HIC1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description hypermethylated in cancer 1|This gene functions as a growth regulatory and tumor repressor gene. Hypermethylation or deletion of the region of this gene have been associated with tumors and the contiguous-gene syndrome, Miller-Dieker syndrome. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2010] (NCBI Entrez Gene Database, 3090)
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Genes

285 genes differentially expressed following the HIC1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
BTNL8 butyrophilin-like 8 2.60268
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like 2.60268
NELL1 NEL-like 1 (chicken) 2.60268
PIWIL3 piwi-like RNA-mediated gene silencing 3 2.60268
HORMAD2 HORMA domain containing 2 2.60268
PCDHB11 protocadherin beta 11 2.60268
WDFY4 WDFY family member 4 2.60268
SCEL sciellin 2.60268
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 2.60268
TMIGD1 transmembrane and immunoglobulin domain containing 1 2.60268
TEX12 testis expressed 12 2.60268
C2ORF78 chromosome 2 open reading frame 78 2.60268
CABP4 calcium binding protein 4 2.60268
MVD mevalonate (diphospho) decarboxylase 2.60268
TAS2R46 taste receptor, type 2, member 46 2.60268
RORC RAR-related orphan receptor C 2.60268
CSNK2A2IP casein kinase 2 subunit alpha' interacting protein 2.60268
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 2.60268
CD22 CD22 molecule 2.60268
NIM1K NIM1 serine/threonine protein kinase 2.60268
HPGDS hematopoietic prostaglandin D synthase 2.60268
TFRC transferrin receptor 2.60268
PGC progastricsin (pepsinogen C) 2.60268
SPIDR scaffolding protein involved in DNA repair 2.54394
CST11 cystatin 11 2.51433
ADGRE1 adhesion G protein-coupled receptor E1 2.51433
PCDHA1 protocadherin alpha 1 2.51433
OR2A25 olfactory receptor, family 2, subfamily A, member 25 2.51433
SELPLG selectin P ligand 2.51433
SLC22A10 solute carrier family 22, member 10 2.51433
CFHR4 complement factor H-related 4 2.51433
CFHR1 complement factor H-related 1 2.51433
GPR75 G protein-coupled receptor 75 2.51433
IGFL2 IGF-like family member 2 2.51433
HMX3 H6 family homeobox 3 2.51433
ANAPC13 anaphase promoting complex subunit 13 2.51433
SCGB3A1 secretoglobin, family 3A, member 1 2.51433
CRYGA crystallin, gamma A 2.51433
KIF25 kinesin family member 25 2.51433
C8ORF74 chromosome 8 open reading frame 74 2.51433
CX3CR1 chemokine (C-X3-C motif) receptor 1 2.51433
SPRR1B small proline-rich protein 1B 2.51433
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 2.51433
TUBB1 tubulin, beta 1 class VI 2.51433
DMRTC1B DMRT-like family C1B 2.51433
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 2.51433
AFM afamin 2.51433
PGBDF plakoglobin binding and degradation factor 2.51433
MBD3L3 methyl-CpG binding domain protein 3-like 3 2.51433
CELF3 CUGBP, Elav-like family member 3 2.51433
PRSS41 protease, serine, 41 2.51433
IRF5 interferon regulatory factor 5 2.51433
CCDC190 coiled-coil domain containing 190 2.51433
CRACDL CRACD like 2.51433
CCN5 cellular communication network factor 5 2.51433
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 2.51433
HTD2 hydroxyacyl-thioester dehydratase type 2 2.51433
STING1 stimulator of interferon response cGAMP interactor 1 2.51433
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 2.51433
PTH1R parathyroid hormone 1 receptor 2.51433
GSTT4 glutathione S-transferase theta 4 2.51433
TENT5D terminal nucleotidyltransferase 5D 2.51433
SPMIP1 sperm microtubule inner protein 1 2.51433
LY6S lymphocyte antigen 6 family member S 2.51433
