| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | HI-TOPK-032 perturbation in COLO 205 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the HI-TOPK-032_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | 0.25826 |
| LCN2 | lipocalin 2 | 0.21743 |
| MACC1 | metastasis associated in colon cancer 1 | 0.119357 |
| MYO1E | myosin IE | 0.106323 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | 0.104019 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.102746 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0849715 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | 0.0719601 |
| SMAD3 | SMAD family member 3 | 0.0695896 |
| KYNU | kynureninase | 0.0602465 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0525615 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0492453 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0485973 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0440536 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0440081 |
| AREG | amphiregulin | 0.0435924 |
| EREG | epiregulin | 0.0428649 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0424097 |
| DUSP10 | dual specificity phosphatase 10 | 0.0423073 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0418678 |
| TJP1 | tight junction protein 1 | 0.0408989 |
| MX1 | MX dynamin-like GTPase 1 | 0.0397911 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0388295 |
| HKDC1 | hexokinase domain containing 1 | 0.0371409 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0363504 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.035694 |
| PDZD8 | PDZ domain containing 8 | 0.0340682 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.033384 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | 0.0330785 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0325757 |
| ETV6 | ets variant 6 | 0.0319942 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0313023 |
| OAS1 | 2'-5'-oligoadenylate synthetase 1, 40/46kDa | 0.0310859 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.030112 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0294888 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.02903 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 0.0287226 |
| EFNB2 | ephrin-B2 | 0.028441 |
| DST | dystonin | 0.0273334 |
| STK24 | serine/threonine kinase 24 | 0.0269126 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0262569 |
| YAP1 | Yes-associated protein 1 | 0.026207 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | 0.0261083 |
| RND3 | Rho family GTPase 3 | 0.0260208 |
| CLDN4 | claudin 4 | 0.0254055 |
| CTBP2 | C-terminal binding protein 2 | 0.024981 |
| TOX3 | TOX high mobility group box family member 3 | 0.0249339 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0248736 |
| C6ORF132 | chromosome 6 open reading frame 132 | 0.0247658 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0245759 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | 0.0243998 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0242997 |
| VMP1 | vacuole membrane protein 1 | 0.0239049 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0232364 |
| INTS6 | integrator complex subunit 6 | 0.0231624 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0231614 |
| ITGB8 | integrin, beta 8 | 0.022844 |
| SLK | STE20-like kinase | 0.0225703 |
| MEIS2 | Meis homeobox 2 | 0.0225422 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.0224404 |
| FNIP2 | folliculin interacting protein 2 | 0.0219669 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0217567 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0215194 |
| DPP4 | dipeptidyl-peptidase 4 | 0.0214537 |
| DUSP16 | dual specificity phosphatase 16 | 0.021317 |
| STS | steroid sulfatase (microsomal), isozyme S | 0.0212399 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.021151 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0209601 |
| TTC39B | tetratricopeptide repeat domain 39B | 0.0209021 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0208609 |
| CYSTM1 | cysteine-rich transmembrane module containing 1 | 0.0207972 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0207079 |
| XDH | xanthine dehydrogenase | 0.0204912 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | 0.0203014 |
| C3ORF52 | chromosome 3 open reading frame 52 | 0.0202858 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0201177 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0201038 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.0199653 |
| EFNA5 | ephrin-A5 | 0.0198604 |
| TMC5 | transmembrane channel-like 5 | 0.0196399 |
| LURAP1L | leucine rich adaptor protein 1-like | 0.0195918 |
| RAB3IP | RAB3A interacting protein | 0.0195219 |
| CD44 | CD44 molecule (Indian blood group) | 0.019489 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.019316 |
| EHBP1 | EH domain binding protein 1 | 0.0190683 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0190076 |
| ADAMTS9 | ADAM metallopeptidase with thrombospondin type 1 motif, 9 | 0.0189624 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0189424 |
| EZR | ezrin | 0.0188408 |
| FN1 | fibronectin 1 | 0.0187663 |
| RBM47 | RNA binding motif protein 47 | 0.0184634 |
| TMEM65 | transmembrane protein 65 | 0.0184494 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0183224 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0183147 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0183085 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | 0.0181942 |
| BCL2L1 | BCL2-like 1 | 0.0180836 |
