HIF-1 signaling pathway Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. It consists of two subunits: an inducibly-expressed HIF-1alpha subunit and a constitutively-expressed HIF-1beta subunit. Under normoxia, HIF-1 alpha undergoes hydroxylation at specific prolyl residues which leads to an immediate ubiquitination and subsequent proteasomal degradation of the subunit. In contrast, under hypoxia, HIF-1 alpha subunit becomes stable and interacts with coactivators such as p300/CBP to modulate its transcriptional activity. Eventually, HIF-1 acts as a master regulator of numerous hypoxia-inducible genes under hypoxic conditions. The target genes of HIF-1 encode proteins that increase O2 delivery and mediate adaptive responses to O2 deprivation. Despite its name, HIF-1 is induced not only in response to reduced oxygen availability but also by other stimulants, such as nitric oxide, or various growth factors. (Kyoto Encyclopedia of Genes and Genomes, hsa04066)
External Link https://www.kegg.jp/entry/hsa04066
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Genes

110 proteins participating in the HIF-1 signaling pathway pathway from the KEGG Pathways 2026 dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALDOB aldolase B, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
ANGPT1 angiopoietin 1
ANGPT2 angiopoietin 2
ANGPT4 angiopoietin 4
BCL2 B-cell CLL/lymphoma 2
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CAMK2D calcium/calmodulin-dependent protein kinase II delta
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDPF1 cysteine-rich, DPF motif domain containing 1
CLSTN1 calsyntenin 1
CREBBP CREB binding protein
CUL2 cullin 2
CYBB cytochrome b-245, beta polypeptide
EDN1 endothelin 1
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EGLN1 egl-9 family hypoxia-inducible factor 1
EGLN2 egl-9 family hypoxia-inducible factor 2
EGLN3 egl-9 family hypoxia-inducible factor 3
EIF4E eukaryotic translation initiation factor 4E
EIF4E1B eukaryotic translation initiation factor 4E family member 1B
EIF4E2 eukaryotic translation initiation factor 4E family member 2
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELOB elongin B
ELOC elongin C
ENO1 enolase 1, (alpha)
ENO2 enolase 2 (gamma, neuronal)
ENO3 enolase 3 (beta, muscle)
EP300 E1A binding protein p300
EPAS1 endothelial PAS domain protein 1
EPX eosinophil peroxidase
ERBB2 erb-b2 receptor tyrosine kinase 2
FLT1 fms-related tyrosine kinase 1
GAPDH glyceraldehyde-3-phosphate dehydrogenase
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HKDC1 hexokinase domain containing 1
HMOX1 heme oxygenase 1
HOOK2 hook microtubule-tethering protein 2
HOOK3 hook microtubule-tethering protein 3
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IL6 interleukin 6
IL6R interleukin 6 receptor
INS insulin
INSR insulin receptor
LDHA lactate dehydrogenase A
LDHAL6A lactate dehydrogenase A-like 6A
LDHAL6B lactate dehydrogenase A-like 6B
LDHB lactate dehydrogenase B
LDHC lactate dehydrogenase C
LNCEGFL7OS lncRNA EGFL7 opposite strand
LOC112694756 uncharaterized LOC112694756
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MIA3 melanoma inhibitory activity family, member 3
MKNK1 MAP kinase interacting serine/threonine kinase 1
MKNK2 MAP kinase interacting serine/threonine kinase 2
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NANOS2 nanos homolog 2 (Drosophila)
NANOS3 nanos homolog 3 (Drosophila)
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NPPA natriuretic peptide A
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1
PDHA2 pyruvate dehydrogenase (lipoamide) alpha 2
PDHB pyruvate dehydrogenase (lipoamide) beta
PDPK1 3-phosphoinositide dependent protein kinase 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFKL phosphofructokinase, liver
PFKM phosphofructokinase, muscle
PFKP phosphofructokinase, platelet
PGK1 phosphoglycerate kinase 1
PGK2 phosphoglycerate kinase 2
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLCG1 phospholipase C, gamma 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCG protein kinase C, gamma
RBX1 ring-box 1, E3 ubiquitin protein ligase
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RPS6 ribosomal protein S6
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TAC4 tachykinin 4 (hemokinin)
TEK TEK tyrosine kinase, endothelial
TF transferrin
TFRC transferrin receptor
TIMP1 TIMP metallopeptidase inhibitor 1
TLR4 toll-like receptor 4
VEGFA vascular endothelial growth factor A
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase