| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | HI-TOPK-032 perturbation in SNU-423 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the HI-TOPK-032_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.132775 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.132504 |
| CD44 | CD44 molecule (Indian blood group) | 0.132461 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.108982 |
| COL6A3 | collagen, type VI, alpha 3 | 0.105588 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.102073 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0943777 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0809159 |
| VEGFA | vascular endothelial growth factor A | 0.0803124 |
| HMGA2 | high mobility group AT-hook 2 | 0.0750255 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0695427 |
| VCAN | versican | 0.0683435 |
| GLIS3 | GLIS family zinc finger 3 | 0.0676503 |
| MT2A | metallothionein 2A | 0.0672249 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.061757 |
| ASPH | aspartate beta-hydroxylase | 0.0601105 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0587569 |
| ADM | adrenomedullin | 0.0579801 |
| NDRG1 | N-myc downstream regulated 1 | 0.0579149 |
| RPS6 | ribosomal protein S6 | 0.0530491 |
| NAV2 | neuron navigator 2 | 0.0510221 |
| MSN | moesin | 0.0481795 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0465089 |
| MKI67 | marker of proliferation Ki-67 | 0.044927 |
| RPS12 | ribosomal protein S12 | 0.0447713 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0445453 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0438984 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0402301 |
| SYNJ2 | synaptojanin 2 | 0.0399862 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0399202 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0398584 |
| RPLP2 | ribosomal protein, large, P2 | 0.0388196 |
| HDAC9 | histone deacetylase 9 | 0.0380784 |
| DUSP10 | dual specificity phosphatase 10 | 0.0376057 |
| FMNL2 | formin-like 2 | 0.0365227 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0352713 |
| CDCP1 | CUB domain containing protein 1 | 0.0351084 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0348376 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0346647 |
| SVIL | supervillin | 0.0343568 |
| VMP1 | vacuole membrane protein 1 | 0.0331642 |
| RPS4X | ribosomal protein S4, X-linked | 0.0331048 |
| ENO1 | enolase 1, (alpha) | 0.0328245 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0323317 |
| FLNA | filamin A, alpha | 0.032299 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0310377 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0306524 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0300431 |
| CALR | calreticulin | 0.0299125 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0295216 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0293507 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0292114 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.028954 |
| KYNU | kynureninase | 0.028628 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 0.0285685 |
| STC1 | stanniocalcin 1 | 0.0283814 |
| HLA-B | major histocompatibility complex, class I, B | 0.0272103 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0261689 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0261537 |
| ICAM1 | intercellular adhesion molecule 1 | 0.026055 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0257903 |
| WEE1 | WEE1 G2 checkpoint kinase | 0.0256106 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0256044 |
| STC2 | stanniocalcin 2 | 0.0254114 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0248669 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0247276 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.0243556 |
| MT1X | metallothionein 1X | 0.0239167 |
| ANGPTL4 | angiopoietin-like 4 | 0.0234407 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0232472 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0231761 |
| ZNF292 | zinc finger protein 292 | 0.0229382 |
| NRP1 | neuropilin 1 | 0.0229371 |
| SFTPA2 | surfactant protein A2 | 0.0228059 |
| RPL3 | ribosomal protein L3 | 0.0225575 |
| FLNB | filamin B, beta | 0.0225248 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0222401 |
| MYO10 | myosin X | 0.0221843 |
| COL1A2 | collagen, type I, alpha 2 | 0.0221134 |
| BICC1 | BicC family RNA binding protein 1 | 0.0219697 |
| MCL1 | myeloid cell leukemia 1 | 0.0219387 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | 0.0217544 |
| TPM3 | tropomyosin 3 | 0.0216991 |
| CENPF | centromere protein F, 350/400kDa | 0.0211685 |
| RPL32 | ribosomal protein L32 | 0.021164 |
| RPL21 | ribosomal protein L21 | 0.0210936 |
| LAMB1 | laminin, beta 1 | 0.021075 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.021028 |
| RPL5 | ribosomal protein L5 | 0.0208357 |
| TMSB4X | thymosin beta 4, X-linked | 0.0207952 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0207119 |
| EZR | ezrin | 0.0203979 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0203 |
| UBC | ubiquitin C | 0.0202033 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0200833 |
| CTSB | cathepsin B | 0.0200712 |
| ARRDC3 | arrestin domain containing 3 | 0.0200332 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0199067 |
| TGM2 | transglutaminase 2 | 0.0198318 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.0197385 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SOD2 | superoxide dismutase 2, mitochondrial | -0.214484 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.166575 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.145421 |