| RPL21 | ribosomal protein L21 | 0.0180705 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0180606 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.018051 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.168491 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.147342 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.122833 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.120442 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.114336 |
| LYZ | lysozyme | -0.111831 |
| B2M | beta-2-microglobulin | -0.100041 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0979758 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0904579 |
| HLA-B | major histocompatibility complex, class I, B | -0.0843807 |
| NPSR1 | neuropeptide S receptor 1 | -0.0806352 |
| TXNIP | thioredoxin interacting protein | -0.0793591 |
| PTMA | prothymosin, alpha | -0.0756837 |
| PHF3 | PHD finger protein 3 | -0.0756406 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0717612 |
| AHI1 | Abelson helper integration site 1 | -0.0716629 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0707858 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0682793 |
| NDRG1 | N-myc downstream regulated 1 | -0.0671042 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0663633 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0646755 |
| PERP | PERP, TP53 apoptosis effector | -0.0642807 |
| CANX | calnexin | -0.0636051 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.0632325 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0579623 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0575156 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.057138 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0567142 |
| GOLGB1 | golgin B1 | -0.0543426 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.053123 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0526285 |
| HDLBP | high density lipoprotein binding protein | -0.0516926 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0509752 |
| NT5C3A | 5'-nucleotidase, cytosolic IIIA | -0.0499504 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0486921 |
| EGR1 | early growth response 1 | -0.0471661 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0461878 |
| RBM39 | RNA binding motif protein 39 | -0.0450167 |
| SQSTM1 | sequestosome 1 | -0.0447385 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0446569 |
| PGK1 | phosphoglycerate kinase 1 | -0.044427 |
| WDR45B | WD repeat domain 45B | -0.0433579 |
| SEC24D | SEC24 family member D | -0.0432702 |
| RPL35A | ribosomal protein L35a | -0.0432063 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0427879 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0427237 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0408341 |
| HM13 | histocompatibility (minor) 13 | -0.0408035 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0403922 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0402316 |
| NF1 | neurofibromin 1 | -0.0397838 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0396069 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0394077 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0386976 |
| HLA-E | major histocompatibility complex, class I, E | -0.0382611 |
| ANXA2 | annexin A2 | -0.0378734 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0378686 |
| ABLIM1 | actin binding LIM protein 1 | -0.0366525 |
| MAP7 | microtubule-associated protein 7 | -0.0366232 |
| HBS1L | HBS1-like translational GTPase | -0.0365447 |
| RPL34 | ribosomal protein L34 | -0.0364626 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0363854 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0360141 |
| RRBP1 | ribosome binding protein 1 | -0.0356201 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | -0.0352917 |
| H1-0 | H1.0 linker histone | -0.035054 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0345232 |
| CTSD | cathepsin D | -0.034138 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0341008 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0339295 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.03391 |
| MCTP2 | multiple C2 domains, transmembrane 2 | -0.033892 |
| DIS3 | DIS3 exosome endoribonuclease and 3'-5' exoribonuclease | -0.0338896 |
| AHNAK | AHNAK nucleoprotein | -0.0338359 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | -0.0334204 |
| COG6 | component of oligomeric golgi complex 6 | -0.0333003 |
| XAF1 | XIAP associated factor 1 | -0.0331125 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0330825 |
| RIGI | RNA sensor RIG-I | -0.0327315 |
| PKM | pyruvate kinase, muscle | -0.0326677 |
| LDHA | lactate dehydrogenase A | -0.0324498 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0323889 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0322869 |
| GOLGA2 | golgin A2 | -0.0322741 |
| PRKCA | protein kinase C, alpha | -0.0322167 |
| HLA-C | major histocompatibility complex, class I, C | -0.0320258 |
| RTN3 | reticulon 3 | -0.0311017 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0310995 |
| MORF4L2 | mortality factor 4 like 2 | -0.0309443 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0308706 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0305788 |
| TM9SF2 | transmembrane 9 superfamily member 2 | -0.030546 |
| GNAS | GNAS complex locus | -0.0302947 |
| RPS24 | ribosomal protein S24 | -0.030285 |
| WASF2 | WAS protein family, member 2 | -0.0300799 |
| TFRC | transferrin receptor | -0.0299422 |
| SSH2 | slingshot protein phosphatase 2 | -0.0298351 |
| TM4SF19 | transmembrane 4 L six family member 19 | -0.0296719 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0293527 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | -0.0292917 |
