| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | HI-TOPK-032 perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the HI-TOPK-032_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AREG | amphiregulin | 0.254417 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.183559 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.155037 |
| VIM | vimentin | 0.101656 |
| NLGN1 | neuroligin 1 | 0.0967168 |
| CALR | calreticulin | 0.0878719 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.0865884 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.082528 |
| RRM2 | ribonucleotide reductase M2 | 0.0759372 |
| CANX | calnexin | 0.0744666 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0718063 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.068447 |
| YAP1 | Yes-associated protein 1 | 0.0652393 |
| MKI67 | marker of proliferation Ki-67 | 0.0625925 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0585061 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0574544 |
| TMSB10 | thymosin beta 10 | 0.0566218 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0560334 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0541577 |
| RPS12 | ribosomal protein S12 | 0.0535935 |
| RPS6 | ribosomal protein S6 | 0.0528342 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0505108 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.050455 |
| RTN4 | reticulon 4 | 0.0498221 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0484885 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0455934 |
| HMGA2 | high mobility group AT-hook 2 | 0.0440197 |
| TPM3 | tropomyosin 3 | 0.0436574 |
| WWOX | WW domain containing oxidoreductase | 0.0432345 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0427949 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0417023 |
| OLR1 | oxidized low density lipoprotein (lectin-like) receptor 1 | 0.0406269 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0392466 |
| CCN2 | cellular communication network factor 2 | 0.038194 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0376883 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0373315 |
| DNAJB11 | DnaJ (Hsp40) homolog, subfamily B, member 11 | 0.0366025 |
| XPOT | exportin, tRNA | 0.0365669 |
| SETX | senataxin | 0.035173 |
| RPS19 | ribosomal protein S19 | 0.035028 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0349452 |
| TUBA1B | tubulin, alpha 1b | 0.0345338 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0343315 |
| NEGR1 | neuronal growth regulator 1 | 0.033877 |
| HYOU1 | hypoxia up-regulated 1 | 0.0335221 |
| TPI1 | triosephosphate isomerase 1 | 0.03335 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0325556 |
| ASPH | aspartate beta-hydroxylase | 0.0325543 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0325236 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0319899 |
| PFN1 | profilin 1 | 0.0317363 |
| RPS8 | ribosomal protein S8 | 0.0314758 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0309936 |
| YBX1 | Y box binding protein 1 | 0.0302817 |
| DIAPH3 | diaphanous-related formin 3 | 0.0300683 |
| JMJD1C | jumonji domain containing 1C | 0.0298932 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0295496 |
| TMEM41B | transmembrane protein 41B | 0.0290548 |
| HDGF | hepatoma-derived growth factor | 0.0284895 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0283421 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0282768 |
| RPL3 | ribosomal protein L3 | 0.028244 |
| RPL9 | ribosomal protein L9 | 0.0279052 |
| PTMS | parathymosin | 0.0278488 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0276071 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0275807 |
| PCBP2 | poly(rC) binding protein 2 | 0.0272336 |
| UBC | ubiquitin C | 0.0270914 |
| POTEF | POTE ankyrin domain family, member F | 0.0269172 |
| ACTG1 | actin gamma 1 | 0.0268169 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | 0.0266983 |
| MAP1B | microtubule-associated protein 1B | 0.0264438 |
| ENO1 | enolase 1, (alpha) | 0.0262804 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0262755 |
| WDPCP | WD repeat containing planar cell polarity effector | 0.0260713 |
| RPL37A | ribosomal protein L37a | 0.0260389 |
| RPL37 | ribosomal protein L37 | 0.026029 |
| RPS27A | ribosomal protein S27a | 0.025945 |
| RPLP2 | ribosomal protein, large, P2 | 0.0258363 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0257145 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0255029 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0253654 |
| PCM1 | pericentriolar material 1 | 0.0253145 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0252052 |
| GOLGA4 | golgin A4 | 0.0250916 |
| PRELID2 | PRELI domain containing 2 | 0.0249527 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0248018 |
| RPL23 | ribosomal protein L23 | 0.0245911 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.0244517 |
| GOLGB1 | golgin B1 | 0.0243235 |
| PCDH7 | protocadherin 7 | 0.024073 |
| MYO10 | myosin X | 0.0238678 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0236418 |
| PTMA | prothymosin, alpha | 0.0234467 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0234223 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0233226 |
| SET | SET nuclear proto-oncogene | 0.0232168 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.022784 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | 0.0226541 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.022366 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0888939 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0847672 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | -0.0818884 |
