HGF Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description hepatocyte growth factor (hepapoietin A; scatter factor)|Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3082)
External Link http://www.ncbi.nlm.nih.gov/gene/3082
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Genes

48 interacting proteins for HGF from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ARF6 ADP-ribosylation factor 6
BCAR1 breast cancer anti-estrogen resistance 1
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CD44 CD44 molecule (Indian blood group)
CDC42 cell division cycle 42
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CLEC3B C-type lectin domain family 3, member B
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNND1 catenin (cadherin-associated protein), delta 1
F11 coagulation factor XI
FN1 fibronectin 1
GAB1 GRB2-associated binding protein 1
GAB2 GRB2-associated binding protein 2
HGFAC HGF activator
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
HPN hepsin
HRAS Harvey rat sarcoma viral oncogene homolog
JUP junction plakoglobin
KLKB1 kallikrein B, plasma (Fletcher factor) 1
KPNB1 karyopherin (importin) beta 1
LCN2 lipocalin 2
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MET MET proto-oncogene, receptor tyrosine kinase
MUC20 mucin 20, cell surface associated
NRP1 neuropilin 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLCG1 phospholipase C, gamma 1
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPRJ protein tyrosine phosphatase, receptor type, J
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1
SDC1 syndecan 1
SDC2 syndecan 2
SH3GL2 SH3-domain GRB2-like 2
SH3KBP1 SH3-domain kinase binding protein 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRPX2 sushi-repeat containing protein, X-linked 2
ST14 suppression of tumorigenicity 14 (colon carcinoma)
VTN vitronectin