| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | HI-TOPK-032 perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the HI-TOPK-032_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.153487 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.118212 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0647783 |
| TPM3 | tropomyosin 3 | 0.059351 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0560078 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0451356 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0433788 |
| MKI67 | marker of proliferation Ki-67 | 0.039944 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0390977 |
| PRELID2 | PRELI domain containing 2 | 0.0385638 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0384547 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0351867 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0343508 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0341968 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0341259 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0340742 |
| CENPF | centromere protein F, 350/400kDa | 0.0310214 |
| PTMA | prothymosin, alpha | 0.0302916 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.029569 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0294553 |
| GOLGB1 | golgin B1 | 0.0283942 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0273482 |
| CALR | calreticulin | 0.0270603 |
| UBC | ubiquitin C | 0.0264572 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0264403 |
| DSPP | dentin sialophosphoprotein | 0.0264256 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0260703 |
| HDGF | hepatoma-derived growth factor | 0.0259011 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0251114 |
| BBX | bobby sox homolog (Drosophila) | 0.0245868 |
| HLA-B | major histocompatibility complex, class I, B | 0.0242562 |
| CANX | calnexin | 0.0240535 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.024032 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0233486 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0227051 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | 0.0224953 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.0222687 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0218323 |
| XPOT | exportin, tRNA | 0.0217497 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0215298 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0213603 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0211571 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0210478 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0210432 |
| CTTN | cortactin | 0.020997 |
| TPM4 | tropomyosin 4 | 0.0208713 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.020347 |
| IER3 | immediate early response 3 | 0.0197255 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0190846 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0189706 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0188391 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0186048 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0184297 |
| SRP72 | signal recognition particle 72kDa | 0.0184291 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0180945 |
| SGO2 | shugoshin 2 | 0.0180143 |
| HDLBP | high density lipoprotein binding protein | 0.0178976 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | 0.0175804 |
| SMARCA5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 | 0.0173875 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0173559 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.017028 |
| SSB | Sjogren syndrome antigen B (autoantigen La) | 0.016915 |
| VCP | valosin containing protein | 0.0169062 |
| DST | dystonin | 0.0168685 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0168405 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0166545 |
| UBB | ubiquitin B | 0.0165927 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0163202 |
| CIP2A | cellular inhibitor of PP2A | 0.0162169 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0161909 |
| S100A10 | S100 calcium binding protein A10 | 0.0159548 |
| AEBP2 | AE binding protein 2 | 0.0159201 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0159013 |
| SET | SET nuclear proto-oncogene | 0.0158714 |
| METTL21A | methyltransferase like 21A | 0.0158146 |
| TUBA1B | tubulin, alpha 1b | 0.0157733 |
| DNAJC2 | DnaJ (Hsp40) homolog, subfamily C, member 2 | 0.0157151 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0155835 |
| WWOX | WW domain containing oxidoreductase | 0.0155687 |
| TPX2 | TPX2, microtubule-associated | 0.0155007 |
| KMT5B | lysine methyltransferase 5B | 0.0154681 |
| MTERF1 | mitochondrial transcription termination factor 1 | 0.0154473 |
| TPR | translocated promoter region, nuclear basket protein | 0.015263 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.0151265 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0151206 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | 0.0151168 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.015006 |
| PRKCE | protein kinase C, epsilon | 0.0149735 |
| H1-3 | H1.3 linker histone, cluster member | 0.0149327 |
| ADAR | adenosine deaminase, RNA-specific | 0.0146778 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0146707 |
| PRC1 | protein regulator of cytokinesis 1 | 0.0146026 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0144816 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0144429 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0144095 |
| KIF4A | kinesin family member 4A | 0.0144044 |
| STC1 | stanniocalcin 1 | 0.0143411 |
| STIP1 | stress-induced phosphoprotein 1 | 0.014098 |
