| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | HI-TOPK-032 perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the HI-TOPK-032_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.190335 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.11608 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0632328 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0492983 |
| RPS12 | ribosomal protein S12 | 0.0484992 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0444229 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0426983 |
| ONECUT3 | one cut homeobox 3 | 0.0423755 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0363372 |
| MYO1E | myosin IE | 0.0355041 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0354763 |
| FHIT | fragile histidine triad | 0.0346521 |
| ACTG1 | actin gamma 1 | 0.0312673 |
| EGFR | epidermal growth factor receptor | 0.0306322 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0293875 |
| H1-0 | H1.0 linker histone | 0.0282016 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0276008 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0273859 |
| RPLP2 | ribosomal protein, large, P2 | 0.0271442 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0269981 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0264625 |
| RPS27A | ribosomal protein S27a | 0.0259551 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0242974 |
| MUC13 | mucin 13, cell surface associated | 0.0234603 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.02325 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0230527 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0230286 |
| RPS8 | ribosomal protein S8 | 0.0226974 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0226797 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0225545 |
| RPS6 | ribosomal protein S6 | 0.0218721 |
| DST | dystonin | 0.0217355 |
| RPS17 | ribosomal protein S17 | 0.021539 |
| CADPS | Ca++-dependent secretion activator | 0.0214889 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0207404 |
| RIGI | RNA sensor RIG-I | 0.0205859 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.020464 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0203618 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0203421 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.020335 |
| RAD51B | RAD51 paralog B | 0.020301 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0201842 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | 0.0197686 |
| LURAP1L | leucine rich adaptor protein 1-like | 0.0196141 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | 0.0194349 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0194031 |
| RPL38 | ribosomal protein L38 | 0.0193269 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0192042 |
| PCDH9 | protocadherin 9 | 0.0189346 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0186555 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0180502 |
| TRAPPC9 | trafficking protein particle complex 9 | 0.0178442 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0176634 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0175907 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.017391 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0173566 |
| MTAP | methylthioadenosine phosphorylase | 0.0173139 |
| MKI67 | marker of proliferation Ki-67 | 0.0172311 |
| SQSTM1 | sequestosome 1 | 0.0171245 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0169312 |
| VCL | vinculin | 0.0168858 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0168083 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0167653 |
| FOXP1 | forkhead box P1 | 0.0165943 |
| B4GALNT3 | beta-1,4-N-acetyl-galactosaminyl transferase 3 | 0.016572 |
| WWOX | WW domain containing oxidoreductase | 0.0165364 |
| PDE10A | phosphodiesterase 10A | 0.0161919 |
| RPL36A | ribosomal protein L36a | 0.0160755 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.015699 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0154198 |
| CCND1 | cyclin D1 | 0.0154166 |
| RPL9 | ribosomal protein L9 | 0.0153938 |
| PDZD8 | PDZ domain containing 8 | 0.0153804 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0152189 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.015145 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.014953 |
| H1-4 | H1.4 linker histone, cluster member | 0.0149438 |
| SET | SET nuclear proto-oncogene | 0.0149066 |
| EXOC4 | exocyst complex component 4 | 0.0148305 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | 0.0148296 |
| FLNA | filamin A, alpha | 0.0145628 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0145156 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0143083 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0141775 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0141371 |
| ASB4 | ankyrin repeat and SOCS box containing 4 | 0.0140045 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0139934 |
| MARCHF3 | membrane associated ring-CH-type finger 3 | 0.013913 |
| TGFBR3 | transforming growth factor, beta receptor III | 0.0138934 |
| OASL | 2'-5'-oligoadenylate synthetase-like | 0.0138108 |
| RPL37A | ribosomal protein L37a | 0.0137896 |
| SSU72 | SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae) | 0.0137696 |
| CD44 | CD44 molecule (Indian blood group) | 0.0137453 |
| HSPE1 | heat shock 10kDa protein 1 | 0.0137192 |
| SAMD5 | sterile alpha motif domain containing 5 | 0.0136906 |
| SP100 | SP100 nuclear antigen | 0.0136603 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0136464 |
| RPL26 | ribosomal protein L26 | 0.0136431 |
| TMSB4X | thymosin beta 4, X-linked | 0.0135537 |
