HI-TOPK-032_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description HI-TOPK-032 perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the HI-TOPK-032_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP1 insulin-like growth factor binding protein 1 0.217038
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.17393
TIMP1 TIMP metallopeptidase inhibitor 1 0.169897
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.149169
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.111794
SPTBN1 spectrin, beta, non-erythrocytic 1 0.106014
RPS6 ribosomal protein S6 0.0922711
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0919803
SVIL supervillin 0.0919183
RPS12 ribosomal protein S12 0.0895786
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0753002
C3 complement component 3 0.0740498
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0703083
CCL20 chemokine (C-C motif) ligand 20 0.0674284
RPL37A ribosomal protein L37a 0.0665518
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0626904
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.06189
RPL23 ribosomal protein L23 0.0609833
SRRM2 serine/arginine repetitive matrix 2 0.0593448
DSPP dentin sialophosphoprotein 0.0580417
BCL2L1 BCL2-like 1 0.0567044
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0544974
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0535419
INTS6 integrator complex subunit 6 0.0530276
PDLIM5 PDZ and LIM domain 5 0.049548
KYNU kynureninase 0.0494532
SLC38A2 solute carrier family 38, member 2 0.0477204
SAMD4A sterile alpha motif domain containing 4A 0.0465599
UBC ubiquitin C 0.0458604
EEF2 eukaryotic translation elongation factor 2 0.0451934
RPL5 ribosomal protein L5 0.0442965
PEG3 paternally expressed 3 0.0431796
RPL19 ribosomal protein L19 0.043175
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.041958
RPLP2 ribosomal protein, large, P2 0.0414347
MBNL2 muscleblind-like splicing regulator 2 0.0412844
FOXP1 forkhead box P1 0.0408834
PNISR PNN-interacting serine/arginine-rich protein 0.0392625
FAT1 FAT atypical cadherin 1 0.0392372
DSTN destrin (actin depolymerizing factor) 0.0384595
RPL26 ribosomal protein L26 0.0383929
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0379417
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0379025
AKAP12 A kinase (PRKA) anchor protein 12 0.0374956
TM4SF1 transmembrane 4 L six family member 1 0.0351379
RPS3 ribosomal protein S3 0.0350417
RPL36 ribosomal protein L36 0.0341551
ANKRD12 ankyrin repeat domain 12 0.0337969
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0337132
RPL21 ribosomal protein L21 0.0327159
LCN2 lipocalin 2 0.0320062
PALLD palladin, cytoskeletal associated protein 0.0298322
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.029757
KLF6 Kruppel-like factor 6 0.0297068
DNAH17 dynein, axonemal, heavy chain 17 0.0296465
RPS25 ribosomal protein S25 0.0294513
RPL3 ribosomal protein L3 0.0294275
EIF5 eukaryotic translation initiation factor 5 0.0294098
RPS19 ribosomal protein S19 0.0292984
ACSL5 acyl-CoA synthetase long-chain family member 5 0.0292116
FERMT2 fermitin family member 2 0.0288377
RPL36A ribosomal protein L36a 0.0285741
ZBTB38 zinc finger and BTB domain containing 38 0.0278855
BPTF bromodomain PHD finger transcription factor 0.0278541
ITGB5 integrin, beta 5 0.0276996
RPS17 ribosomal protein S17 0.0270382
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 0.0270158
RPS27A ribosomal protein S27a 0.026764
NSUN6 NOP2/Sun domain family, member 6 0.0265951
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0265339
JAG1 jagged 1 0.0264632
RPS8 ribosomal protein S8 0.0263416
APOB apolipoprotein B 0.0263276
TCIM transcriptional and immune response regulator 0.026202
DST dystonin 0.0257735
ANKRD11 ankyrin repeat domain 11 0.0257584
RPS15A ribosomal protein S15a 0.0257063
RPL32 ribosomal protein L32 0.0256947
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0253665
CCN2 cellular communication network factor 2 0.0249832
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0248303
EIF1 eukaryotic translation initiation factor 1 0.0247034
TNS3 tensin 3 0.0243938
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 0.024279
AHR aryl hydrocarbon receptor 0.0240728
CPE carboxypeptidase E 0.023889
PLEC plectin 0.0234077
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0233425
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.023208
PRRC2C proline-rich coiled-coil 2C 0.023134
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.02308
MYH9 myosin, heavy chain 9, non-muscle 0.0229715
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0226107
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0225141
RPL18 ribosomal protein L18 0.0225063
RPS14 ribosomal protein S14 0.0222612
HNMT histamine N-methyltransferase 0.0222265
TOP1 topoisomerase (DNA) I 0.022031
FAM107B family with sequence similarity 107, member B 0.0220169
EIF3A eukaryotic translation initiation factor 3, subunit A 0.022

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.155295
