| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | HI-TOPK-032 perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the HI-TOPK-032_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PLAT | plasminogen activator, tissue | 0.176891 |
| CD44 | CD44 molecule (Indian blood group) | 0.149252 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.135209 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.110404 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0927798 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0895653 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0809028 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0769796 |
| MKI67 | marker of proliferation Ki-67 | 0.0718836 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0668159 |
| CENPF | centromere protein F, 350/400kDa | 0.0610974 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.057313 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0538857 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0535942 |
| ASPH | aspartate beta-hydroxylase | 0.0523792 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0511105 |
| FLNA | filamin A, alpha | 0.0505949 |
| SP100 | SP100 nuclear antigen | 0.0502465 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0488885 |
| TPM3 | tropomyosin 3 | 0.0471138 |
| LOX | lysyl oxidase | 0.0470782 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 0.0439739 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0431572 |
| THBS2 | thrombospondin 2 | 0.0421864 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0419949 |
| STC1 | stanniocalcin 1 | 0.0387916 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0384966 |
| GLIS3 | GLIS family zinc finger 3 | 0.0366731 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0364943 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0351737 |
| CALR | calreticulin | 0.0336631 |
| DNMBP | dynamin binding protein | 0.0331353 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0328909 |
| SMC4 | structural maintenance of chromosomes 4 | 0.032838 |
| CKAP2 | cytoskeleton associated protein 2 | 0.0327971 |
| SMAD3 | SMAD family member 3 | 0.0321379 |
| TPX2 | TPX2, microtubule-associated | 0.0319548 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0319383 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0313332 |
| FUS | FUS RNA binding protein | 0.0309967 |
| SVIL | supervillin | 0.0308711 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0306507 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0300905 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0294656 |
| SERPINB6 | serpin peptidase inhibitor, clade B (ovalbumin), member 6 | 0.0293789 |
| FLNB | filamin B, beta | 0.0289706 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0285307 |
| SON | SON DNA binding protein | 0.0283565 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0279493 |
| DST | dystonin | 0.0279054 |
| SCLT1 | sodium channel and clathrin linker 1 | 0.0274265 |
| EHBP1 | EH domain binding protein 1 | 0.027397 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0271808 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0271417 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0270523 |
| ADAR | adenosine deaminase, RNA-specific | 0.0269778 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0269719 |
| NEK7 | NIMA-related kinase 7 | 0.0262105 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0262003 |
| SET | SET nuclear proto-oncogene | 0.026036 |
| CENPE | centromere protein E, 312kDa | 0.0257466 |
| VEGFC | vascular endothelial growth factor C | 0.0257455 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0252981 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0249661 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0243639 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0242155 |
| LAMB1 | laminin, beta 1 | 0.0240939 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0239182 |
| MSN | moesin | 0.0236969 |
| KIF14 | kinesin family member 14 | 0.0231171 |
| LMO7 | LIM domain 7 | 0.0229814 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0229168 |
| BAZ1B | bromodomain adjacent to zinc finger domain, 1B | 0.0228413 |
| KIF4A | kinesin family member 4A | 0.0227455 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0226409 |
| ANLN | anillin, actin binding protein | 0.0225359 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0219958 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0217387 |
| SAMHD1 | SAM domain and HD domain 1 | 0.0216713 |
| SGO2 | shugoshin 2 | 0.021671 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0212428 |
| CDK6 | cyclin-dependent kinase 6 | 0.020659 |
| CDK5RAP2 | CDK5 regulatory subunit associated protein 2 | 0.0206038 |
| SAMD9L | sterile alpha motif domain containing 9-like | 0.0203824 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.0202218 |
| MT2A | metallothionein 2A | 0.020198 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0200151 |
| DTX3L | deltex 3 like, E3 ubiquitin ligase | 0.0199994 |
| CAPRIN1 | cell cycle associated protein 1 | 0.0199023 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0199002 |
| NCKAP1 | NCK-associated protein 1 | 0.0198487 |
| IQGAP3 | IQ motif containing GTPase activating protein 3 | 0.0197801 |
| HMMR | hyaluronan-mediated motility receptor (RHAMM) | 0.0195973 |
| FAT1 | FAT atypical cadherin 1 | 0.0195686 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0194371 |
| ACER3 | alkaline ceramidase 3 | 0.019294 |
