HGS Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description hepatocyte growth factor-regulated tyrosine kinase substrate|The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation. [provided by RefSeq, Dec 2010] (NCBI Entrez Gene Database, 9146)
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Genes

361 genes differentially expressed following the HGS gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
UPB1 ureidopropionase, beta 2.79426
HPSE heparanase 2.79426
RAD51AP2 RAD51 associated protein 2 2.79426
SNPH syntaphilin 2.79426
RASD1 RAS, dexamethasone-induced 1 2.79426
ASMT acetylserotonin O-methyltransferase 2.79426
SPEF1 sperm flagellar 1 2.79426
ANXA8 annexin A8 2.79426
MAGED4 melanoma antigen family D4 2.79426
MCF2 MCF.2 cell line derived transforming sequence 2.79426
RGS22 regulator of G-protein signaling 22 2.79426
HIGD1B HIG1 hypoxia inducible domain family, member 1B 2.79426
ACMSD aminocarboxymuconate semialdehyde decarboxylase 2.79426
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) 2.79426
ZNF497 zinc finger protein 497 2.79426
SP6 Sp6 transcription factor 2.79426
ZNF99 zinc finger protein 99 2.79426
COX8C cytochrome c oxidase subunit VIIIC 2.79426
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 2.79426
ECT2L epithelial cell transforming 2 like 2.79426
CFAP53 cilia and flagella associated protein 53 2.79426
CORO6 coronin 6 2.79426
NEB nebulin 2.79426
NCCRP1 non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) 2.79426
OR9H1 olfactory receptor family 9 subfamily H member 1 pseudogene (gene/pseudogene) 2.79426
SLC35G5 solute carrier family 35, member G5 2.71978
PCDHB9 protocadherin beta 9 2.71978
SIX1 SIX homeobox 1 2.71978
SSTR1 somatostatin receptor 1 2.71978
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 2.71978
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 2.71978
CTRL chymotrypsin-like 2.71978
CTRC chymotrypsin C (caldecrin) 2.71978
SCG2 secretogranin II 2.71978
TP73 tumor protein p73 2.71978
HRH1 histamine receptor H1 2.71978
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 2.71978
ELF4 E74-like factor 4 (ets domain transcription factor) 2.71978
FGF22 fibroblast growth factor 22 2.71978
AKAP5 A kinase (PRKA) anchor protein 5 2.71978
HORMAD1 HORMA domain containing 1 2.71978
C8ORF48 chromosome 8 open reading frame 48 2.71978
C1ORF141 chromosome 1 open reading frame 141 2.71978
SHISA7 shisa family member 7 2.71978
PAX7 paired box 7 2.71978
RGPD6 RANBP2-like and GRIP domain containing 6 2.71978
OXCT2 3-oxoacid CoA transferase 2 2.71978
PTDSS2 phosphatidylserine synthase 2 2.71978
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 2.71978
MUC22 mucin 22 2.71978
PTGER4 prostaglandin E receptor 4 (subtype EP4) 2.71978
HAS1 hyaluronan synthase 1 2.71978
GPR22 G protein-coupled receptor 22 2.71978
VSTM2A V-set and transmembrane domain containing 2A 2.71978
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 2.71978
MTTP microsomal triglyceride transfer protein 2.71978
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit 2.71978
S100A3 S100 calcium binding protein A3 2.71978
MEI1 meiosis inhibitor 1 2.71978
MSC musculin 2.71978
TAS2R1 taste receptor, type 2, member 1 2.71978
CRYGA crystallin, gamma A 2.71978
KRABD1 KRAB domain containing 1 2.71978
CES4A carboxylesterase 4A 2.71978
GBP4 guanylate binding protein 4 2.71978
AVPR1B arginine vasopressin receptor 1B 2.71978
SLC2A7 solute carrier family 2 (facilitated glucose transporter), member 7 2.71978
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) 2.71978
