HI-TOPK-032_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description HI-TOPK-032 perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the HI-TOPK-032_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.175995
LMO7 LIM domain 7 0.168476
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.108462
SPTBN1 spectrin, beta, non-erythrocytic 1 0.106304
LCN2 lipocalin 2 0.0951578
ASPH aspartate beta-hydroxylase 0.0860566
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0785826
ANXA1 annexin A1 0.0751252
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0749305
EMP1 epithelial membrane protein 1 0.0704863
MYOF myoferlin 0.059496
ITGA6 integrin, alpha 6 0.0580004
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0574716
CALR calreticulin 0.0548469
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0547468
MYH9 myosin, heavy chain 9, non-muscle 0.0545307
TM4SF1 transmembrane 4 L six family member 1 0.054194
MBNL2 muscleblind-like splicing regulator 2 0.0535414
MYO1E myosin IE 0.0526848
GDA guanine deaminase 0.0512761
HSPA8 heat shock 70kDa protein 8 0.0505499
EZR ezrin 0.0498871
PLEC plectin 0.0469926
SRRM2 serine/arginine repetitive matrix 2 0.0467711
RPS6 ribosomal protein S6 0.0465033
SLTM SAFB-like, transcription modulator 0.0458675
FLNB filamin B, beta 0.0444858
MACC1 metastasis associated in colon cancer 1 0.0436579
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0433022
AREG amphiregulin 0.04277
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0426637
NCEH1 neutral cholesterol ester hydrolase 1 0.0416403
AKAP13 A kinase (PRKA) anchor protein 13 0.0415724
RPS12 ribosomal protein S12 0.0414448
EHBP1 EH domain binding protein 1 0.0401638
MKI67 marker of proliferation Ki-67 0.0400768
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0389958
PTPRK protein tyrosine phosphatase, receptor type, K 0.0387543
DOCK5 dedicator of cytokinesis 5 0.0386901
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.03774
MCU mitochondrial calcium uniporter 0.0368146
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0363231
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0356967
UBASH3B ubiquitin associated and SH3 domain containing B 0.0352828
IFI6 interferon, alpha-inducible protein 6 0.0350081
CAPN8 calpain 8 0.0343168
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0342982
DST dystonin 0.0341871
EFNA5 ephrin-A5 0.0337379
TPM3 tropomyosin 3 0.033348
LAMA4 laminin, alpha 4 0.0329878
APLP2 amyloid beta (A4) precursor-like protein 2 0.0329669
CATSPERB catsper channel auxiliary subunit beta 0.032919
EPS8 epidermal growth factor receptor pathway substrate 8 0.0328135
FAT1 FAT atypical cadherin 1 0.032749
SMAD3 SMAD family member 3 0.0323323
SEPTIN9 septin 9 0.0313319
DSTN destrin (actin depolymerizing factor) 0.0308739
RPS3 ribosomal protein S3 0.0306083
GMDS GDP-mannose 4,6-dehydratase 0.0304206
S100A10 S100 calcium binding protein A10 0.0304073
TJP1 tight junction protein 1 0.0303148
SLC38A2 solute carrier family 38, member 2 0.0300631
SP100 SP100 nuclear antigen 0.0299365
AHNAK2 AHNAK nucleoprotein 2 0.0296559
SMC1A structural maintenance of chromosomes 1A 0.0295354
ATF7IP2 activating transcription factor 7 interacting protein 2 0.0295288
PDLIM5 PDZ and LIM domain 5 0.029342
MBNL1 muscleblind-like splicing regulator 1 0.0286367
CEMIP cell migration inducing protein, hyaluronan binding 0.0283547
SGMS2 sphingomyelin synthase 2 0.0275866
TMC5 transmembrane channel-like 5 0.0273913
SET SET nuclear proto-oncogene 0.0271114
POF1B premature ovarian failure, 1B 0.0270807
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0266444
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0265943
PTMA prothymosin, alpha 0.0265629
MACF1 microtubule-actin crosslinking factor 1 0.026125
CTTN cortactin 0.0255566
ARHGAP21 Rho GTPase activating protein 21 0.025545
HSPH1 heat shock 105kDa/110kDa protein 1 0.0255278
FLNA filamin A, alpha 0.0254937
SOX4 SRY (sex determining region Y)-box 4 0.0253944
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0251289
SLK STE20-like kinase 0.0242923
SNX9 sorting nexin 9 0.0240302
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0239273
LIMA1 LIM domain and actin binding 1 0.0235941
RPS17 ribosomal protein S17 0.0235786
EDN1 endothelin 1 0.0233089
CSNK1A1 casein kinase 1, alpha 1 0.022899
LMNA lamin A/C 0.0228352
TMSB4X thymosin beta 4, X-linked 0.0227546
IFI27 interferon, alpha-inducible protein 27 0.0226458
PSD3 pleckstrin and Sec7 domain containing 3 0.0224809
ZSWIM6 zinc finger, SWIM-type containing 6 0.0223839
ASTN2 astrotactin 2 0.0221489
MAML2 mastermind-like 2 (Drosophila) 0.0221229
INTS6 integrator complex subunit 6 0.0214091
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0208066

decreased expression

Symbol Name Standardized Value
FGFR2 fibroblast growth factor receptor 2 -0.194957
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.147466
B2M beta-2-microglobulin -0.0912377
