HI-TOPK-032_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description HI-TOPK-032 perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the HI-TOPK-032_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HMGA2 high mobility group AT-hook 2 0.175676
ASPH aspartate beta-hydroxylase 0.152799
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.143658
NRG1 neuregulin 1 0.108951
ITGA1 integrin, alpha 1 0.0767784
HIPK2 homeodomain interacting protein kinase 2 0.0767397
FN1 fibronectin 1 0.0742824
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0742644
TMEM156 transmembrane protein 156 0.0680704
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0648416
EXT1 exostosin glycosyltransferase 1 0.0624206
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0566657
AHR aryl hydrocarbon receptor 0.055578
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0538592
GLIS3 GLIS family zinc finger 3 0.0537018
NRP1 neuropilin 1 0.0530626
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0473141
EREG epiregulin 0.0426363
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0401061
RAI14 retinoic acid induced 14 0.0383985
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.038145
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0370802
STC2 stanniocalcin 2 0.0367972
NTN4 netrin 4 0.0364214
LTBP1 latent transforming growth factor beta binding protein 1 0.0360341
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0350292
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0346832
SVIL supervillin 0.034581
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0341853
PDE4D phosphodiesterase 4D, cAMP-specific 0.0333168
FNDC3B fibronectin type III domain containing 3B 0.0325614
IFI44L interferon-induced protein 44-like 0.0314397
MCTP2 multiple C2 domains, transmembrane 2 0.0314347
TMSB4X thymosin beta 4, X-linked 0.0311053
RNF213 ring finger protein 213 0.0310666
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0308291
IL6ST interleukin 6 signal transducer 0.0306629
OSMR oncostatin M receptor 0.0306098
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0300647
TTC28 tetratricopeptide repeat domain 28 0.0297771
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0294608
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0290146
LIMCH1 LIM and calponin homology domains 1 0.0285703
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0283827
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0283569
IFI16 interferon, gamma-inducible protein 16 0.027712
FOXP1 forkhead box P1 0.0275697
TOP1 topoisomerase (DNA) I 0.0273603
EFNA5 ephrin-A5 0.0272403
NPAS2 neuronal PAS domain protein 2 0.0265635
SOX4 SRY (sex determining region Y)-box 4 0.0258849
FNDC3A fibronectin type III domain containing 3A 0.0258393
ANTXR2 anthrax toxin receptor 2 0.0255957
SRRM2 serine/arginine repetitive matrix 2 0.0253907
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0251508
VEGFC vascular endothelial growth factor C 0.0249128
DOCK5 dedicator of cytokinesis 5 0.0247006
MAP1B microtubule-associated protein 1B 0.0246714
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0245516
SYT1 synaptotagmin I 0.0239631
DST dystonin 0.0238692
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0238515
ANKRD28 ankyrin repeat domain 28 0.0238207
ATXN1 ataxin 1 0.0228784
MKI67 marker of proliferation Ki-67 0.0224813
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0224452
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0222686
DUSP6 dual specificity phosphatase 6 0.0220683
LRMDA leucine rich melanocyte differentiation associated 0.0216246
NRIP1 nuclear receptor interacting protein 1 0.0213619
MAML2 mastermind-like 2 (Drosophila) 0.0213115
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0212167
RAB31 RAB31, member RAS oncogene family 0.0211498
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.021108
TXNIP thioredoxin interacting protein 0.0209768
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0209483
CAPN2 calpain 2, (m/II) large subunit 0.0209221
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0208473
SON SON DNA binding protein 0.0208449
ELL2 elongation factor, RNA polymerase II, 2 0.0207318
ADAR adenosine deaminase, RNA-specific 0.0206292
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0204355
CANX calnexin 0.0203777
SYNJ2 synaptojanin 2 0.0198242
PRRC2C proline-rich coiled-coil 2C 0.0197447
NBEA neurobeachin 0.0194917
ARHGAP35 Rho GTPase activating protein 35 0.0193739
TMEM131 transmembrane protein 131 0.0189643
NAMPT nicotinamide phosphoribosyltransferase 0.0189632
ANKRD11 ankyrin repeat domain 11 0.0189553
NT5E 5'-nucleotidase, ecto (CD73) 0.0189162
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0189075
LMNA lamin A/C 0.0188944
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0188567
PXMP2 peroxisomal membrane protein 2, 22kDa 0.0187875
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0187458