| TUBA1B | tubulin, alpha 1b | 0.0135008 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.206527 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.178885 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | -0.161672 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.109539 |
| GOLGA4 | golgin A4 | -0.101159 |
| NDRG1 | N-myc downstream regulated 1 | -0.100665 |
| ANXA2 | annexin A2 | -0.0996599 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0935547 |
| ITGA6 | integrin, alpha 6 | -0.0910731 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0820465 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0783194 |
| TXNIP | thioredoxin interacting protein | -0.0760199 |
| LDHA | lactate dehydrogenase A | -0.0747809 |
| FAM13A | family with sequence similarity 13, member A | -0.0741057 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.073129 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0704953 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0690946 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0684647 |
| RNF145 | ring finger protein 145 | -0.0656699 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0630155 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0629732 |
| MED13L | mediator complex subunit 13-like | -0.0621615 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0609884 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0603158 |
| FLNB | filamin B, beta | -0.0593729 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.058552 |
| HMGA1 | high mobility group AT-hook 1 | -0.0580794 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0579375 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.057728 |
| SETD5 | SET domain containing 5 | -0.0566546 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0558587 |
| WDR45B | WD repeat domain 45B | -0.0558196 |
| EZR | ezrin | -0.0556851 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0555507 |
| PTEN | phosphatase and tensin homolog | -0.0554963 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0535792 |
| RBM39 | RNA binding motif protein 39 | -0.0535064 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | -0.053375 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0522614 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0515947 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0515271 |
| INSIG1 | insulin induced gene 1 | -0.0510112 |
| S100P | S100 calcium binding protein P | -0.0508697 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0506646 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0504239 |
| CCNY | cyclin Y | -0.0499229 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0499203 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0493987 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0493621 |
| GDF15 | growth differentiation factor 15 | -0.0492841 |
| GPHN | gephyrin | -0.0486815 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0485774 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0484941 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0467069 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | -0.0465008 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | -0.0465 |
| TMSB10 | thymosin beta 10 | -0.0459683 |
| CD46 | CD46 molecule, complement regulatory protein | -0.0446458 |
| PGK1 | phosphoglycerate kinase 1 | -0.0443216 |
| SBF2 | SET binding factor 2 | -0.0440794 |
| FNBP1L | formin binding protein 1-like | -0.0439753 |
| OGA | O-GlcNAcase | -0.0439586 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0439582 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0435545 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0434394 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0434153 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.0430305 |
| CALB1 | calbindin 1, 28kDa | -0.0424901 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0424381 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0422476 |
| COG5 | component of oligomeric golgi complex 5 | -0.0422347 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0420477 |
| COPA | coatomer protein complex, subunit alpha | -0.041398 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0411147 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0404887 |
| PPARG | peroxisome proliferator-activated receptor gamma | -0.0401407 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | -0.0398809 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0398727 |
| USP3 | ubiquitin specific peptidase 3 | -0.0398685 |
| GLG1 | golgi glycoprotein 1 | -0.0395917 |
| EXOC1 | exocyst complex component 1 | -0.0395404 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0391916 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0385545 |
| TFG | TRK-fused gene | -0.0384956 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0382542 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | -0.0381335 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0377858 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0377202 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0376571 |
| NFIA | nuclear factor I/A | -0.0376495 |
| ZNF292 | zinc finger protein 292 | -0.0375109 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0372776 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0371791 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0370455 |
| MED13 | mediator complex subunit 13 | -0.0370193 |
| MUC17 | mucin 17, cell surface associated | -0.035902 |
| PERP | PERP, TP53 apoptosis effector | -0.0356374 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.0355252 |
| ITGB4 | integrin, beta 4 | -0.0353708 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.03507 |