NHLH1 nescient helix loop helix 1 2.71978
ZNF446 zinc finger protein 446 2.71978
CD70 CD70 molecule 2.71978
FAM228A family with sequence similarity 228, member A 2.71978
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 2.71978
GGTA1 glycoprotein alpha-galactosyltransferase 1 (inactive) 2.71978
SMIM41 small integral membrane protein 41 2.71978
CIMAP2 ciliary microtubule associated protein 2 2.71978
CIROZ ciliated left-right organizer protein containing ZP-N domains 2.71978
LOC114841035 uncharacterized LOC114841035 2.71978
SPATA31H1 SPATA31 subfamily H member 1 2.71978
PNMA6F PNMA family member 6F 2.71978
APP-DT APP divergent transcript 2.71978
MAP3K4-AS1 MAP3K4 antisense RNA 1 2.71978
DIPK1C divergent protein kinase domain 1C 2.71978
RNF227 ring finger protein 227 2.71978
CFAP100 cilia and flagella associated protein 100 2.71978
SYT15 synaptotagmin XV 2.71978
LTF lactotransferrin 2.71978
CELA2A chymotrypsin-like elastase family, member 2A 2.71978
TMIE transmembrane inner ear 2.71978
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 2.71978
RHOXF2 Rhox homeobox family, member 2 2.71978
GDA guanine deaminase 2.71978
ACTL10 actin-like 10 2.71978
PVRIG poliovirus receptor related immunoglobulin domain containing 2.71978
TNFRSF18 tumor necrosis factor receptor superfamily, member 18 2.71978
CPED1 cadherin-like and PC-esterase domain containing 1 2.71978
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 2.71978
KBTBD11 kelch repeat and BTB (POZ) domain containing 11 2.71978
STAC SH3 and cysteine rich domain 2.71978
CLDN9 claudin 9 2.71978
CCR9 chemokine (C-C motif) receptor 9 2.71978
FAM186B family with sequence similarity 186, member B 2.71978
ESR1 estrogen receptor 1 2.71978
HSPB6 heat shock protein, alpha-crystallin-related, B6 2.71978
PDE1B phosphodiesterase 1B, calmodulin-dependent 2.71978
TLR7 toll-like receptor 7 2.71978
ULBP1 UL16 binding protein 1 2.71978
BBS5 Bardet-Biedl syndrome 5 2.71978
IRF4 interferon regulatory factor 4 2.71978
CLDN5 claudin 5 2.71978
SYCP2 synaptonemal complex protein 2 2.71978
IL6R interleukin 6 receptor 2.71978
EBF4 early B-cell factor 4 2.71978
AQP4 aquaporin 4 2.71978
ARR3 arrestin 3, retinal (X-arrestin) 2.71978
HHLA2 HERV-H LTR-associating 2 2.71978
MCM8 minichromosome maintenance complex component 8 2.71978
AKNAD1 AKNA domain containing 1 2.71978
C16ORF78 chromosome 16 open reading frame 78 2.71978
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 2.71978
FIBIN fin bud initiation factor homolog (zebrafish) 2.71978
LMOD2 leiomodin 2 (cardiac) 2.71978
C11ORF91 chromosome 11 open reading frame 91 2.71978
CST1 cystatin SN 2.71978
LCNL1 lipocalin-like 1 2.71978
CCDC154 coiled-coil domain containing 154 2.71978
GFI1B growth factor independent 1B transcription repressor 2.71978
CCL26 chemokine (C-C motif) ligand 26 2.71978
KCNK4 potassium channel, two pore domain subfamily K, member 4 2.71978
BRDT bromodomain, testis-specific 2.71978
NIM1K NIM1 serine/threonine protein kinase 2.71978
SHOX2 short stature homeobox 2 2.71978
CNTF ciliary neurotrophic factor 2.71978
EFCC1 EF-hand and coiled-coil domain containing 1 2.71978
CCDC184 coiled-coil domain containing 184 2.71978
CDK20 cyclin-dependent kinase 20 2.71978
CISH cytokine inducible SH2-containing protein 2.71978
KLHL10 kelch-like family member 10 2.71978
C11ORF42 chromosome 11 open reading frame 42 2.71978
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 2.71978
ARHGAP40 Rho GTPase activating protein 40 2.71978
TTC29 tetratricopeptide repeat domain 29 2.71978
TEX26 testis expressed 26 2.71978
