HI-TOPK-032_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description HI-TOPK-032 perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the HI-TOPK-032_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PSD3 pleckstrin and Sec7 domain containing 3 0.165916
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.132851
TM4SF1 transmembrane 4 L six family member 1 0.119458
CAPRIN2 caprin family member 2 0.0717867
BCAR3 breast cancer anti-estrogen resistance 3 0.0639441
MT1E metallothionein 1E 0.0629145
WWTR1 WW domain containing transcription regulator 1 0.0577451
SP100 SP100 nuclear antigen 0.0573783
TPT1 tumor protein, translationally-controlled 1 0.0571231
ZBTB38 zinc finger and BTB domain containing 38 0.0549683
ANGPTL4 angiopoietin-like 4 0.0513763
AREG amphiregulin 0.0505907
CFLAR CASP8 and FADD-like apoptosis regulator 0.044873
UBC ubiquitin C 0.0443449
HDAC9 histone deacetylase 9 0.0411559
GCLM glutamate-cysteine ligase, modifier subunit 0.0387322
NCEH1 neutral cholesterol ester hydrolase 1 0.0373735
PRELID2 PRELI domain containing 2 0.0371054
ARHGAP5 Rho GTPase activating protein 5 0.0370069
FMNL2 formin-like 2 0.0364445
VIM vimentin 0.0355945
MT1X metallothionein 1X 0.0342013
RPS12 ribosomal protein S12 0.0339956
CD44 CD44 molecule (Indian blood group) 0.0339657
ZDHHC14 zinc finger, DHHC-type containing 14 0.0332912
BIRC3 baculoviral IAP repeat containing 3 0.0329789
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0312412
F2R coagulation factor II (thrombin) receptor 0.0301773
TMSB4X thymosin beta 4, X-linked 0.0299308
VCL vinculin 0.0297674
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.029711
HPCAL1 hippocalcin-like 1 0.0296216
SVIL supervillin 0.0295013
CXCL8 chemokine (C-X-C motif) ligand 8 0.0290644
NTSR1 neurotensin receptor 1 (high affinity) 0.0290644
RPL38 ribosomal protein L38 0.0288768
HOMER1 homer scaffolding protein 1 0.0288745
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0279064
BICD1 bicaudal D homolog 1 (Drosophila) 0.0276847
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0272148
SGMS2 sphingomyelin synthase 2 0.0269853
RPS27A ribosomal protein S27a 0.0268635
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0265982
SOX9 SRY (sex determining region Y)-box 9 0.0261601
NT5E 5'-nucleotidase, ecto (CD73) 0.0261195
LPP LIM domain containing preferred translocation partner in lipoma 0.0260519
SON SON DNA binding protein 0.0259526
EREG epiregulin 0.025908
RPS3 ribosomal protein S3 0.0256683
EMP1 epithelial membrane protein 1 0.0250737
KTN1 kinectin 1 (kinesin receptor) 0.0246862
RUNX1 runt-related transcription factor 1 0.0245233
NPAS2 neuronal PAS domain protein 2 0.024438
CAPN2 calpain 2, (m/II) large subunit 0.0243046
RPL37A ribosomal protein L37a 0.0240568
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 0.024016
IGF2 insulin-like growth factor 2 0.023992
LOC102724023 ES1 protein homolog, mitochondrial 0.0237642
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 0.0236921
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.023474
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0232917
RPL26 ribosomal protein L26 0.0231745
RPS17 ribosomal protein S17 0.0225869
RPL12 ribosomal protein L12 0.0215217
RPL36A ribosomal protein L36a 0.0215145
NEK10 NIMA-related kinase 10 0.0213645
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.0212868
MB21D2 Mab-21 domain containing 2 0.0210435
SRRM2 serine/arginine repetitive matrix 2 0.0209497
PDE10A phosphodiesterase 10A 0.0207592
S100A6 S100 calcium binding protein A6 0.0202634
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0193814
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0193758
ERCC1 excision repair cross-complementation group 1 0.0192618
HLA-B major histocompatibility complex, class I, B 0.0189815
BIRC2 baculoviral IAP repeat containing 2 0.0188198
OSBPL8 oxysterol binding protein-like 8 0.0182544
RPL32 ribosomal protein L32 0.0181583
SQSTM1 sequestosome 1 0.0180836
CMIP c-Maf inducing protein 0.0173704
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0173424
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0172821
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0172319
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.017193
RPL18 ribosomal protein L18 0.0170263
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0168127
JUN jun proto-oncogene 0.0165826
KLF6 Kruppel-like factor 6 0.0165211
RPL5 ribosomal protein L5 0.016337
HSPA8 heat shock 70kDa protein 8 0.0163321
TRIM56 tripartite motif containing 56 0.0163063
PLK2 polo-like kinase 2 0.0162964
H1-0 H1.0 linker histone 0.0162731
RPLP2 ribosomal protein, large, P2 0.0161741
THSD4 thrombospondin, type I, domain containing 4 0.0161605
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0158219
MACF1 microtubule-actin crosslinking factor 1 0.0158156
RPL19 ribosomal protein L19 0.0157804
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1 0.0157302
CSF3 colony stimulating factor 3 (granulocyte) 0.0156841

decreased expression

Symbol Name Standardized Value
