| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | HI-TOPK-032 perturbation in CHP-212 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the HI-TOPK-032_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VCL | vinculin | 0.139247 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0811726 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0659321 |
| FMN1 | formin 1 | 0.0571995 |
| TLE4 | transducin-like enhancer of split 4 | 0.0544173 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | 0.0484396 |
| GLCCI1 | glucocorticoid induced 1 | 0.0474191 |
| ANTXR1 | anthrax toxin receptor 1 | 0.0455814 |
| THBS1 | thrombospondin 1 | 0.044718 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0426655 |
| MCL1 | myeloid cell leukemia 1 | 0.0418526 |
| HOMER1 | homer scaffolding protein 1 | 0.0398488 |
| MYO1E | myosin IE | 0.0377751 |
| SP100 | SP100 nuclear antigen | 0.0356907 |
| RNF213 | ring finger protein 213 | 0.0356624 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.0344021 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.034083 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0318963 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | 0.0316123 |
| PTPRE | protein tyrosine phosphatase, receptor type, E | 0.0316083 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0313198 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0309316 |
| STK38L | serine/threonine kinase 38 like | 0.0307938 |
| BPTF | bromodomain PHD finger transcription factor | 0.0304752 |
| PLPP1 | phospholipid phosphatase 1 | 0.0302155 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0292047 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0291859 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0283411 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0279445 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0279204 |
| SETBP1 | SET binding protein 1 | 0.0278421 |
| FLT1 | fms-related tyrosine kinase 1 | 0.0276782 |
| PLAT | plasminogen activator, tissue | 0.0274405 |
| PRKCA | protein kinase C, alpha | 0.0268751 |
| EGR1 | early growth response 1 | 0.0264897 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0264825 |
| AEBP2 | AE binding protein 2 | 0.0262985 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0261941 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0259354 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0259174 |
| TPM1 | tropomyosin 1 (alpha) | 0.0256042 |
| TPST1 | tyrosylprotein sulfotransferase 1 | 0.024584 |
| FERMT2 | fermitin family member 2 | 0.0245786 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0243931 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0231481 |
| ANKS1A | ankyrin repeat and sterile alpha motif domain containing 1A | 0.0228611 |
| ADAMTS9 | ADAM metallopeptidase with thrombospondin type 1 motif, 9 | 0.0227652 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.022518 |
| ASPH | aspartate beta-hydroxylase | 0.0224333 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0218864 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0218778 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0217717 |
| PDLIM5 | PDZ and LIM domain 5 | 0.021648 |
| DNM3 | dynamin 3 | 0.0216133 |
| EXOC4 | exocyst complex component 4 | 0.0210233 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0209557 |
| ACTG1 | actin gamma 1 | 0.0208498 |
| STXBP4 | syntaxin binding protein 4 | 0.0207559 |
| DUSP10 | dual specificity phosphatase 10 | 0.0207439 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0206359 |
| FAM107B | family with sequence similarity 107, member B | 0.0206031 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.020106 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0200072 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0199732 |
| GOLGB1 | golgin B1 | 0.0196519 |
| RIGI | RNA sensor RIG-I | 0.0196448 |
| GPC5 | glypican 5 | 0.0195929 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0194999 |
| EGFR | epidermal growth factor receptor | 0.0193703 |
| DPH6 | diphthamine biosynthesis 6 | 0.0192637 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0191981 |
| DNMBP | dynamin binding protein | 0.0189294 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0188431 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0188408 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0188347 |
| PCDH17 | protocadherin 17 | 0.0180899 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.01791 |
| SIK2 | salt-inducible kinase 2 | 0.0179079 |
| ACTN1 | actinin, alpha 1 | 0.0178359 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0178118 |
| PALLD | palladin, cytoskeletal associated protein | 0.0177978 |
| SMAD3 | SMAD family member 3 | 0.0177918 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0177835 |
| FHL2 | four and a half LIM domains 2 | 0.0177407 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0176674 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0176226 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0174909 |
| PDE10A | phosphodiesterase 10A | 0.0174869 |
| SMYD3 | SET and MYND domain containing 3 | 0.0173862 |
| UNC5C | unc-5 homolog C (C. elegans) | 0.0173633 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0173261 |
| LIMA1 | LIM domain and actin binding 1 | 0.0172617 |
| MYO9A | myosin IXA | 0.0172328 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0171937 |
| GREM2 | gremlin 2, DAN family BMP antagonist | 0.0171587 |
| DNAH14 | dynein, axonemal, heavy chain 14 | 0.0171237 |
| BRD2 | bromodomain containing 2 | 0.0170483 |