| CLDN1 | claudin 1 | -0.0737309 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0647095 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0634951 |
| MMP12 | matrix metallopeptidase 12 | -0.0616381 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0616081 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0610991 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0579323 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.05728 |
| NEBL | nebulette | -0.0567632 |
| DST | dystonin | -0.0554407 |
| LMO7 | LIM domain 7 | -0.0545945 |
| EHBP1 | EH domain binding protein 1 | -0.0545886 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0542884 |
| AHNAK | AHNAK nucleoprotein | -0.0518258 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0517963 |
| RASAL2 | RAS protein activator like 2 | -0.0472212 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0466065 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0457923 |
| PEG10 | paternally expressed 10 | -0.0451332 |
| NF1 | neurofibromin 1 | -0.0447279 |
| SYT1 | synaptotagmin I | -0.0435562 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | -0.0434068 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0431674 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0406623 |
| CMIP | c-Maf inducing protein | -0.0402436 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0391794 |
| TENM3 | teneurin transmembrane protein 3 | -0.0385757 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0385365 |
| CARD16 | caspase recruitment domain family, member 16 | -0.0377636 |
| USP34 | ubiquitin specific peptidase 34 | -0.0377304 |
| TMEM131 | transmembrane protein 131 | -0.0377071 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0373292 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | -0.0370587 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0362981 |
| ELP4 | elongator acetyltransferase complex subunit 4 | -0.0359262 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0348756 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0341158 |
| MTAP | methylthioadenosine phosphorylase | -0.0329663 |
| ITSN1 | intersectin 1 (SH3 domain protein) | -0.0321828 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0320894 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0318976 |
| RAP1GDS1 | RAP1, GTP-GDP dissociation stimulator 1 | -0.031438 |
| ZNF217 | zinc finger protein 217 | -0.0313888 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0313119 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0310336 |
| NABP1 | nucleic acid binding protein 1 | -0.0308738 |
| CXADR | coxsackie virus and adenovirus receptor | -0.0302664 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0299689 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0293537 |
| RAB10 | RAB10, member RAS oncogene family | -0.0292976 |
| CDK6 | cyclin-dependent kinase 6 | -0.0290788 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0288139 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0285885 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0284305 |
| LARS1 | leucyl-tRNA synthetase 1 | -0.0282522 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0282112 |
| RIMKLB | ribosomal modification protein rimK-like family member B | -0.0280528 |
| GCG | glucagon | -0.0279738 |
| TSPAN5 | tetraspanin 5 | -0.027893 |
| NHSL1 | NHS-like 1 | -0.0273663 |
| RNF13 | ring finger protein 13 | -0.02727 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0270829 |
| WDR43 | WD repeat domain 43 | -0.0269307 |
| THOC2 | THO complex 2 | -0.0269052 |
| LARP1 | La ribonucleoprotein domain family, member 1 | -0.0264542 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0264456 |
| SBF2 | SET binding factor 2 | -0.0258662 |
| ZNF804A | zinc finger protein 804A | -0.0258481 |
| FSTL5 | follistatin-like 5 | -0.0256932 |
| ACBD6 | acyl-CoA binding domain containing 6 | -0.0255762 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0255534 |
| NEK7 | NIMA-related kinase 7 | -0.025526 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0254502 |
| PGK1 | phosphoglycerate kinase 1 | -0.0252993 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0251362 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0249542 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0249193 |
| SMYD3 | SET and MYND domain containing 3 | -0.0246757 |
| VPS8 | vacuolar protein sorting 8 homolog (S. cerevisiae) | -0.0246375 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.0243504 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | -0.024307 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0241875 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0240342 |
| ZNF407 | zinc finger protein 407 | -0.0239279 |
| CDK17 | cyclin-dependent kinase 17 | -0.0238945 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0237725 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.023532 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | -0.0235316 |
| R3HDM1 | R3H domain containing 1 | -0.0232937 |
| UBE2K | ubiquitin-conjugating enzyme E2K | -0.0232198 |
| SRPK2 | SRSF protein kinase 2 | -0.0226087 |
| MED13L | mediator complex subunit 13-like | -0.0225598 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0222639 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0222238 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | -0.0220241 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0220145 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0218677 |