CFP complement factor properdin 2.71978
CFB complement factor B 2.71978
NUDC nudC nuclear distribution protein 2.71978
FCRLB Fc receptor-like B 2.71978
PDCD1LG2 programmed cell death 1 ligand 2 2.71978
DHH desert hedgehog 2.71978
CER1 cerberus 1, DAN family BMP antagonist 2.71978
HOPX HOP homeobox 2.71978
EGR3 early growth response 3 2.71978
PTPN20 protein tyrosine phosphatase, non-receptor type 20 2.71978
PRR35 proline rich 35 2.71978
CEL carboxyl ester lipase 2.71978
ZC3H12D zinc finger CCCH-type containing 12D 2.71978
ZGLP1 zinc finger, GATA-like protein 1 2.71978
NLRP14 NLR family, pyrin domain containing 14 2.71978
TRPM2 transient receptor potential cation channel, subfamily M, member 2 2.71978
NMUR1 neuromedin U receptor 1 2.71978
CD80 CD80 molecule 2.71978
PRAP1 proline-rich acidic protein 1 2.71978
CAMK1G calcium/calmodulin-dependent protein kinase IG 2.71978
B3GNT9 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 2.71978
MEIG1 meiosis/spermiogenesis associated 1 2.71978
R3HDML R3H domain containing-like 2.71978
SPINT4 serine peptidase inhibitor, Kunitz type 4 2.71978
IL17B interleukin 17B 2.71978
CBR3 carbonyl reductase 3 2.71978
SLC51B solute carrier family 51, beta subunit 2.71978
TEX38 testis expressed 38 2.71978
NAT16 N-acetyltransferase 16 (GCN5-related, putative) 2.71978
TMPRSS13 transmembrane protease, serine 13 2.71978
PRSS50 protease, serine, 50 2.71978
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 2.71978
PLGLB1 plasminogen-like B1 2.71978
HSF5 heat shock transcription factor family member 5 2.71978
LDHC lactate dehydrogenase C 2.71978
CHD5 chromodomain helicase DNA binding protein 5 2.71978
CEACAM16 carcinoembryonic antigen-related cell adhesion molecule 16 2.71978
BHMT2 betaine--homocysteine S-methyltransferase 2 2.71978
PRSS54 protease, serine, 54 2.71978
KRTDAP keratinocyte differentiation-associated protein 2.64028
LAMP3 lysosomal-associated membrane protein 3 2.64028
ANKRD30BL ankyrin repeat domain 30B-like 2.57073
CELF1 CUGBP, Elav-like family member 1 2.56648
NDEL1 nudE neurodevelopment protein 1-like 1 2.56602
TFCP2L1 transcription factor CP2-like 1 2.50248
CPT1B carnitine palmitoyltransferase 1B (muscle) 2.50248
HMG20B high mobility group 20B 2.50194
CPXM1 carboxypeptidase X (M14 family), member 1 2.50007
HES2 hes family bHLH transcription factor 2 2.47399
SH2D4B SH2 domain containing 4B 2.47399
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7 2.44657
P2RY11 purinergic receptor P2Y, G-protein coupled, 11 2.44537
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2) 2.44537
MEOX2 mesenchyme homeobox 2 2.44537
ZNF626 zinc finger protein 626 2.41269
ELF2 E74-like factor 2 (ets domain transcription factor) 2.41117
FDPS farnesyl diphosphate synthase 2.39818
RWDD1 RWD domain containing 1 2.39171
SHMT1 serine hydroxymethyltransferase 1 (soluble) 2.37875
PRH1 proline-rich protein HaeIII subfamily 1 2.32871
MAP3K2 mitogen-activated protein kinase kinase kinase 2 2.3067
FRMD6 FERM domain containing 6 2.3058
STMN3 stathmin-like 3 2.28756
RNF149 ring finger protein 149 2.23568
TARS1 threonyl-tRNA synthetase 1 2.18896
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 2.18124
FAM107B family with sequence similarity 107, member B 2.16031
EAF2 ELL associated factor 2 2.15528
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 2.15528
HMCES 5-hydroxymethylcytosine (hmC) binding, ES cell-specific 2.15074
PID1 phosphotyrosine interaction domain containing 1 2.14203
TMEM192 transmembrane protein 192 2.12909
AMMECR1L AMMECR1-like 2.12665
