCAN21 | zinc finger and SCAN domain containing 21 | -0.51 |
| KIAA0100 | KIAA0100 | -0.51 |
| ANKLE1 | ankyrin repeat and LEM domain containing 1 | -0.5 |
| MTFR2 | mitochondrial fission regulator 2 | -0.49 |
| AP1S2 | adaptor-related protein complex 1, sigma 2 subunit | -0.49 |
| EVI5 | ecotropic viral integration site 5 | -0.47 |
| SEMG2 | semenogelin II | -0.46 |
| B3GNT3 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 | -0.46 |
| GINS2 | GINS complex subunit 2 (Psf2 homolog) | -0.45 |
| ANKRD16 | ankyrin repeat domain 16 | -0.45 |
| SIMC1 | SUMO-interacting motifs containing 1 | -0.44 |
| PDE4DIP | phosphodiesterase 4D interacting protein | -0.44 |
| KIF1B | kinesin family member 1B | -0.44 |
| CLDN3 | claudin 3 | -0.43 |
| MTG1 | mitochondrial ribosome-associated GTPase 1 | -0.42 |
| RUNX2 | runt-related transcription factor 2 | -0.42 |
| CLIC6 | chloride intracellular channel 6 | -0.41 |
| PPP1R2B | PPP1R2 family member B | -0.4 |
| ZFYVE27 | zinc finger, FYVE domain containing 27 | -0.4 |
| HGH1 | HGH1 homolog (S. cerevisiae) | -0.4 |
| RUSC1 | RUN and SH3 domain containing 1 | -0.4 |
| SOCS2 | suppressor of cytokine signaling 2 | -0.4 |
| LGALSL | lectin, galactoside-binding-like | -0.39 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.39 |
| RPLP1 | ribosomal protein, large, P1 | -0.37 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.37 |
| BRD7 | bromodomain containing 7 | -0.37 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | -0.35 |
| FAM234B | family with sequence similarity 234 member B | -0.35 |
| TRNP1 | TMF1-regulated nuclear protein 1 | -0.35 |
| USP46 | ubiquitin specific peptidase 46 | -0.35 |
| MXRA7 | matrix-remodelling associated 7 | -0.35 |
| DUS4L | dihydrouridine synthase 4-like (S. cerevisiae) | -0.35 |
| TRIM44 | tripartite motif containing 44 | -0.34 |
| TUBB4A | tubulin, beta 4A class IVa | -0.34 |
| KDELR3 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 | -0.34 |
| RAP1GAP2 | RAP1 GTPase activating protein 2 | -0.34 |
| CCNE2 | cyclin E2 | -0.34 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.34 |
| TXN2 | thioredoxin 2 | -0.34 |
| WDR59 | WD repeat domain 59 | -0.33 |
| MOSPD1 | motile sperm domain containing 1 | -0.33 |
| LRP5 | low density lipoprotein receptor-related protein 5 | -0.33 |
| SEPTIN3 | septin 3 | -0.33 |
| PSMB9 | proteasome (prosome, macropain) subunit, beta type, 9 | -0.32 |
| DOT1L | DOT1-like histone H3K79 methyltransferase | -0.32 |
| TNXB | tenascin XB | -0.32 |
| ZC3H6 | zinc finger CCCH-type containing 6 | -0.31 |
| VPS52 | vacuolar protein sorting 52 homolog (S. cerevisiae) | -0.31 |
| TSTD2 | thiosulfate sulfurtransferase (rhodanese)-like domain containing 2 | -0.31 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | -0.31 |
| DDAH2 | dimethylarginine dimethylaminohydrolase 2 | -0.31 |
| HAUS2 | HAUS augmin-like complex, subunit 2 | -0.31 |
| SAYSD1 | SAYSVFN motif domain containing 1 | -0.31 |
| SLC30A7 | solute carrier family 30 (zinc transporter), member 7 | -0.3 |
| MBTD1 | mbt domain containing 1 | -0.3 |
| BID | BH3 interacting domain death agonist | -0.3 |
| MANEA | mannosidase, endo-alpha | -0.3 |
| SLC27A3 | solute carrier family 27 (fatty acid transporter), member 3 | -0.3 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | -0.3 |
| LTBP4 | latent transforming growth factor beta binding protein 4 | -0.3 |
| NFIA | nuclear factor I/A | -0.29 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | -0.29 |
| PLCD1 | phospholipase C, delta 1 | -0.29 |
| MND1 | meiotic nuclear divisions 1 homolog (S. cerevisiae) | -0.29 |
| PRDM15 | PR domain containing 15 | -0.29 |
| ZBED1 | zinc finger, BED-type containing 1 | -0.29 |
| LYPLA2 | lysophospholipase II | -0.29 |
| BTN2A1 | butyrophilin, subfamily 2, member A1 | -0.29 |
| CEP350 | centrosomal protein 350kDa | -0.29 |
| ARHGAP8 | Rho GTPase activating protein 8 | -0.29 |
| TMCO4 | transmembrane and coiled-coil domains 4 | -0.29 |
| SLC17A5 | solute carrier family 17 (acidic sugar transporter), member 5 | -0.28 |
| ENO1 | enolase 1, (alpha) | -0.28 |
| GALNS | galactosamine (N-acetyl)-6-sulfatase | -0.28 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.28 |
| ZNF414 | zinc finger protein 414 | -0.28 |
| ALG14 | ALG14, UDP-N-acetylglucosaminyltransferase subunit | -0.28 |
| RBFA | ribosome binding factor A (putative) | -0.28 |
| FURIN | furin (paired basic amino acid cleaving enzyme) | -0.28 |
| ATXN7L3B | ataxin 7-like 3B | -0.27 |