C3ORF85 chromosome 3 open reading frame 85 2.51433
CIMIP3 ciliary microtubule inner protein 3 2.51433
SERTM2 serine rich and transmembrane domain containing 2 2.51433
MINDY4B MINDY family member 4B 2.51433
IHO1 interactor of HORMAD1 1 2.51433
TEX13D TEX13 family member D 2.51433
LTB4R2 leukotriene B4 receptor 2 2.51433
SPEM1 spermatid maturation 1 2.51433
RPL39L ribosomal protein L39-like 2.51433
MIP major intrinsic protein of lens fiber 2.51433
BHLHA9 basic helix-loop-helix family, member a9 2.51433
TLR8 toll-like receptor 8 2.51433
TLR1 toll-like receptor 1 2.51433
C1ORF162 chromosome 1 open reading frame 162 2.51433
ULBP1 UL16 binding protein 1 2.51433
OR51B5 olfactory receptor, family 51, subfamily B, member 5 2.51433
SPDYC speedy/RINGO cell cycle regulator family member C 2.51433
GKN2 gastrokine 2 2.51433
RD3 retinal degeneration 3 2.51433
TREX2 three prime repair exonuclease 2 2.51433
SAG S-antigen; retina and pineal gland (arrestin) 2.51433
LY6K lymphocyte antigen 6 complex, locus K 2.51433
IMPG1 interphotoreceptor matrix proteoglycan 1 2.51433
DLK2 delta-like 2 homolog (Drosophila) 2.51433
TAS1R3 taste receptor, type 1, member 3 2.51433
STARD6 StAR-related lipid transfer (START) domain containing 6 2.51433
OR9H1 olfactory receptor family 9 subfamily H member 1 pseudogene (gene/pseudogene) 2.51433
CRYAA crystallin, alpha A 2.51433
LY6G6C lymphocyte antigen 6 complex, locus G6C 2.51433
C2CD4B C2 calcium-dependent domain containing 4B 2.51433
EMP1 epithelial membrane protein 1 2.51433
TRIM50 tripartite motif containing 50 2.51433
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 2.51433
BPIFB1 BPI fold containing family B, member 1 2.51433
KLF2 Kruppel-like factor 2 2.51433
CTAGE4 CTAGE family, member 4 2.51433
C9ORF64 chromosome 9 open reading frame 64 2.51433
DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1 2.51433
CXCR6 chemokine (C-X-C motif) receptor 6 2.51433
CPA3 carboxypeptidase A3 (mast cell) 2.51433
ITGA8 integrin, alpha 8 2.51433
SYNE3 spectrin repeat containing, nuclear envelope family member 3 2.51433
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6 2.51433
CT55 cancer/testis antigen 55 2.51433
ERICH3 glutamate-rich 3 2.51433
IGFBP7 insulin-like growth factor binding protein 7 2.51433
PCDHGA2 protocadherin gamma subfamily A, 2 2.51433
CATIP ciliogenesis associated TTC17 interacting protein 2.51433
SPATA9 spermatogenesis associated 9 2.51433
LRRC24 leucine rich repeat containing 24 2.51433
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae) 2.51433
MB myoglobin 2.51433
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1 2.51433
ETV3L ets variant 3-like 2.51433
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 2.51433
LY6G6D lymphocyte antigen 6 complex, locus G6D 2.51433
GSC2 goosecoid homeobox 2 2.51433
SOSTDC1 sclerostin domain containing 1 2.51433
CTSC cathepsin C 2.51433
NR5A1 nuclear receptor subfamily 5, group A, member 1 2.51433
DLX2 distal-less homeobox 2 2.51433
CDH17 cadherin 17, LI cadherin (liver-intestine) 2.51433
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 2.51433
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 2.51433
ARL13A ADP-ribosylation factor-like 13A 2.51433
CFP complement factor properdin 2.51433
GAGE10 G antigen 10 2.51433
FGF10 fibroblast growth factor 10 2.51433
WFDC10A WAP four-disulfide core domain 10A 2.51433
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 2.51433
ANKRD30B ankyrin repeat domain 30B 2.51433
SLC38A8 solute carrier family 38, member 8 2.51433
TGM3 transglutaminase 3 2.51433
FOXG1 forkhead box G1 2.51433
LAMP3 lysosomal-associated membrane protein 3 2.51433