GFOD2 glucose-fructose oxidoreductase domain containing 2 2.12162
CAMK1 calcium/calmodulin-dependent protein kinase I 2.12151
CDCA4 cell division cycle associated 4 2.11123
ACACA acetyl-CoA carboxylase alpha 2.10426
PITRM1 pitrilysin metallopeptidase 1 2.09047
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 2.07782
VPS51 vacuolar protein sorting 51 homolog (S. cerevisiae) 2.07556
XPOT exportin, tRNA 2.07315
PRICKLE1 prickle homolog 1 (Drosophila) 2.06568
NECTIN3 nectin cell adhesion molecule 3 2.06154
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.05339
CCDC51 coiled-coil domain containing 51 2.0515
BAK1 BCL2-antagonist/killer 1 2.04722
CEP97 centrosomal protein 97kDa 2.04347
COL11A1 collagen, type XI, alpha 1 2.03542
RDX radixin 2.02285
PDCD6IP programmed cell death 6 interacting protein 2.02236
VMA12 vacuolar ATPase assembly factor VMA12 2.00672
SLC9B1 solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1 2.00462
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 2.00246

decreased expression

Symbol Name Standardized Value
ZNF599 zinc finger protein 599 -2.79426
SNAI1 snail family zinc finger 1 -2.79426
XK X-linked Kx blood group -2.79426
CRB2 crumbs family member 2 -2.79426
CCKBR cholecystokinin B receptor -2.79426
GPRC5C G protein-coupled receptor, class C, group 5, member C -2.79426
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 -2.79426
SPRYD3 SPRY domain containing 3 -2.79426
SMYD5 SMYD family member 5 -2.79426
H4C6 H4 clustered histone 6 -2.79426
ARRDC2 arrestin domain containing 2 -2.71978
ARRDC3 arrestin domain containing 3 -2.71978
ADAMTSL4 ADAMTS-like 4 -2.71978
RFPL2 ret finger protein-like 2 -2.71978
ARSJ arylsulfatase family, member J -2.71978
ZNF43 zinc finger protein 43 -2.71978
APLN apelin -2.71978
HES3 hes family bHLH transcription factor 3 -2.71978
PEX11B peroxisomal biogenesis factor 11 beta -2.71978
CRIP2 cysteine-rich protein 2 -2.71978
DNAAF3 dynein, axonemal, assembly factor 3 -2.71978
ARHGEF25 Rho guanine nucleotide exchange factor (GEF) 25 -2.71978
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 -2.71978
MADCAM1 mucosal vascular addressin cell adhesion molecule 1 -2.71978
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae) -2.71978
VPREB3 pre-B lymphocyte 3 -2.71978
DAND5 DAN domain family member 5, BMP antagonist -2.71978
ACKR4 atypical chemokine receptor 4 -2.71978
GRHL1 grainyhead-like 1 (Drosophila) -2.71978
CBLN1 cerebellin 1 precursor -2.71978
ZNF639 zinc finger protein 639 -2.71978
TNS1-AS1 TNS1 antisense RNA 1 -2.71978
TOP3A topoisomerase (DNA) III alpha -2.71978
MYH10 myosin, heavy chain 10, non-muscle -2.71978
NBPF14 neuroblastoma breakpoint family, member 14 -2.71978
SKIC2 SKI2 subunit of superkiller complex -2.71978
NPIPA6 nuclear pore complex interacting protein family, member A6 -2.71978
ZFP28 ZFP28 zinc finger protein -2.71978
SLC60A1 solute carrier family 60 member 1 -2.71978
MEI4 meiosis-specific 4 homolog (S. cerevisiae) -2.71978
SRM spermidine synthase -2.71978
MS4A6E membrane-spanning 4-domains, subfamily A, member 6E -2.71978
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma -2.71978
TAS2R30 taste receptor, type 2, member 30 -2.71978
E2F2 E2F transcription factor 2 -2.71978
IFITM2 interferon induced transmembrane protein 2 -2.71978
TMEM229B transmembrane protein 229B -2.71978
LIPT2-AS1 LIPT2 antisense RNA 1 -2.71978
EID2B EP300 interacting inhibitor of differentiation 2B -2.71978
GNG5 guanine nucleotide binding protein (G protein), gamma 5 -2.71978
RPS7 ribosomal protein S7 -2.71978