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0890133
DLG1 discs, large homolog 1 (Drosophila) -0.0763405
POTEF POTE ankyrin domain family, member F -0.0744594
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0704552
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0699304
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0687967
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0680064
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0663127
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0633302
PTMA prothymosin, alpha -0.0593015
RPL35A ribosomal protein L35a -0.0501506
LDHA lactate dehydrogenase A -0.0490013
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0466768
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0463817
FTH1 ferritin, heavy polypeptide 1 -0.0461368
CADM2 cell adhesion molecule 2 -0.0456422
FTL ferritin, light polypeptide -0.0453819
COL5A2 collagen, type V, alpha 2 -0.0451207
PGK1 phosphoglycerate kinase 1 -0.045003
BIRC6 baculoviral IAP repeat containing 6 -0.0436041
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0435223
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0435124
NAMPT nicotinamide phosphoribosyltransferase -0.0430805
PIAS2 protein inhibitor of activated STAT, 2 -0.0414808
APP amyloid beta (A4) precursor protein -0.0403683
WNK1 WNK lysine deficient protein kinase 1 -0.0374451
CENPF centromere protein F, 350/400kDa -0.0371011
EFNA5 ephrin-A5 -0.0370924
EGR1 early growth response 1 -0.0370244
HMGA1 high mobility group AT-hook 1 -0.0369752
SMC4 structural maintenance of chromosomes 4 -0.0357612
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0338095
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0333017
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0325052
PKM pyruvate kinase, muscle -0.0323531
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0322891
GSK3B glycogen synthase kinase 3 beta -0.0322353
XPO1 exportin 1 -0.0321271
PRRC2B proline-rich coiled-coil 2B -0.0321233
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0320123
TNS3 tensin 3 -0.0318333
WARS1 tryptophanyl-tRNA synthetase 1 -0.0317854
TSC22D1 TSC22 domain family, member 1 -0.0311603
ZMYND8 zinc finger, MYND-type containing 8 -0.0308407
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0305442
DST dystonin -0.0304347
ACACA acetyl-CoA carboxylase alpha -0.0302897
RTN4 reticulon 4 -0.030054
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0300003
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -0.0296528
TAPBP TAP binding protein (tapasin) -0.0296093
EPHA4 EPH receptor A4 -0.0293499
ACTG1 actin gamma 1 -0.0289838
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0289586
SRPK2 SRSF protein kinase 2 -0.0289101
ETNK1 ethanolamine kinase 1 -0.0288443
TUBB4B tubulin, beta 4B class IVb -0.0286685
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0285812
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0283749
EZR ezrin -0.0282408
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.028015
DPYD dihydropyrimidine dehydrogenase -0.0279772
TXNRD1 thioredoxin reductase 1 -0.0277754
LOC112694756 uncharaterized LOC112694756 -0.0275205
SERBP1 SERPINE1 mRNA binding protein 1 -0.0275028
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase -0.0274014
WASF2 WAS protein family, member 2 -0.0272769
FNIP1 folliculin interacting protein 1 -0.0272123
AHCTF1 AT hook containing transcription factor 1 -0.0272061
MAP4 microtubule-associated protein 4 -0.0270719
AFF4 AF4/FMR2 family, member 4 -0.0270342
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0270194
TTC28 tetratricopeptide repeat domain 28 -0.0270108
YBX1 Y box binding protein 1 -0.0269726
EEF2 eukaryotic translation elongation factor 2 -0.0267779
PCBP2 poly(rC) binding protein 2 -0.0267752
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0267529
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0266491
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0265235
MATR3 matrin 3 -0.0264268
UBE3C ubiquitin protein ligase E3C -0.0262441
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0259133
CFAP299 cilia and flagella associated protein 299 -0.0255371
PRDX1 peroxiredoxin 1 -0.0254617
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 -0.0253387
OLA1 Obg-like ATPase 1 -0.0253281
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0252808
ZNF292 zinc finger protein 292 -0.0251539
NF1 neurofibromin 1 -0.0247139
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.024558
TRIO trio Rho guanine nucleotide exchange factor -0.0243973
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.023973
AMBRA1 autophagy/beclin-1 regulator 1 -0.0238747
CLTC clathrin, heavy chain (Hc) -0.0238529
FAF1 Fas (TNFRSF6) associated factor 1 -0.0237588
SLC38A1 solute carrier family 38, member 1 -0.0235391
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -0.0234537
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0233999
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0233439
ARF6 ADP-ribosylation factor 6 -0.0233375