HI-TOPK-032_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description HI-TOPK-032 perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the HI-TOPK-032_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 0.168414
CLU clusterin 0.143885
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.139306
RPS6 ribosomal protein S6 0.137303
RPS8 ribosomal protein S8 0.130853
RPLP2 ribosomal protein, large, P2 0.1179
ENO1 enolase 1, (alpha) 0.110165
RPS12 ribosomal protein S12 0.109819
RPS3 ribosomal protein S3 0.0952451
S100A10 S100 calcium binding protein A10 0.0914622
SRRM2 serine/arginine repetitive matrix 2 0.0890252
LMO7 LIM domain 7 0.0828934
MBNL1 muscleblind-like splicing regulator 1 0.0802522
TMSB4X thymosin beta 4, X-linked 0.0788989
UBC ubiquitin C 0.0760117
RPS25 ribosomal protein S25 0.0748523
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0745455
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0728594
RPS13 ribosomal protein S13 0.0724104
RPL37 ribosomal protein L37 0.0723241
RPL31 ribosomal protein L31 0.0719919
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0691714
PDE4D phosphodiesterase 4D, cAMP-specific 0.0682419
RPS19 ribosomal protein S19 0.0678635
IFITM3 interferon induced transmembrane protein 3 0.0677619
RPL26 ribosomal protein L26 0.0651628
RPL11 ribosomal protein L11 0.0647492
TMSB10 thymosin beta 10 0.0645433
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0641201
HLA-B major histocompatibility complex, class I, B 0.0638404
RPL37A ribosomal protein L37a 0.0634872
RPL12 ribosomal protein L12 0.0624807
PTMA prothymosin, alpha 0.0617365
B2M beta-2-microglobulin 0.0610878
IFI6 interferon, alpha-inducible protein 6 0.0606025
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0605773
RPL8 ribosomal protein L8 0.0595551
CD44 CD44 molecule (Indian blood group) 0.0593003
RPS14 ribosomal protein S14 0.0583093
TXNIP thioredoxin interacting protein 0.0576654
MT1E metallothionein 1E 0.0558938
RPS27A ribosomal protein S27a 0.0558417
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0550045
RPL36A ribosomal protein L36a 0.0549265
RPL5 ribosomal protein L5 0.0542217
FOXP1 forkhead box P1 0.0538624
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0529081
RPL19 ribosomal protein L19 0.052793
IFITM1 interferon induced transmembrane protein 1 0.0514711
RPL23 ribosomal protein L23 0.0514078
MT2A metallothionein 2A 0.0512647
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0511845
RPS21 ribosomal protein S21 0.0506353
RACK1 receptor for activated C kinase 1 0.0505009
IFI27 interferon, alpha-inducible protein 27 0.0496733
IFI44L interferon-induced protein 44-like 0.0492766
RPS17 ribosomal protein S17 0.0483089
ASPH aspartate beta-hydroxylase 0.0480788
RPL21 ribosomal protein L21 0.0479855
SP100 SP100 nuclear antigen 0.0479422
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.0479146
BCAR3 breast cancer anti-estrogen resistance 3 0.047449
S100A9 S100 calcium binding protein A9 0.046409
DSTN destrin (actin depolymerizing factor) 0.0463152
EIF1 eukaryotic translation initiation factor 1 0.045035
RPS27 ribosomal protein S27 0.044952
STAU1 staufen double-stranded RNA binding protein 1 0.0443376
RPL36 ribosomal protein L36 0.0441362
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0438176
MKI67 marker of proliferation Ki-67 0.0431924
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0431783
RPL34 ribosomal protein L34 0.0431028
FTL ferritin, light polypeptide 0.0429906
NAP1L1 nucleosome assembly protein 1-like 1 0.0426947
RPL32 ribosomal protein L32 0.041842
ASTN2 astrotactin 2 0.0408361
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0408037
RPL7A ribosomal protein L7a 0.0404458
PRRC2C proline-rich coiled-coil 2C 0.0403081
EEF2 eukaryotic translation elongation factor 2 0.0401602
PLAT plasminogen activator, tissue 0.0395735
RPS23 ribosomal protein S23 0.0391676
RPS4X ribosomal protein S4, X-linked 0.0386414
APLP2 amyloid beta (A4) precursor-like protein 2 0.0380906
CALR calreticulin 0.0378228
HSPA8 heat shock 70kDa protein 8 0.037022
TIMP3 TIMP metallopeptidase inhibitor 3 0.0364641
SAMD9 sterile alpha motif domain containing 9 0.0363682
H1-0 H1.0 linker histone 0.0361381
RPL35 ribosomal protein L35 0.0360169
DUSP4 dual specificity phosphatase 4 0.0355595
KTN1 kinectin 1 (kinesin receptor) 0.0354017
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0353717
HLA-E major histocompatibility complex, class I, E 0.0351031
RPL38 ribosomal protein L38 0.0343887
STC1 stanniocalcin 1 0.0343026
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0342516
ITGA6 integrin, alpha 6 0.0340728
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0336001
RPL9 ribosomal protein L9 0.0330842

decreased expression

Symbol Name Standardized Value
TRIO trio Rho guanine nucleotide exchange factor -0.0900274
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0782683