| FRMD4A | FERM domain containing 4A | -0.113392 |
| CADM1 | cell adhesion molecule 1 | -0.10683 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.100876 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0692369 |
| VCL | vinculin | -0.0686419 |
| PGK1 | phosphoglycerate kinase 1 | -0.0672941 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0594225 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0591493 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0584894 |
| VIM | vimentin | -0.0539616 |
| FRMPD4 | FERM and PDZ domain containing 4 | -0.0513042 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0509679 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0493953 |
| PDE10A | phosphodiesterase 10A | -0.0423393 |
| FTL | ferritin, light polypeptide | -0.0405716 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0395856 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0394026 |
| DIAPH2 | diaphanous-related formin 2 | -0.0370018 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.036909 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0369046 |
| OGA | O-GlcNAcase | -0.0363213 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.036074 |
| DST | dystonin | -0.0356129 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0350727 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.034164 |
| CLIC4 | chloride intracellular channel 4 | -0.0334243 |
| INSIG1 | insulin induced gene 1 | -0.0327512 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0321276 |
| RAI14 | retinoic acid induced 14 | -0.0318148 |
| RPL35A | ribosomal protein L35a | -0.0309192 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0307607 |
| MAP4 | microtubule-associated protein 4 | -0.0305382 |
| CANX | calnexin | -0.0303627 |
| ARFGAP3 | ADP-ribosylation factor GTPase activating protein 3 | -0.030327 |
| FOXO3 | forkhead box O3 | -0.0301733 |
| ACTG1 | actin gamma 1 | -0.0300394 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0300182 |
| MYOF | myoferlin | -0.029885 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0298622 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0297918 |
| CDH13 | cadherin 13 | -0.0297619 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.029562 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0295126 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0291837 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.028642 |
| GRIN2A | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | -0.0284045 |
| CCBE1 | collagen and calcium binding EGF domains 1 | -0.0282513 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0281349 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0273678 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0273105 |
| FAM20C | family with sequence similarity 20, member C | -0.0272711 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | -0.0270025 |
| RTN4 | reticulon 4 | -0.0268556 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0267872 |
| PHF3 | PHD finger protein 3 | -0.0267489 |
| AHNAK | AHNAK nucleoprotein | -0.0266183 |
| TMEM263 | transmembrane protein 263 | -0.0265626 |
| TKT | transketolase | -0.0264814 |
| PTMA | prothymosin, alpha | -0.026472 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0264476 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0264388 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | -0.0259663 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0259252 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0259223 |
| GNAS | GNAS complex locus | -0.0259005 |
| RPS24 | ribosomal protein S24 | -0.0257024 |
| WDR45B | WD repeat domain 45B | -0.0256887 |
| TPM4 | tropomyosin 4 | -0.025436 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0253734 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0252153 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0249971 |
| PCBP3 | poly(rC) binding protein 3 | -0.0248982 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0248633 |
| TENM2 | teneurin transmembrane protein 2 | -0.0248417 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.024678 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0245428 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0245272 |
| PALLD | palladin, cytoskeletal associated protein | -0.0231232 |
| SEC63 | SEC63 homolog (S. cerevisiae) | -0.0230271 |
| EGR1 | early growth response 1 | -0.0228775 |
| SBF2 | SET binding factor 2 | -0.0228037 |
| IER3 | immediate early response 3 | -0.0224918 |
| WTAP | Wilms tumor 1 associated protein | -0.0223369 |
| NR6A1 | nuclear receptor subfamily 6, group A, member 1 | -0.0221741 |
| RBM39 | RNA binding motif protein 39 | -0.0221175 |
| KAZN | kazrin, periplakin interacting protein | -0.0218151 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0217952 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0213671 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0213129 |
| RTN3 | reticulon 3 | -0.0212895 |
| LDHA | lactate dehydrogenase A | -0.0212891 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0210328 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0207588 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0207145 |
| NABP1 | nucleic acid binding protein 1 | -0.0206885 |
| SEC24A | SEC24 family member A | -0.0206809 |
| PLIN2 | perilipin 2 | -0.0206377 |
