| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | HI-TOPK-032 perturbation in SW 1271 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the HI-TOPK-032_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.16937 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.129225 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.12848 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0674131 |
| FMNL2 | formin-like 2 | 0.0618321 |
| ENO1 | enolase 1, (alpha) | 0.0588891 |
| ANGPTL4 | angiopoietin-like 4 | 0.0556592 |
| RPS12 | ribosomal protein S12 | 0.054298 |
| PRKCA | protein kinase C, alpha | 0.0532293 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0526994 |
| SVIL | supervillin | 0.0504355 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0497661 |
| FUS | FUS RNA binding protein | 0.0482657 |
| CALR | calreticulin | 0.0462815 |
| ASPH | aspartate beta-hydroxylase | 0.0459515 |
| CD44 | CD44 molecule (Indian blood group) | 0.0452131 |
| AREG | amphiregulin | 0.0445943 |
| SMAD3 | SMAD family member 3 | 0.0445845 |
| TXNIP | thioredoxin interacting protein | 0.0442633 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0422219 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 0.0409182 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0395277 |
| SET | SET nuclear proto-oncogene | 0.0395007 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0384926 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0366862 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0366063 |
| FLNA | filamin A, alpha | 0.0352223 |
| FN1 | fibronectin 1 | 0.0349454 |
| KLF3 | Kruppel-like factor 3 (basic) | 0.034918 |
| GPC5 | glypican 5 | 0.0347948 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | 0.0344744 |
| PLEC | plectin | 0.0340777 |
| CCND1 | cyclin D1 | 0.0339569 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0336891 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0334898 |
| CDCP1 | CUB domain containing protein 1 | 0.0329839 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0328458 |
| AHNAK | AHNAK nucleoprotein | 0.0327727 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0325793 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0324103 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.031873 |
| RPS3 | ribosomal protein S3 | 0.0316773 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0312445 |
| PRR16 | proline rich 16 | 0.0305343 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0304463 |
| RASAL2 | RAS protein activator like 2 | 0.0304404 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.030426 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0295561 |
| CDK6 | cyclin-dependent kinase 6 | 0.0292854 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | 0.0289942 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0288535 |
| HPCAL1 | hippocalcin-like 1 | 0.0284658 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.028341 |
| TPI1 | triosephosphate isomerase 1 | 0.0282891 |
| HMGA2 | high mobility group AT-hook 2 | 0.028076 |
| RPLP2 | ribosomal protein, large, P2 | 0.0280059 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0280054 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0280006 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0278677 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0274184 |
| INTS6 | integrator complex subunit 6 | 0.026829 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0265842 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0265666 |
| S100A10 | S100 calcium binding protein A10 | 0.0262293 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0261873 |
| RPL38 | ribosomal protein L38 | 0.0258568 |
| SLMAP | sarcolemma associated protein | 0.0256125 |
| ZFHX3 | zinc finger homeobox 3 | 0.0256061 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0256008 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0253826 |
| NOP56 | NOP56 ribonucleoprotein | 0.0248516 |
| CD9 | CD9 molecule | 0.0245271 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0245224 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0244697 |
| E2F7 | E2F transcription factor 7 | 0.0244226 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | 0.0241534 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0234753 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0233253 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0232862 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0232705 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0232648 |
| TNFAIP1 | tumor necrosis factor, alpha-induced protein 1 (endothelial) | 0.0232466 |
| DDX18 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 | 0.02313 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0229777 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0227926 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.022649 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.022553 |
| EZR | ezrin | 0.0224757 |
| CENPB | centromere protein B, 80kDa | 0.0224249 |
| LRP11 | low density lipoprotein receptor-related protein 11 | 0.0224249 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.022409 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0223472 |
| CHD9 | chromodomain helicase DNA binding protein 9 | 0.022294 |
| BRD2 | bromodomain containing 2 | 0.02224 |
| MYO9A | myosin IXA | 0.0222142 |
| CAVIN1 | caveolae associated protein 1 | 0.0222119 |
| FHIT | fragile histidine triad | 0.0220925 |
| ITGA6 | integrin, alpha 6 | 0.0220056 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 0.0219621 |
| ARHGAP35 | Rho GTPase activating protein 35 | 0.0217992 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.115066 |