DCAF12L1 DDB1 and CUL4 associated factor 12-like 1 -2.71978
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae) -2.71978
SMIM24 small integral membrane protein 24 -2.71978
SYPL2 synaptophysin-like 2 -2.71978
GLOD4 glyoxalase domain containing 4 -2.71978
CRYBB1 crystallin, beta B1 -2.71978
FBXL22 F-box and leucine-rich repeat protein 22 -2.71978
TSLP thymic stromal lymphopoietin -2.71978
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 -2.71978
PRKG2 protein kinase, cGMP-dependent, type II -2.71978
INSL3 insulin-like 3 (Leydig cell) -2.71978
CSPG5 chondroitin sulfate proteoglycan 5 (neuroglycan C) -2.71978
SLC22A31 solute carrier family 22, member 31 -2.71978
ZNF540 zinc finger protein 540 -2.71978
RNF214 ring finger protein 214 -2.62817
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -2.61529
HNRNPF heterogeneous nuclear ribonucleoprotein F -2.61385
RPS16 ribosomal protein S16 -2.53677
CNTNAP5 contactin associated protein-like 5 -2.5333
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent -2.5333
CDH23 cadherin-related 23 -2.5333
ZNF585B zinc finger protein 585B -2.50007
MKS1 Meckel syndrome, type 1 -2.48086
FAHD1 fumarylacetoacetate hydrolase domain containing 1 -2.45739
RPL27 ribosomal protein L27 -2.34032
RPS9 ribosomal protein S9 -2.3238
R3HDM4 R3H domain containing 4 -2.3058
EHMT2 euchromatic histone-lysine N-methyltransferase 2 -2.30379
SEPTIN5 septin 5 -2.30103
TMEM60 transmembrane protein 60 -2.29767
CCDC7 coiled-coil domain containing 7 -2.29767
PLEKHA6 pleckstrin homology domain containing, family A member 6 -2.29767
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 -2.29767
RASA1 RAS p21 protein activator (GTPase activating protein) 1 -2.25051
CHCHD10 coiled-coil-helix-coiled-coil-helix domain containing 10 -2.23568
SPIRE2 spire-type actin nucleation factor 2 -2.22507
FIGNL1 fidgetin-like 1 -2.22507
ARAF A-Raf proto-oncogene, serine/threonine kinase -2.22507
COMMD10 COMM domain containing 10 -2.21646
URGCP upregulator of cell proliferation -2.21619
PHF1 PHD finger protein 1 -2.20685
SCUBE1 signal peptide, CUB domain, EGF-like 1 -2.18787
PMM1 phosphomannomutase 1 -2.18249
MSH2 mutS homolog 2 -2.16638
C1RL complement component 1, r subcomponent-like -2.16638
HSF2 heat shock transcription factor 2 -2.15389
RPL29 ribosomal protein L29 -2.13365
OBI1 ORC ubiquitin ligase 1 -2.13134
MDM4 MDM4, p53 regulator -2.12195
RPS20 ribosomal protein S20 -2.1207
ATP5F1A ATP synthase F1 subunit alpha -2.11893
TUSC2 tumor suppressor candidate 2 -2.07782
PLXDC2 plexin domain containing 2 -2.07664
ARHGAP31 Rho GTPase activating protein 31 -2.07315
RABGGTB Rab geranylgeranyltransferase, beta subunit -2.06733
KIF14 kinesin family member 14 -2.06733
DEPTOR DEP domain containing MTOR-interacting protein -2.06568
SORBS3 sorbin and SH3 domain containing 3 -2.06545
PANX1 pannexin 1 -2.0515
POMP proteasome maturation protein -2.0515
KDM4D lysine (K)-specific demethylase 4D -2.05025
SETD1B SET domain containing 1B -2.05025
CCP110 centriolar coiled coil protein 110kDa -2.04722
ABHD17A abhydrolase domain containing 17A -2.03602
HEATR3 HEAT repeat containing 3 -2.03143
H2AZ2 H2A.Z variant histone 2 -2.02684
GATAD2B GATA zinc finger domain containing 2B -2.0243
HDDC2 HD domain containing 2 -2.00911
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A -2.00599
KIF4A kinesin family member 4A -2.00429
WASF2 WAS protein family, member 2 -2.00246
MAPK9 mitogen-activated protein kinase 9 -2.00246
RHOH ras homolog family member H -2.00246
TTF2 transcription termination factor, RNA polymerase II -2.00246