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0881156
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0818601
RPL35A ribosomal protein L35a -0.0812757
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0793765
RPLP1 ribosomal protein, large, P1 -0.0765892
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0619723
HLA-E major histocompatibility complex, class I, E -0.0594504
S100P S100 calcium binding protein P -0.057478
PGK1 phosphoglycerate kinase 1 -0.0573339
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0572663
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0570664
GARS1 glycyl-tRNA synthetase 1 -0.0567375
RAB1A RAB1A, member RAS oncogene family -0.0543387
LOC112694756 uncharaterized LOC112694756 -0.0518886
NPSR1 neuropeptide S receptor 1 -0.0513776
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0509638
INSIG1 insulin induced gene 1 -0.0476935
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0462755
SAMD12 sterile alpha motif domain containing 12 -0.0456984
ZFAND3 zinc finger, AN1-type domain 3 -0.0442317
ATF5 activating transcription factor 5 -0.0439496
ACACA acetyl-CoA carboxylase alpha -0.0433389
BIRC6 baculoviral IAP repeat containing 6 -0.0419808
WDR45B WD repeat domain 45B -0.0412026
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0401679
EIF1 eukaryotic translation initiation factor 1 -0.0399795
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -0.0389909
DLG1 discs, large homolog 1 (Drosophila) -0.0387283
TMEM123 transmembrane protein 123 -0.037764
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0377066
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0374542
RBM39 RNA binding motif protein 39 -0.0372434
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.037236
TES testin LIM domain protein -0.036756
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.036539
KDM3A lysine (K)-specific demethylase 3A -0.0359812
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0359353
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0350104
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0348866
RAB6A RAB6A, member RAS oncogene family -0.034549
POTEF POTE ankyrin domain family, member F -0.0343846
ZNF292 zinc finger protein 292 -0.0339499
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0338271
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0336542
PRSS3 protease, serine, 3 -0.0334622
TMSB10 thymosin beta 10 -0.0329918
IARS1 isoleucyl-tRNA synthetase 1 -0.0329252
RRBP1 ribosome binding protein 1 -0.0328938
RB1CC1 RB1-inducible coiled-coil 1 -0.0325488
CD46 CD46 molecule, complement regulatory protein -0.0324474
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0321823
NF1 neurofibromin 1 -0.0321204
MUC17 mucin 17, cell surface associated -0.0316886
AVL9 AVL9 homolog (S. cerevisiase) -0.0314865
UBE4A ubiquitination factor E4A -0.0314727
CLTC clathrin, heavy chain (Hc) -0.0314599
LYZ lysozyme -0.031277
ANLN anillin, actin binding protein -0.0309863
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0309459
XPO1 exportin 1 -0.0306577
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -0.0306213
RSF1 remodeling and spacing factor 1 -0.0301075
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0300933
EPCAM epithelial cell adhesion molecule -0.0300757
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0299903
ALDOC aldolase C, fructose-bisphosphate -0.0296592
FASN fatty acid synthase -0.0295151
HLA-C major histocompatibility complex, class I, C -0.0294362
PIAS1 protein inhibitor of activated STAT, 1 -0.029189
HMGA1 high mobility group AT-hook 1 -0.0289848
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0288574
DEK DEK proto-oncogene -0.0288316
AGR2 anterior gradient 2 -0.0284286
SEC63 SEC63 homolog (S. cerevisiae) -0.0281519
ACSL1 acyl-CoA synthetase long-chain family member 1 -0.0279153
CLDN7 claudin 7 -0.0279122
CD164 CD164 molecule, sialomucin -0.0278277
RPS21 ribosomal protein S21 -0.0277779
MSMO1 methylsterol monooxygenase 1 -0.0271341
ZMYND8 zinc finger, MYND-type containing 8 -0.0271319
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0270359
LMAN1 lectin, mannose-binding, 1 -0.0267553
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase -0.0267529
KMT2A lysine (K)-specific methyltransferase 2A -0.0266062
WSB1 WD repeat and SOCS box containing 1 -0.0264076
RTN3 reticulon 3 -0.0263745
RPS19 ribosomal protein S19 -0.0260627
ACBD3 acyl-CoA binding domain containing 3 -0.02601
KLHL24 kelch-like family member 24 -0.0260011
ACSS2 acyl-CoA synthetase short-chain family member 2 -0.0259991
CANX calnexin -0.0259962
S100A9 S100 calcium binding protein A9 -0.0259831
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0255245
WARS1 tryptophanyl-tRNA synthetase 1 -0.0254509
HLA-A major histocompatibility complex, class I, A -0.0254299
SLC38A1 solute carrier family 38, member 1 -0.0251267
SREBF2 sterol regulatory element binding transcription factor 2 -0.0249946