| JMJD1C | jumonji domain containing 1C | 0.013942 |
| ENO1 | enolase 1, (alpha) | 0.0138942 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TFPI2 | tissue factor pathway inhibitor 2 | -0.122492 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.113019 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.096564 |
| TXNRD1 | thioredoxin reductase 1 | -0.0932636 |
| VIM | vimentin | -0.0918432 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.080926 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0610546 |
| NABP1 | nucleic acid binding protein 1 | -0.0602999 |
| EGR1 | early growth response 1 | -0.0600978 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0563084 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0521735 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0499434 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.048489 |
| VCL | vinculin | -0.0426213 |
| RPLP1 | ribosomal protein, large, P1 | -0.0425006 |
| RPS21 | ribosomal protein S21 | -0.0416561 |
| OSMR | oncostatin M receptor | -0.0407881 |
| MCL1 | myeloid cell leukemia 1 | -0.0403224 |
| GPHN | gephyrin | -0.0403205 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0400049 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0399323 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0393663 |
| RTN4 | reticulon 4 | -0.0381063 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0379575 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0366258 |
| GATAD2B | GATA zinc finger domain containing 2B | -0.0357206 |
| WNK1 | WNK lysine deficient protein kinase 1 | -0.0352567 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0351936 |
| POTEF | POTE ankyrin domain family, member F | -0.0347888 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0344396 |
| CDK17 | cyclin-dependent kinase 17 | -0.033705 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0329872 |
| RPS27 | ribosomal protein S27 | -0.0327609 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0324926 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0315173 |
| RPLP0 | ribosomal protein, large, P0 | -0.030975 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0307651 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0299763 |
| PDE10A | phosphodiesterase 10A | -0.029864 |
| GRAMD1B | GRAM domain containing 1B | -0.0293091 |
| LRRC23 | leucine rich repeat containing 23 | -0.02922 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0289102 |
| ETNK1 | ethanolamine kinase 1 | -0.028531 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0284811 |
| RPS29 | ribosomal protein S29 | -0.0280785 |
| LATS2 | large tumor suppressor kinase 2 | -0.0278068 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0277525 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.027443 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0269311 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0267613 |
| USP34 | ubiquitin specific peptidase 34 | -0.0264014 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0262973 |
| TMSB10 | thymosin beta 10 | -0.0262896 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | -0.0261735 |
| WDR70 | WD repeat domain 70 | -0.0260252 |
| SRPK2 | SRSF protein kinase 2 | -0.025792 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0252772 |
| VMP1 | vacuole membrane protein 1 | -0.0252005 |
| SMYD3 | SET and MYND domain containing 3 | -0.0249221 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0247057 |
| FMNL2 | formin-like 2 | -0.0245481 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0240589 |
| BRD2 | bromodomain containing 2 | -0.0240283 |
| RPL35A | ribosomal protein L35a | -0.0239832 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.023891 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0237871 |
| RUSC2 | RUN and SH3 domain containing 2 | -0.0236851 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0235627 |
| JAK1 | Janus kinase 1 | -0.0235615 |
| RAB10 | RAB10, member RAS oncogene family | -0.0233305 |
| CALD1 | caldesmon 1 | -0.0233209 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0229764 |
| ITSN1 | intersectin 1 (SH3 domain protein) | -0.0226718 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0226623 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0225787 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0223982 |
| SBF2 | SET binding factor 2 | -0.0222121 |
| ZNF638 | zinc finger protein 638 | -0.0219237 |
| RPL28 | ribosomal protein L28 | -0.021882 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | -0.0217128 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0216266 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0213801 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0212934 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0209193 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0208897 |
| RPS12 | ribosomal protein S12 | -0.0207835 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0207139 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0206108 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0204845 |
| SFPQ | splicing factor proline/glutamine-rich | -0.0204323 |
| TMEM165 | transmembrane protein 165 | -0.020424 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0201297 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.020113 |
| PTK2 | protein tyrosine kinase 2 | -0.0199656 |
| ANKRD28 | ankyrin repeat domain 28 | -0.019862 |
| TPI1 | triosephosphate isomerase 1 | -0.0196481 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0196155 |
| TEX14 | testis expressed 14 | -0.0193956 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0192752 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.019231 |