| JMJD1C | jumonji domain containing 1C | 0.0191464 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0191315 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0189539 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0188398 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.294276 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.145142 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.143764 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.118864 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.118658 |
| CSTB | cystatin B (stefin B) | -0.115671 |
| VIM | vimentin | -0.115284 |
| TMSB10 | thymosin beta 10 | -0.113871 |
| FN1 | fibronectin 1 | -0.108271 |
| NDRG1 | N-myc downstream regulated 1 | -0.100479 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.100114 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0963196 |
| COL5A1 | collagen, type V, alpha 1 | -0.0957263 |
| SLC39A11 | solute carrier family 39, member 11 | -0.0954356 |
| B2M | beta-2-microglobulin | -0.0848013 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0844427 |
| TAGLN2 | transgelin 2 | -0.0814953 |
| AHNAK | AHNAK nucleoprotein | -0.0814576 |
| POTEF | POTE ankyrin domain family, member F | -0.0799102 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0742129 |
| S100A6 | S100 calcium binding protein A6 | -0.0697559 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0687539 |
| SUCNR1 | succinate receptor 1 | -0.0649728 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.064565 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0634569 |
| SLC38A1 | solute carrier family 38, member 1 | -0.063247 |
| MSI2 | musashi RNA-binding protein 2 | -0.0632432 |
| LOXL2 | lysyl oxidase-like 2 | -0.0631724 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | -0.0616789 |
| PTMA | prothymosin, alpha | -0.0610575 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0600104 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0584804 |
| LDHA | lactate dehydrogenase A | -0.0581194 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0574812 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0573967 |
| SQSTM1 | sequestosome 1 | -0.0564582 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | -0.0550955 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0548687 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0548531 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0522726 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0518534 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | -0.0518483 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.051262 |
| FTL | ferritin, light polypeptide | -0.051067 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0504933 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0501243 |
| INSIG1 | insulin induced gene 1 | -0.0478231 |
| S100A4 | S100 calcium binding protein A4 | -0.0476616 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0474079 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.04735 |
| RTN4 | reticulon 4 | -0.047202 |
| PODXL | podocalyxin-like | -0.0463938 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0461451 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0461032 |
| CD109 | CD109 molecule | -0.0447436 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.044466 |
| OGA | O-GlcNAcase | -0.0436359 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0418102 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0413817 |
| SH3BP5 | SH3-domain binding protein 5 (BTK-associated) | -0.040378 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0398372 |
| RPL35A | ribosomal protein L35a | -0.0396371 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0396184 |
| MYADM | myeloid-associated differentiation marker | -0.0390252 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0387906 |
| MEIS2 | Meis homeobox 2 | -0.0387325 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0368559 |
| PGK1 | phosphoglycerate kinase 1 | -0.03679 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0364541 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | -0.0363647 |
| EGFR | epidermal growth factor receptor | -0.0363335 |
| SPAG9 | sperm associated antigen 9 | -0.0362582 |
| ULK1 | unc-51 like autophagy activating kinase 1 | -0.0361289 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0360073 |
| HLA-B | major histocompatibility complex, class I, B | -0.0359407 |
| MAP1B | microtubule-associated protein 1B | -0.0358683 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.035783 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0353487 |
| KRT81 | keratin 81, type II | -0.0353086 |
| S100A11 | S100 calcium binding protein A11 | -0.0351612 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.033703 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0333992 |
| TNS3 | tensin 3 | -0.033189 |
| MX2 | MX dynamin-like GTPase 2 | -0.0331253 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0327961 |
| AUTS2 | autism susceptibility candidate 2 | -0.0327493 |
| COPA | coatomer protein complex, subunit alpha | -0.0326823 |
| CANX | calnexin | -0.0321441 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0320887 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0317646 |
| COL5A2 | collagen, type V, alpha 2 | -0.0312365 |
| PRSS23 | protease, serine, 23 | -0.0311639 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0309695 |
| LMNA | lamin A/C | -0.0300315 |
| GTF2IRD1 | GTF2I repeat domain containing 1 | -0.0297299 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0295266 |
| FAM107B | family with sequence similarity 107, member B | -0.0291501 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0289372 |
| MMP12 | matrix metallopeptidase 12 | -0.0283389 |
| FNIP1 | folliculin interacting protein 1 | -0.0282512 |