FNDC3B fibronectin type III domain containing 3B -0.137515
GPC3 glypican 3 -0.131473
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.114985
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0905838
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0905651
DHRS2 dehydrogenase/reductase (SDR family) member 2 -0.0892701
ZMYND8 zinc finger, MYND-type containing 8 -0.08881
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0873702
FN1 fibronectin 1 -0.0866659
CP ceruloplasmin (ferroxidase) -0.0752209
AHSG alpha-2-HS-glycoprotein -0.0735848
EML4 echinoderm microtubule associated protein like 4 -0.0701518
HMGA1 high mobility group AT-hook 1 -0.0667718
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0664317
TMEM123 transmembrane protein 123 -0.0566344
RBM39 RNA binding motif protein 39 -0.0556702
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0540176
KDM3A lysine (K)-specific demethylase 3A -0.052947
GMDS GDP-mannose 4,6-dehydratase -0.0497498
RPLP1 ribosomal protein, large, P1 -0.0491777
PGK1 phosphoglycerate kinase 1 -0.0485017
MSI2 musashi RNA-binding protein 2 -0.0468169
SDC4 syndecan 4 -0.0466634
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0464491
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0456044
PLIN2 perilipin 2 -0.0446635
NPR2 natriuretic peptide receptor 2 -0.0436258
NPAS2 neuronal PAS domain protein 2 -0.0432962
RUNX1 runt-related transcription factor 1 -0.0421755
SLC38A1 solute carrier family 38, member 1 -0.0409557
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0404442
GPC6 glypican 6 -0.0392427
PERP PERP, TP53 apoptosis effector -0.0391444
GNAS GNAS complex locus -0.0390707
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0388777
BIRC6 baculoviral IAP repeat containing 6 -0.0388765
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0385047
NDRG1 N-myc downstream regulated 1 -0.0378768
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0376605
RPL35A ribosomal protein L35a -0.0375155
MAML2 mastermind-like 2 (Drosophila) -0.0371486
RERE arginine-glutamic acid dipeptide (RE) repeats -0.036827
AFDN afadin, adherens junction formation factor -0.0364725
PEG10 paternally expressed 10 -0.0362483
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0360457
LDHA lactate dehydrogenase A -0.0359895
LOC112694756 uncharaterized LOC112694756 -0.0359194
SOX5 SRY (sex determining region Y)-box 5 -0.0356283
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 -0.0334993
NGLY1 N-glycanase 1 -0.0322055
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -0.0318004
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0317353
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0315874
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0313608
ATP10A ATPase, class V, type 10A -0.0309555
RAB1A RAB1A, member RAS oncogene family -0.0309053
ZBTB20 zinc finger and BTB domain containing 20 -0.0308453
ARFGEF3 ARFGEF family member 3 -0.0305349
OSMR oncostatin M receptor -0.0304688
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0301222
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0300906
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0294956
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0293058
INSIG2 insulin induced gene 2 -0.0291943
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0291394
B2M beta-2-microglobulin -0.029073
FTL ferritin, light polypeptide -0.0287852
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 -0.0287349
DEK DEK proto-oncogene -0.0285095
EGR1 early growth response 1 -0.028383
LRMDA leucine rich melanocyte differentiation associated -0.0282285
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0277707
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0276412
MAPK14 mitogen-activated protein kinase 14 -0.0272497
CYTH1 cytohesin 1 -0.0268622
BHLHE40 basic helix-loop-helix family, member e40 -0.0262993
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 -0.0262389
EHBP1 EH domain binding protein 1 -0.0261986
GLG1 golgi glycoprotein 1 -0.0260308
TRIO trio Rho guanine nucleotide exchange factor -0.0259537
TFRC transferrin receptor -0.0259127
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0258304
AMBP alpha-1-microglobulin/bikunin precursor -0.0256425
TPT1 tumor protein, translationally-controlled 1 -0.0249738
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0247647
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0246957
MX2 MX dynamin-like GTPase 2 -0.0245316
UBE2K ubiquitin-conjugating enzyme E2K -0.0245193
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0245021
APOA2 apolipoprotein A-II -0.0242842
FOXO3 forkhead box O3 -0.0242818
SESTD1 SEC14 and spectrin domains 1 -0.0240627
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0239207
WAC WW domain containing adaptor with coiled-coil -0.023892
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0238819
ZFAND3 zinc finger, AN1-type domain 3 -0.0234208
KCMF1 potassium channel modulatory factor 1 -0.0231627
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 -0.0231127
FOXK2 forkhead box K2 -0.0230339