| SMYD3 | SET and MYND domain containing 3 | -0.0984107 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0970593 |
| RBM39 | RNA binding motif protein 39 | -0.0798405 |
| OSMR | oncostatin M receptor | -0.0767371 |
| LDHA | lactate dehydrogenase A | -0.0707579 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0705459 |
| NF1 | neurofibromin 1 | -0.0699351 |
| MAPKAP1 | mitogen-activated protein kinase associated protein 1 | -0.069295 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0629706 |
| GNAS | GNAS complex locus | -0.0619446 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0611875 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0602566 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0602168 |
| NUP58 | nucleoporin 58 | -0.0585648 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0574813 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0556063 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0553304 |
| SETD5 | SET domain containing 5 | -0.0540922 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0532638 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0523965 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0516029 |
| KIAA1328 | KIAA1328 | -0.0508057 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0503689 |
| SEC24A | SEC24 family member A | -0.0484631 |
| SGO2 | shugoshin 2 | -0.0484281 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0482127 |
| TPX2 | TPX2, microtubule-associated | -0.0477552 |
| PTMA | prothymosin, alpha | -0.0471142 |
| ECT2 | epithelial cell transforming 2 | -0.0469234 |
| ATM | ATM serine/threonine kinase | -0.0465898 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0456504 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0440573 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0438118 |
| DNER | delta/notch-like EGF repeat containing | -0.0435681 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0431875 |
| DIAPH3 | diaphanous-related formin 3 | -0.0430358 |
| RAB33B | RAB33B, member RAS oncogene family | -0.0430235 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0429522 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.042855 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0425946 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0423497 |
| DEK | DEK proto-oncogene | -0.0417186 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0412028 |
| ZBTB10 | zinc finger and BTB domain containing 10 | -0.0410761 |
| CD2AP | CD2-associated protein | -0.0410213 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | -0.0405617 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0400117 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0395247 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | -0.0392446 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.038898 |
| ZNF638 | zinc finger protein 638 | -0.0388426 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0387628 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0385824 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0378569 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0377171 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0369366 |
| RPLP1 | ribosomal protein, large, P1 | -0.0368067 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0366228 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0360741 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0360464 |
| GOLGA4 | golgin A4 | -0.035612 |
| PCNX1 | pecanex 1 | -0.0353053 |
| RCOR1 | REST corepressor 1 | -0.0352422 |
| NAV2 | neuron navigator 2 | -0.0350951 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0348751 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0348234 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0345418 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.034366 |
| TPM4 | tropomyosin 4 | -0.0343161 |
| METTL15 | methyltransferase like 15 | -0.0340972 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0340252 |
| NKTR | natural killer cell triggering receptor | -0.0339833 |
| EHMT1 | euchromatic histone-lysine N-methyltransferase 1 | -0.0339701 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | -0.0338867 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0335871 |
| RPL35A | ribosomal protein L35a | -0.0335641 |
| NCOA6 | nuclear receptor coactivator 6 | -0.0335348 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0334294 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0329685 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0328286 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0327914 |
| PDE8A | phosphodiesterase 8A | -0.0327415 |
| KIF4A | kinesin family member 4A | -0.0323746 |
| CUL5 | cullin 5 | -0.0320514 |
| PDSS2 | prenyl (decaprenyl) diphosphate synthase, subunit 2 | -0.0320353 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0318787 |
| ATP13A3 | ATPase type 13A3 | -0.031837 |
| SDC4 | syndecan 4 | -0.0316297 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0313935 |
| WDR45B | WD repeat domain 45B | -0.031346 |
| FNDC3B | fibronectin type III domain containing 3B | -0.031154 |
| RBM33 | RNA binding motif protein 33 | -0.030923 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.0306212 |
| HDLBP | high density lipoprotein binding protein | -0.0305347 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0305131 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0303463 |
| FNIP1 | folliculin interacting protein 1 | -0.0303443 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0303066 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | -0.0301876 |