TRPM5 transient receptor potential cation channel, subfamily M, member 5 2.51433
CD86 CD86 molecule 2.51433
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 2.51433
PRAP1 proline-rich acidic protein 1 2.51433
THEM5 thioesterase superfamily member 5 2.51433
PSD2 pleckstrin and Sec7 domain containing 2 2.51433
NPAS4 neuronal PAS domain protein 4 2.51433
SPACA3 sperm acrosome associated 3 2.51433
THEMIS thymocyte selection associated 2.51433
IL17REL interleukin 17 receptor E-like 2.51433
OR6J1 olfactory receptor, family 6, subfamily J, member 1 (gene/pseudogene) 2.51433
TECTB tectorin beta 2.51433
PRSS54 protease, serine, 54 2.51433
ALOX5AP arachidonate 5-lipoxygenase-activating protein 2.51433
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 2.51433
ADGRF4 adhesion G protein-coupled receptor F4 2.51433
SLITRK1 SLIT and NTRK-like family, member 1 2.51433
SLITRK6 SLIT and NTRK-like family, member 6 2.51433
METTL21C methyltransferase like 21C 2.51433
TSKS testis-specific serine kinase substrate 2.51433
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 2.39936
CXCL3 chemokine (C-X-C motif) ligand 3 2.38473
PPP2R2B protein phosphatase 2, regulatory subunit B, beta 2.38473
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 2.38244
TDRD7 tudor domain containing 7 2.37802
IGSF6 immunoglobulin superfamily, member 6 2.35327
REP15 RAB15 effector protein 2.34329
CELA2B chymotrypsin-like elastase family, member 2B 2.33571
MAPK8 mitogen-activated protein kinase 8 2.33566
CCSER2 coiled-coil serine-rich protein 2 2.29476
TNNI3 troponin I type 3 (cardiac) 2.23996
AK5 adenylate kinase 5 2.23518
PTGR2 prostaglandin reductase 2 2.20654
GSPT1 G1 to S phase transition 1 2.16967
KIF23 kinesin family member 23 2.15494
PI4K2B phosphatidylinositol 4-kinase type 2 beta 2.15494
DCAF5 DDB1 and CUL4 associated factor 5 2.15494
CKAP2 cytoskeleton associated protein 2 2.1316
TMEM132B transmembrane protein 132B 2.13052
TMEM185B transmembrane protein 185B 2.13052
SERINC5 serine incorporator 5 2.12725
MRPL38 mitochondrial ribosomal protein L38 2.10719
CDC37 cell division cycle 37 2.10713
TM2D1 TM2 domain containing 1 2.0696
CLINT1 clathrin interactor 1 2.06938
TDP2 tyrosyl-DNA phosphodiesterase 2 2.05654
MICU2 mitochondrial calcium uptake 2 2.05391
RABL2A RAB, member of RAS oncogene family-like 2A 2.03125
XRN2 5'-3' exoribonuclease 2 2.03115
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 2.03072
STXBP3 syntaxin binding protein 3 2.02196
CPD carboxypeptidase D 2.02196

decreased expression

Symbol Name Standardized Value
CER1 cerberus 1, DAN family BMP antagonist -2.60268
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial -2.60268
NGEF neuronal guanine nucleotide exchange factor -2.60268
ASIP agouti signaling protein -2.60268
NPIPB7 nuclear pore complex interacting protein family, member B7 -2.60268
H2AZ2 H2A.Z variant histone 2 -2.60268
SEC24D SEC24 family member D -2.60268
CORT cortistatin -2.60268
COL12A1 collagen, type XII, alpha 1 -2.54394
MOGAT3 monoacylglycerol O-acyltransferase 3 -2.51433
GDPD1 glycerophosphodiester phosphodiesterase domain containing 1 -2.51433
ALX1 ALX homeobox 1 -2.51433
C1ORF146 chromosome 1 open reading frame 146 -2.51433
DAND5 DAN domain family member 5, BMP antagonist -2.51433
OR2A14 olfactory receptor, family 2, subfamily A, member 14 -2.51433
TBC1D3L TBC1 domain family, member 3L -2.51433
EPN3 epsin 3 -2.51433
PTCRA pre T-cell antigen receptor alpha -2.51433
A1CF APOBEC1 complementation factor -2.51433
ASGR1 asialoglycoprotein receptor 1 -2.51433
IL1R1 interleukin 1 receptor, type I -2.51433