CARD16 caspase recruitment domain family, member 16 0.0187225
ERRFI1 ERBB receptor feedback inhibitor 1 0.0185088
AOPEP aminopeptidase O (putative) 0.0183265
ZC3H12C zinc finger CCCH-type containing 12C 0.0182237

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.203893
PTMA prothymosin, alpha -0.122422
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0919137
FTL ferritin, light polypeptide -0.0861624
FTH1 ferritin, heavy polypeptide 1 -0.0822752
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0773067
NDRG1 N-myc downstream regulated 1 -0.0767001
RPL35A ribosomal protein L35a -0.0756754
RPS6 ribosomal protein S6 -0.0687845
VIM vimentin -0.0687437
TMSB10 thymosin beta 10 -0.0664528
MT2A metallothionein 2A -0.0629306
B2M beta-2-microglobulin -0.0609574
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0506998
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0433859
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0431339
TPT1 tumor protein, translationally-controlled 1 -0.0416747
RPS29 ribosomal protein S29 -0.041593
ENO2 enolase 2 (gamma, neuronal) -0.0410626
POTEF POTE ankyrin domain family, member F -0.0402868
RPL37 ribosomal protein L37 -0.0393834
RPS8 ribosomal protein S8 -0.0386983
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0385958
RPLP1 ribosomal protein, large, P1 -0.0376753
PEG10 paternally expressed 10 -0.0366618
ACTG1 actin gamma 1 -0.0364866
RPS20 ribosomal protein S20 -0.0357529
RPS16 ribosomal protein S16 -0.0355556
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0354417
RPL31 ribosomal protein L31 -0.0351236
LOC112694756 uncharaterized LOC112694756 -0.0350523
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0345931
EIF1 eukaryotic translation initiation factor 1 -0.0342662
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0340666
RPS11 ribosomal protein S11 -0.0339415
RPL11 ribosomal protein L11 -0.0337472
LDHA lactate dehydrogenase A -0.0330583
HILPDA hypoxia inducible lipid droplet-associated -0.0313974
VMP1 vacuole membrane protein 1 -0.0310008
RPL23 ribosomal protein L23 -0.0304968
EGR1 early growth response 1 -0.0303566
RPL9 ribosomal protein L9 -0.0300765
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0299634
RPS23 ribosomal protein S23 -0.0297506
HMGA1 high mobility group AT-hook 1 -0.0294991
PKM pyruvate kinase, muscle -0.0290686
PGK1 phosphoglycerate kinase 1 -0.0285202
RPS3 ribosomal protein S3 -0.0284884
SOD2 superoxide dismutase 2, mitochondrial -0.0284425
RPL37A ribosomal protein L37a -0.0283215
TMEM165 transmembrane protein 165 -0.0278451
RPS25 ribosomal protein S25 -0.0277697
SEPTIN7 septin 7 -0.0276993
FLNB filamin B, beta -0.0276833
RPS14 ribosomal protein S14 -0.0270712
RPS13 ribosomal protein S13 -0.0258772
PIM3 Pim-3 proto-oncogene, serine/threonine kinase -0.0258172
COG5 component of oligomeric golgi complex 5 -0.0250431
ATP5F1B ATP synthase F1 subunit beta -0.0249203
RPS5 ribosomal protein S5 -0.0237727
RPS12 ribosomal protein S12 -0.0236183
RPL34 ribosomal protein L34 -0.0235337
RAB1A RAB1A, member RAS oncogene family -0.0231634
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0229546
RAB7A RAB7A, member RAS oncogene family -0.0229347
CTSD cathepsin D -0.0224573
RPS24 ribosomal protein S24 -0.0224091
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.022376
GOLGA4 golgin A4 -0.0222477
KDM5B lysine (K)-specific demethylase 5B -0.0222269
RPLP2 ribosomal protein, large, P2 -0.0221612
RPL7 ribosomal protein L7 -0.0218274
RTN3 reticulon 3 -0.0217325
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0213484
RPLP0 ribosomal protein, large, P0 -0.0213019
CADM1 cell adhesion molecule 1 -0.0212794
LRRC23 leucine rich repeat containing 23 -0.0212251
RPS27 ribosomal protein S27 -0.0206338
QSOX1 quiescin Q6 sulfhydryl oxidase 1 -0.0205042
HLA-B major histocompatibility complex, class I, B -0.0203218
RUNX1 runt-related transcription factor 1 -0.0201942
RPL28 ribosomal protein L28 -0.020115
GLS2 glutaminase 2 (liver, mitochondrial) -0.0200739
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0199561
RPL38 ribosomal protein L38 -0.0197496
KPNB1 karyopherin (importin) beta 1 -0.0196563
PCBP2 poly(rC) binding protein 2 -0.0195448
SRSF11 serine/arginine-rich splicing factor 11 -0.0191843
RPL19 ribosomal protein L19 -0.0191761
FOXO3 forkhead box O3 -0.0190411
RPL5 ribosomal protein L5 -0.0189843
RPL13A ribosomal protein L13a -0.0189739
EEF1G eukaryotic translation elongation factor 1 gamma -0.0189129
COPA coatomer protein complex, subunit alpha -0.0187821
RPS19 ribosomal protein S19 -0.0186422
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0185678
RAB6A RAB6A, member RAS oncogene family -0.0184035
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0182066
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0181989
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0181138