| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | HI-TOPK-032 perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the HI-TOPK-032_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.21116 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.167089 |
| COL6A3 | collagen, type VI, alpha 3 | 0.152512 |
| STC1 | stanniocalcin 1 | 0.122114 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0971129 |
| HMGA2 | high mobility group AT-hook 2 | 0.0926623 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0814133 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0760076 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.075969 |
| KYNU | kynureninase | 0.0677839 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0664137 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0601581 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0582959 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0572706 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0572318 |
| ASPH | aspartate beta-hydroxylase | 0.0561237 |
| AHNAK | AHNAK nucleoprotein | 0.0538792 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0513412 |
| WNT5A | wingless-type MMTV integration site family, member 5A | 0.0509869 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.049196 |
| HIP1 | huntingtin interacting protein 1 | 0.0479287 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0461066 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0419946 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0393128 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0387497 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0383524 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0375237 |
| FAM13A | family with sequence similarity 13, member A | 0.0374056 |
| ALK | anaplastic lymphoma receptor tyrosine kinase | 0.0371417 |
| CALR | calreticulin | 0.0370775 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.036133 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0358464 |
| NRXN3 | neurexin 3 | 0.0358284 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0356823 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0338568 |
| GCC2 | GRIP and coiled-coil domain containing 2 | 0.0333299 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0331772 |
| MYOF | myoferlin | 0.032785 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0319456 |
| CD44 | CD44 molecule (Indian blood group) | 0.0312022 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0308798 |
| HPCAL1 | hippocalcin-like 1 | 0.030771 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0307353 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0305509 |
| JMJD1C | jumonji domain containing 1C | 0.0299953 |
| S100A10 | S100 calcium binding protein A10 | 0.02997 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0298636 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0298476 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0292317 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.029151 |
| CANX | calnexin | 0.0288078 |
| ANO6 | anoctamin 6 | 0.0285314 |
| CDK6 | cyclin-dependent kinase 6 | 0.0285308 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0283918 |
| HDLBP | high density lipoprotein binding protein | 0.0282369 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0279561 |
| OXR1 | oxidation resistance 1 | 0.0278885 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0278802 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0278516 |
| TOP1 | topoisomerase (DNA) I | 0.0277154 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0276826 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0276003 |
| CDH13 | cadherin 13 | 0.0274683 |
| SMAD3 | SMAD family member 3 | 0.0273401 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0269439 |
| CAVIN1 | caveolae associated protein 1 | 0.0265822 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0263542 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0261705 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0259056 |
| SON | SON DNA binding protein | 0.0254797 |
| EMP1 | epithelial membrane protein 1 | 0.0254401 |
| ACVR1 | activin A receptor, type I | 0.0253864 |
| MTPN | myotrophin | 0.0253048 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0251602 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0251227 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0250185 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | 0.0249733 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0248468 |
| SETBP1 | SET binding protein 1 | 0.0244696 |
| SYNGAP1 | synaptic Ras GTPase activating protein 1 | 0.024255 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0239509 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | 0.0237856 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0237069 |
| MCL1 | myeloid cell leukemia 1 | 0.0236998 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | 0.0236198 |
| RBM15 | RNA binding motif protein 15 | 0.0234947 |
| UBC | ubiquitin C | 0.0234518 |
| CCND1 | cyclin D1 | 0.0232992 |
| USO1 | USO1 vesicle transport factor | 0.0232274 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.0230673 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0229972 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0228349 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0228302 |
| ITGA11 | integrin, alpha 11 | 0.0225846 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.022418 |
| ECE1 | endothelin converting enzyme 1 | 0.0223593 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0220843 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0219156 |