PRSS36 protease, serine, 36 -2.51433
SCIN scinderin -2.51433
ZKSCAN5 zinc finger with KRAB and SCAN domains 5 -2.51433
PGAP3 post-GPI attachment to proteins 3 -2.51433
NGB neuroglobin -2.51433
MYMK myomaker, myoblast fusion factor -2.51433
PTPN20 protein tyrosine phosphatase, non-receptor type 20 -2.51433
ZNF99 zinc finger protein 99 -2.51433
OGDHL oxoglutarate dehydrogenase-like -2.51433
UNC93A unc-93 homolog A (C. elegans) -2.51433
TENT5C terminal nucleotidyltransferase 5C -2.51433
SRL sarcalumenin -2.51433
PLA2G5 phospholipase A2, group V -2.51433
PLCD4 phospholipase C, delta 4 -2.51433
ATP13A1 ATPase type 13A1 -2.51433
FOXA2 forkhead box A2 -2.51433
ULBP3 UL16 binding protein 3 -2.51433
RSAD2 radical S-adenosyl methionine domain containing 2 -2.51433
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) -2.51433
ZNF541 zinc finger protein 541 -2.51433
GDNF glial cell derived neurotrophic factor -2.51433
DRICH1 aspartate-rich 1 -2.51433
PLET1 placenta expressed transcript 1 -2.51433
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -2.42993
ADD1 adducin 1 (alpha) -2.42601
CDHR1 cadherin-related family member 1 -2.42427
GMFG glia maturation factor, gamma -2.41452
ATG4A autophagy related 4A, cysteine peptidase -2.41452
SGCE sarcoglycan, epsilon -2.40706
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -2.39936
MRPS12 mitochondrial ribosomal protein S12 -2.39327
WDR43 WD repeat domain 43 -2.33571
PKLR pyruvate kinase, liver and RBC -2.30311
FRMPD1 FERM and PDZ domain containing 1 -2.30311
OGN osteoglycin -2.30301
KLHL13 kelch-like family member 13 -2.29973
ZNF593 zinc finger protein 593 -2.27017
PRELID1 PRELI domain containing 1 -2.26915
CEBPB CCAAT/enhancer binding protein (C/EBP), beta -2.26572
SNAP91 synaptosomal-associated protein, 91kDa -2.25607
ACTR3C ARP3 actin-related protein 3 homolog C (yeast) -2.25607
OSTC oligosaccharyltransferase complex subunit (non-catalytic) -2.23646
TRIM61 tripartite motif containing 61 -2.23407
TBC1D24 TBC1 domain family, member 24 -2.18531
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -2.18531
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 -2.18531
CKS2 CDC28 protein kinase regulatory subunit 2 -2.16641
EMC8 ER membrane protein complex subunit 8 -2.16641
VLDLR very low density lipoprotein receptor -2.15596
CCDC141 coiled-coil domain containing 141 -2.13052
ZFYVE26 zinc finger, FYVE domain containing 26 -2.13052
BPNT1 3'(2'), 5'-bisphosphate nucleotidase 1 -2.11181
MASP2 mannan-binding lectin serine peptidase 2 -2.10439
DDI2 DNA-damage inducible 1 homolog 2 (S. cerevisiae) -2.10088
HINT2 histidine triad nucleotide binding protein 2 -2.09546
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) -2.0924
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2 -2.08648
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa -2.08553
ZNF711 zinc finger protein 711 -2.07871
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase -2.07871
ZNF668 zinc finger protein 668 -2.07819
ZNF24 zinc finger protein 24 -2.0774
CUBN cubilin (intrinsic factor-cobalamin receptor) -2.06938
POMZP3 POM121 and ZP3 fusion -2.06022
TRIM44 tripartite motif containing 44 -2.0414
TUBG1 tubulin, gamma 1 -2.03716
MFAP1 microfibrillar-associated protein 1 -2.03299
MRPL35 mitochondrial ribosomal protein L35 -2.03115
GPER1 G protein-coupled estrogen receptor 1 -2.02987
ASXL2 additional sex combs like transcriptional regulator 2 -2.02196
ALOX12B arachidonate 12-lipoxygenase, 12R type -2.01828
DDIT4 DNA-damage-inducible transcript 4 -2.00068
DUSP5 dual specificity phosphatase 5 -2.0005