SULF1 sulfatase 1 -0.0675995
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0606131
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0596532
ABI3BP ABI family, member 3 (NESH) binding protein -0.058527
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0534054
NAMPT nicotinamide phosphoribosyltransferase -0.0489291
NAV2 neuron navigator 2 -0.0469905
PSD3 pleckstrin and Sec7 domain containing 3 -0.0424119
RBM39 RNA binding motif protein 39 -0.0421313
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0417142
GRB10 growth factor receptor-bound protein 10 -0.0413044
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0408509
SLC35F3 solute carrier family 35, member F3 -0.0401527
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0399607
EFHD2 EF-hand domain family, member D2 -0.0391251
HSPG2 heparan sulfate proteoglycan 2 -0.0381668
POTEF POTE ankyrin domain family, member F -0.0371923
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0362415
MYOF myoferlin -0.0362309
SBF2 SET binding factor 2 -0.035976
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0357012
PODXL podocalyxin-like -0.035683
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0347721
FNIP1 folliculin interacting protein 1 -0.0347247
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0329593
PDLIM5 PDZ and LIM domain 5 -0.0326406
DPYD dihydropyrimidine dehydrogenase -0.0313296
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0311314
LAMA5 laminin, alpha 5 -0.030394
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0299776
RIGI RNA sensor RIG-I -0.0290083
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0288056
RUNX1 runt-related transcription factor 1 -0.0274774
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0274475
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.027261
ALCAM activated leukocyte cell adhesion molecule -0.026526
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.0259906
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0253416
ZMYND8 zinc finger, MYND-type containing 8 -0.0251455
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0247016
COG5 component of oligomeric golgi complex 5 -0.0246324
NDRG1 N-myc downstream regulated 1 -0.0245665
RAD51B RAD51 paralog B -0.0242912
KIAA1217 KIAA1217 -0.0242264
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -0.0241698
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0240754
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0234483
C4BPB complement component 4 binding protein, beta -0.0232054
TMEM165 transmembrane protein 165 -0.0231532
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.023059
GNAS GNAS complex locus -0.0229079
TNS3 tensin 3 -0.0224842
FN1 fibronectin 1 -0.0222498
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.022124
FOXO3 forkhead box O3 -0.0214452
CYB5R3 cytochrome b5 reductase 3 -0.0213135
BHLHE40 basic helix-loop-helix family, member e40 -0.0209733
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0209578
SUCO SUN domain containing ossification factor -0.0206886
DLG1 discs, large homolog 1 (Drosophila) -0.0201488
F3 coagulation factor III (thromboplastin, tissue factor) -0.0201193
PLS3 plastin 3 -0.0200285
ANO1 anoctamin 1, calcium activated chloride channel -0.0198604
DIAPH3 diaphanous-related formin 3 -0.0197945
GLS2 glutaminase 2 (liver, mitochondrial) -0.0191612
ARHGAP26 Rho GTPase activating protein 26 -0.0191353
PCDH9 protocadherin 9 -0.0189843
FRMD4B FERM domain containing 4B -0.018946
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0185737
ANKRD33B ankyrin repeat domain 33B -0.0185366
LOXL2 lysyl oxidase-like 2 -0.0184423
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 -0.0184421
RASAL2 RAS protein activator like 2 -0.0184345
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0180844
SPATS2 spermatogenesis associated, serine-rich 2 -0.0179613
NT5C2 5'-nucleotidase, cytosolic II -0.0178023
SPAG9 sperm associated antigen 9 -0.0177598
ARF4 ADP-ribosylation factor 4 -0.0176914
SEC24D SEC24 family member D -0.0174623
ABLIM3 actin binding LIM protein family, member 3 -0.0174214
THBD thrombomodulin -0.0173436
MON2 MON2 homolog (S. cerevisiae) -0.0171467
ANXA5 annexin A5 -0.0170733
SOD2 superoxide dismutase 2, mitochondrial -0.0170548
RNF38 ring finger protein 38 -0.0170283
SEC24A SEC24 family member A -0.0169553
SLC45A4 solute carrier family 45, member 4 -0.0168107
NBEAL1 neurobeachin-like 1 -0.0167854
HMGA2 high mobility group AT-hook 2 -0.0167431
APAF1 apoptotic peptidase activating factor 1 -0.0166329
ZNF217 zinc finger protein 217 -0.016465
TMEM135 transmembrane protein 135 -0.0163018
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0162524
KIAA1549L KIAA1549-like -0.016226
TAGLN2 transgelin 2 -0.0161764
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0161466
DENND2C DENN/MADD domain containing 2C -0.0159507
NDFIP1 Nedd4 family interacting protein 1 -0.0159396