| FOXJ3 | forkhead box J3 | 0.0214816 |
| TRIM56 | tripartite motif containing 56 | 0.0214657 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.17325 |
| POTEF | POTE ankyrin domain family, member F | -0.156576 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.151644 |
| TMSB10 | thymosin beta 10 | -0.132814 |
| B2M | beta-2-microglobulin | -0.105566 |
| FTL | ferritin, light polypeptide | -0.0885312 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0848746 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0784279 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0740215 |
| HLA-B | major histocompatibility complex, class I, B | -0.0703419 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0647408 |
| TPM1 | tropomyosin 1 (alpha) | -0.0630065 |
| PGK1 | phosphoglycerate kinase 1 | -0.0615417 |
| ENO1 | enolase 1, (alpha) | -0.0614401 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0612902 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0585769 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0574069 |
| COL1A1 | collagen, type I, alpha 1 | -0.0549368 |
| KDELR2 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 | -0.0540036 |
| PKM | pyruvate kinase, muscle | -0.0538467 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0538397 |
| LDHA | lactate dehydrogenase A | -0.0533973 |
| RPL35A | ribosomal protein L35a | -0.0500034 |
| NDRG1 | N-myc downstream regulated 1 | -0.0499152 |
| RPLP1 | ribosomal protein, large, P1 | -0.049837 |
| IL6 | interleukin 6 | -0.0472834 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0468529 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0445396 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0415603 |
| RTN4 | reticulon 4 | -0.041484 |
| PTMA | prothymosin, alpha | -0.0414244 |
| GLG1 | golgi glycoprotein 1 | -0.0408539 |
| MT1X | metallothionein 1X | -0.0404797 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0398099 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0397826 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0388441 |
| KAZN | kazrin, periplakin interacting protein | -0.0385464 |
| S100A9 | S100 calcium binding protein A9 | -0.038111 |
| SEPTIN7 | septin 7 | -0.0375506 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0375039 |
| HLA-A | major histocompatibility complex, class I, A | -0.0374401 |
| TMEM165 | transmembrane protein 165 | -0.036669 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0362812 |
| TPM4 | tropomyosin 4 | -0.035486 |
| S100A6 | S100 calcium binding protein A6 | -0.034767 |
| STC2 | stanniocalcin 2 | -0.0345857 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0341407 |
| TAGLN2 | transgelin 2 | -0.033495 |
| TMSB4X | thymosin beta 4, X-linked | -0.0327931 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0324923 |
| COL5A2 | collagen, type V, alpha 2 | -0.0323798 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0321846 |
| H3-3B | H3.3 histone B | -0.0318872 |
| LMNA | lamin A/C | -0.0317938 |
| PFN1 | profilin 1 | -0.0310692 |
| COL1A2 | collagen, type I, alpha 2 | -0.030895 |
| TUBA1B | tubulin, alpha 1b | -0.0305114 |
| RPS21 | ribosomal protein S21 | -0.03015 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | -0.0301256 |
| RBM25 | RNA binding motif protein 25 | -0.0298663 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.0296489 |
| MT2A | metallothionein 2A | -0.0288927 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.028792 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0286916 |
| CTSD | cathepsin D | -0.0286546 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0283417 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.028146 |
| SLPI | secretory leukocyte peptidase inhibitor | -0.0276944 |
| GNAS | GNAS complex locus | -0.0274992 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.027421 |
| TUBB | tubulin, beta class I | -0.0271606 |
| MAP1B | microtubule-associated protein 1B | -0.0269167 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0266646 |
| WASF2 | WAS protein family, member 2 | -0.0265861 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0265613 |
| MYADM | myeloid-associated differentiation marker | -0.0263656 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0263131 |
| PRRC1 | proline-rich coiled-coil 1 | -0.026211 |
| SBF2 | SET binding factor 2 | -0.0261444 |
| TNPO1 | transportin 1 | -0.0260315 |
| YAP1 | Yes-associated protein 1 | -0.0258815 |
| FBN1 | fibrillin 1 | -0.0257777 |
| PLOD1 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 | -0.0250077 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | -0.0250008 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0249688 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.0246944 |
| EIF5AL1 | eukaryotic translation initiation factor 5A-like 1 | -0.0245971 |
| TNS3 | tensin 3 | -0.0243345 |
| RPS23 | ribosomal protein S23 | -0.0237276 |
| MMP24OS | MMP24 opposite strand | -0.0237029 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0236996 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0235847 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | -0.0235426 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0231363 |
| ARF4 | ADP-ribosylation factor 4 | -0.0230977 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0227124 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.022647 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0221296 |
| RPS8 | ribosomal protein S8 | -0.0220668 |
| AP1G1 | adaptor-related protein complex 1, gamma 1 subunit | -0.022035 |