| PCBP3 | poly(rC) binding protein 3 | 0.0164887 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.016477 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0159693 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | -0.45118 |
| IGF2 | insulin-like growth factor 2 | -0.142563 |
| PTMA | prothymosin, alpha | -0.0832747 |
| VIM | vimentin | -0.0728726 |
| COL3A1 | collagen, type III, alpha 1 | -0.0715959 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0679061 |
| FAM13A | family with sequence similarity 13, member A | -0.0644388 |
| COL1A1 | collagen, type I, alpha 1 | -0.0624666 |
| HELZ | helicase with zinc finger | -0.0607684 |
| RPL35A | ribosomal protein L35a | -0.0572564 |
| RPS24 | ribosomal protein S24 | -0.0499604 |
| WDR45B | WD repeat domain 45B | -0.0489043 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0484883 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0474981 |
| RPLP1 | ribosomal protein, large, P1 | -0.0471242 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0457649 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0420044 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0415283 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0415221 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0397522 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0388702 |
| NDRG1 | N-myc downstream regulated 1 | -0.0383455 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0382994 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | -0.0382742 |
| SETD5 | SET domain containing 5 | -0.0381801 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0376415 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0374192 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0368972 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0357735 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0355835 |
| PTK2 | protein tyrosine kinase 2 | -0.0355216 |
| DTNA | dystrobrevin, alpha | -0.03458 |
| MEIS2 | Meis homeobox 2 | -0.0337624 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0327117 |
| RPL34 | ribosomal protein L34 | -0.0324889 |
| SPAG9 | sperm associated antigen 9 | -0.0324319 |
| GNAS | GNAS complex locus | -0.0318924 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0316396 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0313584 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0308789 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0305583 |
| MED13 | mediator complex subunit 13 | -0.0299133 |
| RPL19 | ribosomal protein L19 | -0.0297399 |
| ZNF292 | zinc finger protein 292 | -0.0296603 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0294694 |
| OGA | O-GlcNAcase | -0.0293993 |
| QKI | QKI, KH domain containing, RNA binding | -0.0291772 |
| C1ORF21 | chromosome 1 open reading frame 21 | -0.0289379 |
| RNF145 | ring finger protein 145 | -0.0285096 |
| B2M | beta-2-microglobulin | -0.0284397 |
| RBM39 | RNA binding motif protein 39 | -0.0282645 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0281669 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0281103 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0269892 |
| NUP58 | nucleoporin 58 | -0.026989 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.02663 |
| MEF2A | myocyte enhancer factor 2A | -0.0265965 |
| LMNA | lamin A/C | -0.026346 |
| USP3 | ubiquitin specific peptidase 3 | -0.0261957 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.026176 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0261736 |
| SYT1 | synaptotagmin I | -0.0261483 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | -0.0260445 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0257563 |
| CLTC | clathrin, heavy chain (Hc) | -0.0256186 |
| PCDH9 | protocadherin 9 | -0.0255209 |
| FKBP10 | FK506 binding protein 10, 65 kDa | -0.0254961 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0249964 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0247753 |
| RPS6 | ribosomal protein S6 | -0.0247606 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0244762 |
| GPBP1 | GC-rich promoter binding protein 1 | -0.0242822 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0241479 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0239566 |
| CDC27 | cell division cycle 27 | -0.0239173 |
| RPL7 | ribosomal protein L7 | -0.0238368 |
| CCDC47 | coiled-coil domain containing 47 | -0.023778 |
| MAP1B | microtubule-associated protein 1B | -0.0237292 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0237175 |
| PPM1D | protein phosphatase, Mg2+/Mn2+ dependent, 1D | -0.0236891 |
| POU2F1 | POU class 2 homeobox 1 | -0.0236686 |
| XPR1 | xenotropic and polytropic retrovirus receptor 1 | -0.0236546 |
| RFX7 | regulatory factor X, 7 | -0.0234859 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0234088 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.0233163 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0230408 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0228761 |
| PKM | pyruvate kinase, muscle | -0.0228481 |
| CEP95 | centrosomal protein 95kDa | -0.0227451 |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | -0.0227341 |
| SRP54 | signal recognition particle 54kDa | -0.0226486 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0226147 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | -0.022556 |
| RTN4 | reticulon 4 | -0.0224685 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0224036 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0223654 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0223182 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.02227 |
| HMGB2 | high mobility group box 2 | -0.0221832 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.022155 |
